Article
Nutrition & Dietetics
Annett Hoffmann, Thomas Ebert, Mohammed K. Hankir, Gesine Flehmig, Nora Kloeting, Beate Jessnitzer, Ulrike Lossner, Michael Stumvoll, Matthias Bluher, Mathias Fasshauer, Anke Toenjes, Konstanze Miehle, Susan Kralisch
Summary: Lipodystrophy syndromes are rare disorders characterized by a lack of adipose tissue and metabolic dysfunction. Treatment with leptin can stimulate brown adipose tissue thermogenesis, providing metabolic benefits.
Article
Biology
Xiaoxue Yuan, Hongping Lu, Yu Zhang, Ming Han, Kai Han, Pu Liang, Shunai Liu, Jun Cheng
Summary: HCBP6 is an important enhancer that activates brown fat to produce heat. It increases the activity of brown fat by upregulating UCP1 expression and increasing the number of mitochondria. In addition, the loss of HCBP6 leads to metabolic pathway disorder and reduction in brown adipocyte development genes.
JOURNAL OF THERMAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Sumsen Thapa, Bharath S. Selvaraj, Paige N. Davis, Bryan Smith, Amy H. Givan, Jose A. Perez-Rivera, Pamela K. Woodard, Jon D. Klingensmith, Maria Fernandez-del-Valle
Summary: This study analyzed the relationships between cardiac adipose tissue (CAT), physical activity (PA) and fitness (PFit) in women with obesity, and explored the effects of different exercise modalities. It found that high-intensity aerobic exercise had a significant impact on reducing CAT volume, and all types of PA had a positive influence on body fat content. Furthermore, three weeks of high-intensity circuit training resulted in positive changes in body composition and fitness in women with obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Yolanda Oliveira Pinto, William Tadeu Lara Festuccia, Juliana Magdalon
Summary: Obesity is a chronic disease characterized by excessive body fat, and pharmacological manipulation through brown adipose tissue activation and browning is a promising strategy for the treatment of obesity. However, not all situations that increase adrenergic signaling promote activation or browning of brown adipose tissue in humans. Further research is needed to develop better therapies for obesity.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
C. E. Robertson, F. E. Weaver, C. A. Nurse
Summary: In Peromyscus mice, the developmental shift to endothermy is accompanied by the establishment of the brown adipose tissue sympathetic neural network. During this process, two neurotrophic batokines, S100b and neuregulin-4, are secreted in high quantities by neonatal BAT, while the classic neurotrophic factor NGF is surprisingly low. Despite this, neonatal BAT-conditioned media still has a strong neurotrophic effect. In contrast, cold-exposed adults remodel BAT using all three factors, indicating that BAT-neuron communication is life-stage dependent.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Integrative & Complementary Medicine
Hongru Gao, Xiaoyu Tong, Wei Hu, Yicong Wang, Kuinyu Lee, Xiaoqing Xu, Jiemei Shi, Zhenle Pei, Wenhan Lu, Yuning Chen, Ruonan Zhang, Zheyi Wang, Ziyu Wang, Chengzhi Han, Yu Wang, Yi Feng
Summary: This study focused on the role of brown adipose tissue (BAT) and its sympathetic innervations in polycystic ovary syndrome (PCOS) and electroacupuncture (EA) therapy. The results revealed key factors involved in sympathetic nerves and their modulation in BAT, as well as their relationship with EA treatment.
Article
Neurosciences
Clarissa M. D. Mota, Dominic A. Siler, Kim J. Burchiel, Christopher J. Madden
Summary: This study investigated the effects of electrical stimulation of the hypothalamic paraventricular nucleus (PVN) and the rostral raphe pallidus area (rRPa) on brown adipose tissue (BAT) activity. It was found that PVN stimulation increased BAT activity and thermogenesis, while rRPa stimulation suppressed BAT thermogenesis. These findings contribute to our understanding of the mechanisms underlying deep brain stimulation (DBS) in the regulation of fat metabolism.
NEUROSCIENCE LETTERS
(2023)
Review
Cell Biology
Stephanie C. Puente-Ruiz, Alexander Jais
Summary: This article discusses the reciprocal signaling mechanisms between the central nervous system and adipose tissue to maintain energy balance in the body. It focuses on the integration of external signals in neuronal populations of the hypothalamus and the regulation of adipose tissue function by the central nervous system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Kuikui Fan, Qiang Li, Deng Pan, Haodong Liu, Penghui Li, Rihan Hai, Chenguang Du
Summary: This study found that the intact sympathetic nervous system plays a crucial role in mediating the anorexic and weight-loss effects of Amylin, which is achieved by influencing the nNOS and ChAT signaling in the LDT and locus coeruleus.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Francisco J. Amaro-Gahete, Maria Ruiz-Ruiz, Amalia Cano-Nieto, Guillermo Sanchez-Delgado, Juan M. Alcantara, Francisco M. Acosta, Idoia Labayen, Francisco B. Ortega, Jonatan R. Ruiz
Summary: This study investigated the effect of moderate versus vigorous intensity aerobic + resistance training programs on body composition, and the persistence of the changes after a free-living period. The results showed that both intensity levels of exercise training were effective in reducing body weight, fat mass, and visceral adipose tissue mass. However, these changes returned to baseline levels after the free-living period. There were no significant differences in lean mass changes between the exercise groups and the control group.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)
Article
Biology
Clarissa M. D. Mota, Christopher J. Madden
Summary: This study investigates the effects of modulating the activity of MBH neurons on thermoeffector activity, specifically on BAT thermogenesis and cutaneous vaso-motion. The results show that inhibiting MBH neuron activity reduces BAT thermogenesis, body temperature, heart rate, and induces cutaneous vasodilation, while disinhibition of these neurons increases BAT thermogenesis, body temperature, heart rate, and induces cutaneous vasoconstriction.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Environmental Sciences
Annalise N. VonderEmbse, Sarah E. Elmore, Kyle B. Jackson, Beth A. Habecker, Katherine E. Manz, Kurt D. Pennell, Pamela J. Lein, Michele A. La Merrill
Summary: Exposure to DDTs or p,p'-DDE during the perinatal period impairs thermogenesis by interfering with sympathetic regulation of brown adipose tissue. This effect leads to long-term metabolic dysfunction in female mice. Additionally, alterations in synaptic connectivity in sympathetic circuits that regulate BAT were observed in mice exposed to DDTs or p,p'-DDE.
ENVIRONMENTAL HEALTH
(2021)
Review
Neurosciences
Georgina Cano, Shelby L. Hernan, Alan F. Sved
Summary: The centrally projecting Edinger-Westphal nucleus (EWcp) plays a crucial role in stress responses and energy homeostasis by modulating various physiological functions. It integrates multimodal signals and modulates sympathetic output simultaneously to multiple effector organs to maintain energy balance under different conditions that require adjustments of energy demands.
Article
Biochemistry & Molecular Biology
Christina D. Camell
Summary: Adipose tissue plays a crucial role in nutrient sensing, energy storage, and metabolic health. Impairment of adipose tissue homeostasis during aging leads to metabolic disease. Aging is associated with dysfunction in the immune, nervous, and lymphatic systems, resulting in reduced ability to stimulate lipolysis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Pharmacology & Pharmacy
Fumiko Kihara-Negishi, Naoki Ohkura, Yuka Takahashi, Toshiyuki Fujita, Yasuhiro Nakamura, Keiji Maruyama, Tetsuta Oshitari, Shinji Yamaguchi
Summary: This study found that nobiletin (NOB) can enhance the thermogenic functions of brown adipocytes and promote brown adipokine secretion by enhancing beta-adrenergic stimulation. The metabolite of NOB, 3'-demethyl nobiletin (3'-DMN), also has similar effects. Therefore, NOB may be a potential candidate for activating BAT and preventing the onset of obesity.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Environmental Sciences
Kanako Hamaguchi, Toshiyuki Kurihara, Masahiro Fujimoto, Koji Sato, Motoyuki Iemitsu, Takafumi Hamaoka, Kiyoshi Sanada
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Sport Sciences
Tasuki Endo, Ryotaro Kime, Sayuri Fuse, Norio Murase, Yuko Kurosawa, Takafumi Hamaoka
Summary: This study aimed to investigate changes in optical properties during exercise and compare muscle oxygen dynamics measured by time-resolved NIRS with MBLL calculations. The results showed that optical path length shortened during exercise, and there were significant differences in the kinetics of oxy-, deoxy-, and total[Hb + Mb] when assuming constant PL compared to direct measurement.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Nutrition & Dietetics
Sayuri Fuse, Tasuki Endo, Riki Tanaka, Miyuki Kuroiwa, Akira Ando, Ayami Kume, Akiko Yamamoto, Kanna Kuribayashi, Shinji Somekawa, Masamichi Takeshita, Masaki Hashimoto, Ryotaro Kime, Yuko Kurosawa, Takafumi Hamaoka
Article
Medicine, General & Internal
Miyuki Kuroiwa, Sayuri Hamaoka-Fuse, Masahiro Sugimoto, Yuko Kurosawa, Yasuko Aita, Atsumi Tomita, Mikiko Anjo, Riki Tanaka, Tasuki Endo, Ryotaro Kime, Takafumi Hamaoka
Summary: This study found a relationship between plasma amino acid concentrations and brown adipose tissue density, particularly associating specific amino acid levels with changes in BAT-d levels. Additionally, a combination of anthropometric parameters and plasma amino acid concentrations could serve as a reliable biomarker for BAT-d levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Miyuki Kuroiwa, Sayuri Hamaoka-Fuse, Shiho Amagasa, Ryotaro Kime, Tasuki Endo, Riki Tanaka, Yuko Kurosawa, Takafumi Hamaoka
Summary: This study found a negative correlation between BAT-d and body adiposity in children aged 1 month to 5 years, suggesting that BAT may have a greater impact on childhood obesity than previously thought. Considering the level of BAT-d may be important in preventing or treating obesity in early childhood.
OBESITY SCIENCE & PRACTICE
(2022)
Article
Environmental Sciences
Riki Tanaka, Sayuri Fuse-Hamaoka, Miyuki Kuroiwa, Yuko Kurosawa, Tasuki Endo, Ryotaro Kime, Takeshi Yoneshiro, Takafumi Hamaoka
Summary: This study investigated the effect of whole-body strength training on human brown-like adipose tissue vascular density. The findings suggest that an appropriate combination of strength training and exposure to cold environments may be an effective strategy for modulating brown-like adipose tissue.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Noriko Nara, Yuko Kurosawa, Sayuri Fuse-Hamaoka, Miyuki Kuroiwa, Tasuki Endo, Riki Tanaka, Ryotaro Kime, Takafumi Hamaoka
Summary: This study aimed to determine the effects of a single dose of nattokinase (NK) on changes in skin temperature after cold water immersion. The results showed that the skin temperature of the hands immersed in cold water recovered more quickly with NK intake compared to placebo, indicating that NK may help prevent excessive vasoconstriction.