Article
Immunology
Amro M. Soliman, Taekwan Yoon, Jiahui Wang, James L. Stafford, Daniel R. Barreda
Summary: The study investigates the kinetics of leukocyte recruitment in fish skin infections, demonstrating early upregulation of inflammatory cytokines and migration of neutrophils to the injury site. Resolution of inflammation is marked by reduction in reactive oxygen species and pro-inflammatory cytokines expression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Dengke Ou, Dan Ni, Rong Li, Xiaobo Jiang, Xiaoxiao Chen, Hongfei Li
Summary: The present study reveals that galectin-1 serves a protective role in myocardial ischemia-reperfusion injury by reducing inflammation and apoptosis levels in cardiomyocytes, ultimately improving cardiac function.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Suhail Al-Salam, Karthishwaran Kandhan, Manjusha Sudhadevi, Javed Yasin, Saeed Tariq
Summary: Doxorubicin is a commonly used drug for cancer treatment, but its usage is limited due to serious side effects, including cardiotoxicity. This study found that Gal-3, a protein, is upregulated in conditions such as heart failure. The findings suggest that Gal-3 can affect the redox pathways and regulate cell survival and death in acute Doxorubicin-induced cardiotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xizhi Yu, Junjie Qian, Limin Ding, Shengyong Yin, Lin Zhou, Shusen Zheng
Summary: Galectin-1, a 14-kDa protein that interacts with carbohydrates, plays a crucial role in pathogen recognition and immune response. It has been shown to have immunosuppressive properties, but recent studies have also suggested its pro-inflammatory role in certain diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Victoria Sundblad, Ramiro A. Gomez, Juan C. Stupirski, Pablo F. Hockl, Maria S. Pino, Hugo Laborde, Gabriel A. Rabinovich
Summary: Serum levels of Gal-3 are associated with clinical manifestations of systemic sclerosis, with a particular association with the presence of telangiectasias.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Mab P. Correa, Rebeca D. Correia-Silva, Gisela R. Silva Sasso, Solange C. G. P. D'Avila, Karin Greco, Sonia M. Oliani, Cristiane D. Gil
Summary: This study evaluated the levels of Galectin-1 and Galectin-3 in the skin of patients with atopic dermatitis and psoriasis, and examined their effects on stimulated keratinocytes. The results showed increased levels of Galectin-1 and decreased levels of Galectin-3 in the diseased skin compared to controls. In vitro experiments demonstrated that the addition of these two galectins can modulate cytokine release and promote keratinocyte migration.
Article
Urology & Nephrology
Huiying Li, Xiaoli Zhao, Liyun Zheng, Xiukun Wang, Shuai Lin, Jiajia Shen, Hangjiang Ren, Yi Li, Qiang Qiu, Zhen Wang
Summary: Research has found that Bruceine A is a protective molecule against diabetic kidney disease, with the ability to inhibit inflammatory signal transduction mediated by galectin-1, providing a novel pharmacological therapeutic approach.
KIDNEY INTERNATIONAL
(2022)
Article
Medical Laboratory Technology
Varinder Singh, Rupinder Kaur, Pratima Kumari, Chirag Pasricha, Ravinder Singh
Summary: Leukocyte migration is vital for lymphocyte recirculation and immune response. ICAM-1 and VCAM-1 play a crucial role in leukocyte adherence to endothelial cells in various diseases. They contribute to inflammation, leukocyte migration, and have implications in multiple pathological states. Understanding their immunoregulatory role and pathophysiological effects helps in disease management.
CLINICA CHIMICA ACTA
(2023)
Article
Microbiology
Julia Rubione, Paula S. Perez, Alejandro Czernikier, Gabriel A. Duette, Federico Pehuen Pereyra Gerber, Jimena Salido, Martina P. Fabiano, Yanina Ghiglione, Gabriela Turk, Natalia Laufer, Alejandro J. Cagnoni, Juan M. Perez Saez, Joaquin P. Merlo, Carla Pascuale, Juan C. Stupirski, Omar Sued, Manuel Varas-Godoy, Sharon R. Lewin, Karina Marino, Gabriel A. Rabinovich, Matias Ostrowski
Summary: This study identifies the role of Galectin-1 (Gal-1) in reversing HIV-1 latency and linking inflammation with HIV persistence in cART-treated individuals through activation of the nuclear factor kappa B (NF-kappa B).
Article
Multidisciplinary Sciences
Raquel Roldan-Montero, Juan M. Perez-Saez, Isabel Cerro-Pardo, Jorge Oller, Diego Martinez-Lopez, Estefania Nunez, Sebastian M. Maller, Carmen Gutierrez-Munoz, Nerea Mendez-Barbero, Joan C. Escola-Gil, Jean-Baptiste Michel, Maria Mittelbrunn, Jesus Vazquez, Luis M. Blanco-Colio, Gabriel A. Rabinovich, Jose L. Martin-Ventura
Summary: Galectin-1 (Gal-1) plays a significant role as a therapeutic target for atherosclerosis and abdominal aortic aneurysm (AAA). Lack of Gal-1 leads to severe atherosclerosis and VSMC phenotypic switch, while treatment with recombinant Gal-1 prevents these effects and alleviates the conditions of atherosclerosis and AAA.
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Tingting Shi, Koji Fujita, Joji Tani, Masanori Atsukawa, Tsutomu Masaki
Summary: Immunochemotherapy is gaining popularity, with new developments expected in cancer immunity mechanisms. Apoptosis maintains tissue homeostasis, and disruption of this process can contribute to carcinogenesis. Galectins, a type of lectin, regulate cell growth and signal transduction by interacting with sugar chains on cell surfaces. Galectin-9 induces apoptosis of T lymphocytes and cancer cells, but its detailed pharmacokinetics, cell receptors, and intracellular pathways are still not fully understood. In this article, the effects of galectin-9 on gastrointestinal cancers and its mechanisms are reviewed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Oncology
Charles N. N. Serhan, Megan L. L. Sulciner
Summary: Uncontrolled inflammation can lead to chronic inflammation and tissue destruction, but the activation of specialized proresolving mediators, produced from omega-3 fatty acids, can enhance resolution response and promote tissue recovery. Understanding these mechanisms can help develop new therapeutic approaches to various human diseases and enhance the body's resilience.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Gastroenterology & Hepatology
Diyoly Ayona, Sandra Madariaga Zarza, Ludovic Landemarre, Benoit Roubinet, Philippe Decloquement, Didier Raoult, Pierre-Edouard Fournier, Benoit Desnues
Summary: Tropheryma whipplei is an actinobacterium that causes various infections in humans, including Whipple's disease. The bacterium's complex surface glycoproteins contain different sugars, and they interact with Galectin-1 and Galectin-3 to promote infection.
Article
Genetics & Heredity
Ye Lin Son, Kwang Pak, Nada Muradagha, Kyung Wook Heo, Anke Leichtle, Arwa Kurabi
Summary: This study describes the first use of humanized mice to study otitis media (OM). The results demonstrate that humanized mice with sufficient engraftment can recapitulate a normal middle ear inflammatory response and exhibit normal recovery. This model has many potential uses in OM research.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Daniel E. Kennedy Ii, Perceus Mody, Jean-Francois Gout, Wei Tan, Keun Seok Seo, Alicia K. Olivier, Jason W. Rosch, Justin A. Thornton
Summary: Cell apoptosis at the infection site is necessary for shutting down inflammatory signaling, avoiding tissue damage, and preventing sepsis progression. Puma(-/-) mice exhibited higher levels of inflammatory cytokines and increased susceptibility to bacterial dissemination in pneumococcal pneumonia. The study demonstrates the importance of Puma in preventing the cytokine storm and suggests the potential of targeting immunomodulation of IFN signaling in pulmonary inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Federica Raucci, Anella Saviano, Gian Marco Casillo, Miguel Guerra-Rodriguez, Adel Abo Mansour, Marialuisa Piccolo, Maria Grazia Ferraro, Elisabetta Panza, Valentina Vellecco, Carlo Irace, Francesco Caso, Raffaele Scarpa, Nicola Mascolo, Mohammed Alfaifi, Asif Jilani Iqbal, Francesco Maione
Summary: The study suggests that IL-17 may specifically regulate inflammatory monocytes during later stages of inflammation. The IL-17/mPGES-1/PPAR-gamma pathway could be a potential therapeutic target for inflammatory-based and immune-mediated diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Asif J. Iqbal, Franziska Krautter, Isobel A. Blacksell, Rachael D. Wright, Shani N. Austin-Williams, Mathieu-Benoit Voisin, Mohammed T. Hussain, Hannah L. Law, Toshiro Niki, Mitsuomi Hirashima, Michele Bombardieri, Costantino Pitzalis, Alok Tiwari, Gerard B. Nash, Lucy Norling, Dianne Cooper
Summary: This study investigates the role of immunomodulatory lectin Galectin-9 (Gal-9) in neutrophil recruitment. The results show that Gal-9 is upregulated in inflamed blood vessels and released by activated endothelial cells. Gal-9 binding induces neutrophil activation and can enhance their interaction with endothelial cells. Both soluble and immobilized Gal-9 function as adhesion molecules and can capture neutrophils. These findings provide insights into the importance of Gal-9 in leukocyte recruitment during inflammation.
Article
Hematology
Zhaogong Zhi, Natalie J. Jooss, Yi Sun, Martina Colicchia, Alexandre Slater, Luis A. Moran, Hilaire Yam Fung Cheung, Ying Di, Julie Rayes, Natalie S. Poulter, Steve P. Watson, Asif J. Iqbal
Summary: In this study, Gal-9 was identified as a novel platelet agonist that induces activation through interaction with GPVI and CLEC-2.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Pharmacology & Pharmacy
Anella Saviano, Federica Raucci, Gian Marco Casillo, Adel Abo Mansour, Vincenzo Piccolo, Camilla Montesano, Martina Smimmo, Valentina Vellecco, Gennaro Capasso, Amedeo Boscaino, Vincenzo Summa, Nicola Mascolo, Asif Jilani Iqbal, Raffaella Sorrentino, Roberta d'Emmanuele di Villa Bianca, Mariarosaria Bucci, Vincenzo Brancaleone, Francesco Maione
Summary: In this study, the potential beneficial effects of Mangifera indica L. extract (MIE) in a mouse model of gouty arthritis were analyzed. The results demonstrated that MIE can positively affect the local and systemic inflammatory/immunological perturbance in the onset and progression of gouty arthritis by modulating cellular immune phenotypes, inhibiting joint inflammatory scores, reducing leukocyte infiltration and activation, and regulating the expression of pro-inflammatory cyto-chemokines.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Adel Abo Mansour, Federica Raucci, Mustafa Sevim, Anella Saviano, Jenefa Begum, Zhaogong Zhi, Laleh Pezhman, Samantha Tull, Francesco Maione, Asif Jilani Iqbal
Summary: This study investigates the role of Gal-9 in the migration and adhesion of CD4+ and CD8+ T cells and reveals its potential therapeutic significance in inflammatory-based diseases. The findings suggest that Gal-9 supports T cell adhesion and transmigration in a glycan dependent manner and inhibits the chemotactic function of CXCL12 through direct binding.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Katie L. Fegan, Naomi C. Green, Melanie M. Britton, Asif J. Iqbal, Lauren E. J. Thomas-Seale
Summary: This study simulated the transmural biomechanics of four synthetic graft designs under physiological pressure and found the layer-specific biomechanical characteristics of these grafts and their impact on endothelial function. The results are of great significance for guiding the validation of multi-layered grafts for the treatment of coronary artery disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Hematology
Martina Colicchia, Waltraud C. Schrottmaier, Gina Perrella, Jasmeet S. Reyat, Jenefa Begum, Alexandre Slater, Joshua Price, Joanne C. Clark, Zhaogong Zhi, Megan J. Simpson, Joshua H. Bourne, Natalie S. Poulter, Abdullah O. Khan, Phillip L. R. Nicolson, Matthew Pugh, Paul Harrison, Asif J. Iqbal, George E. Rainger, Steve P. Watson, Mark R. Thomas, Nicola J. Mutch, Alice Assinger, Julie Rayes
Summary: S100A8/A9, secreted by activated myeloid cells, has antimicrobial, proinflammatory, and prothrombotic properties. Increased levels of S100A8/A9 in COVID-19 patients are associated with poor outcomes. S100A8/A9 is mainly detected in neutrophils and deposited on vessel walls in COVID-19 lungs. Platelets interact with S100A8/A9, leading to the formation of procoagulant platelets.
Article
Cardiac & Cardiovascular Systems
Franziska Krautter, Mohammed T. Hussain, Zhaogong Zhi, Danielle R. Lezama, Julia E. Manning, Emily Brown, Noemi Marigliano, Federica Raucci, Carlota Recio, Myriam Chimen, Francesco Maione, Alok Tiwari, Helen M. McGettrick, Dianne Cooper, Edward A. Fisher, Asif J. Iqbal
Summary: This study reveals the pathological role of Gal-9 in promoting monocyte recruitment and atherosclerotic plaque progression, making it a novel target in the prevention of plaque formation and progression.
Review
Cardiac & Cardiovascular Systems
Adel Abo Mansour, Franziska Krautter, Zhaogong Zhi, Asif Jilani Iqbal, Carlota Recio
Summary: Galectins, particularly galectin-1, -3, and -9, are widely expressed by immune cells and play important roles in cellular communication, migration, and survival. These proteins are highly expressed by inflammatory cells and are involved in the regulation of immune responses. They play significant roles in cardiovascular diseases and metabolic disorders and can be potential therapeutic targets.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Pharmacology & Pharmacy
Valentina Vellecco, Anella Saviano, Federica Raucci, Gian Marco Casillo, Adel Abo Mansour, Elisabetta Panza, Emma Mitidieri, Grazia Daniela Femminella, Nicola Ferrara, Giuseppe Cirino, Raffaella Sorrentino, Asif Jilani Iqbal, Roberta d'Emmanuele di Villa Bianca, Mariarosaria Bucci, Francesco Maione
Summary: This study aimed to evaluate the impact of IL17Ab treatment on peripheral features of Alzheimer's disease, such as systemic inflammation, peripheral vascular dysfunction, and related pro-thrombotic state. The results showed that IL17Ab treatment could alleviate these AD features and exhibit systemic and peripheral protective effects.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Immunology
Laleh Pezhman, Sophie J. Hopkin, Jenefa Begum, Silke Heising, Daniela Nasteska, Mussarat Wahid, G. Ed Rainger, David J. Hodson, Asif J. Iqbal, Myriam Chimen, Helen M. McGettrick
Summary: In this study, we demonstrate the therapeutic potential of the immunopeptide PEPITEM in mitigating the pathological impact of obesity, such as low-grade inflammation and pancreatic dysfunction. Further research is needed to assess its efficacy in reducing obesity-related co-morbidities, particularly in high-risk individuals struggling with weight control through lifestyle modifications. This study highlights the importance of targeting cellular and molecular processes in obesity for effective management and presents PEPITEM as a novel therapeutic option.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Joshua H. Bourne, Joana Campos, Sophie J. Hopkin, Katharine Whitworth, James Palis, Yotis A. Senis, Julie Rayes, Asif J. Iqbal, Alexander Brill
Summary: NLRP3 inflammasome plays an important role in megakaryocytes and platelets. By studying Nlrp3(A350V/+)/Gp1ba-Cre(KI/+) mice with a mutation similar to human Muckle-Wells syndrome, it was found that hyperactivation of the NLRP3 inflammasome leads to mild anemia and increased extramedullary erythropoiesis, promoting the acute inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Hongmei Fu, Juho Vuononvirta, Silvia Fanti, Fabrizia Bonacina, Antonio D'Amati, Guosu Wang, Thanushiyan Poobalasingam, Maria Fankhaenel, Davide Lucchesi, Rachel Coleby, David Tarussio, Bernard Thorens, Robert J. Hearnden, M. Paula Longhi, Paul Grevitt, Madeeha H. Sheikh, Egle Solito, Susana A. Godinho, Michele Bombardieri, David M. Smith, Dianne Cooper, Asif J. Iqbal, Jeffrey C. Rathmell, Samuel Schaefer, Valle Morales, Katiuscia Bianchi, Giuseppe Danilo Norata, Federica M. Marelli-Berg
Summary: T cell activation requires increased glucose uptake and engagement of the glycolytic pathway. In this study, researchers found that the glucose transporter 2 (Glut2) plays a key role in regulating the development of CD8(+) T cell effector responses in mice. Glut2 expression is influenced by environmental factors and is regulated by molecular interactions. Furthermore, human T cells also rely on Glut2, making it a potential target for therapeutic immunomodulation.
Article
Cell Biology
Sophie J. Hopkin, Laleh Pezhman, Jenefa Begum, Dean Kavanagh, Helen M. Mcgettrick, Asif J. Iqbal, Myriam Chimen
Summary: Aging is associated with increased systemic inflammation and loss of immune system function. Leukocyte trafficking is affected by aging, particularly in the peritoneal cavity. In aged female mice, there is an increase in leukocyte population within the peritoneal cavity, accompanied by an increase in inflammatory environment and changes in vascular structure, which may contribute to increased leukocyte migration to the cavity. These findings indicate that aging and sex influence leukocyte trafficking in a unique manner.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)