Article
Environmental Sciences
Anna Lovinskaya, Saule Kolumbayeva, Mariya Suvorova
Summary: This study investigates the genotoxic potential in rivers and lakes of the Almaty agglomeration, Kazakhstan, and finds that the surface water contamination poses a threat to both organisms and human populations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Materials Science, Biomaterials
Anna Fakhardo, Elizaveta Anastasova, Victor Makarov, Evgeniia Ikonnikova, Ekaterina Kulko, Nikol Agadzhanian, Marina Yakunina, Liubov Shkodenko, Sofia Tsvetikova, Maria Toropko, Elena Koshel, Mikhail Zakharov, Georgii Alexandrov, Olga Khuttunen, Pavel Kulikov, Oleg Burmistrov, Vladimir Vinogradov, Artur Prilepskii
Summary: The study demonstrates that the prepared heparin-coated iron oxide nanoparticles can be used as a contrast agent for cholangioma tumors in the liver without notable toxic effects on experimental animals, while exhibiting mutagenicity. Pharmacokinetic studies show that these nanoparticles can circulate in the body for up to 14 days.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Environmental Sciences
Md Shahjahan, Khanam Taslima, Moharnmad Shadiqur Rahman, Md Al-Emran, Shanon Iffat Alam, Caterina Faggio
Summary: The pollution by heavy metals poses a serious threat to the aquatic environment and organisms. This review investigates the effects of heavy metals on fish physiology, including hemato-biochemical properties, immunological parameters, organ histopathology, and molecular mechanisms. These parameters are important bio-monitoring tools for assessing heavy metal toxicity.
Article
Environmental Sciences
Sandy de Oliveira Goncalves, Thiarlen Marinho da Luz, Abner Marcelino Silva, Sindoval Silva de Souza, Mateus Flores Montalvao, Abraao Tiago Batista Guimaraes, Mohamed Ahmed Ibrahim Ahmed, Amanda Pereira da Costa Araujo, Sengodan Karthi, Guilherme Malafaia
Summary: The presence of SARS-CoV-2 particles in water ecosystems poses concerns for non-target aquatic organisms. This study investigated the potential mutagenic and genotoxic effects of exposure to Spike protein fragments of the virus in Poecilia reticulata adults. The results showed that exposure to the peptides led to genomic instability, erythrocyte DNA damage, lipid peroxidation, and reduced antioxidant enzyme activity. This study provides new insights into the toxicity associated with the dispersal of SARS-CoV-2 peptide fragments in freshwater environments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Energy & Fuels
Barbara J. Arnold
Summary: With the increasing focus on recovering critical elements from various coal-related sources, evaluating coal preparation technologies for their role in recovery or rejection of these elements is crucial. Past studies on trace element removal from coal, including those considered hazardous air pollutants in the past, need to be reviewed. The mode of occurrence of these elements in coal plays a significant role in their recovery or rejection during coal preparation processes. Future work should consider element partitioning with coal macerals and comprehensive evaluations of hydrometallurgical principles for element recovery.
INTERNATIONAL JOURNAL OF COAL GEOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ana Laura Gadelha Castro, Jorddy Neves Cruz, Daniele Ferreira Sodre, Juliana Correa-Barbosa, Rufine Azonsivo, Mozaniel Santana de Oliveira, Jose Edson de Sousa Siqueira, Natasha Costa da Rocha Galucio, Marcelo de Oliveira Bahia, Rommel Mario Rodriguez Burbano, Andrey Moacir do Rosario Marinho, Sandro Percario, Maria Fani Dolabela, Valdicley Vieira Vale
Summary: This study evaluated the genotoxicity and mutagenicity of isoeleutherin and eleutherin in Eleutherine plicata Herb., showing that eleutherin is more genotoxic than isoeleutherin. The molecular docking and MD simulations demonstrated the compounds' ability to interact with TOPO II and form stable complexes, providing new insights into their genotoxic and mutagenic potential.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Energy & Fuels
Beilei Sun, Fangui Zeng, Tim A. Moore, Sandra Rodrigues, Chao Liu, Guoquan Wang
Summary: Prospecting for trace and rare earth elements is expected to increase in the future as the world adopts sustainable energy and digital technology. This study investigates the distribution of trace elements, especially lithium, in coal beds in Shanxi Province, China. The research finds that trace elements, including lithium, are associated with the inorganic portion of the coal seams.
INTERNATIONAL JOURNAL OF COAL GEOLOGY
(2022)
Review
Environmental Sciences
Ariane Andreola, Daniely Neckel Rosini, Mari Lucia Campos, Josieli Pietro Biasi, Vanilde Citadini-Zanette, Roseli Lopes da Costa Bortoluzzi, Davi Jose Miquelutti, Edilane Rocha Nicoleite
Summary: Mineral coal extraction in Santa Catarina State in Brazil has caused degradation to the local ecosystem, limiting its use. The uncontrolled disposal of waste and sterile mining with high concentrations of pyrite has led to the formation of acid mine drainage, which poses a threat to water resources, soil, and biodiversity. This study characterizes the heavy metal content in the mining waste and tailings, as well as the presence of fern and lycophyte species in the area. The results show that some fern species demonstrate resistance to degraded and contaminated environments, making them potential candidates for monitoring and environmental recovery.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Nairana Santos Fraga, Agnaldo Silva Martins, Adalto Bianchini, Derek R. Faust, Haruya Sakai, Cinthia Carneiro da Silva, A. Alonso Aguirre
Summary: Pollution poses a major threat to marine life, and trace elements are highly toxic pollutants in this environment. Zinc, an essential trace element for biota, becomes toxic at high concentrations. Sea turtles, with their longevity and widespread distribution, are good bioindicators for trace element pollution, accumulating these elements in their tissues over the years. This study compared the bioaccumulation of zinc in the liver, kidney, and muscles of 35 green sea turtles from Brazil, Hawaii, the USA (Texas), Japan, and Australia. The results showed that zinc was present in all specimens, with the highest concentrations in the liver and kidneys. The findings of equal zinc values in the liver suggest a pantropical distribution pattern for this metal, possibly due to its essential nature and bioavailability in marine environments. This study highlights the importance of understanding the distribution patterns of trace elements in marine biota for conservation purposes and suggests that green turtles can serve as useful sentinel species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Ecology
Pedro M. Costa
Summary: The preservation of genomic stability against environmental stressors is a key adaptive feature in both prokaryotes and eukaryotes, and impairing the DNA damage response may lead to accumulation of genomic lesions and subsequent diseases. Understanding how pollutants affect DNA repair mechanisms is crucial for interpreting genotoxicity assessment results effectively.
Article
Chemistry, Medicinal
Elena Lo Piparo, Nicolas Christinat, Flavia Badoud
Summary: This study aims to establish a correspondence between genotoxic structural alerts (SAs) and signature fragment alerts (SFAs), in order to analyze mixtures using computational toxicology. By screening signature fragment alerts, the presence of genotoxic substances in plant-based mixtures can be quickly identified. The SFA analysis can be used for risk prioritization of newly identified PAs and their identification in mixtures, reducing the unnecessary use of animal experimentation for genotoxicity testing.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Flavia Roberta Monteiro Souza, Giovanna Melo Martins Silva, Cesar Orlando Munoz Cadavid, Lucas dos Santos Lisboa, Maylla Maria Correia Leite Silva, Weslley Souza Paiva, Marcelo Jose Pena Ferreira, Riva de Paula Oliveira, Hugo Alexandre Oliveira Rocha
Summary: Obesity is a global health issue related to oxidative stress. The Brazilian folk medicine B. trimera is used for obesity treatment. The leaf extract of B. trimera showed antioxidant activity and anti-obesity effects, without toxicity to cells and C. elegans.
Review
Chemistry, Multidisciplinary
Josefa Domenech, Adriana Rodriguez-Garraus, Adela Lopez de Cerain, Amaya Azqueta, Julia Catalan
Summary: Graphene-based materials (GBMs) are a broad family of carbon-based nanomaterials widely used in nanotechnology. The potential genotoxicity of GBMs has raised concerns in terms of human health. Existing literature suggests that certain GBMs have the potential to induce genetic damage, although the specific damage type depends on the material. However, the variability in GBMs, cellular systems, and research methods used in studies makes it difficult to identify the physico-chemical properties that drive the genotoxicity response to GBMs.
Article
Chemistry, Medicinal
Thalita Vieira Nascimento Ximenes, Raquel Carvalho, Iluska Senna Bonfa, Vanessa Samudio Santos, Luciane Candeloro, Flavio Macedo Alves, Denise Brentan Silva, Carlos Alexandre Carollo, Karine de Cassia Freitas Gielow, Saulo Euclides Silva-Filho, Monica Cristina Toffoli-Kadri
Summary: This study evaluated the efficacy of Baccharis trimera infusion on high-fat diet-induced metabolic disorders and macrophages activation. The results showed that B. trimera prevented the development of obesity and associated comorbidities, as well as the activation of macrophages. This study validates the popular use of this plant tea.
Article
Environmental Sciences
Evgeniya Ushakova, Elena Menshikova, Sergey Blinov, Boris Osovetsky, Pavel Belkin
Summary: This study investigates the contamination of Kosva Bay by acid mine drainage (AMD) from Kizel Coal Basin in Russia. The results show that sediments downstream from abandoned coal mines in the bay are contaminated with heavy metals, especially Cr, Cu, and As. The environmental indices indicate different degrees of contamination, and the potential ecological risk index suggests a certain level of risk to aquatic organisms in the bay.
Article
Engineering, Biomedical
Diogo Scalon, Jaqueline Nascimento Picada, Jayne Torres de Sousa, Ariane Taina da Silva, Josieli Raskopf Colares, Norma Anair Possa Marroni
Summary: Photobiomodulation (PBM) may be an effective intervention to alleviate sarcopenia in cirrhotic patients. The study evaluated the beneficial effects of PBM on the structural and functional properties of skeletal muscle in cirrhotic rats, showing improvements in locomotion, muscle fiber morphology, oxidative stress, and inflammation without causing DNA damage.
LASERS IN MEDICAL SCIENCE
(2022)
Review
Biotechnology & Applied Microbiology
A. Nersesyan, M. Kundi, M. Fenech, H. Stopper, J. da Silva, C. Bolognesi, M. Misik, S. Knasmueller
Summary: Micronucleus (MN) analysis is currently the most widely used method to detect genetic material damage in humans. High MN rates are associated with increased risk of cancer and other diseases, and MN measurements may be a useful tool for diagnosis and prognosis. However, many clinical studies have methodological shortcomings, which limits their usefulness.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2022)
Article
Environmental Sciences
Milton Quintana-Sosa, Grethel Leon-Mejia, Diana M. Narvaez, Alejandra Suarez-Arnedo, Helena Groot de Restrepo, Yurina Sh De Moya, Martha Ruiz-Benitez, Karen Franco Valencia, Cristiano Trindade, Alvaro Miranda-Guevara, Johnny Dias, Joao Antonio Pegas Henriques, Juliana da Silva
Summary: The aim of this study was to evaluate the association between buccal micronucleus cytome assay biomarkers and inorganic elements and genetic polymorphisms in welders. It was found that welders showed higher levels of DNA damage and cell death. The frequency of micronuclei was significantly correlated with the concentrations of Na, Si, Cl, Ti, Cr, Zn, and Mg. The presence of certain genetic polymorphisms was associated with cell death and a higher frequency of micronuclei in welders.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Daiana Dalberto, Ana L. H. Garcia, Melissa R. De Souza, Juliana Picinini, Solange Soares, Guilherme M. S. De Souza, Paola Chytry, Johnny F. Dias, Mirian Salvador, Fernanda R. Da Silva, Juliana Da Silva
Summary: Exposure to dried tobacco leaves by tobacco workers increases the risk of toxicity and respiratory illness due to nicotine and other chemicals. This study evaluated the DNA damage caused by the exposure of tobacco growers during the dry leaf classification process and its relation to cellular mechanisms. Various tests were conducted to assess genotoxicity, oxidative and nitrosative stress, and measurement of telomere length, as well as the presence of inorganic elements.
Article
Pharmacology & Pharmacy
Mariana Uczay, Pricila Pfluger, Jaqueline Nascimento Picada, Joao Denis Medeiros de Oliveira, Iraci Lucena da SilvaTorres, Helouise Richardt Medeiros, Maria Helena Vendruscolo, Gilsane von Poser, Patricia Pereira
Summary: This study investigated the mechanism of action of Asperuloside (ASP) and geniposide (GP) in pilocarpine-induced seizures. The results showed that GP and ASP could reduce the latency to the first seizure, as well as the expression of GluN2B receptor and COX-2.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Juliana da Silva, Natalia Brucker, Solange Cristina Garcia
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2023)
Article
Oncology
Marina Lummertz Magenis, Pamela Souza de Marcos, Adriani Paganini Damiani, Anderson Ricardo Cantareli da Silva, Luiza Martins Longaretti, Ive Bahia Franca, Juliana Da Silva, Carina Rodrigues Boeck, Vanessa Moraes de Andrade
Summary: The study aimed to investigate the effects of caffeine consumption during pregnancy and lactation on female mice and their offspring. The results showed that both pregnant and lactating mice exhibited genotoxic effects after ingesting caffeine. The offspring also displayed low weight and genotoxicity in various tissues.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-TOXICOLOGY AND CARCINOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Jayne Torres de Sousa, Rafael Rodrigues Dihl, Fernanda Briao Menezes Boaretto, Ana Leticia Hilario Garcia, Ivana Grivicich, Juliana da Silva, Jaqueline Nascimento Picada
Summary: This study evaluated the cytotoxic and mutagenic effects of morphine alone and in combination with doxorubicin. Morphine showed cytotoxic effects on neuroblastoma cells and reduced the cytotoxic effects of doxorubicin. Morphine did not induce mutations and decreased the mutagenic effects induced by doxorubicin in certain strains.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Plant Sciences
Francisco Laerte Lopes da Silva, Amanda Souza Scotti, Ana Leticia Hilario Garcia, Maria Luiza Brodt Lemes, Ivana Grivicich, Gabriela Mendonca dos Reis, Johnny Ferraz Dias, Fernanda Briao Menezes Boaretto, Jaqueline Nascimento Picada, Juliana da Silva, Alexandre de Barros Falcao Ferraz
Summary: The present study aimed to determine the chemical composition, cytotoxic, genotoxic, mutagenic potential, and antioxidant activity of an aqueous extract of Aloysia gratissima leaves. Results showed that the extract contained terpenoids, flavonoids, and phenolic acids, and exhibited cytotoxic activities against various cancer cells, as well as DNA damage and mutations. Therefore, caution should be exercised when using this plant preparation, despite its pharmacological potential.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Larissa Aline Carneiro Lobo, Peterson Alves Santos, Jayne Torres de Sousa, Jaqueline Nascimento Picada, Sara Elis Bianchi, Valquiria Linck Bassani, Francisco Carlos da Silva, Eduardo Miranda Ethur, Marcia Ines Goettert, Patricia Pereira
Summary: The aim of this study was to determine the toxicity profile of Hymenaea courbaril stem bark hydroalcoholic extract using various assays including cell lines and in vivo models. The extract showed potent antioxidant activity and low toxicity and mutagenicity in vitro. However, further studies are needed to investigate the biological relevance of the extract's effect on the survival of Caenorhabditis elegans.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Environmental Sciences
Grethel Leon-Mejia, Robinson Alvarez Rueda, Jose Perez Perez, Alvaro Miranda-Guevara, Ornella Fiorillo Moreno, Milton Quintana-Sosa, Cristiano Trindade, Yurina Sh De Moya, Martha Ruiz-Benitez, Yesit Bello Lemus, Ibeth Luna Rodriguez, Ludis Oliveros-Ortiz, Antonio Acosta-Hoyos, Leonardo C. Pacheco-Londono, Amner Munoz, Samuel P. Hernandez-Rivera, Jesus Olivero-Verbel, Juliana da Silva, Antonio Pegas Henriques Joao
Summary: Coal mining activities release compounds into the environment that can negatively impact human health. This study evaluated the cytotoxic and genotoxic effects of chronic exposure to coal residues in individuals. The results showed significant differences in cell aberrations and increased concentrations of certain substances in exposed individuals compared to the control group.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Meeting Abstract
Environmental Sciences
Juliana Da Silva, Daiana Dalberto, Ana Leticia Garcia, Melissa Souza, Juliana Picinini, Fernanda Rabaioli Da Silva
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Julian Stocker, Ana Paula Morel, Micaele Wolfarth, Johnny Ferraz Dias, Liana Appel Boufleur Niekraszewicz, Cristina Cademartori, Fernanda R. da Silva
Summary: This study aimed to determine the basal pattern of micronuclei and other nuclear alterations in peripheral blood erythrocytes of Falco peregrinus and to perform hematological and inorganic elements analysis. The study found similar values compared to previous studies, except for the relative number of monocytes.
GENETICS AND MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Fabiano Moraes Miguel, Jaqueline Nascimento Picada, Juliana Bondan da Silva, Elizangela Goncalves Schemitt, Josieli Raskopf Colares, Renata Minuzzo Hartmann, Claudio Augusto Marroni, Norma Possa Marroni
Summary: This study investigated the pathophysiology of nonalcoholic steatohepatitis (NASH) and DNA damage biomarkers, and found that melatonin can slow down the progression of NASH by reducing hepatic oxidative stress and inflammatory processes and inhibiting DNA damage through anti-inflammatory and antioxidant actions.
Article
Oncology
Jose Lopes Soares Neto, Raine Fogliati de Carli, Mauricio Lehmann, Claudia Telles de Souza, Liana Appel Boufleur Niekraszewicz, Johnny Ferraz Dias, Fernanda Rabaioli da Silva, Juliana da Silva, Rafael Rodrigues Dihl
Summary: The main environmental issue in urban areas, especially in Brazil, is the discharge of untreated sewage. The study found seasonal differences in the genotoxicity of Tocantins River water, and hypothesized that the depletion of ribosomal proteins (RPs) in cells exposed to heavy metals may be related to DNA damage and increased chromosome instability.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-TOXICOLOGY AND CARCINOGENESIS
(2022)
