Article
Critical Care Medicine
Jay B. B. Lusk, Beau Blass, Hannah Mahoney, Molly N. N. Hoffman, Amy G. G. Clark, Jonathan Bae, Deepshikha C. C. Ashana, Christopher E. E. Cox, Bradley G. G. Hammill
Summary: Neighborhood socioeconomic deprivation is strongly associated with 30-day mortality for critically ill patients, independent of individual poverty, demographics, comorbidity burden, access to healthcare, and characteristics of treating healthcare facilities.
Article
Surgery
Sidra N. Bonner, Andrew M. Ibrahim, Nick Kunnath, Justin B. Dimick, Hari Nathan
Summary: Receiving complex cancer surgery at high-quality hospitals was associated with reduced disparities between individuals living in the most and least deprived neighborhoods. Increasing accessibility to high-quality hospitals may improve surgical outcomes and mitigate social disparities.
Review
Oncology
Chad Markey, Oluwaferanmi Bello, Meg Hanley, Andrew P. Loehrer
Summary: This scoping review summarizes the use of composite indices of small-area socioeconomic characteristics in cancer literature and their association with outcomes. The findings indicate that neighborhood deprivation indices are most commonly used at the census tract level and ordinally as quintiles. Despite methodological variations, there is a strong indication that deprived areas are associated with adverse cancer-related outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Nadia K. Palte, Lily S. F. Adler, Justin W. Ady, Huong Truong, Saum A. Rahimi, William E. Beckerman
Summary: The study found that socioeconomic status (SES) was not associated with increased risk of mortality or major adverse limb events (MALE) in patients undergoing open lower extremity revascularization. However, uninsured patients were at a higher risk of mortality after revascularization. There was no difference in the distribution of revascularizations or amputations by SES, but a higher proportion of uninsured patients underwent amputation compared with revascularization.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Surgery
Benjamin D. Powers, William Fulp, Amina Dhahri, Danielle K. DePeralta, Takuya Ogami, Luke Rothermel, Jennifer B. Permuth, Susan T. Vadaparampil, Joon-Kyung Kim, Jose Pimiento, Pamela J. Hodul, Mokenge P. Malafa, Daniel A. Anaya, Jason B. Fleming
Summary: This study found that socioeconomic status did not significantly impact the treatment quality and survival of pancreatic cancer patients at a high-volume cancer center with a standardized clinical pathway.
Article
Public, Environmental & Occupational Health
Jacek Jamiolkowski, Agnieszka Genowska, Andrzej Pajak
Summary: This study aimed to assess the relationship between socioeconomic deprivation (SED) and mortality due to circulatory system diseases (CSD) in 66 sub-regions of Poland. The results showed that more deprived areas experienced a greater decrease in CSD-related mortality, especially for women. Therefore, comprehensive preventive measures addressing socioeconomic factors such as poverty, education, and employment are needed to reduce CSD mortality, particularly in less urbanized areas.
Article
Respiratory System
Jay B. Lusk, Molly N. Hoffman, Amy G. Clark, Hannah Mahoney, Beau Blass, Jonathan Bae, Deepshikha C. Ashana, Christopher E. Cox, Bradley G. Hammill
Summary: Neighborhood socioeconomic deprivation may be a key factor driving poor health outcomes for patients with pulmonary diseases.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Oncology
Claire C. Conley, McKenzie McIntyre, Stephanie Dekkers, Tuya Pal, Susan T. Vadaparampil
Summary: This study examined socioeconomic disparities in psychological service recommendation, attempts to access, and receipt among Black breast cancer survivors. The results showed that being employed was associated with a lower likelihood of attempts to access and receipt of psychological services, and participants from more disadvantaged areas were more likely to receive psychological services. These findings highlight the importance of considering both race/ethnicity and socioeconomic status in mental health care disparities.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Medicine, General & Internal
Janani Ramachandran, Stephanie L. Mayne, Mary Kate Kelly, Maura Powell, Katie E. Mcpeak, George Dalembert, Brian P. Jenssen, Alexander G. Fiks
Summary: The study found that neighborhood conditions have a significant impact on child health outcomes. By using electronic health records, the researchers examined the association between the Childhood Opportunity Index (COI) and various health metrics in pediatric primary care. The findings highlight the importance of understanding these associations in order to identify communities in need of additional support and promote child well-being.
Article
Oncology
Abbas M. Hassan, Huan T. Nguyen, Joseph P. Corkum, Jun Liu, Sahil K. Kapur, Carrie K. Chu, Nina Tamirisa, Anaeze C. Offodile
Summary: This study found that breast cancer patients living in deprived neighborhoods have lower psychological well-being and quality of life. Therefore, the deprivation level of the neighborhood should be taken into consideration in preoperative counseling to provide value-based and personalized care, especially for vulnerable populations.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Victoria L. Mango, Elizabeth M. Stoeckl, Nicholas J. Reid, Randy C. Miles, Efren J. Flores, Ian A. Weissman, Amelia Wagner, Alexander Morla, Oyinloye Jose, Anand K. Narayan
Summary: The study aimed to evaluate the presence of accredited breast imaging facilities in ZIP codes with high or low neighborhood socioeconomic deprivation. The results showed that there was lower accessibility to breast imaging facilities in high-disadvantage ZIP codes.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2023)
Article
Critical Care Medicine
Victor de Cos, Alexandra S. Rooney, Alicia G. Sykes, Claudio B. Ghetti, Owen S. Henry, Andrea Krzyzaniak, Hari Thangarajah, Stephen W. Bickler, Vishal Bansal, Matthew Martin, David Lazar, Romeo C. Ignacio
Summary: This study aimed to identify the clinical and traffic factors that influence pediatric pedestrian versus automobile collisions, with a focus on health care disparities. The findings revealed that a larger proportion of Hispanic children injured in P-ACs lived in neighborhoods with more socioeconomic disadvantage. Poor streetlight conditions and close proximity to home were associated with the most socioeconomically disadvantaged neighborhoods.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Review
Psychology, Multidisciplinary
Maria Vassilaki, Ronald C. Petersen, Prashanthi Vemuri
Summary: This article aims to summarize the current literature on the area deprivation index (ADI) and its link to cognitive impairment outcomes, suggest potential mechanisms through which ADI may impact AD/ADRD outcomes, and discuss important considerations when studying the relationships between ADI and cognitive as well as brain health.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Julia J. Shi, Xiudong Lei, Ying-Shiuan Chen, Mariana Chavez-MacGregor, Elizabeth Bloom, Pamela Schlembach, Simona F. Shaitelman, Thomas A. Buchholz, Kelsey Kaiser, Kimberly Ku, Benjamin D. Smith, Grace L. Smith
Summary: This study found that socioeconomic disadvantage is associated with decreased trial retention among breast cancer patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Review
Clinical Neurology
Susan E. Ellsperman, Emily Bellile, Rachel Fryatt, Karen Hoi, JiCi Wang, Shannon Fayson, Renee M. Banakis M. Hartl, Emily Z. Stucken
Summary: This study aims to evaluate the impact of social determinants of health on the management of vestibular schwannoma (VS). A retrospective chart review of 811 patients revealed that social determinants of health, including race, ethnicity, and socioeconomic status, were associated with treatment recommendations. Factors such as patient age, area deprivation index (ADI), and tumor grade influenced the treatment recommendation.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Allergy
Torie L. Grant, Meredith C. McCormack, Roger D. Peng, Corinne A. Keet, Ana M. Rule, Meghan F. Davis, Michelle Newman, Susan Balcer-Whaley, Elizabeth C. Matsui
Summary: This study aimed to investigate the effectiveness of home environmental control strategies on persistent asthma in low-income, Black children. The results showed that the addition of home environmental control strategies did not reduce indoor allergen concentrations or the need for controller medication compared to controller medication titration alone.
Article
Physiology
Charles R. Esther Jr, Wanda K. O'Neal, Neil E. Alexis, Abigail L. Koch, Christopher B. Cooper, Igor Barjaktarevic, Laura M. Raffield, Russel P. Bowler, Alejandro P. Comellas, Stephen P. Peters, Annette T. Hastie, Jeffrey L. Curtis, Bonnie Ronish, Victor E. Ortega, J. Michael Wells, Eitan Halper-Stromberg, Stephen I. Rennard, Richard C. Boucher
Summary: This study shows that nicotine and its metabolites can be detected in sputum supernatants and serve as biological markers of smoke exposure. The concentrations of nicotine in the airways of smokers remain elevated even when they have not smoked within 24 hours, suggesting a potential contribution to cigarette-induced airway disease.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Critical Care Medicine
Spyridon Fortis, Pedro M. Quibrera, Alejandro P. Comellas, Surya P. Bhatt, Donald P. Tashkin, Eric A. Hoffman, Gerard J. Criner, MeiLan K. Han, R. Graham Barr, Mehrdad Arjomandi, Mark B. Dransfield, Stephen P. Peters, Brett A. Dolezal, Victor Kim, Nirupama Putcha, Stephen I. Rennard, Robert Paine, Richard E. Kanner, Jeffrey L. Curtis, Russell P. Bowler, Fernando J. Martinez, Nadia N. Hansel, Jerry A. Krishnan, Prescott G. Woodruff, Igor Z. Barjaktarevic, David Couper, Wayne H. Anderson, Christopher B. Cooper
Summary: This study found that consistent bronchodilator responsiveness (BDR) is associated with specific features of obstructive lung disease, such as asthma history and small airways disease, in tobacco-exposed individuals with or without COPD. Additionally, consistent BDR is also associated with lung function decline and increased risk of COPD progression in patients with GOLD stage 0 disease.
Article
Critical Care Medicine
Michael Waters, James A. McKinnell, Andre C. Kalil, Greg S. Martin, Timothy G. Buchman, Wiebke Theess, Xiaoying Yang, Annemarie N. Lekkerkerker, Tracy Staton, Carrie M. Rosenberger, Rajita Pappu, Yehong Wang, Wenhui Zhang, Logan Brooks, Dorothy Cheung, Joshua Galanter, Hubert Chen, Divya Mohan, Melicent C. Peck
Summary: The study aimed to evaluate the safety and efficacy of astegolimab and efmarodocokin alfa for the treatment of severe COVID-19 pneumonia. The results showed that neither of the drugs improved the time to recovery and no new safety signals were observed.
CRITICAL CARE MEDICINE
(2023)
Article
Environmental Sciences
Anjum Hajat, Christina Park, Claire Adam, Annette L. Fitzpatrick, Sindana D. Ilango, Cindy Leary, Tanya Libby, Oscar Lopez, Erin O. Semmens, Joel D. Kaufman
Summary: Air pollution is associated with Alzheimer's disease and related dementias (ADRD), possibly due to oxidative stress, neuroinflammation, and the deposition of beta-amyloid in the brain. A study found that exposure to fine particulate matter (PM2.5), particulate matter (PM10), and nitrogen dioxide (NO2) was positively associated with higher levels of beta-amyloid, indicating a link between air pollution and ADRD.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Genetics & Heredity
Fang Chen, Xingyan Wang, Seon-Kyeong Jang, Bryan C. Quach, J. Dylan Weissenkampen, Chachrit Khunsriraksakul, Lina Yang, Renan Sauteraud, Christine M. Albert, Nicholette D. D. Allred, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, R. Graham Barr, Diane M. Becker, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Meher Preethi Boorgula, Daniel Chasman, Sameer Chavan, Yii-Der Chen, Lee-Ming Chuang, Adolfo Correa, Joanne E. Curran, Sean P. David, Lisa de Las Fuentes, Ranjan Deka, Ravindranath Duggirala, Jessica D. Faul, Melanie E. Garrett, Sina A. Gharib, Xiuqing Guo, Michael E. Hall, Nicola L. Hawley, Jiang He, Brian D. Hobbs, John E. Hokanson, Chao A. Hsiung, Shih-Jen Hwang, Thomas M. Hyde, Marguerite R. Irvin, Andrew E. Jaffe, Eric O. Johnson, Robert Kaplan, Sharon L. R. Kardia, Joel D. Kaufman, Tanika N. Kelly, Joel E. Kleinman, Charles Kooperberg, I-Te Lee, Daniel Levy, Sharon M. Lutz, Ani W. Manichaikul, Lisa W. Martin, Olivia Marx, Stephen T. McGarvey, Ryan L. Minster, Matthew Moll, Karine A. Moussa, Take Naseri, Kari E. North, Elizabeth C. Oelsner, Juan M. Peralta, Patricia A. Peyser, Bruce M. Psaty, Nicholas Rafaels, Laura M. Raffield, Muagututi'a Sefuiva Reupena, Stephen S. Rich, Jerome Rotter, David A. Schwartz, Aladdin H. Shadyab, Wayne H-H Sheu, Mario Sims, Jennifer A. Smith, Xiao Sun, Kent D. Taylor, Marilyn J. Telen, Harold Watson, Daniel E. Weeks, David R. Weir, Lisa R. Yanek, Kendra A. Young, Kristin L. Young, Wei Zhao, Dana B. Hancock, Bibo Jiang, Scott Vrieze, Dajiang J. Liu
Summary: Most TWASs conducted so far have focused on European ancestry and lacked diversity. To address this limitation, researchers aggregated GWAS summary statistics, whole-genome sequences, and eQTL data from diverse ancestries. They developed a new approach called TESLA, which integrates eQTL datasets with multi-ancestry GWAS, improving power and identifying more genes associated with tobacco use phenotypes compared to alternative TWAS methods. The study also suggests potential drug repurposing options for treating nicotine addiction.
Article
Pediatrics
Gabriela R. R. Oates, Lindsay Lock, Valerie Tarn, Robin Geurs, Jennifer S. S. Guimbellot, Elizabeth Baker, Teresa Magruder
Summary: Electronic screening of caregivers of pediatric patients with asthma and cystic fibrosis revealed that unmet basic needs and associated stress levels are linked to adverse pediatric pulmonary outcomes. Such screenings can identify vulnerable patients for targeted interventions and referral to available community resources.
PEDIATRIC PULMONOLOGY
(2023)
Review
Clinical Neurology
Erin R. Kulick, Joel D. Kaufman, Coralynn Sack
Summary: Despite recent advances in treatment and prevention, stroke remains a leading cause of morbidity and mortality. A body of evidence suggests that elevated levels of ambient air pollutants may trigger cerebrovascular events in susceptible people and increase the risk of future events. This review assesses the evidence for both short and long-term exposure to ambient air pollution as a risk factor for stroke incidence and outcomes, and makes recommendations for mitigating exposure.
Letter
Critical Care Medicine
Alejandro P. Comellas, John D. Newell, Miranda Kirby, Jered P. Sieren, Sam Peterson, Charles Hatt, Craig J. Galban, Ella A. Kazerooni, David A. Lynch, MeiLan K. Han, Eric A. Hoffman
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Physiology
Abhilash S. Kizhakke Puliyakote, Emma M. Stapleton, Kumar Durairaj, Kesavan Karuppusamy, Geetha B. Kathiresan, Kumaran Shanmugam, Sirajunnisa Abdul Rahim, Suresh Navaneethakrishnan, Monalisa Bilas, Rui Huang, Nervana Metwali, Matthew Jeronimo, Kung-Sik Chan, Junfeng Guo, Prashant Nagpal, Thomas M. Peters, Peter S. Thorne, Alejandro P. Comellas, Eric A. Hoffman
Summary: This study used quantitative computed tomography (qCT) to compare the lung function of women cooking with wood and liquified petroleum gas (LPG). The qCT results showed that women cooking with wood had more small airways disease, which may be related to inhaling biomass smoke. These findings are important for understanding the phenotypes of chronic lung disease and associated environmental lung pathologies in non-smoking women in the developing world.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Lyndia C. C. Brumback, Leah I. B. Andrews, David R. R. Jacobs, Daniel A. A. Duprez, Elizabeth Hom Thepaksorn, Joel D. D. Kaufman, Julie O. O. Denenberg, Matthew A. A. Allison
Summary: This study found that age, sex, and race/ethnicity are associated with differences in arterial compliance, which is related to cardiovascular disease. PTC1 and PTC2, derived from a Windkessel model, were used to assess arterial compliance. Arterial compliance decreases with age and is relatively lower in females and Blacks.
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Thuonghien V. Tran, Gregory L. Kinney, Alejandro Comellas, Karin F. Hoth, Arianne K. Baldomero, A. James Mamary, Jeffrey L. Curtis, Nicola Hanania, Richard Casaburi, Kendra A. Young, Victor Kim, Barry Make, Emily S. Wan, Alejandro A. Diaz, John Hokanson, James D. Crapo, Edwin K. Silverman, Surya P. Bhatt, Elizabeth Regan, Spyridon Fortis
Summary: Recent evidence suggests a high prevalence of undiagnosed chronic obstructive pulmonary disease (COPD). Factors associated with abnormal spirometry and incident diagnosis of COPD were analyzed in an at-risk population using data from the COPDGene study. The results can be used to identify individuals at risk for undiagnosed COPD and facilitate earlier diagnosis and treatment.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Elsa D. Angelini, Jie Yang, Pallavi P. Balte, Eric A. Hoffman, Ani W. Manichaikul, Yifei Sun, Wei Shen, John H. M. Austin, Norrina B. Allen, Eugene R. Bleecker, Russell Bowler, Michael H. Cho, Christopher S. Cooper, David Couper, Mark T. Dransfield, Christine Kim Garcia, MeiLan K. Han, Nadia N. Hansel, Emlyn Hughes, David R. Jacobs, Silva Kasela, Joel Daniel Kaufman, John Shinn Kim, Tuuli Lappalainen, Joao Lima, Daniel Malinsky, Fernando J. Martinez, Elizabeth C. Oelsner, Victor E. Ortega, Robert Paine, Wendy Post, Tess D. Pottinger, Martin R. Prince, Stephen S. Rich, Edwin K. Silverman, Benjamin M. Smith, Andrew J. Swift, Karol E. Watson, Prescott G. Woodruff, Andrew F. Laine, R. Graham Barr
Summary: Unsupervised machine learning on CT scans identified six distinct CT emphysema subtypes with different characteristics, prognoses, and genetic associations, providing new insights for the treatment and prevention of COPD.
Article
Developmental Biology
Michael R. Hussey, Daniel A. Enquobahrie, Christine T. Loftus, James W. MacDonald, Theo K. Bammler, Alison G. Paquette, Carmen J. Marsit, Adam A. Szpiro, Joel D. Kaufman, Kaja Z. LeWinn, Nicole R. Bush, Frances Tylavsky, Qi Zhao, Catherine J. Karr, Sheela Sathyanarayana
Summary: This study investigated the impact of prenatal traffic-related air pollution (TRAP) on placental gene expression. The results showed associations between TRAP and expression of genes STRIP2, CEBPA, and RASSF7, with interactions with infant sex. These findings suggest that TRAP may influence placental cell proliferation, autophagy, and growth, but additional research is needed for validation.
Article
Surgery
Burkely P. Smith, Isabel Girling, Robert H. Hollis, Michael Rubyan, Connie Shao, Bayley Jones, Alizeh Abbas, Ivan Herbey, Gabriela R. Oates, Maria Pisu, Daniel I. Chu
Summary: This study aims to identify social determinants of health that impact surgical care among colorectal surgery patients at different socioecological levels. Key social determinants of health were identified at the individual, interpersonal, organizational, community, and policy levels through focus groups and interviews. These determinants may serve as intervention targets to reduce surgical disparities.
