Article
Oncology
Jiang Li, Haisu Tao, Erlei Zhang, Zhiyong Huang
Summary: The study evaluated the diagnostic value of GAPR combined with GAR and AAR in AFP-negative hepatocellular carcinoma patients. The combination of these ratios was effective in distinguishing AFP-negative HCC group from control, chronic hepatitis, and liver cirrhosis groups, especially in patients with good liver function, early stage, or small tumor size.
Article
Cardiac & Cardiovascular Systems
Athiththan Yogeswaran, Khodr Tello, Jonas Lund, Hans Klose, Lars Harbaum, Natascha Sommer, Tim Oqueka, Jan K. Hennigs, Friedrich Grimminger, Werner Seeger, Hossein Ardeschir Ghofrani, Manuel J. Richter, Henning Gall
Summary: This study assessed the prognostic value of gamma-glutamyl transferase (GGT), aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio, and neutrophil-to-lymphocyte ratio (NLR) in patients with pulmonary arterial hypertension (PAH). A scoring system based on these biomarkers showed high predictive power and was comparable to the existing risk stratification scheme.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Oncology
Wentao Zhu, Pei Shi, An Liang, Ying Zhu, Jiwei Fu, Songsong Yuan, Xiaoping Wu
Summary: This study compared the diagnostic value of serum oligosaccharide chain (G-test), alpha-fetoprotein (AFP), and aspartic aminotransferase to alanine aminotransferase ratios (AAR) in predicting hepatocellular carcinoma (HCC) onset. The combination of all three biomarkers provided the most optimal outcomes for predicting HCC onset. G-test had the highest diagnostic capability for HCC in healthy and liver cirrhosis patients, while AAR had the highest diagnostic capability for HCC in chronic hepatitis patients.
Article
Virology
Xiangjun Qian, Yanna Liu, Fengping Wu, Siyu Zhang, Jiao Gong, Yuemin Nan, Bo Hu, Junhui Chen, Jingmin Zhao, Xiangmei Chen, Weidong Pan, Shuangsuo Dang, Fengmin Lu
Summary: This study aimed to identify factors associated with elevated serum AFP in non-HCC and early-stage HCC patients and evaluate their influence on the performance of AFP in detecting early-stage HCC. The study found that antiviral therapy was negatively associated with elevated AFP, while HBeAg and AST levels were positively associated with elevated AFP. The study also demonstrated that AFP had better diagnostic performance under specific conditions.
Article
Cardiac & Cardiovascular Systems
Shamar Young, Nathan Rubin, Donna D'Souza, Pranav Sharma, John Pontolillo, Siobhan Flanagan, Jafar Golzarian, Tina Sanghvi
Summary: This study aimed to evaluate the ability of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), aspartate aminotransferase-to-lymphocyte ratio (ALRI), and systemic-inflammation index (SII) to predict clinical outcomes in hepatocellular carcinoma (HCC) patients undergoing transarterial radioembolization (TARE). The results showed that post-treatment NLR and SII were significantly associated with overall survival (OS), while post-treatment ALRI was correlated with progression-free survival (PFS) and local PFS.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yongjiang Li, Yangxun Pan, Ximeng Lin, Jingyu Hou, Zili Hu, Li Xu, Zhongguo Zhou, Yaojun Zhang, Minshan Chen, Dandan Hu
Summary: The modified HCC-GRIm-Score system demonstrated superior predictive ability in identifying HCC patients who may benefit from ICIs therapies compared to the original GRIm-Score and the BCLC staging system, with a higher area under curve of 0.719.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medical Laboratory Technology
Gjin Ndrepepa, Stefan Holdenrieder, Adnan Kastrati
Summary: It is unclear whether the aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (De Ritis ratio) with AST and ALT activities within the reference range has prognostic value in stable coronary artery disease patients. This study found that an elevated De Ritis ratio within the reference range was associated with an increased risk of mortality.
CLINICA CHIMICA ACTA
(2023)
Article
Oncology
Daiki Kobayashi, Kazuki Yamamoto, Takeshi Kimura, Takuro Shimbo
Summary: The study found that men with higher AST/ALT ratios tended to have a higher risk of developing any type of cancer, especially among regular drinkers, while the risk was lower among abstainers. However, among women, there was no significant association between AST/ALT ratio and the development of any type of cancer.
Article
Oncology
Shamar Young, Isa Cam, Mehmet Gencturk, Nathan Rubin, Donna D'souza, Siobhan Flanagan, Jafar Golzarian, Tina Sanghvi
Summary: The study found that in HCC patients undergoing TACE, neutrophil-to-lymphocyte ratio (NLR) is more predictive of progression-free survival (PFS) and overall survival (OS) than other inflammatory scores, while lymphocyte count may be more predictive of OS.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Medicine, General & Internal
Gjin Ndrepepa, Salvatore Cassese, Maria Scalamogna, Shqipdona Lahu, Alp Aytekin, Erion Xhepa, Heribert Schunkert, Adnan Kastrati
Summary: The De Ritis ratio obtained from AST and ALT activity in the healthy range was not independently associated with higher risk of mortality. However, the De Ritis ratio obtained from aminotransferase activity outside the healthy range (but still in the reference range) was independently associated with the risk of mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Peng-Zhan Deng, Bi-Geng Zhao, Xian-Hui Huang, Ting-Feng Xu, Zi-Jun Chen, Qiu-Feng Wei, Xiao-Yi Liu, Yu-Qi Guo, Sheng-Guang Yuan, Wei-Jia Liao
Summary: This study developed and validated a contrast-enhanced computed tomography-based radiomics model for predicting the overall survival of HCC patients after radical hepatectomy, using a combination of radiomics features, NLR, and AFP into a predictive nomogram.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Takeshi Hatanaka, Atsushi Naganuma, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Noritomo Shimada, Kazuhito Kawata, Hisashi Kosaka, Satoru Kakizaki, Takaaki Tanaka, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa, Takashi Kumada
Summary: This study demonstrates that the HCC-GRIm score serves as a novel prognostic score for HCC patients treated with Atez/Bev, with a high score being associated with unfavorable prognosis in terms of disease progression and overall survival.
Article
Oncology
M. Nakano, R. Kuromatsu, T. Niizeki, S. Okamura, H. Iwamoto, S. Shimose, T. Shirono, Y. Noda, N. Kamachi, H. Koga, T. Torimura
Summary: The neutrophil-to-lymphocyte ratio is an independent prognostic factor for patients with advanced hepatocellular carcinoma receiving molecular-targeted agents as primary treatment, affecting survival significantly. Decreases in the neutrophil-to-lymphocyte ratio after one month of treatment are associated with longer survival among these patients.
Article
Medical Laboratory Technology
Gjin Ndrepepa, Stefan Holdenrieder, Adnan Kastrati
Summary: This study investigated the association between the aspartate aminotransferase to alanine aminotransferase ratio (De Ritis ratio) and the prognosis of patients with acute myocardial infarction (AMI). The results showed that an elevated De Ritis ratio was associated with an increased risk of 3-year mortality in AMI patients.
CLINICA CHIMICA ACTA
(2022)
Article
Immunology
Zeming Liu, Di Hu, Jinpeng Li, Qing Xia, Yan Gong, Zhengwei Li, Qian Wu, Meilin Yi, Yihui Huang, Meng Wu, Liang Guo, Xiaohui Wu
Summary: Elevated levels of AST and AST/ALT are correlated with severity and mortality of COVID-19. Liver function tests may aid clinicians in determining prognosis for patients undergoing treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Rheumatology
Jinchao Jia, Luyu Yang, Zhujun Cao, Mengyan Wang, Yuning Ma, Xiong Ma, Qiaoyan Liu, Jialin Teng, Hui Shi, Honglei Liu, Xiaobing Cheng, Junna Ye, Yutong Su, Yue Sun, Huihui Chi, Tingting Liu, Zhihong Wang, Liyan Wan, Chengde Yang, Qiongyi Hu
Summary: The study identified Lipocalin-2 (LCN2) as a potential biomarker for liver damage in adult-onset Still's disease (AOSD). LCN2 levels were found to be significantly elevated in AOSD patients compared to healthy controls, and were closely correlated with inflammatory markers and liver dysfunction. This suggests that LCN2 could be a useful tool for identifying AOSD patients with systemic inflammation, particularly those with liver involvement.
Letter
Gastroenterology & Hepatology
Zhujun Cao, Qing Xie
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Physiology
Qinyi Gan, Beilei Gong, Manli Sun, Zhujun Cao, Yuyan Zheng, Yajie Zhang, Pengfei Wen, Yuanbing Shen, Lei Hong, Tingting Hou, Yuqin Jia, Wei Li, Hecheng Li, Qing Xie
Summary: Liver function test abnormality is common in COVID-19 patients and more prevalent in severe cases. A significant percentage of patients still had abnormal liver functions at the time of discharge. Younger age, hypertension, and low lymphocyte counts were identified as independent risk factors for persistent abnormal liver functions during hospitalization.
FRONTIERS IN PHYSIOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Zhujun Cao, Honglian Gui, Zike Sheng, Haiguang Xin, Qing Xie
Article
Immunology
Yan Huang, Qinyi Gan, Rongtao Lai, Weijing Wang, Simin Guo, Zike Sheng, Lu Chen, Qing Guo, Wei Cai, Hui Wang, Gangde Zhao, Zhujun Cao, Qing Xie
Summary: Concurrent non-alcoholic fatty liver disease (NAFLD) is common in chronic hepatitis B (CHB) patients, and non-alcoholic steatohepatitis (NASH) is an independent risk factor potentiating significant fibrosis by 2.53-fold and severe fibrosis by 1.83-fold. Routine assessment of co-existing NAFLD or NASH is important while coping with chronic HBV infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Zhujun Cao, Chenxi Zhang, Shuang Zhao, Zike Sheng, Xiaogang Xiang, Ruokun Li, Zhuping Qian, Yinling Wang, Bin Chen, Ziqiang Li, Yuhan Liu, Baoyan An, Huijuan Zhou, Wei Cai, Hui Wang, Honglian Gui, Haiguang Xin, Qing Xie
Summary: The COVID-19 vaccination rate is low in patients with decompensated cirrhosis in eastern China, particularly in those with a history of ACLF or hepatic encephalopathy and liver transplantation recipients. Factors associated with remaining unvaccinated include the experience of hepatic encephalopathy or ACLF and post-liver transplantation status. Vaccination against COVID-19 is safe in this population.
INFECTIOUS DISEASES OF POVERTY
(2022)
Letter
Gastroenterology & Hepatology
Nahum Mendez-Sanchez, Elisabetta Bugianesi, Robert G. Gish, Frank Lammert, Herbert Tilg, Mindie H. Nguyen, Shiv K. Sarin, Nuria Fabrellas, Shira Zelber-Sagi, Jian-Gao Fan, Gamal Shiha, Giovanni Targher, Ming-Hua Zheng, Wah-Kheong Chan, Shlomo Vinker, Takumi Kawaguchi, Laurent Castera, Yusuf Yilmaz, Marko Korenjak, C. Wendy Spearman, Mehmet Ungan, Melissa Palmer, Mortada El-Shabrawi, Hans-Juergen Gruss, Jean-Francois Dufour, Anil Dhawan, Heiner Wedemeyer, Jacob George, Luca Valenti, Yasser Fouad, Manuel Romero-Gomez, Mohammed Eslam
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Liu Chuan, Cao Zhujun, Yan Huadong, Wong Yu Jun, Xie Qing, Masashi Hirooka, Hirayuki Enomoto, Tae Hyung Kim, Amr Shaaban Hanafy, Liu Yanna, Huang Yifei, Li Xiaoguo, Kang Ning, Yohei Koizumi, Yoichi Hiasa, Takashi Nishimura, Hiroko Iijima, Young Kul Jung, Hyung Joon Yim, Guo Ying, Zhang Linpeng, Ma Jianzhong, Manoj Kumar, Ankur Jindal, Kok Ban Teh, Shiv Kumar Sarin, Qi Xiaolong
Summary: This study developed a new score (SAVE score) that accurately predicts the risk of hepatic decompensation in cACLD patients and also accurately predicts clinically significant portal hypertension.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Qinyi Gan, Yan Huang, Chuanwu Zhu, Shuang Zhao, Haoshuang Fu, Minghao Cai, Jiexiao Wang, Chenxi Zhang, Simin Guo, Zhujun Cao, Qing Xie
Summary: This study aimed to evaluate the utility of serum qHBsAg in detecting histological abnormalities in HBeAg-negative chronic HBV infection patients. The results showed that qHBsAg level was associated with the severity of hepatic inflammation and fibrosis, and it was identified as an independent predictor along with age, AST level, and family history of HBV infection.
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Zhujun Cao, Weiyi Gao, Hong Bao, Haiyan Feng, Shuya Mei, Peizhan Chen, Yueqiu Gao, Zhilei Cui, Qin Zhang, Xianmin Meng, Honglian Gui, Weijing Wang, Yimei Jiang, Zijia Song, Yiqing Shi, Jing Sun, Yifei Zhang, Qing Xie, Yiping Xu, Guang Ning, Yuan Gao, Ren Zhao
Summary: Among adults with mild-to-moderate Covid-19 at risk for progression, VV116 was noninferior to nirmatrelvir-ritonavir in terms of time to sustained clinical recovery, with fewer safety concerns.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Infectious Diseases
Honglian Gui, Zhenglan Zhang, Bin Chen, Yaoxing Chen, Yue Wang, Zhuo Long, Chuanwu Zhu, Yinling Wang, Zhujun Cao, Qing Xie
Summary: This study aimed to determine the predictors of prolonged viral RNA shedding in patients with non-severe COVID-19 and construct a nomogram to predict patients at risk of 14-day PCR conversion failure. The study found that older age, increasing comorbidities, incomplete vaccinations, and lack of antiviral therapy are risk factors for persistent infection with Omicron variant for > 14 days. A nomogram based on these predictors could be used as a prediction tool to guide treatment and isolation strategies.
INFECTIOUS DISEASES OF POVERTY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Jasmohan S. Bajaj, Florence Wong, Qing Xie, Mark Topazian, Torre Aldo, Ramazan Idilman, Mario Reis Alvares-Da-Silva, Peter C. Hayes, Thomas George, Marie Jeanne Darc Lohoues Epse Kouacou, Belimi Hibat Allah, Hailemichael Desalegn, Helena Katchman, Liane Rabinowich, Ponan C. Regis Lah, Nabil Debzi, Henok Fisseha, Edith Okeke, David P. Nyam, Dalia Allam, Yashwi Haresh Kumar Patwa, Ruveena Rajaram, Nik Ma Nik Arsyad, Hiang Keat Tan, Liou Wei Lun, Sombat Treeprasertsuk, Salisa Wejnaruemarn, Jacob George, Chinmay Bera, Zhujun Cao, Aabha Nagral, Amey Sonavane, Ajay Haveri, Anand V. Kulkarni, Mithun Sharma, C. E. Eapen, Ashish Goel, Virender Singh, Ajay K. Duseja, Anoop Saraya, Jatin Yegurla, Mohamed Rela, Dinesh K. Jothimani, Anil Arora, Ashish Kumar, Jose Luis Perez-Hernandez, Miranda Godolfino, Mauricio Castillo-Barradas, Rene Male Velazquez, Lilian Montserrat Torres Made, Sebastian Marciano, Carlos Benitez, Feyza Gunduz, Rahmi Aslan, Abdullah Emre Yildirim, Sezgin Barutcu, Zeki Karasu, Aloysious Aravinthan, Suresh Vasan Venkatachalapathy, Neil Rajoriya, Rosemary Faulkes, Damien Leith, Ewan Forrest, Adebayo Danielle, James Kennedy, Somaya Albhaisi, Sumeet K. Asrani, Mohammad Amin Fallahzadeh, K. Rajender Reddy, Suditi Rahematpura, Hugo E. Vargas, David Bayne, Scott W. Biggins, Natalia Filipek, Paul J. Thuluvath, Somya Sheshadri, Andrew Paul Keaveny, Andres Duarte-Rojo, Ricardo Cabello Negrillo, Wai-Kay Seto, James Fung, Puneeta Tandon, Monica Dahiya, Chuanwu Zhu, Yingling Wang, Mingquin Liu, Yijing Cai, Xin Zheng, Jing Liu, Radha Dhiman, Akash Roy, Anil Anand, Dibyalochan Praharaj, Jose Velarde Ruiz Velasco, Francisco Felix-Tellez, Jacqueline Cordova, Haydar Adanir, Dinc Dincer, Brian J. Bush, Leroy Thacker, Shiv K. Sarin, Patrick S. Kamath, Ashok Kumar Choudhury
Meeting Abstract
Gastroenterology & Hepatology
Florence Wong, Ashok Kumar Choudhury, Qing Xie, Ramazan Idilman, Jacob George, Marie Jeanne Darc Lohoues Epse Kouacou, Belimi Hibat Allah, Ponan Claude Regis Lah, Nabil Debzi, Hailemichael Desalegn, Helena Katchman, Henok Fisseha, Liane Rabinowich, Edith Okeke, Nyam P. David, Dalia Allam, Yashwi Haresh Kumar Patwa, Ruveena Rajaram, Nik Ma Nik Arsyad, Hiang Keat Tan, Liou Wei Lun, Sombat Treeprasertsuk, Salisa Wejnaruemarn, Chinmay Bera, Zhujun Cao, Aabha Nagral, Amey Sonavane, Ajay Haveri, Anand V. Kulkarni, Mithun Sharma, C. E. Eapen, Ashish Goel, Virender Singh, Ajay K. Duseja, Anoop Saraya, Jatin Yegurla, Mohamed Rela, Dinesh K. Jothimani, Anil Arora, Ashish Kumar, Jose Luis Perez-Hernandez, Godolfino Miranda, Mauricio Castillo-Barradas, Renee Male-Velazquez, Lilian Montserrat Torres Made, Sebastian Marciano, Carlos Benitez, Feyza Gunduz, Rahmi Aslan, Abdullah Emre Yildirim, Sezgin Barutcu, Zeki Karasu, Aloysious Aravinthan, Suresh Vasan Venkatachalapathy, Neil Rajoriya, Rosemary Faulkes, Damien Leith, Ewan Forrest, Adebayo Danielle, James Kennedy, Somaya Albhaisi, Sumeet K. Asrani, Mohammad Amin Fallahzadeh, K. Rajender Reddy, Suditi Rahematpura, Hugo E. Vargas, David Bayne, Scott W. Biggins, Natalia Filipek, Paul J. Thuluvath, Somya Sheshadri, Andrew Paul Keaveny, Andres Duarte-Rojo, Ricardo Cabello Negrillo, Mario Silva, Wai-Kay Seto, James Fung, Puneeta Tandon, Monica Dahiya, Chuanwu Zhu, Yingling Wang, Mingquin Liu, Yijing Cai, Xin Zheng, Jing Liu, Radha Dhiman, Akash Roy, Anil Anand, Dibyalochan Praharaj, Jose Velarde Ruiz Velasco, Francisco Felix-Tellez, Jacqueline Cordova, Haydar Adanir, Dinc Dincer, Brian J. Bush, Shiv K. Sarin, Peter C. Hayes, Patrick S. Kamath, Mark Topazian, Leroy Thacker, Jasmohan S. Bajaj
Letter
Gastroenterology & Hepatology
Zhujun Cao, Qing Xie