期刊
FRONTIERS IN MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.00634
关键词
cyanobacterium; oleochemicals; metabolic engineering; carbon dioxide conversion; lipid metabolism
类别
资金
- National Natural Science Foundation of China [31871303, 21978071, U1932141]
- National Key Research and Development Program of China [2018YFC1801200]
- Key Laboratory of Biofuel, Chinese Academy of Sciences [CASKLB201802]
- State Key Laboratory of Freshwater Ecology and Biotechnology [2018FB09]
Sustainable production of biofuels and biochemicals has been broadly accepted as a solution to lower carbon dioxide emissions. Besides being used as lubricants or detergents, oleochemicals are also attractive biofuels as they are compatible with existing transport infrastructures. Cyanobacteria are autotrophic prokaryotes possessing photosynthetic abilities with mature genetic manipulation systems. Through the introduction of exogenous or the modification of intrinsic metabolic pathways, cyanobacteria have been engineered to produce various bio-chemicals and biofuels over the past decade. In this review, we specifically summarize recent progress on photosynthetic production of fatty acids, fatty alcohols, fatty alk(a/e)nes, and fatty acid esters by genetically engineered cyanobacteria. We also summarize recent reports on fatty acid and lipid metabolisms of cyanobacteria and provide perspectives for economic cyanobacterial oleochemical production in the future.
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