期刊
FRONTIERS IN NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2020.00363
关键词
amyotrophic lateral sclerosis; cerebral cortex; hyperexcitability; network dysfunction; intrinsic; extrinsic
资金
- European Research Council (ERC) [639737]
- Marie Curie career integration grant [618764]
- Association Francaise contre les Myopathies (AFM)-Telethon trampoline grant [16923]
- Federation pour la Recherche sur le Cerveau (FRC)
- Neurex grant
- French Ministry of Research
- AFM-Telethon [21993]
- European Research Council (ERC) [639737] Funding Source: European Research Council (ERC)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects selected cortical and spinal neuronal populations, leading to progressive paralysis and death. A growing body of evidences suggests that the disease may originate in the cerebral cortex and propagate in a corticofugal manner. In particular, transcranial magnetic stimulation studies revealed that ALS patients present with early cortical hyperexcitability arising from a combination of increased excitability and decreased inhibition. Here, we discuss the possibility that initial cortical circuit dysfunction might act as the main driver of ALS onset and progression, and review recent functional, imaging and transcriptomic studies conducted on ALS patients, along with electrophysiological, pathological and transcriptomic studies on animal and cellular models of the disease, in order to evaluate the potential cellular and molecular origins of cortical hyperexcitability in ALS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据