Article
Biochemistry & Molecular Biology
Anna Julia Elias, Lajos Balogh, Tomas Branyik, Erzsebet Mak, Eva Csajbokne Csobod, Marta Veresne Balint, Csilla Benedek
Summary: The study aimed to investigate the antitumorigenic potential of a xanthohumol-enriched beer. The results showed that adding xanthohumol to beer did not have a protective effect on tumor growth or enhance plasma antioxidant capacity. However, it had a less harmful effect on the liver compared to an ethanolic solution.
Article
Multidisciplinary Sciences
Ramya M. Subramani, Robert Lotha, Bhanuvalli R. Shamprasad, Sriram Sridharan, Ravichandran Natesan, Saisubramanian Nagarajan, Arvind Sivasubramanian
Summary: This study optimized the extraction conditions of C.candicans flavonoids and found that antioxidant flavonoids can be used to functionalize nanoparticles. The prepared nanoparticles were tested as antibiofilm agents on MRSA, and it was found that ZVCuF and ZVAgF showed inhibitory effects on MRSA, with no side effects on the liver.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Larissa Gabriela Faqueti, Layzon Antonio Lemos da Silva, Gabriela Salim Gomes Moreira, Scheila Kraus, Gustavo dos Santos Catarina de Jesus, Luciana Aparecida Honorato, Bibiana Verlindo de Araujo, Adair Roberto Soares dos Santos, Teresa Dalla Costa, Maique Weber Biavatti
Summary: This study aimed to investigate the pre-clinical pharmacokinetics behavior and antinociceptive activity of 5'-methoxynobiletin (5'-MeONB). The results showed that 5'-MeONB exhibited one-compartment model in rats and mice plasma, with oral bioavailability ranging from 8 to 11%, and it demonstrated inhibitory effects on acute nocifensive behavior induced by formalin.
PHARMACEUTICAL RESEARCH
(2022)
Article
Food Science & Technology
Yangyang Liu, Yonglu Li, Wen Chen, Xiang Ye, Ruoyi Jia, Lushuang Yu, Qiong Tang, Pengcheng Tu, Yong Jiang, Qiang Chu, Xiaodong Zheng
Summary: This study investigated the antitumor activity of the flavones-rich fraction of Tetrastigma hemsleyanum root in vitro and in vivo. The results showed that this fraction inhibited proliferation and migration of HepG2 cells through the PI3K/AKT pathway. It also induced changes in cellular oxidative stress levels and mitochondrial membrane potential. In vivo experiments demonstrated that the treatment suppressed tumor growth and regulated the expression of proteins involved in tumor growth and apoptosis. These findings suggest Tetrastigma hemsleyanum as a promising candidate for liver cancer treatment.
FOOD QUALITY AND SAFETY
(2021)
Article
Oncology
Venkataswarup Tiriveedhi, Michael T. Ivy, Elbert L. Myles, Roy Zent, Jeffrey C. Rathmell, Jens Titze
Summary: Cell based immunotherapy is showing promise in cancer treatment, and salt treatment has been found to induce anti-cancer response in immune cells, which could potentially be applied in future human clinical settings.
Article
Chemistry, Medicinal
Wenjuan Zhang, Pengyun Li, Shiyang Sun, Changkai Jia, Ning Yang, Xiaomei Zhuang, Zhibing Zheng, Song Li
Summary: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are widely used in the treatment of non-small cell lung cancer (NSCLC), but drug resistance and side effects are the main challenges. Researchers designed, synthesized and evaluated a series of CRBN-recruiting EGFR degraders, and found that compounds 13a and 13b can effectively induce cell apoptosis, cell cycle arrest, and inhibit downstream signaling pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Bhanuvalli R. Shamprasad, Robert Lotha, Saisubramanian Nagarajan, Arvind Sivasubramanian
Summary: This study attempted to synthesize silver and copper nanoparticles using C. juncea extract and kaempferitrin, and explored their antibacterial effects and possible mechanisms. The results showed that these nanoparticles significantly reduced biofilm formation and bacterial bioburden in MRSA. Moreover, the nanoparticles altered the membrane permeability and cell surface hydrophobicity of the bacteria. This study is of great importance for the research of novel antimicrobial biofilm materials.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Alan A. Veiga, Ana Carolina Irioda, Bassam E. Mogharbel, Sandro J. R. Bonatto, Lauro M. Souza
Summary: This study investigated the cytotoxic effects of quercetin-rich onion extracts on adrenocortical carcinoma cells and compared its efficacy with the approved adrenolytic drug mitotane. The results showed that quercetin exhibited higher cytotoxicity and altered cell cycle dynamics, promoting apoptosis and affecting intracellular calcium levels in cancer cells. These findings suggest that quercetin-rich onions have the potential to be a natural source of anticancer agents for adrenocortical carcinoma.
Article
Biophysics
Joana B. Ferrado, Adrian A. Perez, Maria E. Baravalle, Maria Sol Renna, Hugo H. Ortega, Liliana G. Santiago
Summary: The research investigates the use of bovine serum albumin nanovehicles to improve the bioavailability and antitumor activity of the flavonoid genistein in breast cancer cells. Results show that genistein binds to the nanovehicles forming inclusion complexes via a fluorescence quenching mechanism, leading to a significant decrease in cell viability and cytotoxic effects through apoptosis. This study demonstrates the potential of using nanovehicles for incorporating flavonoids in pharmaceutical and nutraceutical formulations.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Medicinal
Zhonghua Li, Tingting Qin, Zhongrui Li, Xuan Zhao, Xinhui Zhang, Taoqian Zhao, Nian Yang, Jinxin Miao, Jinlian Ma, Zhenqiang Zhang
Summary: In this study, a highly water-soluble erlotinib analog 5k was developed with significantly enhanced inhibitory activity against LSD1, demonstrating effectiveness in inhibiting tumor growth in MGC-803 cells and xenograft mouse model, indicating its potential as a novel candidate for the treatment of LSD1-overexpressing cancers.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Anley Teferra Kiddane, Min-Jae Kang, Truc Cong Ho, Adane Tilahun Getachew, Maheshkumar Prakash Patil, Byung-Soo Chun, Gun-Do Kim
Summary: Cancer is a major global health challenge and a leading cause of death. Cervical cancer is caused by various factors, including the persistent infection of oncogenic human papillomavirus. In this study, we found that crude extract from G. applanatum has an anti-proliferative effect on cervical cancer cells and is non-toxic. Furthermore, the extract induces apoptosis and decreases NF kappa B expression.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nguyen Huy Du, Truong Thi Bich Ngoc, Huynh Qui Cang, Nguyen Thi Thuy Luyen, Tran Linh Thuoc, Tran Le Quan, Dang Thi Phuong Thao
Summary: KTt-45 inhibits the growth of various cancer cell lines and induces cell apoptosis. It shows high selectivity towards cervical cancer cells and less toxicity towards other cancer cells.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Rahman Md Moshikur, Md Korban Ali, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto
Summary: This study transformed methotrexate (MTX) into a series of five ionic liquids to improve its oral bioavailability, with proline ethyl ester MTX (IL[ProEt][MTX]) showing the highest oral bioavailability in mice. IL[ProEt][MTX] had significantly higher plasma concentration, longer half-life, larger area under the plasma concentration, longer absorption time, and lower body clearance compared to MTX sodium, indicating improved in vivo absorption and reduced systemic toxicity. Mechanistic studies suggested that the spherical structures formed by IL[ProEt][MTX] solution contributed to its improved oral absorption performance. Antitumor studies also showed that IL[ProEt][MTX] had better tumor growth inhibition than MTX sodium.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Medicinal
Weilin Chen, Xin Chen, Dongdong Li, Xianghan Wang, Guanlu Long, Zhengyu Jiang, Qidong You, Xiaoke Guo
Summary: The MLL1-WDR5 interaction is crucial for the formation of the MLL core complex and its H3K4 methyltransferase activity. Disrupting this interaction has been suggested as a potential therapeutic approach for leukemia. By developing a novel MLL1-WDR5 interaction blocker, the research team successfully identified the best inhibitor 24 with high binding affinity and improved drug-like properties.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Gang Yu, Lizhen Chen, Yuanhua Hu, Zhen Yuan, Yao Luo, Yuanhuan Xiong
Summary: This study aimed to identify an inhibitor of the TGF beta pathway from natural flavonoids, with baicalein showing the most significant inhibitory effect on TGF beta expression. Baicalein was found to suppress cell proliferation and migration in cervical cancer HeLa cells by targeting the mTOR/p70S6K pathway and EMT pathway through the TGF beta pathway.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
