期刊
CHEMOSPHERE
卷 153, 期 -, 页码 75-77出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2015.12.085
关键词
BPA; HUVEC; HT29; MDD biomarkers; Gene transcription
资金
- Fundacao para a Ciencia e Tecnologia (Portugal) [UID/AGR/04129/2013]
- [SFRH/BD/44277/2008]
- [SFRH/BPD/111935/2015]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/111935/2015] Funding Source: FCT
Bisphenol A (BPA) is capable of mimicking endogenous hormones with potential consequences for human health and BPA exposure has been associated with several human diseases including neuropsychiatric disorders. Here, quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) results show that BPA at low concentrations (10 ng/mL and 1 mu g/mL) induces differential transcript levels of four biomarker genes for Major. Depressive Disorder (MDD) in HT29 human colon adenocarcinona cell line and Human Umbilical Vein Endothelial Cells (HUVEC). These results substantiate increasing concerns of BPA exposure in levels currently detected in humans. (C) 2016 Elsevier Ltd. All rights reserved.
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