期刊
CURRENT STEM CELL RESEARCH & THERAPY
卷 16, 期 1, 页码 66-73出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1574888X15666200521084417
关键词
Antibiotic resistance; antibacterial; nucleic acid aptamers; antisense oligonucleotides (ASOs); antimicrobial peptides (AMP); DNA nanostructures; metallic nanoparticles
资金
- National Natural Science Foundation of China [81970986, 81771125]
This article highlights the emergence of multiple drug-resistant pathogenic bacteria due to the misuse of antibiotics, emphasizing the need for developing alternative therapeutic strategies. Nanoparticles and DNA nanostructures have been widely studied and utilized as antibacterial agents, showing promise in combating resistant bacteria.
Due to the misuse of antibiotics, multiple drug-resistant pathogenic bacteria have increasingly emerged. This has increased the difficulty of treatment as these bacteria directly affect public health by diminishing the potency of existing antibiotics. Developing alternative therapeutic strategies is the urgent need to reduce the mortality and morbidity related to drug-resistant bacterial infections. In the past 10 to 20 years, nanomedicines have been widely studied and applied as an antibacterial agent. They have become a novel tool for fighting resistant bacteria. The most common innovative substances, metal and metal oxide nanoparticles (NPs), have been widely reported. Until recently, DNA nanostructures were used alone or functionalized with specific DNA sequences by many scholars for antimicrobial purposes which were alternatively selected as therapy for severe bacterial infections. These are a potential candidate for treatments and have a considerable role in killing antibiotic-resistant bacteria. This review involves the dimensions of multidrug resistance and the mechanism of bacteria developing drug resistance. The importance of this article is that we summarized the current study of nano-materials based on nucleic acids in antimicrobial use. Meanwhile, the current progress and the present obstacles for their antibacterial and therapeutic use and special function of stem cells in this field are also discussed.
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