Review
Immunology
Jinhang Zhu, Jiaxi Liu, Chao Yan, Dahui Wang, Wei Pan
Summary: This article reviews the current status of parasitic vaccines and anti-infectious immunity, as well as the application prospect of trained immunity in the prevention and control of parasitic diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Siroon Bekkering, Jorge Dominguez-Andres, Leo A. B. Joosten, Niels P. Riksen, Mihai G. Netea
Summary: Trained immunity is a newly recognized phenomenon where cells of the innate immune system exhibit memory characteristics and enhanced responses upon secondary challenge. It explains the heterologous effects of vaccines, but can also lead to maladaptive effects in chronic inflammatory conditions.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Review
Immunology
Amy Dagenais, Carlos Villalba-Guerrero, Martin Olivier
Summary: Innate immune cells can enhance the response to reinfection through trained immunity, a form of immunological memory. The potential of trained immunity in prophylaxis and therapy has attracted great interest in the field of infectious diseases. In the context of antimicrobial resistance and climate change, harnessing the advantages of trained immunity could be game-changing. This article presents recent research linking trained immunity and infectious diseases, highlighting important discoveries, questions, concerns, and novel avenues for its modulation in practice, with a focus on problematic and understudied pathogens.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xiaowu Bai, Weixin Liu, Hongxia Chen, Tao Zuo, Xiaojian Wu
Summary: By analyzing RNA-seq data from patients with IBD (including CD and UC) and healthy individuals, this study revealed increased numbers of immune cells in different intestinal regions and disease-specific immune features in CD and UC. These findings provide important insights into the pathogenesis of IBD and serve as a valuable resource for future targeted studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Borros Arneth
Summary: The innate immune system acts rapidly in a nonspecific way upon exposure to pathogens and lacks the ability to establish immunological memory, while trained immunity is influenced by intracellular metabolic pathways and epigenetic remodeling. Despite limited understanding of the molecular and cellular processes mediating a trained immune response in animals, alterations in cell phenotypes and specific cell numbers may play a critical role. Trained innate immune cells, although short-lived in memory, assist in combating pathogens and providing cross-protection.
IMMUNOLOGIC RESEARCH
(2021)
Review
Immunology
Jiajie Li, Lin Liu, Dianhui Chen, Weiguo Yin, Jun Huang
Summary: The immune system of vertebrates consists of innate immunity and adaptive immunity. Recent studies have found that immune memory exists in innate immunity, supporting efficient responses against reinfection or restimulation. In the case of Plasmodium infection, the innate immune system is the first line of defense and can develop memory to play a role in subsequent infections. This review discusses the role of trained immunity in malaria and other diseases, providing insights for therapeutic strategies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Anne-Sophie Beignon, Caroline Galeotti, Mickael M. M. Menager, Adrien Schvartz
Summary: Autoimmune disorders have well-studied pathophysiology, but autoinflammatory disorders are not fully understood. Trained immunity challenges the notion of adaptive immunity's exclusivity to memory response. It improves innate cell responsiveness and function in the long term through metabolic and epigenetic changes in hematopoietic stem and progenitor cells or tissue-resident cells. This article explores how trained immunity may contribute to the pathophysiology of autoimmune and autoinflammatory diseases.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Valentina P. Mora, Ricardo A. Loaiza, Jorge A. Soto, Karen Bohmwald, Alexis M. Kalergis
Summary: Recently, it has been discovered that innate immune cells can develop a non-specific immune response called trained immunity. Limited information exists about trained immunity in noninfectious diseases like autoimmune illnesses. However, understanding the role of trained immunity in autoimmune diseases is important for potential therapeutic targets.
JOURNAL OF AUTOIMMUNITY
(2023)
Review
Biology
Xinxin Chi, Miaozhen Huang, Hailin Tu, Bin Zhang, Xin Lin, Huji Xu, Chen Dong, Xiaoyu Hu
Summary: Except for a few cases caused by single gene mutations, the majority of autoimmune diseases are influenced by both environmental and genetic factors. Despite progress in understanding certain effector cells and molecules associated with inflammation and tissue damage, the exact cause of common autoimmune disorders remains unknown. Population genetics approaches have contributed greatly to our knowledge of genetic susceptibility to autoimmunity, allowing for a comprehensive re-examination of genes and pathways. This review aims to discuss the etiology and pathogenesis of common autoimmune disorders from a human genetics perspective, covering innate immunity, adaptive immunity, and inflammatory cell death processes. By exploring new molecules and pathways, we hope to broaden our understanding of autoimmunity beyond the current limited therapeutic targets.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Review
Endocrinology & Metabolism
Mingyue Gao, Dawei Cui, Jue Xie
Summary: As an essential regulator of the immune system, adiponectin plays a crucial role in regulating the function of innate and adaptive immune cells in the development of obesity and its related diseases. It also has positive effects on systemic metabolism by regulating associated downstream signalling pathways. This review highlights the biological function of adiponectin in regulating innate and adaptive immunity and its key role in various metabolic diseases, providing a potential direction for adiponectin-based therapeutic interventions.
DIABETES OBESITY & METABOLISM
(2023)
Article
Immunology
Anna Sophie Heinemann, Jan Lennart Stalp, Joao Pedro Pereira Bonifacio, Filo Silva, Maike Willers, Julia Heckmann, Beate Fehlhaber, Lena Voellger, Dina Raafat, Nicole Normann, Andreas Klos, Gesine Hansen, Mirco Schmolke, Dorothee Viemann
Summary: Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. Silent neonatal influenza infections have a remote beneficial impact on the later control of unrelated pathogen infections. This effect is mediated by improved pathogen clearance and enhanced antimicrobial functions of the innate immune system.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yufeng Liu, Jialiang Zhou, Baozhu Chen, Xiao Liu, Yao Cai, Wei Liu, Hu Hao, Sitao Li
Summary: Mass cytometry time-of-flight technology was used to identify specific immune cell populations in the blood and intestinal mucosa tissue of patients with necrotizing enterocolitis, providing insights into the dysregulated immune response and cell localization in this disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
P. Spencer Gill, Tammy R. Ozment, Nicole H. Lewis, Edward R. Sherwood, David L. Williams
Summary: Aging and infection severity are closely related, with age as an independent predictor of mortality in sepsis. Trained immunity can improve immune function in aging and/or sepsis patients, but there is limited data on trained immunity in the aging immune system or in the presence of sepsis. This study found that trained immunity can be induced in aging monocytes and monocytes from sepsis patients, resulting in enhanced metabolic capacity and cytokine production.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Charlotte Theroude, Marta Reverte, Tytti Heinonen, Eleonora Ciarlo, Irene T. Schrijver, Nikolaos Antonakos, Nicolas Maillard, Florian Pralong, Didier Le Roy, Thierry Roger
Summary: Trained immunity induced by beta-glucan training can confer long-term protection against lethal bacterial infections by increasing cytokine levels, antimicrobial activity, cell migration, and metabolic activity of white blood cells. The study suggests that training enhances the generation and antimicrobial activity of white blood cells, providing prolonged protection against lethal bacterial infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Pablo Mata-Martinez, Marta Bergon-Gutierrez, Carlos del Fresno
Summary: Dectin-1, a C-type lectin receptor, plays a crucial role in antifungal responses and immune memory. It recognizes various ligands and triggers different immune reactions. However, the underlying mechanisms of its involvement in trained immunity are not fully understood.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Immunology
Tim Niehues, Tuba Turul Oezguer, Marie Bickes, Rebecca Waldmann, Jennifer Schoening, Jan Braesen, Christian Hagel, Matthias Ballmaier, Jan-Henning Klusmann, Alexandra Niedermayer, Ulrich Pannicke, Anselm Enders, Gregor Dueckers, Kathrin Siepermann, Julyia Hempel, Klaus Schwarz, Dorothee Viemann
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Nutrition & Dietetics
Ingmar Fortmann, Janina Marissen, Bastian Siller, Juliane Spiegler, Alexander Humberg, Kathrin Hanke, Kirstin Faust, Julia Pagel, Leila Eyvazzadeh, Kim Brenner, Claudia Roll, Sabine Pirr, Dorothee Viemann, Dimitra Stavropoulou, Philipp Henneke, Birte Troeger, Thorsten Koerner, Anja Stein, Christoph Derouet, Michael Zemlin, Christian Wieg, Jan Rupp, Egbert Herting, Wolfgang Goepel, Christoph Haertel
Article
Multidisciplinary Sciences
Sarina Ravens, Alina S. Fichtner, Maike Willers, Dennis Torkornoo, Sabine Pirr, Jennifer Schoening, Malte Deseke, Inga Sandrock, Anja Bubke, Anneke Wilharm, Daniel Dodoo, Beverly Egyir, Katie L. Flanagan, Lars Steinbrueck, Paul Dickinson, Peter Ghazal, Bright Adu, Dorothee Viemann, Immo Prinz
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Pediatrics
Nagoud Schukfeh, Amr Elyas, Dorothee Viemann, Benno M. Ure, Stephanie Froemmel, Joon-Keun Park, Joachim F. Kuebler, Gertrud Vieten
Summary: The study demonstrates that lineage marker expression of peritoneal macrophages in neonates differs from that in adults. The findings may provide insights into the complex interaction of neonatal tissue resident macrophages and potentially inform therapeutic approaches utilizing specific macrophage properties.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Gastroenterology & Hepatology
Maike Willers, Thomas Ulas, Lena Voellger, Thomas Vogl, Anna S. Heinemann, Sabine Pirr, Julia Pagel, Beate Fehlhaber, Olga Halle, Jennifer Schoening, Sabine Schreek, Ulrike Loeber, Morgan Essex, Peter Hombach, Simon Graspeuntner, Marijana Basic, Andre Bleich, Katja Cloppenborg-Schmidt, Sven Kuenzel, Danny Jonigk, Jan Rupp, Gesine Hansen, Reinhold Foerster, John F. Baines, Christoph Haertel, Joachim L. Schultze, Sofia K. Forslund, Johannes Roth, Dorothee Viemann
Article
Nutrition & Dietetics
Christoph Haertel, Juliane Spiegler, Ingmar Fortmann, Mariana Astiz, Henrik Oster, Bastian Siller, Dorothee Viemann, Thomas Keil, Tobias Banaschewski, Marcel Romanos, Egbert Herting, Wolfgang Goepel
Letter
Oncology
Sabine Pirr, Louise Dauter, Thomas Vogl, Thomas Ulas, Bettina Bohnhorst, Johannes Roth, Dorothee Viemann
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
I. Martynov, W. Goepel, T. K. Rausch, C. Haertel, A. Franke, A. R. Franz, D. Viemann, U. H. Thome, M. Lacher, B. W. Ackermann
Summary: Infants with blood group AB are at a higher risk of developing surgical NEC/FIP, while those with non-AB blood groups have a lower risk of these conditions.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Kerstin Felgentreff, Catharina Schuetz, Ulrich Baumann, Christian Klemann, Dorothee Viemann, Simona Ursu, Eva-Maria Jacobsen, Klaus-Michael Debatin, Ansgar Schulz, Manfred Hoenig, Klaus Schwarz
Summary: DNA damage occurs constantly in cells due to internal and external factors, triggering different responses in lymphocyte subsets depending on maturation levels. These differences in DNA damage response play a role in cell survival and could be important for diagnostic purposes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maike Willers, Dorothee Viemann
Summary: Colonization of the intestine with commensal bacteria is essential for maintaining human health and can impact airway immunity and host defense against respiratory infections. Specific compositions and functions of gut commensal microbiota can provide protection against respiratory infections caused by bacterial and viral pathogens. Understanding these relationships can help in modulating gut microbiome maturation to enhance lifelong resistance to respiratory infections.
BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Andre Schreiber, Dorothee Viemann, Jennifer Schoening, Sebastian Schloer, Angeles Mecate Zambrano, Linda Brunotte, Aileen Faist, Michael Schoefbaenker, Eike Hrincius, Helen Hoffmann, Markus Hoffmann, Stefan Poehlmann, Ursula Rescher, Oliver Planz, Stephan Ludwig
Summary: The Raf/MEK/ERK signaling pathway may represent a target for therapeutic intervention against SARS-CoV-2 infections, and ATR-002 shows promising potential as a candidate drug with strong antiviral activity and the ability to prevent COVID-19-associated inflammation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Kerstin Felgentreff, Ulrich Baumann, Christian Klemann, Catharina Schuetz, Dorothee Viemann, Martin Wetzke, Ulrich Pannicke, Sandra von Hardenberg, Bernd Auber, Klaus-Michael Debatin, Eva-Maria Jacobsen, Manfred Hoenig, Ansgar Schulz, Klaus Schwarz
Summary: DNA damage is a common event in every cell, and proteins of the DNA damage response network play a crucial role in sensing and repairing DNA lesions. Genetic defects in DNA repair proteins can lead to immunodeficiency, bone marrow failure syndromes, and increased cancer susceptibility. DDR biomarkers are useful for diagnosing NHEJ defects and AT, with some limitations depending on the specific DNA repair deficiency.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Microbiology
Jonas Klopp, Pamela Ferretti, Claudius U. Meyer, Katja Hilbert, Annette Haiss, Janina Marissen, Philipp Henneke, Hannes Hudalla, Sabine Pirr, Dorothee Viemann, Michael Zemlin, Sofia Kirke Forslund, Christoph Haertel, Peer Bork, Stephan Gehring, Thea Van Rossum
Summary: This study characterized the meconium microbiome in premature infants and found that it was dominated by Bifidobacterium, Staphylococcus, and Enterococcus spp. The abundance of Bifidobacterium was negatively correlated with potentially pathogenic bacteria. The amount of bacterial DNA in meconium samples varied and was associated with the time since birth. Only half of the meconium samples contained sufficient bacterial material for microbiome studies.
Article
Hematology
Anna Rafiei Hashtchin, Beate Fehlhaber, Miriam Hetzel, Felix Manstein, Jan Lennart Stalp, Silke Glage, Markus Abeln, Robert Zweigerdt, Antje Munder, Dorothee Viemann, Mania Ackermann, Nico Lachmann
Summary: Primary or secondary immunodeficiencies disrupt cellular and humoral immunity, leading to increased susceptibility to respiratory infections. Adoptive transfer of macrophages can enhance pulmonary immunity against Staphylococcus aureus, reducing bacterial load and tissue damage. Studies demonstrate that induced pluripotent stem cell-derived macrophages are more effective in combating S aureus infections compared to monocyte-derived macrophages.