Article
Biophysics
Narges Ashrafi, Behzad Shareghi, Sadegh Farhadian, Mansoore Hosseini-Koupaei
Summary: This study investigated the effect of polyamine on the compound and function of lysozyme using UV-Visible and fluorescence spectroscopy as well as simulation method. The results showed that increasing polyamine concentration reduced the intrinsic quenching fluorescence of lysozyme and altered its secondary and tertiary structures. Polyamine also inhibited the enzymatic activity of lysozyme.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Chemistry, Organic
Gabriele Travagliante, Massimiliano Gaeta, Roberto Purrello, Alessandro D'Urso
Summary: Self-assembly is a powerful strategy for constructing complex supramolecules. Water-soluble porphyrinoids, which can form aggregates in aqueous media via weak non-covalent forces, are ideal paradigms to study self-assembly. Studies have shown that even achiral porphyrin aggregates can exhibit supramolecular chirality. This mini-review discusses strategies for designing and building chiral aggregates in water from achiral porphyrin monomers, with a particular focus on their chiroptical features.
CURRENT ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Riddhi P. Dave, Man Singh
Summary: This study designed thermodynamically, kinetically, and tentropically stable homogeneous solutions of bovine serum albumin (BSA 66), hemoglobin (Hb 64.5), and double stranded deoxyribonucleic acid (dsDNA 130 kDa) with water and different concentrations of aqueous carboxymethyl cellulose sodium salt (NaCMC). The physicochemical properties of these solutions were studied, and various methods were used to analyze their structural recognition and interaction. The results showed that the interaction mechanism of BSA, Hb, and dsDNA with NaCMC involved salt bridges, electrostatic dipoles, and hydrogen bonds, and these interactions could affect the solubilization of biomolecules. The findings of this study have implications for areas such as biochemical, biophysical, bioengineering, tissue, and genetic engineering, and can be extended to pharmaceutical and cosmetic processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Gayane Ananyan, Nelli H. Karapetyan, Yeva B. Dalyan
Summary: The binding characteristics of water-soluble porphyrins and their Cu and Co derivatives with synthetic polynucleotides were studied, showing different binding modes at different concentrations. The calculated binding constants and exclusion parameters for each complex aligned well with proposed models.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Multidisciplinary
Alberto Gimenez-Gomez, Benjamin Rollins, Andrew Steele, Helen Holzel, Nicolo Baggi, Kasper Moth-Poulsen, Ignacio Funes-Ardoiz, Diego Sampedro
Summary: Solar energy utilization has gained attention for its abundance and renewability. Developing energy storing compounds that capture and release solar energy on demand is a potential solution. These compounds undergo a photochemical transformation, storing solar energy in high-energy photoisomers. While the photoisomerization of MOlecular Solar Thermal (MOST) systems has been extensively studied, the back-conversion using heterogeneous catalysts is still underexplored. In this study, the performance of 27 catalysts in releasing stored energy in a Norbornadiene/Quadricyclane MOST system is compared using UV-Vis spectroscopy. The findings provide insights for the development of effective catalysts in MOST systems and highlight the importance of further investigation on heterogeneous catalysis.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Food Science & Technology
Jessica Laika, Giampiero Sacchetti, Annalaura Sabatucci, Junior Bernardo Molina-Hernandez, Antonella Ricci, Romolo Laurita, Silvia Tappi, Alessandro Di Michele, Lilia Neri
Summary: This study investigated the effect of different CAP exposures on the activity of horseradish peroxidase (HRP) and the potential role of sugars in enzyme inactivation. The results showed that the inactivation of HRP in phosphate buffer depended on both treatment time and ozone concentration. Sugars reduced the efficacy of CAP, with a greater effect observed for disaccharides. In addition, sugars preserved the tertiary structure of HRP and prevented protein loss. This study deepened our understanding of the effect of CAP on peroxidase activity and demonstrated the effectiveness of sugars in mitigating enzyme inactivation.
Article
Chemistry, Physical
Zetan Cao, Jia He, Chuangwei Jiao, Zhiwen Liu, Linfeng Xu, Cheng Zheng, Simin Peng, Bin Chen
Summary: In this study, the enantioselective synthesis of intrinsically chiral perovskite-like CsCuCl3 nanocrystals was achieved at room temperature using chiral amino acids as additives in an antisolvent crystallization method. The resulting D-/L-ligand-induced enantiomeric nanocrystals exhibited characteristic chiroptical responses. By adjusting the amino acid types and Cs/Cu feed ratios, the chiroptical activity of the nanocrystals could be controlled. This research opens up new pathways for the controllable synthesis of intrinsically chiral inorganic materials and provides a better understanding of the origins of precursor-ligand-associated chiral discrimination and crystallization phenomena.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Physical
Zetan Cao, Jia He, Chuangwei Jiao, Zhiwen Liu, Linfeng Xu, Cheng Zheng, Simin Peng, Bin Chen
Summary: Enantiomeric control of intrinsically chiral inorganic nanocrystals was achieved through enantioselective synthesis using chiral amino acids. The chiroptical activity of the nanocrystals could be tailored by adjusting the Cs/Cu feed ratios and amino acid types. This strategy enables the controllable synthesis of intrinsically chiral inorganics and provides insights into the origins of chiral discrimination and crystallization phenomena.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Physical
Zetan Cao, Jia He, Chuangwei Jiao, Zhiwen Liu, Linfeng Xu, Cheng Zheng, Simin Peng, Bin Chen
Summary: In this study, enantioselective synthesis of intrinsically chiral CsCuCl3 nanocrystals was achieved using chiral amino acids as ligands through an antisolvent crystallization method at room temperature. The chiroptical activity of the nanocrystals could be tailored by adjusting the Cs/Cu feed ratios and amino acid types upon addition of D- or L-form ligands. The polarity of the amino acids and their coordination configurations with the nanocrystal structures played important roles in determining the chiroptical responses.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Physical
Trent R. Graham, Brandy N. Gartman, Anjelica Bautista, Lindsay E. I. Irwin, Eden J. Shelby, Danielle L. Saunders, Timothy J. Johnson, Mark K. Murphy, Nicolas Uhnak, Andrew M. Ritzmann, James M. Bowen
Summary: This study explores the sensitivity and limitations of various spectroscopic techniques in detecting changes in iodine speciation. The results show that commonly used spectroscopies have different sensitivities to various iodine species. Through the analysis of Raman, FTIR, and NMR spectra, high-resolution autocorrelation spectra are generated to track the acidification-induced and gamma irradiation-induced transformations of iodine. This research provides insights for designing optimal combinations of techniques to detect different forms of iodine.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Luca Botti, Sebastian Meier, Ceri Hammond
Summary: This study investigates the catalytic conversion of glucose using Lewis acidic silicates in a continuous flow reactor with operando UV-vis spectroscopy. Transient absorption features related to glucose activation and conversion at various operational conditions are identified, and the deactivation of the stannosilicate catalyst is shown to affect the overall performance of the glucose upgrading reaction during continuous operation. The study highlights the nonuniform deactivation of the catalyst and its implications for improving the selectivity of catalysts for glucose upgrading.
Article
Biochemistry & Molecular Biology
Milena Mlakic, Ivona Cipor, Petra Kovacec, Goran Kragol, Ana Ratkovic, Tatjana Kovacevic, Rahela Zadravec, Valentina Milasinovic, Kresimir Molcanov, Ivo Piantanida, Irena Skoric
Summary: A new series of 4H-1,3-benzothiazine dyes were synthesized and characterized. Two synthetic pathways, Buchwald-Hartwig amination and electrochemical synthesis, were used to prepare benzothiazine salts. Electrochemical intramolecular dehydrogenative cyclization was employed to form 4H-1,3-benzothiazines. The binding of these compounds to polynucleotides was examined, and compounds 1 and 2 showed potential as DNA/RNA groove binders.
Article
Biochemical Research Methods
Neelam Kumari, Deepika Singh, Priya Singh, Akanksha Mishra, Chandraprakash Gond, Himanshu Ojha, Anjani Kumar Tiwari
Summary: The methoxy derivatives of arylpiperazinyl-alkyl benzothiazolone were evaluated as specific probes for 5HT(7). Through in-vitro/vivo studies, the C-2 substituted [C-11]ABT showed specific binding to the 5HT(7) receptor. Photophysical analysis of the interaction between BSA and ABT provided insights into the ADME properties of this drug candidate.
JOURNAL OF FLUORESCENCE
(2023)
Article
Chemistry, Physical
Qin Yang, Josef Kapitan, Petr Bour, Julien Bloino
Summary: Combining Raman scattering and Raman optical activity (ROA) with computer simulations allows for the characterization of chiral molecules' fine structure and physicochemical properties. This study presents an accurate and simple approach based on three-quanta anharmonic perturbative mode, showing the significance of anharmonic Raman and ROA spectroscopies in understanding chiral molecules' vibrations and calibrating computational models.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Environmental Sciences
S. Tamilselvan, R. M. Soniya, R. Vasantharaja, M. Kannan, S. Supriya, B. Prabhu Dass Batvari, T. Ramesh, K. Govindaraju
Summary: This study investigated a simple silver nanoparticle that can be used for the qualitative and quantitative sensing of heavy metal ions in aqueous solutions. The particles exhibited changes in their UV-vis absorption spectrum, indicating the presence of different metal ions.
ENVIRONMENTAL RESEARCH
(2022)