Article
Materials Science, Multidisciplinary
Jisu Hong, Yonghwan Kwon, Min Sang Kwon, Chaenyung Cha
Summary: This paper presents a brush copolymer, P(AzPEG), as a multifunctional polymeric cross-linker for carboxylate-containing acrylic adhesives. The density and length of the AzPEG brush can be conveniently controlled to effectively regulate the mechanical and adhesive properties of the adhesive without significant changes in concentration.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ekkachai Martwong, Yvette Tran
Summary: The study reports on the synthesis and temperature-responsive properties of poly(PEGMA) hydrogel thin films. Surface-attached poly(PEGMA) hydrogel films were synthesized using a simple, versatile, and well-controlled thiol-ene click reaction method, with the transition temperature finely tunable by adjusting the number of PEG units. The LCST properties of the hydrogel films are not sensitive to salt, holding promise for applications in biology such as injectable hydrogels, drug delivery systems, microfluidic valves, and flow switches for biotechnologies.
Article
Biochemistry & Molecular Biology
Irina M. Le-Deygen, Oxana E. Musatova, Victor N. Orlov, Nikolay S. Melik-Nubarov, Irina D. Grozdova
Summary: This study provides the first evidence of the interaction between PEG and HA in aqueous solutions. The binding of PEG to HA requires multiple free primary hydroxyls regularly distributed along the polysaccharide chain. Additionally, PEG-induced compaction of HA may be related to changes in plasma membrane properties and resealing of mechanical injuries.
Article
Polymer Science
Hanru Liu, Huimin Geng, Xiaohui Zhang, Xu Wang, Jingcheng Hao, Jiwei Cui
Summary: This paper reports the rapid synthesis of hot melt super glue (HMSG) through the formation of adhesive supramolecular networks. The advantages of HMSG include ease of assembly, excellent adhesion strength on various substrates, resistance to low temperature and organic solvents, and recyclable adhesion strength.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Luke Juckett, Tiam Mana Saffari, Benjamin Ormseth, Jenna-Lynn Senger, Amy M. M. Moore
Summary: Peripheral nerve injuries (PNI) often result in lifelong disability with rare complete functional recovery. Intraoperative electrical stimulation (ES) is a promising surgical adjunct that can augment the intrinsic molecular pathways of nerve regeneration. Clinical trials have shown that ES can be an efficacious therapy to improve patient outcomes following PNIs.
Article
Polymer Science
Graham Hayes, Ben Drain, C. Remzi Becer
Summary: Poly(2-oxazoline)s are promising for biomedical applications, but limited synthetic approaches exist for star-shaped polymers. A novel bis-oxazoline cross-linker was developed via a fast thiol click reaction, allowing the preparation of well-controlled core cross-linked star polymers. The synthesized star-shaped polymers were characterized extensively and showed potential for encapsulation of dihydroxyanthroquinone.
Article
Chemistry, Multidisciplinary
Oana Dobre, Mariana A. G. Oliva, Giuseppe Ciccone, Sara Trujillo, Aleixandre Rodrigo-Navarro, Douglas Cormac Venters, Virginia Llopis-Hernandez, Massimo Vassalli, Cristina Gonzalez-Garcia, Matthew J. Dalby, Manuel Salmeron-Sanchez
Summary: Laminins are crucial structural proteins in the ECM that bind growth factors and play tissue-specific roles. A new LM-PEG hydrogel platform inspired by Matrigel offers controlled stiffness and degradability, enabling specific targeting of tissues through GFs presented at ultralow doses. This platform demonstrates the potential to induce stem cell differentiation and promote neural cell growth in a synthetic, reproducible 3D microenvironment mimicking the native ECM.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Cell Biology
Jingxin Zhang, Binjing Zhang, Jinglan Zhang, Weimin Lin, Shiwen Zhang
Summary: Magnesium as a suitable material for promoting peripheral nerve regeneration has both challenges and potentials, but there is currently limited research on this topic, requiring further exploration to address the shortcomings and challenges identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xing Yu, Deteng Zhang, Chang Liu, Zhaodi Liu, Yujun Li, Qunzi Zhao, Changyou Gao, Yong Wang
Summary: The grafting of KHI peptides onto a porous and micropatterned PLCL film, loaded with NGF, significantly improved Schwann cell adhesion, ratio of length/width, and elongation percentage in vitro. In vivo, electromyography and nerve morphological changes after severe traction injury were significantly improved in the MPLCL-peptide group and MPLCL-peptide-NGF group compared to the PLCL group.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Xiaolan Li, Xiang Zhang, Ming Hao, Dongxu Wang, Ziping Jiang, Liqun Sun, Yongjian Gao, Ye Jin, Peng Lei, Yue Zhuo
Summary: This review summarizes the importance of collagen in peripheral nerve regeneration, focusing on its characteristics, role, and optimization methods. Collagen, as a biomaterial, plays a crucial role in peripheral nerve repair and can be further optimized by adjusting its structure and physical properties, as well as combining it with bioactive components.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Derya Burcu Hazer Rosberg, Baki Hazer, Lena Stenberg, Lars B. Dahlin
Summary: The study showed that conduits modified with gold and cobalt-oxide nanoparticles improved axonal outgrowth and decreased the number of apoptotic Schwann cells, leading to enhanced nerve regeneration after reconstruction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Moein Zarei, Miroslawa El Fray
Summary: Polymeric materials have a wide range of applications due to their controllable properties. In this study, a series of PBS-DLS-PEG copolymers were synthesized with different molecular weights of PEG to investigate their surface and thermal properties. The incorporation of higher molecular weight PEG improved the surface wettability of the materials while maintaining their thermal properties.
Article
Nanoscience & Nanotechnology
Qiuquan Cai, Jiahong Jiang, Hongjie Zhang, Pengfei Ge, Liu Yang, Weipu Zhu
Summary: A PTX-loaded nanodrug was prepared through self-assembly of PTX and an amphiphilic PEG derivative, showing good biocompatibility and selective drug release under intratumor reducing conditions. This nanodrug has potential for delivering hydrophobic drugs to treat malignant tumors with prolonged circulation time and excellent antitumor efficacy in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Yasuhiro Nakagawa, Kotaro Ushidome, Keita Masuda, Kazunori Igarashi, Yu Matsumoto, Tatsuya Yamasoba, Yasutaka Anraku, Madoka Takai, Horacio Cabral
Summary: Multi-arm star-shaped block copolymers consisting of poly(furfuryl glycidol) (PFG) and poly(ethylene glycol) (PEG) were developed for drug delivery. The block copolymers showed controlled sizes and effectively loaded and released model drugs. When injected intravenously, they exhibited prolonged blood circulation, indicating their potential as long-circulating nanocarriers.
Article
Polymer Science
Wasana Nonkrathok, Tatiya Trongsatitkul, Nitinat Suppakarn
Summary: In this study, the shape memory properties of poly(lactic acid) (PLA)/poly(ethylene glycol) (PEG) blends were improved by adding maleic anhydride-grafted poly(lactic acid) (PLA-g-MA) as a compatibilizer. The PLA-g-MA improved interfacial adhesion between phases and promoted chain entanglement, leading to enhanced mechanical properties and shape fixity performance. The compatibilized blend containing 2 wt% PLA-g-MA exhibited the best shape fixity and recovery performance.
Article
Nanoscience & Nanotechnology
Feifei Sun, Yazhong Bu, Yourong Chen, Fei Yang, Jiakuo Yu, Decheng Wu
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Cell Biology
Dandan Tan, Haowen Zhang, Junyao Deng, Jingmin Liu, Jinkun Wen, Lixia Li, Xianghai Wang, Mengjie Pan, Xiaofang Hu, Jiasong Guo
Article
Neurosciences
Muhua Lai, Mengjie Pan, Longjiao Ge, Jingmin Liu, Junyao Deng, Xianghai Wang, Lixia Li, Jinkun Wen, Dandan Tan, Haowen Zhang, Xiaofang Hu, Lanya Fu, Yizhou Xu, Zhenlin Li, Xiaozhong Qiu, Gong Chen, Jiasong Guo
EXPERIMENTAL NEUROLOGY
(2020)
Article
Engineering, Biomedical
Xiaofang Hu, Xianghai Wang, Yizhou Xu, Lixia Li, Jingmin Liu, Yutong He, Ying Zou, Lei Yu, Xiaozhong Qiu, Jiasong Guo
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Nanoscience & Nanotechnology
Pengxu Wang, Yuan Zhu, Luyao Feng, Yinghui Wang, Yazhong Bu
Summary: In this study, a succinyl ester-based bioadhesive (SEgel) with self-deactivating properties was successfully fabricated for postoperative antiadhesion. The SEgel used N-hydroxysuccinimide esters (NHS-esters) as the adhesive group, enabling quick covalent anchorage to tissues while undergoing rapid hydrolysis on the superficial layer, preventing indiscriminate adhesion. The SEgel showed significant reduction in tissue adhesion in both cecum-sidewall adhesion and hepatic adhesion models.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Immunology
Jiawei Xu, Jinkun Wen, Lanya Fu, Liqiang Liao, Ying Zou, Jiaqi Zhang, Junyao Deng, Haowen Zhang, Jingmin Liu, Xianghai Wang, Daming Zuo, Jiasong Guo
Summary: The depletion of RhoA in macrophages has a negative impact on Wallerian degeneration and nerve regeneration, mainly due to impaired migration and phagocytosis of macrophages resulting from disrupted RhoA/ROCK/MLCK pathway. Since previous research has shown that RhoA inhibition in neurons promotes axonal regeneration, the study highlights the importance of considering cellular specificity of RhoA-targeted drugs in future applications for treating peripheral nerve injuries.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Jingmin Liu, Lixia Li, Ying Zou, Lanya Fu, Xinrui Ma, Haowen Zhang, Yizhou Xu, Jiawei Xu, Jiaqi Zhang, Mi Li, Xiaofang Hu, Zhenlin Li, Xianghai Wang, Hao Sun, Hui Zheng, Lixin Zhu, Jiasong Guo
Summary: Wallerian degeneration, the degeneration of distal axons and myelin after nerve injury, is crucial for nerve regeneration. This study found that microtubule dynamics are involved in this process, with microtubule stabilization promoting degeneration and dedifferentiation, while microtubule destabilization inhibiting these processes.
NEURAL REGENERATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ying Zou, Jiaqi Zhang, Jiawei Xu, Lanya Fu, Yizhou Xu, Xianghai Wang, Zhenlin Li, Lixin Zhu, Hao Sun, Hui Zheng, Jiasong Guo
Summary: SIRT6 plays a crucial role in macrophage function following peripheral nerve injury, with its inhibition impairing migration, phagocytosis, and M2 polarization of macrophages, thus suggesting it as a potential therapeutic target for peripheral nerve injury.
CELL AND BIOSCIENCE
(2021)
Article
Engineering, Biomedical
Yazhong Bu, Abhay Pandit
Summary: Bioadhesives are transforming clinical practices by their strength and cohesion mechanisms, which are crucial for their overall function and application. While there is extensive research on adhesion mechanisms, cohesion mechanisms have received less attention.
BIOACTIVE MATERIALS
(2022)
Article
Neurosciences
Changnan Xie, Yihan Wang, Jinfeng Wang, Yizhou Xu, Haining Liu, Jiasong Guo, Lixin Zhu
Summary: This study found that Perlecan is specifically expressed in the basement membranes (BMs) of the spinal cord and undergoes degradation/remodeling after spinal cord injury (SCI). Overexpression of Perlecan significantly enhances locomotor recovery and neural regeneration, reduces blood-spinal cord barrier (BSCB) permeability, and decreases the neuroinflammatory response. Perlecan interacts with integrin beta 1 and inhibits downstream signaling pathway to improve BSCB integrity.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Engineering, Biomedical
Ye Zhu, Lining Zhang, Wanglin Duan, Sergio Martin-Saldana, Chaowei Li, Hongwen Yu, Luyao Feng, Xianpeng Zhang, Baoji Du, Guanying Li, Xifu Zheng, Yazhong Bu
Summary: Based on cryopolymerization, a succinic ester-based sponge (Ssponge) is fabricated and shows better hemostasis performance and tissue regeneration in liver hemorrhage and liver regeneration models compared to commercially available gelatin sponge (Csponge).
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Luyao Feng, Liqun Wang, Yao Ma, Wanglin Duan, Sergio Martin-Saldana, Ye Zhu, Xianpeng Zhang, Bin Zhu, Chaowei Li, Shibo Hu, Mingjie Bao, Ting Wang, Yuan Zhu, Fei Yang, Yazhong Bu
Summary: Intrauterine adhesion (IUA) is a fibrosis condition in the uterus that is the second most common cause of female infertility, adversely affecting women's physical and mental well-being. Current treatment strategies for IUA fail to provide satisfactory outcomes, posing a significant challenge for reproductive science. This study presents a series of self-healing adhesive hydrogels with antioxidant properties (P10G15, P10G20, and P10G25) that exhibit good self-healing, adaptability, injectability, and tissue adhesiveness. In vitro experiments using P10G20 showed effective scavenging of oxidative stress markers and promising biocompatibility. Further, P10G20 demonstrated a reduction in oxidative stress and prevention of IUA with improved tissue regeneration in an animal model, highlighting its potential as a clinical treatment option.
BIOACTIVE MATERIALS
(2023)
Review
Medicine, General & Internal
Wang-Lin Duan, Li-Ning Zhang, Raghvendra Bohara, Sergio Martin-Saldana, Fei Yang, Yi-Yang Zhao, Yong Xie, Ya-Zhong Bu, Abhay Pandit
Summary: This review summarizes the advances in using adhesive hydrogel for osteoarthritis (OA) treatment, including commonly used hydrogels with their adhesion mechanisms and components, as well as bioactive therapeutic strategies. By presenting an interdisciplinary perspective, this review aims to provide a comprehensive insight for designing novel bioadhesive systems for OA therapy.
MILITARY MEDICAL RESEARCH
(2023)
