Article
Infectious Diseases
Yoowon Kwon, Young-Sun Cho, Yoo-Mi Lee, Seok-jin Kim, Jaewoong Bae, Su-Jin Jeong
Summary: This study evaluated the gut microbiome state in infants following systemic antibiotic treatment. The results showed that the composition of the gut microbiome in the antibiotic treatment group was altered, with increased relative abundance of Escherichia/Shigella and Bifidobacterium, and decreased relative abundance of Bacteroides. Additionally, the antibiotic treatment group had lower microbiome diversity. Long-term studies are needed to further understand the impact of antibiotics on the gut microbiome.
Article
Environmental Sciences
Serguei Drovetski, Brian K. Schmidt, Jonas E. Lai, Michael S. Gross, Michelle L. Hladik, Kenan O. Matterson, Natalie K. Karouna-Renier
Summary: Chemically intensive crop production has detrimental effects on wildlife, including depletion of food resources, hindrance of animal development and health, suppression of immune systems, and facilitation of infectious diseases. This study shows that exposure to modern crop production significantly impacts the gut microbiota of sharp-tailed grouse and greater prairie chickens, leading to changes in composition and potential pathogen overgrowth.
ENVIRONMENTAL POLLUTION
(2022)
Article
Immunology
Xiao Yu, Ye Jin, Wangxiao Zhou, Tingting Xiao, Zhongwen Wu, Junwei Su, Hainv Gao, Ping Shen, Beiwen Zheng, Qixia Luo, Lanjuan Li, Yonghong Xiao
Summary: This study assessed the impact of long-term prophylactic use of rifaximin on the gut microbiota and resistome in cirrhotic patients. The results showed that rifaximin did not significantly alter the gut microbiota and did not induce the emergence of new antimicrobial resistance genes. Rifaximin improved hyperammonemia and cognitive function, potentially through modulating HE-related metabolic pathways.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Infectious Diseases
Gianluca Bossu, Riccardo Di Sario, Alberto Argentiero, Susanna Esposito
Summary: This review analyzes the literature on the widespread use of antibiotic prophylaxis in children with cancer and its effects on the gut microbiome, finding that there is currently insufficient data to define universal guidelines for antimicrobial prophylaxis in this population. Further studies are needed to understand the impact of dysbiosis in response to therapy and to determine how to modulate the microbiome for better therapeutic outcomes in these children.
Review
Immunology
Marcela Mizuhira Gobbo, Marina Bocamino Bomfim, Wille Ygor Alves, Karen Cristina Oliveira, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: This review evaluates the effects of antibiotic therapy on gut microbiota and its impact on autoimmune diseases through preclinical studies. The findings suggest that antibiotic therapy can both improve and worsen autoimmune conditions, with the outcome being influenced by factors such as gender, IL-10, and Treg cells.
AUTOIMMUNITY REVIEWS
(2022)
Article
Microbiology
Xuanji Li, Jakob Stokholm, Asker Brejnrod, Gisle Alberg Vestergaard, Jakob Russel, Urvish Trivedi, Jonathan Thorsen, Shashank Gupta, Mathis Hjort Hjelmso, Shiraz A. Shah, Morten Arendt Rasmussen, Hans Bisgaard, Soren Johannes Sorensen
Summary: The study found a clear bimodal distribution of antibiotic resistance genes (ARGs) acquired in early life, driven by the composition of the gut microbiome. Various environmental factors significantly impacted ARG load, with the importance of antibiotics diminishing over time since treatment.
CELL HOST & MICROBE
(2021)
Article
Biochemistry & Molecular Biology
Michelle Ren, Shahrdad Lotfipour
Summary: Communication between the brain and gut bacteria affects drug and addiction behaviors. Researchers investigated the impact of gut microbiota on fentanyl reinforcement and reward by depleting gut bacteria in adult male and female rats using antibiotics and allowing them to self-administer fentanyl. The results showed that antibiotic treatment increased fentanyl self-administration in males, but not females, at the lowest reinforcement schedule. Both males and females treated with antibiotics self-administered higher amounts of fentanyl at higher reinforcement schedules. Replenishing microbial metabolites restored normal fentanyl self-administration levels, indicating a significant relationship between gut microbiome and opioid use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Zoology
Huihui Sun, Hu LI, Xue Zhang, Yan Liu, Hao Chen, Li Zheng, Yifan Zhai, Hao Zheng
Summary: There is growing concern about antibiotic resistance, and evidence shows that gut microbiota plays a critical role in providing antibiotic resistance. Honeybees, as important pollinators, have antibiotic resistance genes in their gut, posing potential risks to their own and public health. The honeybee gut serves as a reservoir for antibiotic resistance genes and could transfer these genes to pathogens, potentially spreading them during pollination and social interactions.
INTEGRATIVE ZOOLOGY
(2023)
Article
Microbiology
Hyokeun Song, Saehah Yi, Woo-Hyun Kim, Jae-Ho Guk, Minjong Ha, Insik Kwak, Janghee Han, Seong-Chan Yeon, Seongbeom Cho
Summary: Rehabilitation period can affect the gut microbiome and antibiotic resistance of wild migratory birds, potentially impacting their adaptability to natural environments and contributing to the spread of antibiotic resistance after release.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Pamornya Buthasane, Sittiruk Roytrakul, Narumon Phaonakrop, Paiboon Tunsagool, Wannapol Buthasane, Nutthee Am-in, Gunnaporn Suriyaphol
Summary: This study compares the metaproteomic profiles of the gut resistome and related metabolism in the cecal microbiota of fattening pigs raised under antibiotic-free conditions with those of ordinary industrial pigs. The study found that certain bacteria, such as Escherichia coli, Lactobacillus, and Bacteroides, were increased in the control group, while Ruminococcus and Clostridium were greater in the antibiotic-free group. Additionally, the expression of antibiotic resistance proteins, such as Tet(r) and AMG(r), was significantly increased in Bacteroides in the control group. In the antibiotic-free group, CRISPR-associated endonucleases Cas1 and Cas9 were markedly observed in Ruminococcus and Lactobacillus, respectively.
MICROBIOLOGY SPECTRUM
(2023)
Article
Engineering, Environmental
Qi Zhang, Yitian Yu, Mingkang Jin, Yu Deng, Bingyu Zheng, Tao Lu, Haifeng Qian
Summary: The study revealed the dose-dependent effects of azoxystrobin on the gut microbial community of Enchytraeus crypticus, leading to a decrease in the relative abundance of beneficial bacteria, growth of opportunistic pathogens, and disruption of gut microecology stability. Additionally, trace amounts of azoxystrobin may increase the number of antibiotic resistance genes in the gut.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Microbiology
Xianfeng Yi, Muha Cha
Summary: The composition of gut microbiota may affect the sexual attractiveness and mate choice in mammals. Dysbiosis of gut microbiota can reduce the sexual attractiveness of females to males, which may benefit the offspring by avoiding immune and sociability disorders.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Neurosciences
Paloma T. Birmann, Angela M. Casaril, Ana Paula Pesarico, Rafael R. Rodrigues, Fabricio R. Conceicao, Fernanda Severo Sabedra Sousa, Tiago Collares, Fabiana K. Seixas, Lucielli Savegnago
Summary: This study evaluated the antidepressant-like effects of Komagataella pastoris KM71H in a model of antibiotic-induced intestinal dysbiosis in mice. The results showed that KM71H administration reduced immobility time and increased grooming activity, accompanied by the modulation of the intestinal microbiota and preservation of intestinal barrier integrity. These findings suggest the potential of KM71H as a new probiotic with antidepressant-like effects.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Microbiology
Simen Fredriksen, Stef de Warle, Peter van Baarlen, Jos Boekhorst, Jerry M. Wells
Summary: This study re-analyzed human gut microbiome data from 26 case-control studies and found that diseases commonly treated with antibiotics, such as cystic fibrosis and diarrhea, are associated with significantly elevated antibiotic resistance gene (ARG) abundances in patient microbiomes compared to controls. The association between disease and the resistome exists even in the absence of large taxonomic differences. A trend for increased ARG abundance was also found in cases from some studies on diseases that are not treated with antibiotics, such as colorectal cancer.
Article
Biochemistry & Molecular Biology
Changlu Qi, Yiting Cai, Kai Qian, Xuefeng Li, Jialiang Ren, Ping Wang, Tongze Fu, Tianyi Zhao, Liang Cheng, Lei Shi, Xue Zhang
Summary: The gut microbiota plays a crucial role in maintaining health, and disruptions can lead to disorders. The gutMDisorder database provides a valuable resource for studying dysbiosis, and the latest version offers expanded data and improved features.
NUCLEIC ACIDS RESEARCH
(2023)