期刊
NANOMATERIALS
卷 10, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/nano10061066
关键词
BY-2 cells; ZnO nanoparticles; oxidative stress; autophagy; programmed cell death; phytotoxicity
类别
资金
- Slovak Agency for Science and Development [APVV-18-0357]
- Slovak Grant Agency VEGA [2/0044/18]
Nanomaterials, including zinc oxide nanoparticles (ZnO NPs), have a great application potential in many fields, such as medicine, the textile industry, electronics, and cosmetics. Their impact on the environment must be carefully investigated and specified due to their wide range of application. However, the amount of data on possible negative effects of ZnO NPs on plants at the cellular level are still insufficient. Thus, we focused on the effect of ZnO NPs on tobacco BY-2 cells, i.e., a widely accepted plant cell model. Adverse effects of ZnO NPs on both growth and biochemical parameters were observed. In addition, reactive oxygen and nitrogen species visualizations confirmed that ZnO NPs may induce oxidative stress. All these changes were associated with the lipid peroxidation and changes in the plasma membrane integrity, which together with endoplasmatic reticulum and mitochondrial dysfunction led to autophagy and programmed cell death. The present study demonstrates that the phytotoxic effect of ZnO NPs on the BY-2 cells is very complex and needs further investigation.
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