Article
Biochemistry & Molecular Biology
Changyong Guo, Di Wen, Yihong Zhang, Richie Mustaklem, Basil Mustaklem, Miou Zhou, Tao Ma, Yao-Ying Ma
Summary: This study suggests that the synaptic insertion mechanism of CP-AMPARs in the nucleus accumbens is crucial for mediating synaptic degeneration in Alzheimer's Disease. Blocking CP-AMPARs can prevent Aβ O-associated spine loss and reduced synaptic transmission.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Dmitry Amakhin, Elena B. Soboleva, Anton Chizhov, Aleksey Zaitsev
Summary: The study demonstrates that epileptic activity leads to the rapid insertion of CP-AMPARs into neuronal synapses, affecting the generation rate of epileptiform discharges. The expression of CP-AMPARs in principal neurons reduces the discharge generation rate, potentially serving as a protective mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Brett A. Eyford, Maciej J. Lazarczyk, Kyung Bok Choi, Merina Varghese, Hitesh Arora, Suresh Kari, Lonna Munro, Cheryl G. Pfeifer, Allison Sowa, Daniel R. Dickstein, Dara L. Dickstein, Wilfred A. Jefferies
Summary: This study investigates the significance of the cytoplasmic tail of MHC-I in synaptic signaling and its impact on the expression of synaptic glutamate receptors. The findings reveal that the Y321F substitution influences the expression of AMPAR subunits and alters the phosphorylation of key kinases. These results illuminate the crucial role of MHC-I in AMPAR function and synaptic plasticity modulation.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Amit Walia, Choongheon Lee, Jared Hartsock, Shawn S. Goodman, Roland Dolle, Alec N. Salt, Jeffery T. Lichtenhan, Mark A. Rutherford
Summary: The cochlear afferent synapses may contain GluA2-lacking CP-AMPARs, which can be acutely antagonized with systemic dosing to protect from glutamate excitotoxicity while transmission at GluA2-containing AMPARs persists to mediate hearing during the protection.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2021)
Letter
Clinical Neurology
Kazuya Okamura, Takashi Komori, Mai Sugimoto, Yoshitaka Kawashima, Mitsuhiko Yamada, Toshifumi Kishimoto
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2021)
Article
Health Care Sciences & Services
Yosuke Sugiyama, Rei Tanaka, Tetsu Sato, Tetsumi Sato, Akiyoshi Saitoh, Daisuke Yamada, Michihiro Shino
Summary: This study suggests that there is no significant difference in the incidence of delirium among previously opioid-naive patients taking oral morphine sulfate, oxycodone hydrochloride, and tapentadol hydrochloride extended-release tablets.
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE
(2022)
Article
Behavioral Sciences
Toshinori Yoshioka, Daisuke Yamada, Riho Kobayashi, Eri Segi-Nishida, Akiyoshi Saitoh
Summary: Adult hippocampal neurogenesis is closely related to depressive disorders, and psychological stress can decrease cell survival rate in the hippocampus of mice, influencing the validity of emotional stress in animal models of depression.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Hiroki Furuie, Mitsuhiko Yamada
Summary: During the postnatal period, NR2A-containing NMDA receptor plays a crucial role in proper brain development in rats, and disturbances in its functioning result in impaired spatial working memory in adulthood.
NEUROSCIENCE RESEARCH
(2022)
Article
Behavioral Sciences
Ayako Kawaminami, Daisuke Yamada, Shoko Yanagisawa, Motoki Shirakata, Keita Iio, Hiroshi Nagase, Akiyoshi Saitoh
Summary: KNT-127, a selective agonist of the delta-opioid receptor (DOP), has been shown to facilitate fear extinction in mice. This study identified the basolateral nucleus of the amygdala (BLA) and infralimbic subregion of the medial prefrontal cortex (IL) as the brain regions where KNT-127 reduces freezing response during fear memory testing. The effect of KNT-127 was mediated by MEK/ERK signaling in the BLA, PI3K/Akt signaling in the IL, and DOPs in both brain regions.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mana Murae, Yoshimi Shimizu, Yuichiro Yamamoto, Asuka Kobayashi, Masumi Houri, Tetsuya Inoue, Takuya Irie, Ryutaro Gemba, Yosuke Kondo, Yoshio Nakano, Satoru Miyazaki, Daisuke Yamada, Akiyoshi Saitoh, Isao Ishii, Taishi Onodera, Yoshimasa Takahashi, Takaji Wakita, Masayoshi Fukasawa, Kohji Noguchi
Summary: Viral spike proteins, especially the SARS-CoV-2 spike protein, play crucial roles in viral entry and infection. The cysteine residue at position 488 in the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is essential for its functions and infectivity. Targeting this residue could be a potential strategy for anti-SARS-CoV-2 therapeutics.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Akiko Oota-Ishigaki, Keizo Takao, Daisuke Yamada, Masayuki Sekiguchi, Masayuki Itoh, Yumie Koshidata, Manabu Abe, Rie Natsume, Masaki Kaneko, Toma Adachi, Toshie Kaizuka, Nami Suzuki, Kenji Sakimura, Hiroyuki Okuno, Keiji Wada, Masayoshi Mishina, Tsuyoshi Miyakawa, Takashi Hayashi
Summary: This study suggests that impairment of AMPA receptor palmitoylation specifically causes symptoms resembling posttraumatic stress disorder (PTSD), including prolonged contextual fear memory formation and increased fear generalization. However, this mutation has no effect on anxiety levels, locomotion, sociability, depression-related behaviors, and spatial learning and memory.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Akiyoshi Saitoh, Yoshifumi Nagayama, Daisuke Yamada, Kosho Makino, Toshinori Yoshioka, Nanami Yamanaka, Momoka Nakatani, Yoshino Takahashi, Mayuna Yamazaki, Chihiro Shigemoto, Misaki Ohashi, Kotaro Okano, Tomoki Omata, Etsuko Toda, Yoshitake Sano, Hideyo Takahashi, Kouji Matsushima, Yuya Terashima
Summary: This study found that Disulfiram produces anxiolytic-like effects in rodents by inhibiting the presynaptic inhibitory effects on glutaminergic neurons. Unlike diazepam, Disulfiram does not have adverse effects and may be an effective novel anxiolytic drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Tsugumi Yamauchi, Toshinori Yoshioka, Daisuke Yamada, Takumi Hamano, Maika Ikeda, Masato Kamei, Takaya Otsuki, Yasuo Sato, Kyoko Nii, Masashi Suzuki, Satoshi Iriyama, Kazumi Yoshizawa, Shoichi Nishino, Hiroko Ichikawa, Satoru Miyazaki, Akiyoshi Saitoh
Summary: This study used olfactory bulbectomized rats as an animal model of depression and found that high-frequency ultrasound exposure had a significant impact on the emotional state of rats, improving their depressive-like behavior.
Article
Neurosciences
Toshinori Yoshioka, Misaki Ohashi, Kenjiro Matsumoto, Tomoki Omata, Takumi Hamano, Mayuna Yamazaki, Sayaka Kimiki, Kotaro Okano, Riho Kobayashi, Daisuke Yamada, Noriyasu Hada, Shinichi Kato, Akiyoshi Saitoh
Summary: Increasing evidence suggests a connection between emotional states and intestinal conditions in brain-gut interactions. This study focused on a validated animal model of stress-induced psychiatric disorders (cVSDS model mice) and found that these mice exhibited symptoms similar to irritable bowel syndrome (IBS), including changes in intestinal motility and increased visceral pain. These symptoms persisted for a month after the stress session. Additionally, a traditional Chinese medicine used for the treatment of IBS normalized the intestinal motility changes in the model mice.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Toshinori Yoshioka, Daisuke Yamada, Eri Segi-Nishida, Hiroshi Nagase, Akiyoshi Saitoh
Summary: This study investigates the effects of DOP agonist KNT-127 on the pathophysiological factors of depression in cVSDS mice. KNT-127 improves social interaction behaviors and corticosterone levels in cVSDS mice, as well as regulates neurogenesis and neuroinflammation. It also suppresses microglial overactivation in the hippocampal dentate gyrus.
Review
Neurosciences
Yoshitaka Kawashima, Misa Yamada, Hiroki Furuie, Hiroshi Kuniishi, Kie Akagi, Tomoko Kawashima, Takamasa Noda, Mitsuhiko Yamada
Summary: This study aimed to evaluate the efficacy and tolerability of riluzole for patients with psychiatric disorders characterized by anxiety or fear. The findings indicate insufficient evidence to confirm the effects of riluzole for these patients.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)
Article
Neurosciences
Junpei Takahashi, Yudai Ueta, Daisuke Yamada, Sachie Sasaki-Hamada, Takashi Iwai, Tomomi Akita, Chikamasa Yamashita, Akiyoshi Saitoh, Jun-Ichiro Oka
Summary: This study aimed to investigate the potential therapeutic effects of oxytocin on cognitive impairment in Alzheimer's disease. The results showed that both intracerebroventricular and intranasal administration of oxytocin improved memory deficits in mice in Y-maze and Morris water maze tests. Fluorescence imaging revealed the successful delivery of oxytocin to the mouse brain following intranasal administration.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2022)
Article
Neurosciences
Kazumi Yoshizawa, Saki Ukai, Junpei Kuroda, Tsugumi Yamauchi, Daisuke Yamada, Akiyoshi Saitoh, Satoshi Iriyama, Shoichi Nishino, Satoru Miyazaki
Summary: Stress affects brain activity and has complex modulatory effects on pain. In mice, restraint stress lowers tactile thresholds and increases anxiety sensitivity. GABAergic function appears to play a critical role in regulating stress-induced hyperalgesia and anxiety.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2022)
Article
Pharmacology & Pharmacy
Tsugumi Yamauchi, Toshinori Yoshioka, Daisuke Yamada, Takumi Hamano, Misaki Ohashi, Maki Matsumoto, Keita Iio, Maika Ikeda, Masato Kamei, Takaya Otsuki, Yasuo Sato, Kyoko Nii, Masashi Suzuki, Hiroko Ichikawa, Hiroshi Nagase, Satoshi Iriyama, Kazumi Yoshizawa, Shoichi Nishino, Satoru Miyazaki, Akiyoshi Saitoh
Summary: This study investigates the effects of stress-induced ultrasonic vocalization (USVs) in adult mice and evaluates the impact of psychiatric drugs on stress-induced USVs. The results show that cold-restraint stress significantly increases the number of USVs and plasma corticosterone levels compared to stress alone. Benzodiazepine anxiolytic and delta-opioid receptor agonist reduce the stress-induced USV number and plasma corticosterone levels, while monoaminergic antidepressant and N-methyl-D-aspartic acid receptor antagonist antidepressant do not reduce the USV numbers. The study suggests that cold-restraint stress-induced USVs can be used as a novel tool to measure rodent anxiety and assess the effects of anxiolytics.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)