Review
Immunology
Frauke Zipp, Stefan Bittner, Dorothy P. Schafer
Summary: Cytokines play a crucial role in immune cell communication and regulate various physiological processes, including immune and inflammatory responses. Recent studies have shown that these cytokines also impact neuronal structure and function, from fine-tuning neurotransmission to regulating synapse number and influencing global neuronal networks and behavior. These findings highlight the significance of immune system cytokines in regulating synapse and neural network structure and function.
Review
Plant Sciences
Meiying He, Xiangjin Kong, Yueming Jiang, Hongxia Qu, Hong Zhu
Summary: MiRNAs, as a major class of endogenous small RNAs in plants, play critical roles in regulating the development and growth of horticultural crops.
TRENDS IN PLANT SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Lin Zhang, Wenya Du, Jin-Hoon Kim, Chia-Chen Yu, Canan Dagdeviren
Summary: Piezoelectric-based conformable ultrasound electronics (cUSE) are intensively studied due to their unique capabilities for various applications. This review provides a comprehensive understanding of cUSE for use in biomedical and healthcare monitoring systems, as well as a synopsis of its recent advancements.
ADVANCED MATERIALS
(2023)
Review
Plant Sciences
Dongyang Zheng, Mengqi Li, Ying Yang, Ranran Huang, Wenli Zhang
Summary: R-loops, as key regulators, play important roles in various cellular processes in plants. Pioneering studies suggest that they may be involved in plant growth, development, and stress responses. This review provides an updated understanding of the biological implications of R-loops in plants and suggests future directions for research.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Oncology
Maria Papatsirou, Pinelopi Artemaki, Paraskevi Karousi, Andreas Scorilas, Christos K. Kontos
Summary: Signal transduction is crucial for regulating fundamental cellular processes, and circRNAs are emerging as a type of endogenous transcripts with regulatory roles in various diseases, including cancer. Aberrantly expressed circRNAs can mediate cancer progression by impacting the activity of major signaling cascades.
Article
Cell & Tissue Engineering
Martina Rauner, Marta Murray, Sylvia Thiele, Deepika Watts, Drorit Neumann, Yankel Gabet, Lorenz C. Hofbauer, Ben Wielockx
Summary: High levels of erythropoietin (Epo) can be harmful to bone health in adult organisms, and EpoR in osteoprogenitor cells plays a crucial role in regulating osteoblast function and osteoblast-mediated osteoclastogenesis.
Article
Medicine, General & Internal
Hratch Baghdassarian, Sarah A. Blackstone, Owen S. Clay, Rachael Philips, Brynja Matthiasardottir, Michele Nehrebecky, Vivian K. Hua, Rachael McVicar, Yang Liu, Suzanne M. Tucker, Davide Randazzo, Natalie Deuitch, Sofia Rosenzweig, Adam Mark, Roman Sasik, Kathleen M. Fisch, Pallavi Pimpale Chavan, Elif Eren, Norman R. Watts, Chi A. Ma, Massimo Gadina, Daniella M. Schwartz, Anwesha Sanyal, Giffin Werner, David R. Murdock, Nobuyuki Horita, Shimul Chowdhury, David Dimmock, Kristen Jepsen, Elaine F. Remmers, Raphaela Goldbach-Mansky, William A. Gahl, John J. O'Shea, Joshua D. Milner, Nathan E. Lewis, Johanna Chang, Daniel L. Kastner, Kathryn Torok, Hirotsugu Oda, Christopher D. Putnam, Lori Broderick
Summary: Genetic analyses of three families with disabling pansclerotic morphea uncovered the cause of the disease and led to an experimental targeted treatment. STAT4 gene mutations were found to be responsible for the disease, and inhibition of JAK signaling using ruxolitinib improved the clinical symptoms in affected patients.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Chemistry, Physical
Xiaolei Yu, Vincent Mukwaya, Stephen Mann, Hongjing Dou
Summary: In recent years, significant progress has been made in constructing biomimetic soft compartments with life-like behaviors. This development requires the integration of signal transduction modules in artificial cells, which can respond to invasive biochemical signals or non-invasive physical stimuli. Although challenges remain, advances have been made in establishing rudimentary protocell communication networks, providing new avenues for the development of life-like microsystems and protoliving technologies.
Article
Chemistry, Multidisciplinary
Junjie Shan, Sha Wang, Fan Zhou, Jingyi Hu, Qingqing Liu, Shuyu Lin, Yanfeng Zhang, Zhongfan Liu
Summary: This study achieved the first synthesis of a novel multi-D graphene/AlN ceramic hybrid, significantly reducing the temperature rise caused by self-heating in the new generation of CPETs. Additionally, the electroacoustic energy conversion efficiency was dramatically improved, promoting new applications in the fields of new-generation energy conversion and thermal management.
ADVANCED MATERIALS
(2021)
Article
Cell Biology
Peng An, Wenyi Xu, Junjie Luo, Yongting Luo
Summary: Three decades after its discovery, the TOR pathway, specifically TORC2, is still a central regulator of cell processes such as survival, proliferation, and metabolism. Dysregulation of TORC2 activity can lead to disruptions in cellular homeostasis and various pathophysiological conditions. Recent research has accelerated the pace of discovery in TORC2 regulation, revealing a diverse array of upstream regulators and unexpected modes of regulation, as well as intricate crosstalk with other major signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Hematology
Yi Qiu, Mingjiang Xu, Suming Huang
Summary: Genome-wide analyses have shown that long noncoding RNAs (lncRNAs) play crucial roles in regulating genome structure and transcription, impacting various biological processes. Aberrant expression of thousands of lncRNAs has been observed in different cancer types, suggesting their involvement in malignant transformation. Despite extensive efforts, the specific functions and molecular mechanisms of lncRNAs remain unclear.
Review
Biochemistry & Molecular Biology
Haejin Yoon, Jillian L. Shaw, Marcia C. Haigis, Anna Greka
Summary: This article discusses the roles of lipids in metabolism, including signal transduction, structural integrity of cellular membranes, energy metabolism, and introduces the latest research advancements and technical methods in lipid metabolism. The authors specifically analyze the effects of specific lipid species in physiological pathways, providing a framework for understanding newly identified targets for regulating lipid homeostasis.
Review
Immunology
Qinzhi Yang, Fang Lin, Yanan Wang, Min Zeng, Mao Luo
Summary: Long noncoding RNAs (lncRNAs) play important roles in regulating the strong inflammatory response, immune dysfunction, and thrombosis induced by COVID-19 infection. Understanding the expression and function of lncRNAs can provide insights into the development of lncRNA-based methods for COVID-19 treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xiaojun Gao, Dan Fang, Yu Liang, Xin Deng, Ni Chen, Min Zeng, Mao Luo
Summary: This review summarizes recent progress on the roles and underlying mechanisms of circRNAs that regulate inflammatory response, viral replication, immune evasion, and cytokines induced by SARS-CoV-2 infection, highlighting the diagnostic and therapeutic challenges in the treatment of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Ze-Rong Cai, Yan Hu, Kun Liao, Hao Li, Dong-Liang Chen, Huai-Qiang Ju
Summary: This review summarizes the recent advances in circular RNA research on cancer glucose metabolism, including their roles as miRNA sponges, protein interactors, and protein translators. Future research directions in the field of glucose metabolism are also discussed.
