Review
Neurosciences
Ehsan Shekari, Nazbanou Nozari
Summary: This study provides a comprehensive review of the role of white matter in connecting cortical areas involved in language processing. Hypotheses about the functions of major tracts connecting these areas are evaluated using data from studies in neurotypical individuals, neuropsychological data, and intraoperative stimulation studies. The study highlights the conclusions supported by the data and identifies areas requiring further investigation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Oncology
Mia Andreoli, Melissa-Ann Mackie, David Aaby, Matthew C. Tate
Summary: This study investigates the relationship between white matter tract disruption and cognitive deficits in glioma patients using diffusion tensor imaging (DTI). The findings suggest that WM tract disruption predicts cognitive dysfunction in glioma patients, emphasizing the importance of understanding WM tract organization for surgical resection and functional preservation in these patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Anna Manelis, Adriane Soehner, Yaroslav O. Halchenko, Skye Satz, Rachel Ragozzino, Mora Lucero, Holly A. Swartz, Mary L. Phillips, Amelia Versace
Summary: The study identified differences in white matter microstructure between individuals with bipolar disorder type-II and unipolar depression, suggesting that these distinctions can help differentiate between the two mood disorders. Additionally, the research demonstrated the impact of depression and subthreshold mania interaction on white matter microstructure.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Evie Kourtidou, Dimitrios Kasselimis, Georgia Angelopoulou, Efstratios Karavasilis, Georgios Velonakis, Nikolaos Kelekis, Ioannis Zalonis, Ioannis Evdokimidis, Constantin Potagas, Michael Petrides
Summary: This study investigated the white matter structure in the right hemisphere of chronic post-stroke aphasic patients, and found increased axial diffusivity in the RH tracts of the aphasic patients. The results suggest a compensatory role of the right hemisphere tracts in language functions when the LH networks are disrupted.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Jie Zhang, Ye Yao, Jin-song Wu, Edmund T. Rolls, Ce-chen Sun, Ling-hao Bu, Jun-feng Lu, Ching-po Lin, Jian-feng Feng, Ying Mao, Liang-fu Zhou
Summary: This study used multi-modal neuroimaging analyses to localize the cortical regions and white matter tracts responsible for auditory language comprehension. The results showed that cortical areas in the posterior temporal lobe are crucial for language comprehension. The fiber integrity of the arcuate fasciculus and the inferior longitudinal fasciculus was strongly correlated with auditory comprehension and the grey matter volume of the inferior temporal and middle temporal gyri.
HUMAN BRAIN MAPPING
(2023)
Article
Psychology, Experimental
Walker S. Pedersen, Douglas C. Dean, Nagesh Adluru, Lauren K. Gresham, Seungbeum D. Lee, Michael P. Kelly, Jeanette A. Mumford, Richard J. Davidson, Stacey M. Schaefer
Summary: The study investigated the association between uncinate fasciculus fractional anisotropy (FA) and emotional recovery, as well as corrugator activity. It found that higher FA was linked to better recovery from negative provocation, and also identified potential associations between other white matter fibers and emotion regulation.
Article
Neurosciences
Arash Aghamohammadi-Sereshki, Fraser Olsen, Peter Seres, Nikolai V. Malykhin
Summary: The study reveals an association between age and structural properties of certain limbic white matter tracts, as well as a link between the COMT gene polymorphism and white matter properties in the right rostral cingulum.
BRAIN CONNECTIVITY
(2022)
Article
Anatomy & Morphology
Katherine L. Bryant, Paul R. Manger, Mads F. Bertelsen, Alexandre A. Khrapitchev, Jerome Sallet, R. Austin Benn, Rogier B. Mars
Summary: The study constructs the first white matter atlas of a lesser ape using diffusion MRI and finds that the white matter architecture of the gibbon is similar to that of great apes, suggesting these features might have originated in their common ancestor approximately 16 million years ago and further developed in the evolution of great apes and humans.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Psychiatry
Tsafrir Greenberg, Michele A. Bertocci, Amelia Versace, Joao Paulo Lima Santos, Henry W. Chase, Ricki Siffler, Haris A. Aslam, Simona Graur, Genna Bebko, Jeanette C. Lockovich, Mary L. Phillips
Summary: The study found a relationship between white matter microstructure in the right uncinate fasciculus and depressive symptoms, general distress, and QoL. These findings emphasize the role of white matter microstructure in the right uncinate fasciculus in relation to emotional and general distress symptoms and QoL in young adults.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Natalia Tesli, Lars T. Westlye, Guttorm B. Storvestre, Tiril P. Gurholt, Ingrid Agartz, Ingrid Melle, Ole A. Andreassen, Unn K. Haukvik
Summary: Research suggests that schizophrenia patients (SCZ) have white matter abnormalities in the brain compared to healthy controls (HC), but there are no significant differences in these abnormalities between SCZ patients with a history of violence (SCZ-V) and those without (SCZ-NV). Additionally, there are no significant associations between measures of violence or aggression and DTI metrics in SCZ.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Psychiatry
Ben D. A. Gorman, Fernando Calamante, Oren Civier, Marilena M. DeMayo, Eleni Andrea Demetriou, Ian B. Hickie, Adam J. Guastella
Summary: Social anxiety disorder (SAD) is associated with changes in brain structural connectivity, with increased FDC in the right superior longitudinal fasciculus (SLF) and right inferior longitudinal fasciculus (R-ILF) regions. The study also revealed a correlation between white matter structural changes and symptom severity.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Oncology
Jun Wang, Liang Yi, Qing-mei Kang, Ji Zhou, Tian-qing Chen, Jean-philippe Hugnot, Shi-cang Yu
Summary: Invasive growth along white matter tracts is a prominent clinicopathological feature of glioma and understanding the relevant clinical features and mechanisms is crucial for identifying new therapeutic targets and treatment strategies. Additionally, the correlation between glioma molecular typing, radiotherapy, TTFields, and glioma invasion along white matter tracts is also discussed.
Article
Multidisciplinary Sciences
Vanessa Siffredi, Maria Chiara Liverani, Dimitri Van de Ville, Lorena G. A. Freitas, Cristina Borradori Tolsa, Petra Susan Huppi, Russia Ha-Vinh Leuchter
Summary: This study aims to assess the effects of mindfulness-based intervention (MBI) on neurobehavioral functioning and changes in white-matter microstructure in very preterm (VPT) young adolescents. After completing an 8-week MBI program, the VPT adolescents showed improved global executive functioning and changes in white-matter tracts involved in executive processes. Lower gestational age at birth was associated with greater gains in white-matter microstructural changes after MBI.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Dongha Lee, Hae-Jeong Park
Summary: This study investigates the three-dimensional organization of neural fiber connections in the white matter of the brain. By analyzing connection distribution maps and related parameters, the study reveals the patterns of major fiber bundle connections in the white matter.
Article
Immunology
Tiffany C. Ho, Artenisa Kulla, Giana I. Teresi, Lucinda M. Sisk, Yael Rosenberg-Hasson, Holden T. Maecker, Ian H. Gotlib
Summary: This study is the first to explore the relationship between peripheral inflammation and white matter microstructure in fronto-cingulatelimbic tracts in depressed and nondepressed adolescents. The results show that depressed adolescents had higher levels of inflammation compared to controls, but there was no significant difference in white matter connectivity between the two groups. While there was an association between inflammation levels and white matter structure, the diagnostic group did not moderate this relationship.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Neuroimaging
Chenxi Pan, Jingru Ren, Lanting Li, Yuqian Li, Jianxia Xu, Chen Xue, Guanjie Hu, Miao Yu, Yong Chen, Li Zhang, Wenbing Zhang, Xiao Hu, Yu Sun, Weiguo Liu, Jiu Chen
Summary: The study found distinct differences in insular subdivision functional connectivity among Parkinson's disease patients with different cognitive levels, which are associated with various cognitive domains. Particularly, alterations in functional connectivity were observed in PD-MCI group compared to PD-NC group and healthy controls, with implications for attention, working memory, visuospatial function, language, executive function, and memory levels.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Genetics & Heredity
Fuquan Zhang, Ancha Baranova, Chao Zhou, Hongbao Cao, Jiu Chen, Xiangrong Zhang, Mingqing Xu
Summary: The study found that neuroticism is genetically correlated with most health-related traits, and has causal effects on 12 mental traits and two physical diseases. Conversely, major depressive disorder, subjective well-being, and insomnia also have causal effects on neuroticism.
Article
Biochemical Research Methods
Shuquan Rao, Ancha Baranova, Hongbao Cao, Jiu Chen, Xiangrong Zhang, Fuquan Zhang
Summary: This study found that smoking has a significant impact on the risk of severe COVID-19 and COVID-19-induced hospitalization, while alcohol consumption has no significant association with COVID-19 outcomes. Analysis of risk genes and genomic loci identified several genes related to COVID-19 outcomes.
BRIEFINGS IN BIOINFORMATICS
(2021)
Correction
Biochemical Research Methods
Shuquan Rao, Ancha Baranova, Hongbao Cao, Jiu Chen, Xiangrong Zhang, Fuquan Zhang
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Biochemistry & Molecular Biology
Shanshan Chen, Yu Song, Huimin Wu, Honglin Ge, Wenzhang Qi, Yue Xi, Jiayi Wu, Yuxiang Ji, Kexin Chen, Xingjian Lin, Jiu Chen
Summary: In patients with amnestic mild cognitive impairment (aMCI), anosognosia is associated with increased tau accumulation in specific brain regions, disrupted functional connectivity, and accelerates progression to Alzheimer's disease dementia.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Wen-ying Ma, Min-jie Tian, Qun Yao, Qian Li, Fan-yu Tang, Chao-yong Xiao, Jing-Ping Shi, Jiu Chen
Summary: The study aimed to identify brain regions with abnormalities in patients with DLB and differences between DLB and AD. Neural networks involved in these abnormal brain regions were described. DLB patients showed dysfunction in certain brain regions compared to control groups and distinction from AD, suggesting potential markers for diagnosis and specific interventions for both DLB and AD.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Chenxi Pan, Yuqian Li, Jingru Ren, Lanting Li, Peiyu Huang, Pingyi Xu, Li Zhang, Wenbing Zhang, Min-Ming Zhang, Jiu Chen, Weiguo Liu
Summary: The study evaluated the frequency and clinical features of mild cognitive impairment in prodromal Parkinson's disease in elderly Chinese individuals. It found that memory, attention/working memory, and executive function were the most commonly impaired domains in pPD, and that cognitive performance was correlated with motor symptoms in this population.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Jiu Chen, Rong Chen, Chen Xue, Wenzhang Qi, Guanjie Hu, Wenwen Xu, Shanshan Chen, Jiang Rao, Fuquan Zhang, Xiangrong Zhang
Summary: This study provides experimental evidence that repetitive transcranial magnetic stimulation (rTMS) can restore altered hippocampal subregions (HIPsub) and their network connectivity, leading to improvement in episodic memory in amnestic mild cognitive impairment (aMCI) patients. The connectivity between HIPsub and the left middle temporal gyrus (MTG.L) plays a significant role in enhancing episodic memory.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Yingying Yue, Rui Liu, Jiu Chen, Yin Cao, Yanfeng Wu, Shining Zhang, Huajie Li, Jijun Zhu, Aiqin Wu, Yonggui Yuan
Summary: The self-rating post stroke depression scale (PSDS) demonstrated good reliability and validity in assessing depressive symptoms among stroke patients. The study retested the psychometric properties of PSDS in different types of post-stroke depression (PSD) and found it to be a useful screening tool with acceptable properties for estimating different subtypes of PSD patients.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Neurosciences
Chenxi Pan, Jingru Ren, Ping Hua, Lei Yan, Miao Yu, Yajie Wang, Gaiyan Zhou, Ronggui Zhang, Jiu Chen, Weiguo Liu
Summary: SCCs are common in early PD patients, with distinct prevalence and risk factors between PD-MCI and PD-NC patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neuroimaging
Wen-Ying Ma, Qun Yao, Guan-Jie Hu, Hong-Lin Ge, Chen Xue, Ying-Ying Wang, Yi-Xin Yan, Chao-Yong Xiao, Jing-Ping Shi, Jiu Chen
Summary: The study revealed different patterns of functional reorganization in DLB and AD patients, with the conversion and redistribution of rich club nodes possibly playing a causal role in disease-specific outcomes. This could serve as a potential biomarker for more accurate prevention and treatment strategies.
NEUROIMAGE-CLINICAL
(2022)
Article
Psychiatry
Chao Zhou, Chen Xue, Jiu Chen, Nousayhah Amdanee, Xiaowei Tang, Hongying Zhang, Fuquan Zhang, Xiangrong Zhang, Caiyi Zhang
Summary: This study revealed abnormal patterns of FC in the NAcc network between DS and NDS, with altered LNAcc-CAL FC potentially involved in the pathogenesis of negative symptoms in schizophrenia. Aberrant FC values within the NAcc network were correlated with severity of clinical symptoms and neurocognitive impairments in DS and NDS patients.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Ju Gao, Rongtao Jiang, Xiaowei Tang, Jiu Chen, Miao Yu, Chao Zhou, Xiang Wang, Hongying Zhang, Chengbing Huang, Yong Yang, Xiaobin Zhang, Zaixu Cui, Xiangrong Zhang
Summary: This study demonstrated that local properties of brain regions extracted from multimodal imaging data could be used to distinguish deficit schizophrenia (DS) from non-deficit schizophrenia (NDS) with a machine learning approach, and confirmed the relationship between these features and the negative symptoms subdomain. These findings may improve the identification of potential neuroimaging signatures and enhance the clinical assessment of deficit syndrome.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Behavioral Sciences
Qianqian Yuan, Chen Xue, Xuhong Liang, Wenzhang Qi, Shanshan Chen, Yu Song, Huimin Wu, Xulian Zhang, Chaoyong Xiao, Jiu Chen
Summary: This study investigates the functional changes in patients with early-stage Alzheimer's disease (aMCI) and compares the changes before and after repetitive transcranial magnetic stimulation (rTMS) targeting the precuneus. The results show that rTMS targeting the precuneus can improve cognitive function in aMCI patients and is closely related to brain connectivity modulation.
BRAIN AND BEHAVIOR
(2023)
Article
Medicine, Research & Experimental
Fuquan Zhang, Shuquan Rao, Hongbao Cao, Xiangrong Zhang, Qiang Wang, Yong Xu, Jing Sun, Chun Wang, Jiu Chen, Xijia Xu, Ning Zhang, Lin Tian, Jianmin Yuan, Guoqiang Wang, Lei Cai, Mingqing Xu, Ancha Baranova
Summary: This study investigates the relationship between PTSD and three types of depressive phenotypes, namely MDD, DAF, and DEP. The results suggest that PTSD shares genetic factors with MDD and supports the idea that PTSD can be considered as a subtype of MDD, which can help reduce heterogeneity in psychiatric diagnosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
