Article
Immunology
Ariel Kenig, Yuval Ishay, Fadi Kharouf, Limor Rubin
Summary: This study demonstrates the therapeutic efficacy of convalescent plasma and plasma-based products in a subgroup of immunocompromised patients with iatrogenic B-cell depletion, showing significant clinical improvement and rapid viral clearance following plasma administration.
CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
A. E. Ades, Fabiana Gordon, Karen Scott, Intira Jeannie Collins, Claire Thorne, Lucy Pembrey, Elizabeth Chappell, Eugenia Marine-Barjoan, Karina Butler, Giuseppe Indolfi, Diana M. Gibb, Ali Judd
Summary: Based on the largest purely prospective dataset assembled to date, this study found that 66% of confirmed vertically acquired hepatitis C virus infections clear spontaneously by age 5 years, rather than the 25%-40% assumed in current guidelines. Treatment before age 3 would avoid loss to follow-up but result in substantial overtreatment.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Immunology
Anna Furlan, Gabriella Forner, Ludovica Cipriani, Elisa Vian, Roberto Rigoli, Filippo Gherlinzoni, Piergiorgio Scotton
Summary: The study demonstrates significant effects of B cell-depleting agents on adaptive immunity, which should be considered in the selection of SARS-CoV-2 diagnostics and guiding therapeutic approaches. Combination therapeutic strategies may play a crucial role in the setting of B cell immune deficiencies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Shaher M. Samrah, Abdel-Hameed Al-Mistarehi, Tariq Kewan, Sohaib M. Al-Khatib, Ali M. Ibnian, Randa S. Samrah, Basheer Y. Khassawneh
Summary: This study conducted in Northern Jordan investigated the incubation period and viral clearance time of COVID-19 hospitalized cases. The median incubation period was 6 days and the median viral clearance time was 13 days. Symptomatic presentation and abnormal chest radiograph were predictors for a prolonged viral clearance time.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2021)
Article
Immunology
Shima Shahbaz, Lai Xu, Wendy Sligl, Mohammed Osman, Najmeh Bozorgmehr, Siavash Mashhouri, Desiree Redmond, Eliana Perez Rosero, John Walker, Shokrollah Elahi
Summary: Understanding the function of SARS-CoV-2 Ag-specific T cells is crucial for antiviral immunity monitoring and vaccine design. This study reveals that while there are variations in T cell responses to viral peptide pools among COVID-19 patients, the expression of coinhibitory receptors is associated with increased frequencies of cytokine-producing T cells. A Th2 phenotype may be linked to milder disease, while a robust Th17 response is associated with severe disease.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Microbiology
Ji Qiu, Anna Engelbrektson, Lusheng Song, Jin Park, Vel Murugan, Stacy Williams, Yunro Chung, Ericka Nelly Pompa-Mera, Jorge Luis Sandoval-Ramirez, Jose Antonio Mata-Marin, Jesus Gaytan-Martinez, Eliana Troiani, Maurizio Sanguinetti, Paola Roncada, Andrea Urbani, Giacomo Moretti, Javier Torres, Joshua LaBaer
Summary: In an immunoproteomics study, researchers found that patients with severe COVID-19 had higher levels of antibodies against SARS-CoV-2, HCoV-229E, and HcoV-NL63 compared to patients with mild disease. This study provides insights into the risk factors for disease severity in COVID-19.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pediatrics
Giusi Mangone, Daniele Serranti, Elisa Bartolini, Veronica Vigna, Greta Mastrangelo, Silvia Ricci, Sandra Trapani, Chiara Azzari, Massimo Resti, Giuseppe Indolfi
Summary: The study confirms the association between interferon-lambda genes and the outcome of HCV infection in children. Specific SNPs in these genes have been shown to be associated with spontaneous clearance of HCV in children, indicating the important role of the innate immune system in vertically acquired HCV infection. Interferons-lambda activate the Janus kinase-Stat pathway, leading to suppression of HCV replication both in vivo and in vitro.
PEDIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Michala Jakubikova, Michaela Tyblova, Adam Tesar, Magda Horakova, Daniela Vlazna, Irena Rysankova, Iveta Novakova, Kristyna Doleckova, Pavel Dusek, Jiri Pitha, Stanislav Vohanka, Josef Bednarik
Summary: In MG patients, lower FVC, long-term high-dose corticosteroid treatment, older age, presence of cancer, and recent rituximab treatment were identified as the most important predictors of severe COVID-19.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Weitao Zhuang, Shujie Huang, Dongya Wang, Lulu Zha, Wei Xu, Guibin Qiao
Summary: This study found that fever at illness onset, a high serum level of AST, and a high titer of SARS-CoV-2 IgG were independent risk factors associated with delayed viral clearance in patients with refractory COVID-19.
Article
Immunology
Xiao-Yu Zhang, Tao Li, Haibing Wu, Yun Ling, Zhi-Ping Qian, Liang Chen
Summary: This study aimed to evaluate the effect of proton-pump inhibitors on the course of COVID-19. The results showed that proton-pump inhibitors did not significantly affect the duration of SARS-CoV-2 clearance and hospital stay in COVID-19 patients, indicating that the use of proton-pump inhibitors is not recommended during treatment.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemical Research Methods
Bingbo Wang, Xianan Dong, Jie Hu, Xiujuan Ma, Chao Han, Yajun Wang, Lin Gao
Summary: This paper analyses the molecular perturbations induced by SARS-CoV-2 infection and reveals the core and peripheral regions of the virus-host network. The study suggests a core-periphery pattern that can help identify comorbidities and potential drug candidates for COVID-19, offering insights into therapeutic drug research.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Virology
Denise Utami Putri, Cheng-Hui Wang, Po-Chun Tseng, Wen-Sen Lee, Fu-Lun Chen, Han-Pin Kuo, Chih-Hsin Lee, Chiou-Feng Lin
Summary: The study aims to evaluate the changes in immune cell profile of COVID-19 patients and found that in patients with longer viral RNA-shedding period, certain immune cells show abnormal upregulation or downregulation. Additionally, during the disease course, the pro-inflammatory Th1 cells showed a declining trend, while immunoregulatory cells were upregulated before declining.
Article
Microbiology
Nana Wei, Guangqi Zhu, Tingxiao Zhao, Yan Wang, Haifei Lou, Haoxuan Li, Zhejuan Yang, Zheen Zhang, Qiujing Wang, Mingfang Han, Zhibing Lin, Shibo Li
Summary: The oral microbiome of COVID-19 recovered patients was found to be nearly normalized, with a decrease in opportunistic pathogens and an increase in butyrate-producing organisms. These differences persisted even 12 months after recovery, highlighting the importance of long-term monitoring.
Article
Public, Environmental & Occupational Health
Narongwit Nakwan
Summary: Nocardial infection is a rare opportunistic infection with high morbidity and mortality, especially in patients with HIV infection. The lung is a common site involved in this infection, leading to potential complications.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Public, Environmental & Occupational Health
Tairong Wang, Yue Zhang, Rong Zhang, Ye Mao, Junhai Yan, Yiwen Long, Qiaofeng Chen, Xiaojing Li, Huixiang Wang, Shuai Huang, Chao Zhu, Bin Teng, Xu Wang
Summary: The purpose of this study is to assess the effect of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance among COVID-19 patients. The study found that nasal irrigation and oral rinse with 5% sodium bicarbonate solution can effectively clear the SARS-CoV-2 virus among COVID-19 patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Rheumatology
Agnes Kocher, Michael Simon, Andrew A. Dwyer, Catherine Blatter, Jasmina Bogdanovic, Patrizia Kuenzler-Heule, Peter M. Villiger, Diana Dan, Oliver Distler, Ulrich A. Walker, Dunja Nicca
Summary: The study found that patients had a relatively high comprehension of eHealth information, but lacked confidence in evaluating information reliability and finding related apps. Patients and professionals had little experience with web-based self-management support. Education/training for patients and professionals to support uptake of eHealth resources was highlighted as crucial.
Article
Rheumatology
Stavros Giaglis, Douglas Daoudlarian, Reinhard E. Voll, Diego Kyburz, Nils Venhoff, Ulrich A. Walker
Summary: The study found that circulating mtDNA levels are significantly increased in SLE patients compared to healthy controls, and are associated with SLE disease activity. mtDNA levels can sensitively distinguish SLE patients from healthy individuals and serve as an independent marker of SLE activity.
Article
Rheumatology
Ulrich A. Walker, Hugh H. Tilson, Philip N. Hawkins, Tom van der Poll, Stephanie Noviello, Jeremy Levy, Eleni Vritzali, Hal M. Hoffman, Jasmin B. Kuemmerle-Deschner
Summary: This study reported the long-term safety and effectiveness of canakinumab in patients with CAPS, showing sustained response over 6 years with a favorable safety profile. The drug demonstrated significant efficacy in reducing disease activity in CAPS patients.
Article
Rheumatology
Yomei Shaw, Delphine S. Courvoisier, Almut Scherer, Adrian Ciurea, Thomas Lehmann, Veronika K. Jaeger, Ulrich A. Walker, Axel Finckh
Summary: The study found that rheumatic disease patients who discussed app data with their rheumatologist had better shared decision making and physician awareness of disease fluctuations. On the other hand, patients who only used the app without discussing data did not show significant improvement in patient-provider interactions.
Article
Medicine, General & Internal
Craig Kingston, Gunther Zech, Caroline Pauli, Ulrich Walker
CASE REPORTS IN MEDICINE
(2020)
