Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity

Fexinidazole: First Global Approval

(2019) Emma D. Deeks   DRUGS

The past, present and future of anti-malarial medicines

(2019) Edwin G. Tse et al.   MALARIA JOURNAL

The ReFRAME library as a comprehensive drug repurposing library to identify mammarenavirus inhibitors

(2019) Yu-Jin Kim et al.   ANTIVIRAL RESEARCH

A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open-Access Malaria Box

(2018) R. S. Jumani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Brain-penetrant, triazolopyrimidine and phenylpyrimidine microtubule-stabilizers as potential leads to treat human African trypanosomiasis

(2018) Ludovica Monti et al.   ChemMedChem

In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri

(2018) Anjan Debnath et al.   Frontiers in Microbiology

The Long Wait for a New Drug for Human African Trypanosomiasis

(2018) Catriona H. Baker et al.   TRENDS IN PARASITOLOGY

High-Throughput Screening of Entamoeba Identifies Compounds Which Target Both Life Cycle Stages and Which Are Effective Against Metronidazole Resistant Parasites

(2018) Gretchen M. Ehrenkaufer et al.   Frontiers in Cellular and Infection Microbiology

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Gregory A Roth et al.   LANCET

Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy

(2018) Valentin Buchter et al.   Parasites & Vectors

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis

(2018) Jeff Janes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris

(2018) Matthew T. Laurie et al.   mBio

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

(2017) Anjan Debnath et al.   PLoS Neglected Tropical Diseases

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

(2016) Anju Singh et al.   ACS Chemical Biology

Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments

(2016) Finny S. Varghese et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

The Prenylated Proteome ofPlasmodium falciparumReveals Pathogen-specific Prenylation Activity and Drug Mechanism-of-action

(2016) Jolyn E. Gisselberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Determination of anisomycin in tissues and serum by LC-MS/MS: application to pharmacokinetic and distribution studies in rats

(2016) Ljiljana Tolić et al.   RSC Advances

High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni

(2016) Nuha R. Mansour et al.   PLoS Neglected Tropical Diseases

Drug resistance in eukaryotic microorganisms

(2016) Alan H. Fairlamb et al.   Nature Microbiology

Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case: Table 1.

(2015) Jennifer R. Cope et al.   CLINICAL INFECTIOUS DISEASES

Novel culture medium for the axenic growth of Balamuthia mandrillaris

(2015) Luis Fernando Lares-Jiménez et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

In vitro antiparasitic activity of microbial pigments and their combination with phytosynthesized metal nanoparticles

(2015) Suryawanshi Rahul et al.   PARASITOLOGY INTERNATIONAL

World Health Organization Estimates of the Global and Regional Disease Burden of 11 Foodborne Parasitic Diseases, 2010: A Data Synthesis

(2015) Paul R. Torgerson et al.   PLOS MEDICINE

Hsp90 Inhibitors as New Leads To Target Parasitic Diarrheal Diseases

(2014) Anjan Debnath et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Chemical Rescue Screen Identifies a Plasmodium falciparum Apicoplast Inhibitor Targeting MEP Isoprenoid Precursor Biosynthesis

(2014) Wesley Wu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Multicenter Phase I/II Study of Obatoclax Mesylate Administered as a 3- or 24-Hour Infusion in Older Patients with Previously Untreated Acute Myeloid Leukemia

(2014) Aaron D. Schimmer et al.   PLoS One

Inhibition or Knockdown of ABC Transporters Enhances Susceptibility of Adult and Juvenile Schistosomes to Praziquantel

(2014) Ravi S. Kasinathan et al.   PLoS Neglected Tropical Diseases

In VitroEfficacy of Corifungin against Acanthamoeba castellanii Trophozoites and Cysts

(2013) Anjan Debnath et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Drug Repurposing Screen Reveals FDA-Approved Inhibitors of Human HMG-CoA Reductase and Isoprenoid Synthesis That Block Cryptosporidium parvum Growth

(2013) Kovi Bessoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

In vitro antiviral activity of dehydroepiandrosterone, 17 synthetic analogs and ERK modulators against herpes simplex virus type 1

(2012) Nicolás I. Torres et al.   ANTIVIRAL RESEARCH

Experience with obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist in patients with relapsed or refractory classical Hodgkin lymphoma

(2012) Y. Oki et al.   BLOOD

Obatoclax, Saliphenylhalamide, and Gemcitabine Inhibit Influenza A Virus Infection

(2012) Oxana V. Denisova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

(2012) Anjan Debnath et al.   NATURE MEDICINE

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

(2012) Wanjuan Yang et al.   NUCLEIC ACIDS RESEARCH

Susceptibility or resistance of praziquantel in human schistosomiasis: a review

(2012) Wei Wang et al.   PARASITOLOGY RESEARCH

Pathogenic free-living amoebae: Epidemiology and clinical review

(2012) H. Trabelsi et al.   PATHOLOGIE BIOLOGIE

P. falciparum In Vitro Killing Rates Allow to Discriminate between Different Antimalarial Mode-of-Action

(2012) Laura M. Sanz et al.   PLoS One

New approaches to the treatment of giardiasis

(2011) Noa Tejman-Yarden et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Antimalarial Activity of Natural and Synthetic Prodiginines

(2011) Kancharla Papireddy et al.   JOURNAL OF MEDICINAL CHEMISTRY

High-ThroughputGiardia lambliaViability Assay Using Bioluminescent ATP Content Measurements

(2010) Catherine Z. Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prolonged Episodes of Acute Diarrhea Reduce Growth and Increase Risk of Persistent Diarrhea in Children

(2010) Sean R. Moore et al.   GASTROENTEROLOGY

Balamuthia mandrillaris: Role of galactose in encystment and identification of potential inhibitory targets

(2009) Ruqaiyyah Siddiqui et al.   EXPERIMENTAL PARASITOLOGY

Evaluation of Three Different Methods to Establish Animal Models of Acanthamoeba Keratitis

(2009) Meiyu Ren et al.   YONSEI MEDICAL JOURNAL

Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia

(2008) S. M. O'Brien et al.   BLOOD

In silicoactivity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

(2008) David Plouffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA