Article
Biochemistry & Molecular Biology
Chieh Ming Liao, Tianjiao Luo, Juliane von der Ohe, Blanca de Juan Mora, Roland Schmitt, Ralf Hass
Summary: Exosomes derived from MSC have been shown to promote proliferation and reduce senescence in kidney cells, suggesting their therapeutic potential in combating renal senescence. This study demonstrates that exosome treatment efficiently reduces senescence markers and SASP factors in kidney cells, indicating a promising approach for organ rejuvenation and regenerative therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Sijia Chen, Dian Zhou, Ousheng Liu, Huan Chen, Yuehong Wang, Yueying Zhou
Summary: Oral health plays a crucial role in overall health, and tooth loss is closely associated with aging and periodontitis. Targeting cellular senescence may offer potential therapeutic strategies for age-related conditions, including tooth loss. This review explores the role of cellular senescence in oral health and discusses potential treatment options for excessive alveolar bone loss in periodontitis.
Review
Cell Biology
Jack Crouch, Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Vladimir Botchkarev, Daniel Roh
Summary: Senescence is a complex cellular stress response that leads to loss of proliferative capacity and changes in secretory pattern. Transcriptional regulation of multiple genes and epigenetic alterations to DNA and chromatin play crucial roles in the induction and maintenance of senescence. This review highlights the changes in chromatin, DNA methylation, histone alterations, and the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).
Review
Cell Biology
Ashish Kumar, Kavitha Thirumurugan
Summary: Normal somatic cells undergo finite cellular divisions, but they can be arrested in response to various stressors such as oxidative stress, oncogene-induced abnormalities, genotoxic stress, and telomere attrition. Repair mechanisms are activated during the cell cycle pause caused by stress, and the nature of the stress determines whether repair or permanent arrest occurs. Quiescence allows damaged cells to repair and return to the cell cycle, while senescence is irreversible and leads to age-related disorders.
Article
Cell Biology
Jonathan J. Petrocelli, Alec I. McKenzie, Naomi M. M. P. de Hart, Paul T. Reidy, Ziad S. Mahmassani, Alexander R. Keeble, Katie L. Kaput, Matthew P. Wahl, Matthew T. Rondina, Robin L. Marcus, Corrine K. Welt, William L. Holland, Katsuhiko Funai, Christopher S. Fry, Micah J. Drummond
Summary: The purpose of this study was to determine the effects of metformin monotherapy on muscle fibrosis and cellular senescence/SASP during the recovery period in older adults. The study found that individuals treated with metformin during bed rest had less muscle fiber atrophy, reduced inflammation, and lower collagen deposition during the recovery period. The use of metformin also reduced cellular senescence and promoted a shift in fibroblast fate in muscle resident fibro-adipogenic progenitors.
Review
Physiology
Toby Chin, Xin Er Lee, Pei Yi Ng, Yaelim Lee, Oliver Dreesen
Summary: Aging is characterized by gradual functional decline at the cellular and organismal level, leading to a higher risk of chronic illnesses. Skin, as the largest organ of the human body, displays visible signs of aging such as thinning, dryness, sagging, loss of elasticity, and wrinkles. Cellular senescence, a state of permanent growth arrest, is a key hallmark of aging and contributes to tissue dysfunction and inflammation. Senescent cells accumulate in aging tissues, including the skin, and secrete molecules that further disrupt tissue homeostasis. This review focuses on the role of cellular senescence in skin aging and age-related skin pathologies, and explores potential strategies for rejuvenating aged skin.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cell Biology
Yongyu He, Wenqing Xie, Hengzhen Li, Hongfu Jin, Yi Zhang, Yusheng Li
Summary: Aging promotes degenerative pathologies in mammals, including sarcopenia. New findings suggest that age-related sarcopenia can be delayed by modulating mechanisms such as cellular senescence. Studies have shown that targeting cellular senescence is an effective strategy for alleviating sarcopenia. However, more research is needed to understand the mechanisms through which senescent cells contribute to sarcopenia progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Geriatrics & Gerontology
Zehua Wang, Jianwen Gao, Congjian Xu
Summary: Cellular senescence plays a dual role in promoting cancer and exacerbating aging-related diseases, while microRNAs play a crucial role in regulating SASP, especially as potential therapeutic targets, offering new possibilities for treating aging-related diseases.
Review
Biochemistry & Molecular Biology
Helene Martini, Joao F. Passos
Summary: The article discusses how the accumulation of senescent cells in multiple tissues leads to tissue dysfunction and age-related diseases, and emphasizes the important role and mechanisms of mitochondria in senescence. It also proposes the establishment of a detailed road map of mitochondrial biology to guide future research on treatments.
Article
Cell Biology
Jennifer L. St. Sauver, Susan A. Weston, Elizabeth J. Atkinson, Michaela E. Mc Gree, Michelle M. Mielke, Thomas A. White, Amanda A. Heeren, Janet E. Olson, Walter A. Rocca, Allyson K. Palmer, Steven R. Cummings, Roger A. Fielding, Suzette J. Bielinski, Nathan K. LeBrasseur
Summary: A study found that the secretory phenotype of senescent cells is associated with mortality risk. GDF15, RAGE, VEGFA, PARC, and MMP2 are the senescence biomarkers most strongly associated with an increased risk of death. The combination of biomarkers with clinical and demographic covariates improves the accuracy of predicting mortality risk.
Article
Biochemistry & Molecular Biology
Takeshi Uemura, Miki Matsunaga, Yuka Yokota, Koichi Takao, Takemitsu Furuchi
Summary: The aging of the global population has led to the need for effective anti-aging technologies supported by scientific evidence. Polyamines, such as putrescine, spermidine, and spermine, play crucial roles in cell growth and function. This study investigated the relationship between increased expression of spermine oxidase (SMOX) and cellular senescence, using human-liver-derived HepG2 cells. The results suggest that SMOX-mediated degradation of spermine plays a pivotal role in cellular senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Rongjun Wan, Prakhyath Srikaram, Vineeta Guntupalli, Chengping Hu, Qiong Chen, Peisong Gao
Summary: Asthma is a chronic respiratory disease affecting approximately 10% of the global population. The accumulation of senescent cells has been identified as a trigger for the pathophysiology of asthma. This review focuses on the relationship between cellular senescence and asthma, including triggers such as telomere shortening, DNA damage, oncogene activation, oxidative-related senescence, and senescence-associated secretory phenotype (SASP). The connection between cellular senescence and asthma phenotypes, including airway inflammation and remodeling, is also discussed. Promising approaches targeting cellular senescence, such as senolytics and senomorphics, have emerged as potential strategies for asthma treatment.
Article
Biochemistry & Molecular Biology
Rocio Mato-Basalo, Miriam Morente-Lopez, Onno J. Arntz, Fons A. J. van de Loo, Juan Fafian-Labora, Maria C. Arufe
Summary: Mesenchymal stem cells have potential in treating age-related diseases, and small extracellular vesicles derived from these cells have been proposed as therapies. The activation of p65 is found to be important in cellular senescence and inflammatory activation in mesenchymal stem cells. Inhibiting p65 can prevent cellular senescence and the activation of proinflammatory molecules, highlighting its role in restoring functionality and preventing inflamm-aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Oleh Lushchak, Markus Schosserer, Johannes Grillari
Summary: Cellular senescence refers to a stable cell cycle arrest state with specific characteristics. Senescent cells accumulate in the body during normal aging, limiting lifespan and promoting aging-related as well as unrelated diseases. Diseases associated with cellular senescence are referred to as senopathies, and targeting senescent cells through senolytics or senomorphics may help mitigate these diseases. Animal studies provide mechanistic evidence for the connection between senescent cell accumulation and disease progression in various senopathies, including cardiovascular, metabolic, musculoskeletal, liver, kidney, lung diseases, and neurodegeneration. The development of novel senotherapies is hindered by the heterogeneity of senescence phenotypes, resulting in a lack of universal biomarkers and difficulties in distinguishing senescent from non-senescent cells.
Review
Oncology
Jorge Morales-Valencia, Gregory David
Summary: Senescent cells play a crucial role in cancer progression by altering cancer cell properties and promoting tumor growth through the generation of a supportive microenvironment. Recent studies indicate that senescent cells have the capacity to resume proliferation and drive cancer relapse, highlighting the potential use of senolytics and SASP modulators to prevent tumor resurgence. Understanding the mechanisms of senescence and the impact of SASP may lead to the development of targeted therapeutic strategies to exploit vulnerabilities associated with this cellular state.
FRONTIERS IN ONCOLOGY
(2021)
Review
Food Science & Technology
Gianvito Caggiano, Alessandra Stasi, Rossana Franzin, Marco Fiorentino, Maria Teresa Cimmarusti, Annamaria Deleonardis, Rita Palieri, Paola Pontrelli, Loreto Gesualdo
Summary: The gut microbiome plays a crucial role in kidney disease, with dysbiosis-related uremic toxins and pro-inflammatory mediators contributing to kidney function deterioration. The toxicity of uremic compounds has been well-documented in various pathophysiological mechanisms, such as cardiovascular injury, metabolic dysfunction, and inflammation. Accumulating evidence supports the use of fecal microbiota transplantation (FMT) as a promising treatment to reduce uremic toxin accumulation. This review presents the current state of FMT application in kidney disease to restore a healthy microbiome and reverse uremic toxin retention.
Review
Endocrinology & Metabolism
Barbara Infante, Francesca Conserva, Paola Pontrelli, Serena Leo, Alessandra Stasi, Marco Fiorentino, Dario Troise, Andrea dello Strologo, Carlo Alfieri, Loreto Gesualdo, Giuseppe Castellano, Giovanni Stallone
Summary: Several insults, especially diabetes, can lead to acute kidney injury (AKI) in both native kidney and transplant patients. High glucose levels disrupt signaling pathways within the kidney, causing maladaptive repair and kidney dysfunction. Diabetic kidneys are often vulnerable to hypoxia due to reduced oxygenation, vascular damage, and increased inflammation. Patients with a history of AKI have a worse prognosis, highlighting the importance of monitoring diabetic patients for AKI. This review focuses on the molecular mechanisms underlying increased susceptibility to AKI in diabetes and the potential biomarkers for diagnosis and prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fabio Sallustio, Angela Picerno, Francesca Montenegro, Maria Teresa Cimmarusti, Vincenzo Di Leo, Loreto Gesualdo
Summary: The human virome, consisting of prokaryotes, viruses, fungi, and parasites, is intricately connected with the human host. Different viral community states have been identified as indicators of health or undesirable outcomes for the host. The virome can collaborate with the human host in maintaining mutualistic functions and preserving human health. This Review explores the role of viruses in health and disease, the relationship between the virobiota and immune system control, and the potential molecular mechanisms linking viruses to glomerulonephritis and IgA nephropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Davide Fiore Bavaro, Lucia Diella, Alessandra Belati, Giuliana Metrangolo, Laura De Santis, Vito Spada, Michele Camporeale, Angelo Dargenio, Gaetano Brindicci, Flavia Balena, Deborah Fiordelisi, Fabio Signorile, Giacomo Loseto, Crescenza Pasciolla, Carla Minoia, Immacolata Attolico, Tommasina Perrone, Simona Simone, Maria Rendina, Nicoletta Giovine, Francesco Di Gennaro, Pellegrino Musto, Attilio Guarini, Alfredo Di Leo, Loreto Gesualdo, Maria Dell'Aera, Annalisa Saracino
Summary: Remdesivir (REM) and monoclonal antibodies (mAbs) may alleviate severe COVID-19 in at-risk hospitalized patients, particularly in elderly or immunocompromised hosts. The use of REM and mAbs was associated with a reduced risk of severe COVID-19, and the combination therapy was particularly beneficial for immunocompromised patients.
Review
Cell Biology
Francesca Giannuzzi, Silvia Maiullari, Loreto Gesualdo, Fabio Sallustio
Summary: Long non-coding RNAs (lncRNAs) are a diverse group of transcripts that regulate gene expression at different levels in various cellular contexts and biological processes. Understanding their mechanisms of action and their involvement in disease can lead to potential therapeutic approaches. In the context of renal pathogenesis, the role of lncRNAs is still not well understood, particularly in healthy kidneys and adult renal stem/progenitor cells (ARPC). This review provides an overview of lncRNA biogenesis, degradation, and functions, focusing on their functional roles in kidney diseases and their regulation of stem cell biology, with a specific emphasis on the lncRNA HOTAIR's ability to prevent senescence in ARPC.
Article
Cell Biology
Rossana Franzin, Alessandra Stasi, Giuseppe De Palma, Angela Picerno, Claudia Curci, Serena Sebastiano, Monica Campioni, Antonella Cicirelli, Alessandro Rizzo, Vito Francesco Di Lorenzo, Paola Pontrelli, Giovanni Battista Pertosa, Giuseppe Castellano, Loreto Gesualdo, Fabio Sallustio
Summary: In this study, it was found that tubular adult renal progenitor cells (tARPC) can influence the gene expression of renal proximal tubular cell (RPTEC) during cisplatin-induced nephrotoxicity via the release of extracellular vesicles (EV) enriched with CYP1B1 and miR-27b-3p. CYP1B1 expression was correlated with renal function.
Article
Infectious Diseases
Davide Fiore Bavaro, Nicolo De Gennaro, Alessandra Belati, Lucia Diella, Roberta Papagni, Luisa Frallonardo, Michele Camporeale, Giacomo Guido, Carmen Pellegrino, Maricla Marrone, Alessandro Dell'Erba, Loreto Gesualdo, Nicola Brienza, Salvatore Grasso, Giuseppe Columbo, Antonio Moschetta, Giovanna Elisiana Carpagnano, Antonio Daleno, Anna Maria Minicucci, Giovanni Migliore, Annalisa Saracino
Summary: The introduction of a pro-active Infectious Disease (ID) consultation in a COVID-19 hospital can reduce the mortality risk of patients with MDROs infections by optimizing treatment and diagnostic strategies to improve patient outcomes.
Review
Biochemistry & Molecular Biology
Marco Fiorentino, Francesca Bagagli, Annamaria Deleonardis, Alessandra Stasi, Rossana Franzin, Francesca Conserva, Barbara Infante, Giovanni Stallone, Paola Pontrelli, Loreto Gesualdo
Summary: Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD). Kidney transplant recipients (KTRs) are at a higher risk of ICU admission, mainly in the late post-transplant period. Urosepsis and bloodstream infections are the main reasons for ICU admissions, and side effects of immunosuppressive treatment should also be accounted for. AKI incidence is common in KTRs during ICU stay, and in-hospital mortality can be high. The present review aims to explore the impact of AKI on outcomes in KTRs and provide insights into its diagnosis, management, and immunosuppression modulation.
Article
Medicine, General & Internal
Alessandra Stasi, Marco Fiorentino, Rossana Franzin, Francesco Staffieri, Sabrina Carparelli, Rosa Losapio, Alberto Crovace, Luca Lacitignola, Maria Teresa Cimmarusti, Francesco Murgolo, Monica Stufano, Cesira Cafiero, Giuseppe Castellano, Fabio Sallustio, Chiara Ferrari, Mario Ribezzi, Nicola Brienza, Annalisa Schirinzi, Francesca Di Serio, Salvatore Grasso, Paola Pontrelli, Cyrille Tupin, Ronald Barbaras, Constance Keyserling-Peyrottes, Antonio Crovace, Loreto Gesualdo
Summary: CER-001 shows promise as a therapeutic strategy for sepsis management, improving outcomes and mitigating inflammation and organ damage.
Article
Critical Care Medicine
Sadudee Peerapornratana, Marco Fiorentino, Priyanka Priyanka, Raghavan Murugan, John A. Kellum
Summary: This study aimed to investigate the impact of kidney recovery on mortality, dialysis, and kidney transplantation up to 15 years after AKI. The findings showed that the recovery status of AKI at hospital discharge was associated with long-term mortality, with the highest mortality rate observed in patients who did not recover. These results have important implications for acute care, follow-up, and endpoint selection in clinical trials.
JOURNAL OF CRITICAL CARE
(2023)
Article
Urology & Nephrology
Silvia De Rosa, Marita Marengo, Marco Fiorentino, Vito Fanelli, Nicola Brienza, Enrico Fiaccadori, Giacomo Grasselli, Santo Morabito, Vincenzo Pota, Stefano Romagnoli, Fabrizio Valente, Vincenzo Cantaluppi, SIAARTI-SIN Joint Commission
Summary: Sepsis-associated acute kidney injury (AKI) is a life-threatening condition with high morbidity and mortality in critically ill patients. Despite the development of various extracorporeal blood purification therapies for sepsis and sepsis-associated AKI, there are still unresolved questions regarding the indications and timing of renal replacement therapy, optimal dialysis dose, and rationale for using these therapies in septic patients without AKI. There is also growing interest in novel blood purification therapies using adsorption devices for specific mediators clearance and antibiotic removal. A joint commission of the Italian Society of Anesthesiology and Critical Care and the Italian Society of Nephrology addressed these issues, proposed recommendations, and developed a framework for future research in this field.
JOURNAL OF NEPHROLOGY
(2023)
Review
Hematology
Rossana Franzin, Alessandra Stasi, Gianvito Caggiano, Elena Squiccimarro, Vincenzo Losappio, Marco Fiorentino, Carlo Alfieri, Giovanni Stallone, Loreto Gesualdo, Giuseppe Castellano
Summary: ESRD is associated with immune dysregulation caused by factors such as uremia and hemodialysis membrane biocompatibility. Understanding the molecules involved in altered immune response is important for therapeutic intervention. PMMA-based membranes have adsorptive properties for uremic toxins and can modulate adaptive immune response.
BLOOD PURIFICATION
(2023)
Review
Surgery
Matteo Abinti, Evaldo Favi, Carlo Maria Alfieri, Francesca Zanoni, Silvia Armelloni, Mariano Ferraresso, Vincenzo Cantaluppi, Giuseppe Castellano
Summary: Kidney transplantation is the best treatment for end-stage kidney disease, but early diagnosis of graft injury and improving graft outcomes remain challenging. Extracellular vesicles have shown potential as precise markers of damage and therapeutic targets in the field of kidney transplantation. They can be used to determine organ quality and aging, identify transplant-related pathologies, and are suitable for drug delivery and therapy development.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Urology & Nephrology
Marco Fiorentino, Francesco La Fergola, Silvia De Rosa
Summary: Uremic toxins accumulate in patients with renal failure and can cause organ dysfunction. New dialytic approaches, such as the use of medium cut-off membranes, have been proposed to improve uremic toxin removal. However, longer observational studies are needed to confirm the efficacy and safety of these membranes.
JOURNAL OF NEPHROLOGY
(2023)
