Article
Multidisciplinary Sciences
Vanessa Polanetzki, Franziska Froeb, Tina Baroti, Margit Schimmel, Ernst R. Tamm, Michael Wegner
Summary: The study suggests that Pbrm1 and the PBAF complex are dispensable for proper Schwann cell development, and previous observed defects in Schwann cells upon Brg1 deletion are mainly due to altered or absent function of the BAF complex.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Theodore Busby, Yuechuan Chen, Tanner C. Godfrey, Mohammad Rehan, Benjamin J. Wildman, Caris M. Smith, Quamarul Hassan
Summary: This article investigates tissue-specific regulation in mineralized tissues through chromatin remodeling, focusing on the expression of Baf45a and Baf45d. The study finds that Baf45a and Baf45d are preferentially expressed in osteoblasts and odontoblasts, and their expression is associated with the differentiation and maturation of these cells. The research also reveals the importance of the interaction between BAF45A, PBAF subunits, and the transcription factor RUNX2 in regulating gene expression in mineralized tissues.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anton O. Chugunov, Nadezhda A. Potapova, Natalia S. Klimenko, Victor V. Tatarskiy, Sofia G. Georgieva, Nataliya Soshnikova
Summary: The DPF domain of PHF10 is important for transcription activation, although its structure remains undetermined. Our homology modeling revealed common and distinct features in structure and histone modifications recognition capabilities of the PHF10 DPF domain, which may impact the recruitment of the PBAF complex to chromatin. Additionally, we traced the evolution of DPF1-3 and PHF10 genes from unicellular to vertebrate organisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Nataliya V. Soshnikova, Asya M. Azieva, Nataliya S. Klimenko, Alvina I. Khamidullina, Alexey V. Feoktistov, Andrey A. Sheynov, Alexander V. Brechalov, Victor V. Tatarskiy, Sofia G. Georgieva
Summary: dcPBAF, a variant of the PBAF complex, is present in differentiated neuronal cells and is responsible for the transcription of specific neuron-specific and housekeeping genes in adult neurons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Katrin Radeloff, Dorothee Weiss, Rudolf Hagen, Norbert Kleinsasser, Andreas Radeloff
Summary: Adipose-derived stromal cells show chondrogenic differentiation capacity in vitro and have potential for cartilage replacement. Implantation of predifferentiated cell-seeded constructs into rabbit ear cartilage defects resulted in deposition of cartilage-like structures with evidence of endochondral ossification.
Article
Cell & Tissue Engineering
Hae-Ri Lee, Seung-Jip Yang, Hyun-Kyung Choi, Jin-A Kim, Il-Hoan Oh
Summary: Regulation of CHD1 expression levels hierarchically determines the primitive state of MSCs and their ability to support stem cells, ultimately influencing tissue regeneration.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Bo Liang, Yi Liang, Rui Li, Hui Zhang, Ning Gu
Summary: This study utilized a systematic pharmacology-based approach to uncover the mechanisms of Guanxin V in treating ventricular remodeling. It was found that Guanxin V could alleviate and reverse ventricular remodeling through its anti-apoptosis and anti-fibrosis effects.
BIOORGANIC CHEMISTRY
(2021)
Article
Engineering, Biomedical
Mengmeng Yang, Chao Qin, Linlin Tao, Gang Cheng, Jingjing Li, Fangnan Lv, Nan Yang, Zuhang Xing, Xinyu Chu, Xiaopeng Han, Meirong Huo, Lifang Yin
Summary: A nanomedicine platform (HA-LSL/siTGF-ss) with dual-targeting, hyaluronidase (HAase), and glutathione (GSH) triggered release was developed to efficiently deliver TGF-β small interference RNA (siTGF-β) and improve the efficacy of anti-PD-L1 therapy in TNBC. The siTGF-β nanosystem effectively silenced TGF-β-related signaling pathways and reduced stroma deposition, promoting penetration of nanomedicines into the tumor microenvironment for deep remodeling. This dual-suppression of TGF-β enhanced antitumor immunity and inhibited tumor growth and metastasis in TNBC.
Article
Hematology
Sayantani Sinha, Shankha Subhra Chatterjee, Mayukh Biswas, Arijit Nag, Debasis Banerjee, Rajib De, Amitava Sengupta
EXPERIMENTAL HEMATOLOGY
(2018)
Article
Oncology
Shankha Subhra Chatterjee, Mayukh Biswas, Liberalis Debraj Boila, Debasis Banerjee, Amitava Sengupta
MOLECULAR CANCER RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Mayukh Biswas, Shankha Subhra Chatterjee, Liberalis Debraj Boila, Sayan Chakraborty, Debasis Banerjee, Amitava Sengupta
Article
Oncology
Subha Saha, Krushna Chandra Murmu, Mayukh Biswas, Sohini Chakraborty, Jhinuk Basu, Swati Madhulika, Srinivasa Prasad Kolapalli, Santosh Chauhan, Amitava Sengupta, Punit Prasad
FRONTIERS IN ONCOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Sayan Chakraborty, Sayantani Sinha, Amitava Sengupta
Summary: The integration of epigenetic regulation with transcriptional and cell signaling machinery plays a crucial role in determining tissue resident adult pluripotent mesenchymal stem/stromal cell (MSC) activity, lineage commitment, and immunomodulation. Histone modifying enzymes and chromatin remodeling complexes are central features influencing gene regulation and tissue identity establishment in MSCs. Modulation of transcription factor expression gradient and flexibility of chromatin architecture are exciting approaches to regulate MSC activity.
Article
Hematology
Silvia Alvarez, Ana C. da Silva Almeida, Robert Albero, Mayukh Biswas, Angelica Barreto-Galvez, Thomas S. Gunning, Anam Shaikh, Tomas Aparicio, Agnieszka Wendorff, Erich Piovan, Pieter Van Vlierberghe, Steven Gygi, Jean Gautier, Advaitha Madireddy, Adolfo A. Ferrando
Summary: Research has shown that the PHF6 gene is involved in multiple molecular mechanisms, including nucleosome remodeling and DNA repair. After DNA damage, PHF6 localizes to the sites of injury and its absence impairs the resolution of DNA breaks. Furthermore, PHF6 specifically associates with difficult-to-replicate heterochromatin, making it an important regulator of genomic stability.
Meeting Abstract
Hematology
Sayantani Sinha, Zhiyan Silvia Liu, Maxwell Bannister, Erica Arriaga-Gomez, Axia Song, Dawei Zong, Martina Sarchi, Elizabeth Bonner, Victor Corral, Cassandra Leibson, Wannasiri Chiraphapphaiboon, Derek Stirewalt, Joachim Deeg, Sumit Rai, Matthew J. Walter, Timothy A. Graubert, Sergei Doulatov, Dang Hai Nguyen, Stanley Chun-Wei Lee
Article
Oncology
Liberalis Debraj Boila, Subhadeep Ghosh, Subham K. Bandyopadhyay, Liqing Jin, Alex Murison, Andy G. X. Zeng, Wasim Shaikh, Satyaki Bhowmik, Siva Sai Naga Anurag Muddineni, Mayukh Biswas, Sayantani Sinha, Shankha Subhra Chatterjee, Nathan Mbong, Olga I. Gan, Anwesha Bose, Sayan Chakraborty, Andrea Arruda, James A. Kennedy, Amanda Mitchell, Eric R. Lechman, Debasis Banerjee, Michael Milyavsky, Mark D. Minden, John E. Dick, Amitava Sengupta
Summary: Acute myeloid leukemia (AML) is a heterogeneous and aggressive malignancy with limited targeted therapies. This study found that KDM6-demethylase function critically regulates DNA-damage-repair-(DDR) gene expression in AML. KDM6A loss-of-function mutations are linked to chemoresistance, while upregulated KDM6A is associated with venetoclax tolerance. Combination therapy targeting PARP and BCL2 was shown to be superior in inducing AML apoptosis, particularly in AML cells carrying KDM6A-domain mutations. Therefore, KDM6A could be a potential molecular regulator for determining therapeutic efficacy in AML.
Article
Biochemical Research Methods
Sayantani Sinha, Sayan Chakraborty, Amitava Sengupta
