Article
Cardiac & Cardiovascular Systems
Ekkehard Gruenig, Alison MacKenzie, Andrew J. Peacock, Christina A. Eichstaedt, Nicola Benjamin, Robert Nechwatal, Silvia Ulrich, Stephanie Saxer, Maurizio Bussotti, Marinella Sommaruga, Stefano Ghio, Lina Gumbiene, Egle Paleviciute, Elena Jureviciene, Antonio Cittadini, Anna A. Stanziola, Alberto M. Marra, Gabor Kovacs, Horst Olschewski, Joan-Albert Barbera, Isabel Blanco, Martijn A. Spruit, Frits M. E. Franssen, Anton Vonk Noordegraaf, Abilio Reis, Mario Santos, Sofia Goncalves Viamonte, Heleen Demeyer, Marion Delcroix, Eduardo Bossone, Martin Johnson
Summary: This study demonstrated that exercise training for patients with PAH and CTEPH can significantly improve quality of life, WHO functional class, and peak oxygen consumption, and is feasible, safe, and well-tolerated as an add-on to medical therapy.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Ekkehard Gruenig, Alison MacKenzie, Andrew J. Peacock, Christina A. Eichstaedt, Nicola Benjamin, Robert Nechwatal, Silvia Ulrich, Stephanie Saxer, Maurizio Bussotti, Marinella Sommaruga, Stefano Ghio, Lina Gumbiene, Egle Paleviciute, Elena Jureviciene, Antonio Cittadini, Anna A. Stanziola, Alberto M. Marra, Gabor Kovacs, Horst Olschewski, Joan-Albert Barbera, Isabel Blanco, Martijn A. Spruit, Frits M. E. Franssen, Anton Vonk Noordegraaf, Abilio Reis, Mario Santos, Sofia Goncalves Viamonte, Heleen Demeyer, Marion Delcroix, Eduardo Bossone, Martin Johnson
Summary: This study is the first multicentre and largest randomized, controlled study on the feasibility, safety, and efficacy of exercise training as add-on to medical therapy in PAH and CTEPH patients, showing that exercise training can improve patients' exercise capacity, quality of life, and WHO functional class.
EUROPEAN HEART JOURNAL
(2021)
Article
Oncology
Li Jin, Wencan An, Zhenshuang Li, Liyong Jiang, Caili Chen
Summary: The study showed that pulmonary rehabilitation training combined with drug therapy significantly improved pulmonary function, exercise tolerance, sleep quality, and quality of life in stable COPD patients, with better outcomes observed in the group that underwent training five times a week.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Rehabilitation
Simone Pancera, Riccardo Buraschi, Luca Nicola Cesare Bianchi, Roberto Porta, Stefano Negrini, Chiara Arienti
Summary: Continuous chest wall vibration with concurrent aerobic training in addition to a standard pulmonary rehabilitation program may improve functional exercise capacity in COPD patients compared with usual care, but does not significantly impact dyspnea, respiratory muscle function, or quality of life.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Pharmacology & Pharmacy
Elisabetta Zampogna, Nicolino Ambrosino, Federico Mattia Oliva, Monica Rudi, Giovanni Sotgiu, Laura Saderi, Antonio Spanevello, Dina Visca
Summary: This study evaluated the impact of pulmonary rehabilitation on heart rate recovery (HRR) in individuals with asthma compared to those with COPD. The findings showed that individuals with asthma had a lower prevalence of slow HRR than those with COPD. However, exercise training significantly improved exercise capacity in both populations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rehabilitation
Patricia M. Bamonti, Julia T. Boyle, Christina L. Goodwin, Emily S. Wan, Amy K. Silberbogen, Elizabeth B. Finer, Marilyn L. Moy
Summary: The study suggests that early psychoeducation on dyspnea management and smoking and alcohol cessation may increase completion of PR.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Review
Orthopedics
Sonia Wing Mei Cheng, Zoe J. McKeough, Renae J. McNamara, Jennifer A. Alison
Summary: This systematic review and meta-analysis found that pulmonary rehabilitation programs using minimal equipment can effectively improve exercise capacity and health-related quality of life in people with COPD, and are comparable to exercise equipment-based programs.
Review
Sport Sciences
Norman R. Morris, Kylie Hill, James Walsh, Surendran Sabapathy
Summary: Exercise training has been shown to improve exercise capacity, reduce symptoms and enhance HRQoL in adults with COPD. Alternative modes of exercise training such as HIIT, aquatic therapy, tai chi and neuromuscular electrical stimulation are emerging as effective interventions for improving exercise outcomes in this population.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2021)
Article
Respiratory System
M. Vitacca, A. Malovini, A. Spanevello, P. Ceriana, M. Paneroni, M. Maniscalco, B. Balbi, L. Rizzello, R. Murgia, R. Bellazzi, N. Ambrosino
Summary: Due to the low availability of pulmonary rehabilitation (PR) for individuals recovering from a COPD exacerbation (ECOPD), this study aimed to identify subpopulations with different responses to PR based on clustering analysis of baseline characteristics. The results can be used to define priority criteria for PR.
Article
Integrative & Complementary Medicine
Linhong Jiang, Peijun Li, Jiacheng Shi, Yidie Bao, Zhenwei Wang, Weibing Wu, Xiaodan Liu
Summary: This study aimed to investigate the rehabilitative effects of pulmonary-based Qigong exercise (PQE) on stable patients with chronic obstructive pulmonary disease (COPD). The results showed that after 3 months of PQE intervention, exercise capacity, skeletal muscle strength, and quality of life significantly improved.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Review
Health Care Sciences & Services
Gregory Reychler, Elise Piraux, Marc Beaumont, Gilles Caty, Giuseppe Liistro
Summary: This study compared the effects of classical supervised pulmonary rehabilitation and tele-pulmonary rehabilitation. The results showed that tele-rehabilitation is safe and well accepted by patients, and can improve functional exercise capacity, quality of life, anxiety and depression, and the impact of COPD on personal life. However, this conclusion cannot be extended to other chronic lung diseases due to the lack of data.
Article
Medicine, General & Internal
Katrina O. Tonga, Brian G. Oliver
Summary: Chronic obstructive pulmonary disease (COPD) is a complex and serious disease with various physical and psychological manifestations. Pulmonary rehabilitation, including exercise, is an effective intervention for COPD. However, the efficacy of non-traditional forms of exercise in alternative medicine remains poorly understood. This study aims to fill this knowledge gap and provide a summary of the clinical evidence for traditional exercise regimens in the pulmonary rehabilitation of COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Regina W. M. Leung, Jennifer A. Alison, Sue C. Jenkins, Anne E. Holland, Kylie Hill, Norman R. Morris, Lissa M. Spencer, Catherine J. Hill, Annemarie L. Lee, Helen E. Seale, Nola M. Cecins, Christine F. McDonald, Zoe J. McKeough
Summary: The majority of Australian pulmonary rehabilitation programs monitor oxygen saturation and provide supplemental oxygen during testing and training. Most programs prescribe oxygen during exercise training to maintain SpO(2) above a threshold of 80-88%, but few have a protocol for supplemental oxygen prescription. This may be due to lack of strong evidence supporting the use of supplemental oxygen during exercise training.
BRAZILIAN JOURNAL OF PHYSICAL THERAPY
(2021)
Article
Sport Sciences
Amine Ghram, Yaser Jenab, Rahman Soori, Siroos Choobineh, Ali Hosseinsabet, Sepideh Niyazi, Shapoor Shirani, Akbar Shafiee, Arash Jalali, Carl J. Lavie, Ulrik Wisloff
Summary: This study investigated the effects of high-intensity interval training (HIIT) in patients with acute pulmonary embolism (PE) and found that HIIT could improve exercise capacity, lung function, RV function, and health-related quality of life without serious adverse events. The control group did not show significant improvements in these aspects.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Respiratory System
Henrik Hansen, Andre Torre, Thomas Kallemose, Charlotte Suppli Ulrik, Nina Skavlan Godtfredsen
Summary: This study analyzed the proportion of minimal important changes in patients with COPD who received home-based pulmonary telerehabilitation (PTR) or traditional hospital-based outpatient pulmonary rehabilitation (PR). The results showed no significant difference in the improvement of walking distance between home-based PTR and traditional PR at 10 and 62 weeks. While home-based PTR is an effective alternative, outpatient PR remains the preferred option.
Review
Respiratory System
Patrizia Pignatti, Dina Visca, Stelios Loukides, Anne -Grete Martson, Jan-Willem C. Alffenaar, Giovanni Battista Migliori, Antonio Spanevello
Summary: This narrative review examines the relationship between fractional nitric oxide (FeNO) and the physiopathologic characteristics of asthmatic patients, as well as the factors affecting FeNO levels and the impact of corticosteroid therapy, target therapies, and rehabilitation programs. The review also discusses the potential of using FeNO as a marker for evaluating airway inflammation and monitoring adherence to inhaled corticosteroid therapy, particularly in low income countries.
Letter
Respiratory System
Dina Visca, Giovanni Battista Migliori, Anh-Tuan Dinh-Xuan, Rosella Centis, Stefano Belli, Michele Vitacca, Maria Aliani, Elisabetta Zampogna, Davide Feci, Patrizia Pignatti, Martina Zappa, Laura Saderi, Giovanni Sotgiu, Antonio Spanevello
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Article
Critical Care Medicine
Monica Kraft, Matthew Richardson, Brian Hallmark, Dean Billheimer, Maarten Van den Berge, Leonardo M. Fabbri, Thys Van der Molen, Gabriele Nicolini, Alberto Papi, Klaus F. Rabe, Dave Singh, Chris Brightling, Salman Siddiqui
Summary: Small airway disease, as measured by physiological tests, is longitudinally associated with clinically important asthma outcomes, such as asthma control and exacerbations.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Critical Care Medicine
Tessa M. Kole, Elise Vanden Berghe, Monica Kraft, Judith M. Vonk, Martijn C. Nawijn, Salman Siddiqui, Kai Sun, Leonardo M. Fabbri, Klaus F. Rabe, Kian Fan Chung, Gabriele Nicolini, Alberto Papi, Chris Brightling, Dave Singh, Thys van der Molen, Sven-Erik Dahlen, Alvar Agusti, Rosa Faner, Jadwiga A. Wedzicha, Gavin C. Donaldson, Ian M. Adcock, Lies Lahousse, Huib A. M. Kerstjens, Maarten van den Berge
Summary: This post-hoc analysis investigates the determinants, clinical implications, and outcome of persistent airflow limitation (PAL) in patients with asthma. The study reveals that PAL is not only present in severe asthma, but also in a considerable proportion of patients with milder disease. In patients with mild asthma, PAL is associated with eosinophilic inflammation and a higher risk of exacerbations, suggesting the need for increased treatment intensity.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Michele Vitacca, Mara Paneroni, Beatrice Salvi, Antonio Spanevello, Piero Ceriana, Claudio Bruschi, Bruno Balbi, Maria Aliani, Nicolino Ambrosino
Summary: This study suggests that the success rate of pulmonary rehabilitation (PR) is not affected by airflow severity and outcome measures in individuals with severe COPD recovering from exacerbation. In addition to the commonly used outcome measures, Barthel dyspnoea index and Short Physical Performance Battery are also sensitive to PR.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Letter
Medicine, General & Internal
Martina Zappa, Paolo Verdecchia, Fabio Angeli
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Martina Zappa, Paolo Verdecchia, Antonio Spanevello, Michele Golino, Fabio Angeli
Summary: Hypertension is the most common cardiovascular risk factor worldwide, contributing significantly to the risk of cardiovascular events and death. Despite stable prevalence, the number of hypertensive patients have doubled in the last 30 years, with a low proportion of controlled hypertension. Understanding the pathogenesis of hypertension and modulating RNA metabolism pharmacologically have been explored as potential therapeutic strategies.
Review
Medicine, General & Internal
Fabio Angeli, Gianpaolo Reboldi, Francesco Giuseppe Solano, Antonietta Prosciutto, Antonella Paolini, Martina Zappa, Claudia Bartolini, Andrea Santucci, Stefano Coiro, Paolo Verdecchia
Summary: Several outcome-based prospective investigations have shown the prognostic value of 24-hour ambulatory blood pressure monitoring in cardiovascular risk stratification. Average 24-hour, daytime, and nighttime blood pressures are essential components that improve risk assessment beyond traditional factors. However, the interpretation and clinical use of ambulatory blood pressure monitoring need standardization, and implementing its results in individual patient management remains challenging.
Letter
Medicine, General & Internal
Fabio Angeli, Gianpaolo Reboldi, Martina Zappa, Paolo Verdecchia
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Fabio Angeli, Martina Zappa, Paolo Verdecchia
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Letter
Medicine, General & Internal
Martina Zappa, Paolo Verdecchia, Andrea Andolina, Fabio Angeli
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Martina Zappa, Paolo Verdecchia, Fabio Angeli
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Respiratory System
Alberto Papi, Diogenes S. Ferreira, Ioana Agache, Eugenio Baraldi, Richard Beasley, Guy Brusselle, Courtney Coleman, Mina Gaga, Carolina Maria Gotera Rivera, Erik Melen, Ian D. Pavord, Deborah Penate Gomez, Daniel Schuermans, Antonio Spanevello, Thomy Tonia, Florence Schleich
Summary: Recent clinical trials have shown that using as-needed ICS/formoterol could be a potential treatment option for mild asthma. The European Respiratory Society's Task Force has provided evidence-based recommendations, suggesting that adults with mild asthma should use as-needed ICS/formoterol instead of regular ICS maintenance treatment plus as-needed SABA, while adolescents can choose either as-needed ICS/formoterol or ICS maintenance treatment plus as-needed SABA.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Infectious Diseases
D. Visca, R. Centis, E. Pontali, E. Zampogna, A. -M. Russell, G. B. Migliori, C. Andrejak, M. Aro, H. Bayram, K. Berkani, J. Bruchfeld, J. M. Chakaya, J. Chorostowska-Wynimko, B. Crestani, M. P. Dalcolmo, L. D'Ambrosio, A-T. Dinh-Xuan, S. Duong-Quy, C. Fernandes, J. -M. Garcia-Garcia, A. de Melo Kawassaki, L. Carrozzi, M. A. Martinez-Garcia, P. Carreiro Martins, M. Mirsaeidi, Y. Mohammad, R. N. Naidoo, N. Neuparth, L. Sese, D. R. Silva, I. Solovic, T. M. Sooronbaev, A. Spanevello, N. Sverzellati, L. Tanno, S. Tiberi, T. Vasankari, E. Vasarmidi, M. Vitacca, I. Annesi-Maesano
Summary: This is the first consensus-based set of clinical standards for the diagnosis, treatment, and prevention of post-COVID-19 lung disease. The aim is to improve patient care and quality of life by guiding clinicians, program managers, and public health officers in planning and implementing a pulmonary rehabilitation program to manage post-COVID-19 lung disease.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2023)
