Article
Clinical Neurology
Alberto Averna, Sara Marceglia, Mattia Arlotti, Marco Locatelli, Paolo Rampini, Alberto Priori, Tommaso Bocci
Summary: This study evaluated the spectrum of local field potentials (LFP) obtained from different contacts within the subthalamic nucleus in Parkinson's disease patients, and their correlations with clinical symptoms. The results showed differences in spectral patterns and correlations with motor symptoms between LFP12 and LFP03 before and after levodopa administration, suggesting potential for optimizing adaptive deep brain stimulation protocols for Parkinson's disease.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Maximilian Scherer, Leon A. Steiner, Suneil K. Kalia, Mojgan Hodaie, Andrea A. Kuhn, Andres M. Lozano, William D. Hutchison, Luka Milosevic
Summary: Deep brain stimulation procedures provide an opportunity to study disease through intracranial recordings. This study investigates the relationship between single-neuron and aggregate-level activities in patients with Parkinson's disease and essential tremor. The findings suggest that periodic single-neuron bursts encode pathophysiological LFP oscillations, and the phase-coupling relationship between LFP and high-frequency oscillation signals is similar to that between LFP and single-neuron bursting. These results shed light on the origin of pathophysiological oscillations in movement disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Elena M. Belova, Ulia Semenova, Anna A. Gamaleya, Alexey A. Tomskiy, Alexey Sedov
Summary: The study shows that beta oscillations in the 8-30 Hz range exhibit different functional features and are related to clinical symptoms and motor functioning in Parkinson's disease.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Zixiao Yin, Ruoyu Ma, Qi An, Yichen Xu, Yifei Gan, Guanyu Zhu, Yin Jiang, Ning Zhang, Anchao Yang, Fangang Meng, Andrea A. Kuehn, Hagai Bergman, Wolf-Julian Neumann, Jianguo Zhang
Summary: Parkinson's disease is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance is one of the most common non-motor symptoms in PD, but its relationship with beta activity is unknown.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Federica Avantaggiato, AmirAli Farokhniaee, Andrea Bandini, Chiara Palmisano, Ibrahem Hanafi, Gianni Pezzoli, Alberto Mazzoni, Ioannis U. Isaias
Summary: This study aimed to assess the relationship between subthalamic neural activity and speech production and intelligibility. The findings revealed that there were separate contributions from frequency and brain lateralization of the STN in the execution of an overt reading motor task and its intelligibility. These subcortical organization could be utilized for developing new adaptive stimulation strategies to improve speech function.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Jean-Francois Daneault, Gloria Vergara-Diaz, Federico Parisi, Chen Admati, Christina Alfonso, Matilde Bertoli, Edoardo Bonizzoni, Gabriela Ferreira Carvalho, Gianluca Costante, Eric Eduardo Fabara, Naama Fixler, Fatemah Noushin Golabchi, John Growdon, Stefano Sapienza, Phil Snyder, Shahar Shpigelman, Lewis Sudarsky, Margaret Daeschler, Lauren Bataille, Solveig K. Sieberts, Larsson Omberg, Steven Moore, Paolo Bonato
Summary: Parkinson's disease is a neurodegenerative disorder with motor and non-motor symptoms. Current treatments focus on managing motor symptoms, but treatment side-effects may emerge. The Levodopa Response Study aimed to objectively quantify symptom severity in PD patients using wearable sensor data.
Article
Anesthesiology
Antonio Martinez-Simon, Miguel Valencia, Elena Cacho-Asenjo, Cristina Honorato-Cia, Jorge M. Nunez-Cordoba, Oscar Manzanilla, Azucena Aldaz, Alfredo Panadero, Jorge Guridi, Manuel Alegre
Summary: Dexmedetomidine can be used for sedation during deep brain stimulator implantation in patients with Parkinson's disease. Increasing doses of dexmedetomidine can significantly decrease subthalamic nucleus activity, but doses up to 0.6 mg kg(-1) h(-1) do not alter baseline activity levels. Patients can easily awaken with external stimuli and recover baseline activity within 10 minutes.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Clinical Neurology
Elena Belova, Ulia Semenova, Anna Gamaleya, Alexey Tomskiy, Alexey Sedov
Summary: This study identified different subbands in the subthalamic nucleus of Parkinson's disease patients, which had stable oscillatory peaks within a broad alpha-beta range and were associated with motor symptoms. Additional alpha-beta oscillations were found in some patients with beta peaks, suggesting that they may complement beta oscillations and indicate disease progression and affect deep brain stimulation setup.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Jing Wei, Zhifan Zou, Jiping Li, Yuqing Zhang
Summary: Deep-brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for motor symptoms of advanced Parkinson's disease (PD). This study aimed to investigate the local field potential (LFP) distribution patterns in dorsomedial and dorsolateral subparts of STN. The results showed weaker gamma oscillations and coherence in the dorsomedial part compared to the dorsolateral part, indicating the potential of targeting the dorsomedial STN for DBS in PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Mitesh Patel, Maria H. Nilsson, Stig Rehncrona, Fredrik Tjernstrom, Mans Magnusson, Rolf Johansson, Per-Anders Fransson
Summary: The study found that Parkinson's disease patients exhibit greater body coupling during balance perturbations and adopt a more direct strategy compared to the control group. In Parkinson's patients, deep brain stimulation and eyes open increase flexibility. However, posture strategies in Parkinson's patients are influenced by DBS and are delayed.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Neurosciences
Bin Xiao, Eng-King Tan
Summary: In a recent study, researchers including Zhang and Roy discovered that neurons in the parafascicular thalamus project to three distinct neural structures in the basal ganglia. These neural circuits were found to be associated with specific motor and non-motor symptoms in a Parkinson's disease mouse model. The findings offer potential therapeutic targets for the treatment of this disease.
TRENDS IN NEUROSCIENCES
(2023)
Article
Neurosciences
Piniel Alphayo Kambey, Wen Ya Liu, Jiao Wu, Chuanxi Tang, Wokuheleza Buberwa, Adonira Saro, Alphonce M. K. Nyalali, Dianshuai Gao
Summary: This study revealed the crucial role of Amphiregulin (Areg) gene in levodopa-induced dyskinesia in Parkinson's disease. Inhibition of Areg was found to alleviate dyskinetic movements and decrease the expression of related proteins. Therefore, Areg may serve as a potential target for therapy development.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Pharmacology & Pharmacy
Ritam Bandopadhyay, Nainshi Mishra, Ruhi Rana, Gagandeep Kaur, Mohammed M. Ghoneim, Sultan Alshehri, Gulam Mustafa, Javed Ahmad, Nabil. A. Alhakamy, Awanish Mishra
Summary: This study focuses on the recent updates in molecular mechanisms and therapeutic approaches for the effective management of levodopa-induced dyskinesia (LID) in Parkinson's disease patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Carla Fernandez-Garcia, Mariana H. G. Monje, Victor Gomez-Mayordomo, Guglielmo Foffani, Rafael Herranz, Maria Jose Catalan, Mercedes Gonzalez-Hidalgo, Jorge Matias-Guiu, Fernando Alonso-Frech
Summary: This study evaluated the effectiveness of directional subthalamic stimulation in Parkinson's disease based on intraoperatively recorded beta oscillations. The results showed a strong correlation between clinical efficacy and beta activity, and selecting the contacts with the highest beta peaks improved the therapeutic window. Long-term follow-up showed similar improvements in both groups, validating the efficacy of directional stimulation guided by intraoperative beta oscillations.
Article
Multidisciplinary Sciences
Tomasz Gutowski, Ryszard Antkiewicz, Stanislaw Szlufik
Summary: This paper presents a solution for creating personalized medicine intake schedules for Parkinson's disease patients. By using machine learning models and optimization algorithms, it can reduce treatment errors and the time required to establish medication schedules, with the potential to significantly improve treatment outcomes.
Article
Clinical Neurology
Benjamin J. Dorfman, Joohi Jimenez-Shahed
Summary: Deutetrabenazine is effective in reducing dyskinesia in TD, but ongoing studies are exploring drug selection and cost-effectiveness among existing VMAT2 inhibitors. Other areas of investigation include novel anti-dyskinetic agents and the use of deep brain stimulation.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2021)
Article
Engineering, Biomedical
Murtadha D. Hssayeni, Joohi Jimenez-Shahed, Michelle A. Burack, Behnaz Ghoraani
Summary: This study developed a novel algorithm using wearable technology to continuously estimate the severity of Parkinson's disease at home. The algorithm was successful in estimating PD severity scores without requiring patients to perform specific tasks, showing potential for effective disease management.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Article
Engineering, Biomedical
Joohi Jimenez-Shahed
Summary: Recent advancements in software and hardware in the field of deep brain stimulation (DBS) have led to the development of devices from three manufacturers. The Percept (TM) PC platform offers unique sensing and diary functions for refining therapeutic stimulation and tracking symptoms. Future work is needed to demonstrate the clinical utility and added value of using sensing to optimize DBS therapy.
EXPERT REVIEW OF MEDICAL DEVICES
(2021)
Review
Clinical Neurology
Davide Martino, Wissam Deeb, Joohi Jimenez-Shahed, Irene Malaty, Tamara M. Pringsheim, Alfonso Fasano, Christos Ganos, Winifred Wu, Michael S. Okun
Summary: The selection of patients with Tourette syndrome for deep brain stimulation surgery relies on 5 fundamental pillars, including tic severity, treatment failure, stability of comorbid psychiatric disorders, and an 18-year age limit. Future advances should focus on consensus-based definitions of treatment failure, stability of comorbid behavioral issues, and use of international registry data to identify predictors of positive response to DBS.
Letter
Clinical Neurology
Behnaz Ghoraani, E. James Galvin, Joohi Jimenez-Shahed
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Biology
Musa Ozturk, Ashwin Viswanathan, Sameer A. Sheth, Nuri F. Ince
Summary: Therapeutic high-frequency stimulation induces high-frequency oscillations similar to those observed with pharmacological treatment, along with evoked compound activity. The interaction between stimulation pulse and the phase of ECA affects the degree of enhancement in HFO power. High-frequency STN-DBS tunes neural oscillations to their healthy state, and the stimulation frequency can be inferred from the phase of ECA waveforms of individual subjects.
COMMUNICATIONS BIOLOGY
(2021)
Article
Clinical Neurology
Mustafa S. Siddiqui, Joohi Jimenez-Shahed, Zoltan Mari, Benjamin L. Walter, Sol De Jesus, Fedor Panov, Jason M. Schwalb, Michele K. York, Harini Sarva, John M. Bertoni, Neepa Patel, Lin Zhang, James McInerney, Joshua M. Rosenow
Summary: The initial COVID-19 pandemic shutdown caused the cancellation of elective surgeries in most of the USA and Canada. This survey aimed to understand the impact of the shutdown on deep brain stimulation (DBS) practices in North America. The results showed that the pandemic-related shutdown led to significant changes in DBS practices in almost all North American sites that participated in the survey. This information could help in developing future contingency plans to reduce patient delays in care under similar circumstances.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Hubert H. Fernandez, Per Odin, David G. Standaert, Tove Henriksen, Joohi Jimenez-shahed, Sharon Metz, Ali Alobaidi, Connie H. Yan, Pavnit Kukreja, Juan Carlos Parra, Jorge Zamudio, Koray Onuk, Jack Wright, Angelo Antonini
Summary: This study categorized Parkinson's disease patients using MANAGE-PD and examined their quality of life, healthcare resource utilization, and discussions about device-aided therapies. The findings showed that patients with poorly controlled symptoms and eligible for device-aided therapies had higher burden on healthcare resources but a significant portion did not discuss device-aided therapies with providers.
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Clinical Neurology
Nbaa Masood, Joohi Jimenez-Shahed
Summary: Motor complications and the lack of disease modifying therapy counterbalance the discovery of levodopa as the cornerstone of PD treatment. Pathological changes in the striatum lead to OFF episodes caused by non-physiologic stimulation of dopamine receptors. Current research focuses on optimizing dopaminergic stimulation and implementing rescue therapies.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Meeting Abstract
Clinical Neurology
R. Hauser, H. Barkay, H. Fernandez, S. Factor, J. Jimenez-Shahed, N. Gross, L. Marinelli, A. Wilhelm, M. Gordon, J. M. Savola, K. Anderson
MOVEMENT DISORDERS
(2020)
Meeting Abstract
Clinical Neurology
Leonard Verhagen Metman, Jan Vesper, Pablo Mir, Matthew Brodsky, Sergiu Groppa, Ramiro Alvarez, Andrew Evans, Marta Blazquez Estrada, Sean Nagel, Witold Libionka, Julie Pilitsis, Monica Poetter-Nerger, Winona Tse, Leonardo Almeida, Nestor Tomycz, Joohi Jimenez-Shahed, Fatima Carrillo, Christian Hartmann, Florence Defresne, Edward Karst, Binith Cheeran, Alfons Schnitzler
Meeting Abstract
Clinical Neurology
Joohi Jimenez-Shahed, Hadas Barkay, Karen E. Anderson, Hubert H. Fernandez, Stewart A. Factor, Robert A. Hauser, Maria Wieman, Mark Forrest Gordon, Juha-Matti Savola
Meeting Abstract
Clinical Neurology
Steven Bellows, Hannah Combs, Joohi Jimenez-Shahed
Meeting Abstract
Clinical Neurology
A. Schnitzler, P. Mir, M. Brodsky, L. Verhagen, S. Groppa, R. Alvarez, A. Evans, M. Blazquez Estrada, S. Nagel, J. Pilitsis, M. Poetter-Nerger, W. Tse, L. Almeida, N. Tomycz, J. Jimenez-Shahed, F. Carrillo, C. J. Hartmann, S. J. Groiss, F. Defresne, E. Karst, B. Cheeran, J. Vesper
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Meeting Abstract
Clinical Neurology
A. Schnitzler, S. Groppa, A. Fasano, J. Ostrem, J. Pilitsis, F. Phibbs, K. Lyons, J. Jimenez-Shahed, N. Pouratian, J. Neimat, F. Defresne, E. Karst, B. Cheeran, R. Pahwa
EUROPEAN JOURNAL OF NEUROLOGY
(2020)