Article
Nanoscience & Nanotechnology
Ilya E. Kolesnikov, Elena Afanaseva, Mikhail A. Kurochkin, Elena Vaishlia, Evgenii Yu Kolesnikov, Erkki Lahderanta
Summary: Luminescence thermometry has become a popular research field for real-time contactless temperature sensing. This study focuses on the development of a dual-center thermometer using LuVO4:Nd3+/Yb3+ thermal sensors. Two approaches were compared in terms of energy transfer efficiency, sensitivity, and temperature resolution.
Article
Chemistry, Multidisciplinary
Davide Blasi, Nerea Gonzalez-Pato, Xavier Rodriguez Rodriguez, Inigo Diez-Zabala, Sumithra Yasaswini Srinivasan, Nuria Camarero, Oriol Esquivias, Monica Roldan, Judith Guasch, Anna Laromaine, Pau Gorostiza, Jaume Veciana, Imma Ratera
Summary: Ratiometric fluorescent nanothermometers with near-infrared emission are designed and studied, based on the dual emission of monomer and excimer species, for in vivo sensing with high spatial resolution and sensitivity. The temperature-dependent fluorescence of the organic nanoparticles allows them to act as internal reference probes. The nanoparticles show great temperature sensitivity and response, excellent reversibility and stability, and are able to monitor temperature changes at the nano-microscale.
Article
Materials Science, Biomaterials
Yi Han, Yanran Liu, Haiguang Zhao, Alberto Vomiero, Ronggui Li
Summary: Optical nanothermometers have high sensitivity and high spatial resolution, and C-dots show promise as a highly sensitive thermal sensor. C-dots@OH demonstrate a clear temperature trend in intracellular temperature monitoring.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Analytical
Daniel A. May-Arrioja, Miguel A. Fuentes-Fuentes, Ivan Hernandez-Romano, Rodolfo Martinez-Manuel, Natanael Cuando-Espitia
Summary: This paper presents a ratiometric approach to sensing temperature variations using specialty fiber optic devices. By analyzing the transmission response of cascaded segments of multicore fibers (MCFs), it was found that dissimilar lengths can generate an adequate scheme for ratiometric operation. The perturbation of optical parameters in the MCFs results in a rich spectral behavior, allowing for highly sensitive ratiometric measurements.
Article
Chemistry, Multidisciplinary
Chang Wang, Yu-Zhe Chen, Qing-Zheng Yang, Chen-Ho Tung, Da-Yong Wu, Li-Zhu Wu
Summary: A covalently encapsulated dual-dye silica nanoprobe was reported for ratiometric hypoxia detection and imaging, achieving high phosphorescence brightness, long lifetime, and excellent stability. The nanoprobe can respond to different oxygen levels in both solution and living cells with impressive sensitivity and stability.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Yubin Wang, Lei Lei, Enyang Liu, Yao Cheng, Shiqing Xu
Summary: The concept of indirectly thermally coupled levels was introduced in this study to achieve high-performance temperature sensing, utilizing temperature-dependent phonon-assisted non-radiative relaxation to indirectly thermally couple the excited states of Er3+ under certain excitation. This method was experimentally realized in specially designed NaErF4:10Yb@NaYF4 nanocrystals, demonstrating excellent luminescence thermal sensing performance with a maximum relative sensitivity value of up to 3.76% K-1 at 295 K.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Haobin Chen, Jiangbo Yu, Xiaoxiao Men, Jicheng Zhang, Zhaoyang Ding, Yifei Jiang, Changfeng Wu, Daniel T. Chiu
Summary: NADH is a key coenzyme in cells that plays a crucial role in cell metabolism, and NADH-sensitive polymer dots serve as nano-probes for measuring NADH. The mechanism of electron transfer in Pdots upon UV excitation allows for different sensing methods, achieving high sensitivity, selectivity, and rapid response.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Rachel Lee, Jacob A. Erstling, Joshua A. Hinckley, Dana Chapman, Ulrich B. Wiesner
Summary: This study introduces ultrasmall fluorescent core-shell aluminosilicate nanoparticle sensors that can enhance the resolution of pH sensor maps beyond the optical diffraction limit by combining different microscopy methods. This analysis provides detailed spatial and functional information of nanoparticle processing by cells, paving the way for applications in nanomedicine.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Analytical
Vedran Budinski, Denis Donlagic
Summary: This paper introduces a miniature all-silica flow-injection sensor with optical fiber-coupled microcell for spectral absorption measurements and microfluidic reagent injection system, allowing for colorimetric chemical sensing in compact spaces and at very low flow rates.
Article
Chemistry, Analytical
Hong Dinh Duong, Jong Il Rhee
Summary: Ratiometric fluorescent glucose and lactate biosensors were developed with high sensitivity, selectivity, fast reversibility, and long-term stability for reliable detection of glucose and lactate in artificial human serum.
Article
Chemistry, Multidisciplinary
V. Kalaparthi, B. Peng, S. A. M. A. Peerzade, S. Palantavida, B. Maloy, M. E. Dokukin, I. Sokolov
Summary: The study introduces the first ultrabright fluorescent nanothermometers capable of measuring temperature in 3D and at the nanoscale, with high accuracy and constant sensitivity. The nanothermometers demonstrate the potential for accurate 3D temperature distribution measurements in hydrogels, with confirmation through numerical simulations. The use of single nanothermometers is also shown to be effective in measuring temperature with minimal error.
NANOSCALE ADVANCES
(2021)
Article
Chemistry, Applied
Ping Zhang, Yuchi Zhang, Xianliang Li, Yan Xu
Summary: A dual-functional mSiO(2)-CDs-Eu nanocomposite was successfully prepared and demonstrated specific ratiometric fluorescence sensing properties towards tetracycline and temperature changes. The blue fluorescence of CDs was quenched by tetracycline, while the red fluorescence intensity of Eu3+ ions was enhanced. The nanocomposite showed a minimum detection limit of 30 nM for tetracycline and high-temperature sensitivity with a temperature resolution greater than 0.04 degrees C. These findings have promising applications in food security and temperature monitoring.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Review
Agriculture, Multidisciplinary
Mingming Xu, Xiaoying Wang, Xiangping Liu
Summary: Heavy metal pollution has become increasingly serious, posing serious threats to human health and the ecological environment. This paper systematically summarizes the harm and limit standards of heavy metals, and provides an overview and comparison of common analysis methods. The latest research progress, advantages, disadvantages, and future directions of ratiometric photoelectric sensors are also discussed.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Analytical
Kayla F. Presley, Bonnie M. Reinsch, Daniel B. Cybyk, Jack T. Ly, Ryan M. Schweller, Matthew J. Dalton, John J. Lannutti, Tod A. Grusenmeyer
Summary: The study successfully constructed implantable optical oxygen sensors by incorporating an oxygen-sensitive chromophore into biocompatible polymers, rigorously evaluating their performance in vitro. Although sensors with different compositions exhibited varied sensitivity, all sensors demonstrated linear Stern-Volmer behavior within the physiologically relevant dissolved oxygen range.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Pramod K. Kalambate, Nutcha Larpant, Rupali P. Kalambate, Wisanu Niamsi, Vitsarut Primpray, Chanpen Karuwan, Wanida Laiwattanapaisal
Summary: In this study, a new sensitive nanocomposite modified glassy carbon electrode with an intrinsic built-in-correction was developed for the sensitive detection of the anticancer agent mitoxantrone. The electrode showed excellent electrocatalytic response, low limit of detection, rapid response time, and good anti-interference ability. Additionally, a portable, smartphone-compatible ratiometric sensor was developed for point-of-care testing.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Haibin Wang, Hao Zhang, Yan Huang, Haiyu Wang, Adnan Ozden, Kaili Yao, Huamin Li, Qianying Guo, Yongchang Liu, Alberto Vomiero, Yuhang Wang, Zhao Qian, Jun Li, Ziyun Wang, Xuhui Sun, Hongyan Liang
Summary: Elastic strains in metallic catalysts can enhance the selectivity for valuable multicarbon (C2+) products in carbon dioxide reduction (CO2R). However, the structure of catalysts often undergoes reconstruction under harsh conditions, leading to the loss of initial strain. In this study, a metal/metal oxide synthetic strategy is developed to introduce and maintain tensile strain in a copper/ceria heterostructure, resulting in improved C2+ selectivity and efficiency in CO2R.
Article
Chemistry, Multidisciplinary
Oleg Dimitriev, Yuri Slominskii, Mariangela Giancaspro, Federica Rizzi, Nicoletta Depalo, Elisabetta Fanizza, Tsukasa Yoshida
Summary: Functionalization of colloidal nanoparticles with organic dyes enhances light absorption. The binding behavior of the dye molecules on the nanoparticle surface depends on the solvent used, affecting their properties and functionalities.
Article
Chemistry, Multidisciplinary
Letizia Liccardo, Matteo Bordin, Polina M. Sheverdyaeva, Matteo Belli, Paolo Moras, Alberto Vomiero, Elisa Moretti
Summary: Defect-engineered nanostructured TiO2 photocatalysts were obtained by hydrogenation strategy to extend its light absorption into the near-infrared region. The hydrogenation process enhanced the photocatalytic activity and resulted in significant degradation of organic pollutants.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Simona De Zio, Maila Becconi, Alice Solda, Marco Malferrari, Andreas Lesch, Stefania Rapino
Summary: Mapping the metabolic activity of tumor tissues is crucial for identifying tumor types, understanding metastatic mechanisms, and developing targeted cancer therapies. However, visualizing the metabolic characteristics of a tumor using miniaturized electrochemical biosensors is challenging due to the limited oxygen in tumor environments. In this study, a new glucose micro-biosensor was developed that can operate reliably under hypoxic conditions, improving the sensitivity of glucose detection compared to normoxic conditions.
BIOELECTROCHEMISTRY
(2023)
Article
Materials Science, Biomaterials
Fabio Vischio, Livianna Carrieri, Giuseppe Valerio Bianco, Francesca Petronella, Nicoletta Depalo, Elisabetta Fanizza, Maria Principia Scavo, Luciano De Sio, Antonella Calogero, Marinella Striccoli, Angela Agostiano, Gianluigi Giannelli, Maria Lucia Curri, Chiara Ingrosso
Summary: A novel hybrid nanocomposite comprising carboxylated Nano Graphene Oxide (c-NGO) and monodisperse citrate-coated Au nanoparticles (c-NGO/Au NPs) is synthesized and characterized for photothermal applications. The study investigates the factors influencing the decoration of c-NGO with Au NPs and provides insights into the synthesis mechanism. The c-NGO/Au NPs composite demonstrates a higher coating density and size dispersion compared to existing systems. The composite exhibits enhanced photothermal properties and shows compatibility for photothermal therapy based on in vitro cell viability tests.
BIOMATERIALS ADVANCES
(2023)
Article
Chemistry, Physical
Giulia Siciliano, Antonio Turco, Anna Grazia Monteduro, Elisabetta Fanizza, Alessandra Quarta, Roberto Comparelli, Elisabetta Primiceri, M. Lucia Curri, Nicoletta Depalo, Giuseppe Maruccio
Summary: The removal of pollutants from water remains a challenge. Adsorption-based techniques, specifically polydopamine-coated magnetic nanoparticles, have shown promise for the removal of heavy metals. In this study, polydopamine-coated Super Paramagnetic Iron Oxide Nanoparticles (PDA@SPIONs) were synthesized and evaluated for their ability to bind and remove Cu2+ ions from water by applying a magnetic field. The results indicate that these nanostructures hold great potential for future bioremediation applications.
Article
Oncology
Maila Becconi, Simona De Zio, Francesco Falciani, Marzia Santamaria, Marco Malferrari, Stefania Rapino
Summary: 3D bioprinting is a useful method for fabricating in vitro cellular models that resemble the complexity of real tissues. In this study, a cervical tumor model was built using HeLa cells and characterized in terms of dimension and cell adhesion proteins. The oxygen concentration within the tumor model and the diffusion of a molecule in the bioprinted construct were analyzed using scanning electrochemical microscopy.
Article
Oncology
Annalisa Schirizzi, Marialessandra Contino, Livianna Carrieri, Chiara Riganti, Giampiero De Leonardis, Maria Principia Scavo, Maria Grazia Perrone, Morena Miciaccia, Joanna Kopecka, Maria Grazia Refolo, Claudio Lotesoriere, Nicoletta Depalo, Federica Rizzi, Gianluigi Giannelli, Caterina Messa, Rosalba D'Alessandro
Summary: This study aimed to investigate the molecular processes underlying PTX-mediated resistance in gastric cancer cells. The key features of PTX-resistant cells were found to be the overexpression of pro-angiogenic factors and the elevated level of TUB beta III and P-glycoprotein. The findings also highlighted the effectiveness of Ramucirumab and Elacridar in treating resistant cells.
FRONTIERS IN ONCOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Roberto Negro, Rita Mastrogiacomo, Livianna Carrieri, Federica Rizzi, Valentina Arre, Gianluca Minervini, Elisabetta Fanizza, Giusy Bianco, Annamaria Panniello, Marinella Striccoli, Roberto Comparelli, Raffaele Armentano, Maria Lucia Curri, Gianluigi Giannelli, Nicoletta Depalo, Maria Principia Scavo
Summary: Inflammasome activation plays a crucial role in the progression to more severe stages of non-alcoholic fatty liver disease (NAFLD), making it a promising therapeutic target. MCC950, encapsulated in PEG liposomes functionalized with an antibody against FZD1, inhibits NLRP3 inflammasome activation at concentrations 10 times lower than the free drug. Luminescent carbon dots were also co-encapsulated with MCC950 to obtain traceable nanoformulations, showing enhanced internalization into THP-1 cells. Encapsulation of MCC950 into targeted LPs offers a valuable strategy for reducing the dosage and effectively inhibiting inflammasome activation in NAFLD.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Applied
Nicolo Spigariol, Letizia Liccardo, Edlind Lushaj, Enrique Rodriguez-Castellon, Isabel Barroso Martin, Federico Polo, Alberto Vomiero, Elti Cattaruzza, Elisa Moretti
Summary: TiO2 thin films have photocatalytic properties and can degrade dyes and pollutants in water solutions. The use of nanostructures, such as TiO2 nanorod arrays, can enhance the photocatalytic activity by improving molecular adsorption and electronic transfer properties. By depositing a thin layer of sub-stoichiometric TiO2_x on top of the nanorod arrays, a vacancy doped homojunction is formed, leading to a lower band gap and enhanced photochemical activity. The photocatalytic activity was tested using methylene blue as the target molecule, and significant degradation was achieved under both UV and simulated solar light irradiation.
Article
Chemistry, Physical
Oleg Dimitriev, Ryohei Yamakado, Ayumu Nagaoka, Mariangela Giancaspro, Federica Rizzi, Nicoletta Depalo, Elisabetta Fanizza, Lina Yoshida, Anna Kosar, Tsukasa Yoshida
Summary: This study investigates the interaction between near-infrared dyes and plasmonic nanoparticles and finds that different interaction modes can result in changes in the intensity of anti-Stokes emission, while the effect of the plasmonic field depends on the excitation wavelength.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Mariangela Giancaspro, Roberto Grisorio, Gabriele Alo, Nicola Margiotta, Annamaria Panniello, Gian Paolo Suranna, Nicoletta Depalo, Marinella Striccoli, M. Lucia Curri, Elisabetta Fanizza
Summary: Room temperature ligand-assisted reprecipitation syntheses of CsPbBr3 nanoparticles (NPs) have emerged as viable strategies for large-scale production of highly emissive NPs under open air conditions and with non-polar solvents. These methods meet industrial requirements for high-quality materials, low cost, and synthesis scalability.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Materials Science, Multidisciplinary
Chiara Ingrosso, Michela Corricelli, Anna Testolin, Valentina Pifferi, Francesca Bettazzi, Giuseppe V. Bianco, Nicoletta Depalo, Elisabetta Fanizza, Marinella Striccoli, Ilaria Palchetti, M. Lucia Curri, Luigi Falciola
Summary: A novel colloidal hybrid nanocomposite has been synthesized through a facile and cost-effective in situ colloidal procedure. The nanocomposite exhibits good dispersibility and high electrical conductivity, and shows superior performance in the detection of biomarkers such as dopamine. It holds great potential for medical applications.
MATERIALS ADVANCES
(2023)