Article
Chemistry, Multidisciplinary
Tomoaki Banno, Shuhei Tsuruhara, Yu Seikoba, Ryohei Tonai, Koji Yamashita, Shinnosuke Idogawa, Yuto Kita, Ko Suzuki, Yuki Yagi, Yuki Kondo, Rika Numano, Kowa Koida, Takeshi Kawano
Summary: Microscale needle-like electrodes offer high spatiotemporal resolution for in vivo extracellular recording. However, reducing the size to the nanoscale increases electrical impedance. By stacking a nanoelectrode on an amplifier module, the quality of neuronal signal recording can be improved. In experiments conducted on the mouse cortex, the nanoelectrode with amplifier could record a wider range of neural signals compared to the electrode without the amplifier.
Review
Biochemistry & Molecular Biology
Ivana T. Drvenica, Ana Z. Stancic, Irina S. Maslovaric, Drenka I. Trivanovic, Vesna Lj. Ilic
Summary: Hemoglobin is not only crucial in maintaining cellular bioenergetic homeostasis by binding and transporting oxygen, but also plays significant roles in cellular signaling and modulation of the inflammatory response. The latest research reveals the impact of extracellular hemoglobin on various cellular functions such as redox status, inflammatory state, proliferation and chemotaxis, mitochondrial dynamics, chemoresistance, and differentiation.
Review
Developmental Biology
Sydney Leaman, Nicolas Marichal, Benedikt Berninger
Summary: Cellular identity can be reprogrammed through gene regulatory networks, and recent research suggests that this reprogramming can mitigate disease phenotypes.
Article
Biochemistry & Molecular Biology
Azin EbrahimAmini, Shanthini Mylvaganam, Paolo Bazzigaluppi, Mohamad Khazaei, Alexander Velumian, Bojana Stefanovic, Peter L. Carlen
Summary: The study investigated the effect of astrocytic photostimulation on extracellular potassium ion concentration, finding that stimulating astrocytes led to a decrease in [K]o. This suggests that modifying astrocytic membrane potential could be a potential tool for adjusting [K]o levels in the nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Nuerbiyemu Abulikemu, Xin Gao, Wei Wang, Qingyuan He, Gang Wang, Tao Jiang, Xiaodong Wang, Yumeng Cheng, Min Chen, Yanran Li, Lulu Liu, Jingjing Zhao, Jin Li, Chunhui Jiang, Yunling Wang, Hongbin Han, Jian Wang
Summary: This study investigated the changes in extracellular space (ECS) in cryptococcal brain granuloma using MRI with a gadolinium tracer. The results showed that the distribution of the tracer was faster and broader in the internal area of the granuloma, while it was slower and narrower at the edge of the granuloma. These findings provide a theoretical basis for the treatment of brain granuloma via ECS.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Immunology
Neel K. Krishna, Kenji M. Cunnion, Grace A. Parker
Summary: EPICC peptides are a group of peptides developed from the capsid protein sequence of human astrovirus type 1, which have been shown to inhibit the classical and lectin pathways of complement. The lead EPICC molecule, RLS-0071, has demonstrated multiple mechanisms of action including complement blockade, inhibition of neutrophil-driven myeloperoxidase (MPO) activity, inhibition of neutrophil extracellular trap (NET) formation, and intrinsic antioxidant activity. RLS-0071 has shown promise in the treatment of immune-mediated hematological diseases and tissue-based diseases driven by both complement and neutrophil pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Alessandro Mongera, Marie Pochitaloff, Hannah J. Gustafson, Georgina A. Stooke-Vaughan, Payam Rowghanian, Sangwoo Kim, Otger Campas
Summary: Cells constantly monitor and adapt their behaviors to the biochemical and mechanical cues in their 3D microenvironment. This study investigates the mechanical parameters of the cellular microenvironment probed by cells in vivo during zebrafish presomitic mesoderm differentiation. The findings reveal that cells perceive tissue stiffness associated with deformations of the supracellular architecture and that these mechanical parameters vary along the anteroposterior axis during mesodermal differentiation.
Review
Cell Biology
Nathalia Leal Santos, Silvina Odete Bustos, Darshak Bhatt, Roger Chammas, Luciana Nogueira de Sousa Andrade
Summary: Extracellular vesicles (EVs) play a crucial role in cancer progression by affecting continuous tumor growth, angiogenesis, metastasis, immune infiltrating cells, and treatment response. Understanding the mechanisms controlling EVs secretion and cargo sorting is essential to impede tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Azin EbrahimAmini, Bojana Stefanovic, Peter L. Carlen
Summary: This study investigates the effect of decreased intracellular ATP concentration on the extracellular potassium ion concentration. It found that reduction in ATP concentration leads to an increase in extracellular potassium ion concentration, possibly due to the impairment of the Na/K ATPase pump and ATP-sensitive potassium channel.
Article
Chemistry, Multidisciplinary
Kunanon Chattrairat, Takao Yasui, Shunsuke Suzuki, Atsushi Natsume, Kazuki Nagashima, Mikiko Iida, Min Zhang, Taisuke Shimada, Akira Kato, Kosuke Aoki, Fumiharu Ohka, Shintaro Yamazaki, Takeshi Yanagida, Yoshinobu Baba
Summary: Extracellular vesicles (EVs) have great potential as biomarkers for early cancer diagnosis. The membrane protein expression ratio of CD31/CD63 was found to be significantly higher in tumor organoid-derived EVs and urine samples from glioblastoma patients compared to noncancer subjects, indicating the potential of the nanowire assay system for EV-mediated tumor-microenvironment crosstalk analysis.
Article
Biochemistry & Molecular Biology
Maxim O. Politko, Alexandra Y. Tsidulko, Oxana A. Pashkovskaya, Konstantin E. Kuper, Anastasia V. Suhovskih, Galina M. Kazanskaya, Lyubov S. Klyushova, Dmitry K. Sokolov, Alexander M. Volkov, Evgenii E. Kliver, Alexander A. Zheravin, Svetlana V. Aidagulova, Elvira V. Grigorieva
Summary: The study found that multiple irradiation affects the cellular and extracellular glycosylated components of normal brain tissue, resulting in changes in PGs and GAGs, and an increased adhesion and proliferation of GBM cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Vijay K. Samineni, Jose G. Grajales-Reyes, Gary E. Grajales-Reyes, Eric Tycksen, Bryan A. Copits, Christian Pedersen, Edem S. Ankudey, Julian N. Sackey, Sienna B. Sewell, Michael R. Bruchas, Robert W. Gereau
Summary: Studies have shown that chloroquine-activated neurons in the CeA play a crucial role in regulating itch sensation and associated aversion, as well as in itch-related comorbidities such as anxiety-like behaviors. These neurons modulate itch through differentially expressed genes and signaling pathways, projecting to key brain regions involved in itch modulation.
Article
Engineering, Biomedical
Libing Fu, Bingyang Shi, Shihui Wen, Marco Morsch, Guoying Wang, Zhiguang Zhou, Chao Mi, Mohammad Sadraeian, Gungun Lin, Yiqing Lu, Dayong Jin, Roger Chung
Summary: This study successfully synthesized bright UCNPs with different aspect ratios using a seed-mediated approach and systematically evaluated the effects of physical aspect ratios and PEGylation on cellular uptake. The findings demonstrated that PEGylated UCNPs can enhance their stability and cellular uptake capacity, and an optimal aspect ratio for UCNP uptake was identified. These results provide crucial insights for optimizing UCNPs as drug carriers.
ACTA BIOMATERIALIA
(2022)
Review
Biochemistry & Molecular Biology
Tom Dufor, Ann M. Lohof, Rachel M. Sherrard
Summary: Neurological and psychiatric diseases often have no cure, so non-invasive brain stimulation techniques, such as pulsed magnetic fields, are being explored as potential therapeutic tools. However, the use of different stimulation parameters makes the study of magnetic brain stimulation complex. This review aims to bring together research from human, animal, and in vitro studies to understand the biology of magnetic brain stimulation. The review identifies common effects, interactions with nervous tissue, and underlying cellular mechanisms. Recent advances in magneto-biology provide insights into the mechanisms underlying low-intensity stimulation effects, suggesting the potential of low-intensity focal magnetic stimulation as a powerful treatment tool for humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Thanh Lan Chu, Garima Tripathi, Sang Ho Bae, Byong-Taek Lee
Summary: The combination of chitosan/gelatin (CG) enriched with decellularized liver extracellular matrix powder (dLECM) was optimized to enhance wound healing and reduce postoperative complications. The CG-E4 sponge scaffold showed fast post-operative recovery, higher blood absorption, and faster clotting time, demonstrating its potential as a hemostatic material in surgeries.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Neurosciences
Jan Kaminski, Aneta Brzezicka, Adam N. Mamelak, Ueli Rutishauser
Article
Immunology
Songlin Li, Eric Y. Hayden, Veronica J. Garcia, Dieu-Trang Fuchs, Julia Sheyn, David A. Daley, Altan Rentsendorj, Tania Torbati, Keith L. Black, Ueli Rutishauser, David B. Teplow, Yosef Koronyo, Maya Koronyo-Hamaoui
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
N. Chandravadia, D. Liang, A. G. P. Schjetnan, A. Carlson, M. Faraut, J. M. Chung, C. M. Reed, B. Dichter, U. Maoz, S. K. Kalia, T. A. Valiante, A. N. Mamelak, U. Rutishauser
Article
Neurosciences
Sruti Mallik, Srinath Nizampatnam, Anirban Nandi, Debajit Saha, Baranidharan Raman, ShiNung Ching
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Ueli Rutishauser, Leila Reddy, Florian Mormann, Johannes Sarnthein
Summary: Recordings from neurons in humans implanted with electrodes reveal the existence of different types of cells related to memory, including those encoding selective and invariant representations of abstract concepts, and memory-selective cells associated with familiarity and episodic retrieval. Insights derived from observing these cells include the activation of semantic representations before episodic representations, the segregation of memory content and memory strength, and the relationship between cell activity and subjective awareness in declarative memory.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Clayton P. Mosher, Adam N. Mamelak, Mahsa Malekmohammadi, Nader Pouratian, Ueli Rutishauser
Summary: The study reveals that human STN neurons play distinct roles in action selection and cancellation, with movement-related neurons showing suppression and stop-signal neurons showing activation. Neuronal properties varied by recording location, indicating anatomical segregation of functions within the STN.
Article
Clinical Neurology
Nathaniel D. Sisterson, April A. Carlson, Ueli Rutishauser, Adam N. Mamelak, Mitchell Flagg, Nader Pouratian, Yousef Salimpour, William S. Anderson, R. Mark Richardson
Summary: Through analyzing data from 367 DBS surgeries, the study found that conducting ECoG research during surgery did not significantly increase complication rates, providing confirmation of the safety of such procedures.
Review
Neurosciences
Zuzanna Roma Kubska, Jan Kaminski
Summary: Understanding human cognition is a key goal of contemporary neuroscience. Animal studies and noninvasive techniques have limitations in providing a full understanding of human cognition due to the complexity of the human brain. Human single-neuron recordings have revealed concept cells, novelty-dependent cells, and activity patterns behind working memory like persistent activity, offering insights for future research and opportunities in investigating pathological brain conditions.
Article
Neurosciences
Cooper Penner, Juri Minxha, Nand Chandravadia, Adam N. Mamelak, Ueli Rutishauser
Summary: This study recorded neuronal activity in the human hippocampus and found differences between the left and right hemispheres at a neural level. The right hippocampus had higher average frequency of theta bouts compared to the left hippocampus, while the left hippocampus had lower amplitude and higher prevalence of theta bouts. Additionally, visually tuned neurons were only present in the right hippocampus.
Article
Neurosciences
Jie Zheng, Andrea G. P. Schjetnan, Mar Yebra, Bernard A. Gomes, Clayton P. Mosher, Suneil K. Kalia, Taufik A. Valiante, Adam N. Mamelak, Gabriel Kreiman, Ueli Rutishauser
Summary: This study reveals that neurons in the human brain respond to cognitive boundaries, predicting memory encoding success and influencing subsequent recognition accuracy and event order memory. While experience is continuous, memories are organized discretely, with cognitive boundaries thought to play a key role in structuring memory.
NATURE NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Zhongzheng Fu, Danielle Beam, Jeffrey M. Chung, Chrystal M. Reed, Adam N. Mamelak, Ralph Adolphs, Ueli Rutishauser
Summary: Monitoring one's own performance is crucial for flexibly achieving desired goals. In this study, single neurons in the human medial frontal cortex were recorded while subjects performed two tasks involving cognitive conflict. The findings suggest that neuronal representations of evaluative signals can be both abstract and task-specific, providing insights into the neuronal mechanism for estimating control demand.
Review
Neurosciences
Zhongzheng Fu, Amirsaman Sajad, Steven P. Errington, Jeffrey D. Schall, Ueli Rutishauser
Summary: In this Review, the authors discuss the neuronal mechanisms underlying performance monitoring in macaques and humans. They review the discovery of single-neuron correlates of error monitoring and the clinical relevance of these findings for understanding psychopathology. They also propose a theoretical framework that offers new insights into how error signals are computed in both species.
NATURE REVIEWS NEUROSCIENCE
(2023)
Article
Psychology, Biological
Tomas G. G. Aquino, Jeffrey Cockburn, Adam N. N. Mamelak, Ueli Rutishauser, John P. P. O'Doherty
Summary: Aquino et al. demonstrate that the pre-supplementary motor area encodes an integrated utility signal for choice options and decisions in human brain. Adaptive behavior in real-world environments requires integration of multiple variables, including novelty, expected value, and uncertainty. Neurons from preSMA, VMPFC, and dACC were recorded to investigate how integration occurs during decision-making. PreSMA neurons encode separate pre-decision variables for each option and an integrated utility signal, while post-decision encoding is more distributed and prominent in VMPFC. The findings highlight the importance of the human preSMA in value-based decisions.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Multidisciplinary Sciences
Tobias Staudigl, Juri Minxha, Adam N. Mamelak, Katalin M. Gothard, Ueli Rutishauser
Summary: The coordination between neural communication in the human amygdala and hippocampus during the free viewing of images is found to be related to the execution of eye movements, especially when fixating on human faces. This suggests that the state of the human medial temporal lobe network is selectively coordinated with motor behavior, with interareal neural communication being facilitated for social stimuli.