Article
Clinical Neurology
Joerg B. Schulz, Peter Berlit, Hans-Christoph Diener, Christian Gerloff, Andreas Greinacher, Christine Klein, Gabor C. Petzold, Marco Piccininni, Sven Poli, Rainer Roehrig, Helmuth Steinmetz, Thomas Thiele, Tobias Kurth
Summary: The study found a higher incidence of cerebral sinus and venous thrombosis (CVT) after ChAdOx1 vaccination in Germany, especially among females. Among the 45 CVT patients, 26 were highly probable cases of vaccine-induced immune thrombotic thrombocytopenia (VITT).
ANNALS OF NEUROLOGY
(2021)
Article
Hematology
Damon E. Houghton, Waldemar Wysokinski, Ana Casanegra, Leslie J. Padrnos, Surbhi Shah, Ewa Wysokinska, Rajiv Pruthi, Aneel Ashrani, Meera Sridharan, Lisa Baumann-Kreuziger, Robert McBane, Anand Padmanabhan
Summary: This study analyzed the incidence of VTE before and after COVID-19 vaccination. The results showed that there was no increased risk of acute VTE post-vaccination for the authorized vaccines in the United States.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Christophe Vandenbriele, Diana A. Gorog
Summary: Pulmonary thromboembolism and deep venous thrombosis are common in hospitalized COVID-19 patients, especially in ICU and ECMO cases. Screening for thrombosis is recommended, with different approaches for ICU and general ward patients based on clinical features and D-dimer levels. Therapeutic anticoagulation may be considered in high-risk patients before screening.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Review
Cardiac & Cardiovascular Systems
Mouhand F. H. Mohamed, Shaikha D. Al-Shokri, Khaled M. Shunnar, Sara F. Mohamed, Mostafa S. Najim, Shahd I. Ibrahim, Hazem Elewa, Lina O. Abdalla, Ahmed El-Bardissy, Mohamed Nabil Elshafei, Ibrahim Y. Abubeker, Mohammed Danjuma, Khalid M. Dousa, Mohamed A. Yassin
Summary: Recent studies have shown a high prevalence of VTE in critically ill COVID-19 patients, with nearly 50% of patients detected with VTE through systematic screening. Initial analysis suggests that prophylactic anticoagulation may significantly increase the risk of VTE compared to therapeutic anticoagulation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Clinical Neurology
Adrian Scutelnic, Katarzyna Krzywicka, Joshua Mbroh, Anita van de Munckhof, Mayte Sanchez van Kammen, Diana Aguiar de Sousa, Erik Lindgren, Katarina Jood, Albrecht Guenther, Sini Hiltunen, Jukka Putaala, Andreas Tiede, Frank Maier, Rolf Kern, Thorsten Bartsch, Katharina Althaus, Alfonso Ciccone, Markus Wiedmann, Mona Skjelland, Antonio Medina, Elisa Cuadrado-Godia, Thomas Cox, Avinash Aujayeb, Nicolas Raposo, Katia Garambois, Jean-Francois Payen, Fabrice Vuillier, Guillaume Franchineau, Serge Timsit, David Bougon, Marie-Cecile Dubois, Audrey Tawa, Clement Tracol, Emmanuel De Maistre, Fabrice Bonneville, Caroline Vayne, Annerose Mengel, Dominik Michalski, Johann Pelz, Matthias Wittstock, Felix Bode, Julian Zimmermann, Judith Schouten, Alina Buture, Sean Murphy, Vincenzo Palma, Alberto Negro, Alexander Gutschalk, Simon Nagel, Silvia Schoenenberger, Giovanni Frisullo, Carla Zanferrari, Francesco Grillo, Fabrizio Giammello, Mar Morin Martin, Alvaro Cervera, Jim Burrow, Carlos Garcia Esperon, Beng Lim Alvin Chew, Timothy J. Kleinig, Cristina Soriano, Domenico S. Zimatore, Marco Petruzzellis, Ahmed Elkady, Miguel S. Miranda, Joao Fernandes, Aslog Hellstrom Vogel, Elias Johansson, Anemon Puthuppallil Philip, Shelagh B. Coutts, Simerpreet Bal, Brian Buck, Catherine Legault, Dylan Blacquiere, Hans D. Katzberg, Thalia S. Field, Vanessa Dizonno, Thomas Gattringer, Christian Jacobi, Annemie Devroye, Robin Lemmens, Espen Saxhaug Kristoffersen, Monica Bandettini di Poggio, Masoud Ghiasian, Theodoros Karapanayiotides, Sophie Chatterton, Miriam Wronski, Karl Ng, Robert Kahnis, Thomas Geeraerts, Peggy Reiner, Charlotte Cordonnier, Saskia Middeldorp, Marcel Levi, Eric C. M. van Gorp, Diederik van de Beek, Justine Brodard, Johanna A. Kremer Hovinga, Marieke J. H. A. Kruip, Turgut Tatlisumak, Jose M. Ferro, Jonathan M. Coutinho, Marcel Arnold, Sven Poli, Mirjam R. Heldner
Summary: This study evaluated adherence to VITT treatment recommendations in patients with VITT-CVT and found that adherence improved over time. Immunomodulation is crucial for reducing mortality in VITT-CVT.
ANNALS OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Warley Cezar da Silveira, Lucas Emanuel Ferreira Ramos, Rafael Tavares Silva, Bruno Barbosa Miranda de Paiva, Polianna Delfino Pereira, Alexandre Vargas Schwarzbold, Andresa Fontoura Garbini, Bruna Schettino Morato Barreira, Bruno Mateus de Castro, Carolina Marques Ramos, Caroline Danubia Gomes, Christiane Correa Rodrigues Cimini, Elayne Crestani Pereira, Eliane Wurdig Roesch, Emanuele Marianne Souza Kroger, Felipe Ferraz Martins Graca Aranha, Fernando Anschau, Fernando Antonio Botoni, Fernando Graca Aranha, Gabriela Petry Crestani, Giovanna Grunewald Vietta, Gisele Alsina Nader Bastos, Jamille Hemetrio Salles Martins Costa, Jessica Rayane Correa Silva da Fonseca, Karen Brasil Ruschel, Leonardo Seixas de Oliveira, Lilian Santos Pinheiro, Liliane Souto Pacheco, Luciana Borges Segala, Luciana Siuves Ferreira Couto, Luciane Kopittke, Maiara Anschau Floriani, Majlla Magalhaes Silva, Marcelo Carneiro, Maria Angelica Pires Ferreira, Maria Auxiliadora Parreiras Martins, Marina Neves Zerbini de Faria, Matheus Carvalho Alves Nogueira, Milton Henriques Guimaraes Junior, Natalia da Cunha Severino Sampaio, Neimy Ramos de Oliveira, Nicole de Moraes Pertile, Pedro Guido Soares Andrade, Pedro Ledic Assaf, Reginaldo Aparecido Valacio, Rochele Mosmann Menezes, Saionara Cristina Francisco, Silvana Mangeon Meirelles Guimaraes, Silvia Ferreira Araujo, Suely Meireles Rezende, Susany Anastacia Pereira, Tatiana Kurtz, Tatiani Oliveira Fereguetti, Carisi Anne Polanczyk, Magda Carvalho Pires, Marcos Andre Goncalves, Milena Soriano Marcolino
Summary: This study investigated predictors of VTE in COVID-19 patients, finding that obesity, surgical history, high D-dimer levels, and others are independent predictors of VTE, while atrial fibrillation, prophylactic use of anticoagulants, etc. are protective factors.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Clinical Neurology
Christian Hoelscher, Ahmad Sweid, Ritam Ghosh, Fadi Al Saiegh, Kavantissa M. Keppetipola, Christopher J. Farrell, Jack Jallo, Pascal Jabbour, Stavropoula Tjoumakaris, Reid Gooch, Robert H. Rosenwasser, Syed O. Shah
Summary: A 54-year-old male diagnosed with COVID-19 developed pneumonia and encephalopathy, with brain MRI showing abnormalities. Despite negative results in CSF and hypercoagulable workup, deep venous thrombosis was attributed to COVID-19, leading to the patient's deteriorating condition and withdrawal of care.
JOURNAL OF NEUROSURGERY
(2021)
Review
Biochemistry & Molecular Biology
Vittoriano Della Corte, Renata Riolo, Stefania Scaglione, Rosaria Pecoraro, Antonino Tuttolomondo
Summary: In recent years, innovations in the field of venous thromboembolism have led to the discovery of new therapeutic targets through biomarkers and metabolomics. Various studies have characterized the metabolic changes in this condition, including alterations in pathways related to carnitine, tryptophan, purine, and fatty acids metabolism. The recent COVID-19 pandemic has also provided new evidence of hypercoagulability, with factors such as altered von Willebrand factor activity, renin-angiotensin-aldosterone system, and immune dysregulation playing a role. This literature review is the first to bring together the latest evidence on biomarkers, metabolomics, and COVID-19 in venous thromboembolism, as well as current therapeutic protocols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yi Lee, Qasim Jehangir, Chun-Hui Lin, Pin Li, Anupam A. Sule, Laila Poisson, Venugopal Balijepally, Abdul R. Halabi, Kiritkumar Patel, Geetha Krishnamoorthy, Girish B. Nair
Summary: Hypercoagulability is a recognized feature in SARS-CoV-2 infection, and there is a need for a risk assessment model to predict venous thromboembolism (VTE) in COVID-19 patients. This study aimed to build a simple clinical model based on commonly available parameters to predict VTE in COVID-19 patients. The model was trained and validated on a large cohort of hospitalized patients and showed a sensitivity of 83% and specificity of 53%. This clinical tool can help personalize thromboprophylaxis for COVID-19 patients based on their VTE risk category.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Sadjad Riyahi, Stefanie J. Hectors, Martin R. Prince, Elizabeth M. Sweeney, Elizabeth G. Lane, Ricky Honya, Daniel J. Margolis
Summary: Deep venous thrombosis (DVT) in COVID-19 patients is associated with high mortality. Prophylactic anti-coagulation reduces the risk of DVT, but full anti-coagulation therapy may lead to hemorrhagic complications. Regular monitoring of d-dimer levels may be useful for predicting DVT in COVID-19 patients.
Article
Immunology
Michael Dalager-Pedersen, Lars Christian Lund, Theis Mariager, Rannva Winther, Maja Hellfritzsch, Torben Bjerregaard Larsen, Reimar Wernich Thomsen, Nanna Borup Johansen, Ole Schmeltz Sogaard, Stig Lonberg Nielsen, Lars Haukali Omland, Lene Fogt Lundbo, Simone Bastrup Israelsen, Zitta Barrella Harboe, Anton Pottegard, Henrik Nielsen, Jacob Bodilsen
Summary: In a population-based setting, the risk of VTE among individuals with SARS-CoV-2 infection is low to moderate and not significantly increased compared to SARS-CoV-2 test-negative and influenza patients. However, ICU patients may face a higher risk of bleeding while receiving thromboprophylaxis.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Hematology
Ahmed K. Pasha, Robert D. McBane, Rahul Chaudhary, Leslie J. Padrnos, Ewa Wysokinska, Rajiv Pruthi, Aneel Ashrani, Paul Daniels, Meera Sridharan, Waldemar E. Wysokinski, Damon E. Houghton
Summary: The study found a 29-fold increased rate of VTE within the first week after COVID-19 diagnosis, which then steadily decreased and returned to baseline by the 6th week. Most VTE events occurred during or after hospitalization, with only a small percentage (3.0%) in non-hospitalized patients.
THROMBOSIS RESEARCH
(2021)
Article
Virology
Antoni Riera-Mestre, Luis Jara-Palomares, Ramon Lecumberri, Javier Trujillo-Santos, Enric Grau, Angeles Blanco-Molina, Ana Piera Carbonell, Sonia Jimenez, Manuel Frias Vargas, Mari Paz Fuset, Sergi Bellmunt-Montoya, Manuel Monreal, David Jimenez
Summary: The study used DELPHI methodology to answer PICO questions related to anticoagulation in patients with COVID-19 and reached a consensus on seven recommendations, including avoiding pharmacological thromboprophylaxis, LMWH treatment, and routine monitoring of D-Dimer levels.
Article
Health Care Sciences & Services
Carles Garcia-Cervera, Vicente Giner-Galvan, Philip Wikman-Jorgensen, Jaime Laureiro, Manuel Rubio-Rivas, Anthony Gurjian Arena, Francisco Arnalich-Fernandez, Jose Luis Beato Perez, Juan Antonio Vargas Nunez, Jesus Javier Gonzalez Igual, Jesus Diez-Manglano, Manuel Mendez Bailon, Maria Jose Garcia Blanco, Santiago J. Freire Castro, Judit Aranda Lobo, Luis Manzano, Jeffrey Oskar Magallanes Gamboa, Luis Arribas Perez, Julio Gonzalez Moraleja, Ruth Calderon Hernaiz, Javier Garcia Alegria, Amara Gonzalez Noya, Ricardo Gomez Huelgas, Carlos Lumbreras Bermejo, Juan Miguel Anton Santos
Summary: In hospitalized patients with COVID-19, a pDd value greater than 3.0 μg/ml can be considered to screen VTE and to consider full-dose anticoagulation.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Clinical Neurology
Margy E. McCullough-Hicks, Daniel J. Halterman, David Anderson, Kenneth Cohen, Kamakshi Lakshminarayan
Summary: This study reports the incidence of cerebral venous sinus thrombosis (CVST) in COVID-19-positive hospitalized patients. The study found a high risk of CVST in COVID-19 patients, and older age and male gender were associated with a higher likelihood of death in hospital.