Article
Medicine, General & Internal
Ang Gao, Jun-Yu Li, Rui Shao, Tong-Xuan Wu, Yong-Qiang Wang, Xiao-Guang Liu, Miao Yu
Summary: For AIS patients with Risser 3-5 and Cobb angle 20 degrees-40 degrees, Schroth exercises improved health-related quality of life and halted curve progression during the follow-up period. Cervical spine alignment and shoulder balance also significantly improved after Schroth exercises. Schroth exercises are recommended for patients with AIS.
CHINESE MEDICAL JOURNAL
(2021)
Review
Clinical Neurology
Ishraq Joarder, Seika Taniguchi, Andrea Mendoza, Mary Elizabeth Snow
Summary: This study analyzed the measures used to define treatment success for adolescent idiopathic scoliosis (AIS). It found that qualitative measures describing the psychosocial implications of AIS were rarely used, suggesting that there is value in using qualitative methods to guide patient care.
EUROPEAN SPINE JOURNAL
(2023)
Article
Medicine, General & Internal
Edyta Kinel, Krzysztof Korbel, Mateusz Kozinoga, Dariusz Czaprowski, Lukasz Stepniak, Tomasz Kotwicki
Summary: This study compared the validity of ISYQOL-PL and SRS-22 questionnaire scores in patients with scoliosis, showing a significantly better quality of life in mild scoliosis with ISYQOL-PL. The severity of scoliosis had a direct statistically significant impact on patients' quality of life when evaluated using ISYQOL-PL.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Abdulmajeed Alzakri, Faisal AlMuhid, Nasser Almousa, Muaath Aljehani, Hashem Alhalabi
Summary: This study aims to explore the factors that affect patient satisfaction with surgical treatment of scoliosis and evaluate the impact of satisfaction on the different domains of the SRS-22 questionnaire and radiographic parameters. The analysis reveals a significant positive correlation between self-image and satisfaction, indicating its crucial role in postoperative quality of life and surgical decision making.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Clinical Neurology
Omer Ersen, Ugur Yuzuguldu, Ali Murat Basak, Rifat Guveli, Tolga Ege
Summary: The aim of this study is to evaluate the factors affecting health-related quality of life in untreated adolescent idiopathic scoliosis patients in adulthood. Negative correlations were found between BMI, thoracic gibbosity, lumbar/thoracolumbar gibbosity, thoracic Cobb angle, clavicle angle, coronal pelvic tilt, and apical vertebral translation with SRS-22 domains.
EUROPEAN SPINE JOURNAL
(2023)
Article
Medicine, General & Internal
Marlene Dufvenberg, Elias Diarbakerli, Anastasios Charalampidis, Birgitta Oberg, Hans Tropp, Anna Aspberg Ahl, Hans Moller, Paul Gerdhem, Allan Abbott
Summary: Adolescents with idiopathic scoliosis showed high adherence and motivation to treatment, especially in the night shift Boston brace group. Patients in the scoliosis-specific exercise and physical activity alone groups increased their physical activity levels without significant differences in other clinical measures or patient-reported outcomes compared to the night shift Boston brace group. The prescribed treatments seem to be feasible first-step options during the first 6 months.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Tsutomu Akazawa, Toshiaki Kotani, Tsuyoshi Sakuma, Yasushi Iijima, Yoshiaki Torii, Jun Ueno, Tasuku Umehara, Masahiro Iinuma, Atsuhiro Yoshida, Ken Tomochika, Sumihisa Orita, Yawara Eguchi, Kazuhide Inage, Yasuhiro Shiga, Junichi Nakamura, Yusuke Matsuura, Takane Suzuki, Hisateru Niki, Seiji Ohtori, Shohei Minami
Summary: This retrospective study aimed to clarify the health-related quality of life (QOL) of patients with adolescent idiopathic scoliosis (AIS) at a minimum of 40 years after surgery. The study found that the QOL of these patients remained good over the last 13 years, indicating relatively good QOL for middle-aged and older patients.
Article
Clinical Neurology
Jessica Hughes, Burt Yaszay, Tracey P. Bastrom, Carrie E. Bartley, Stefan Parent, Patrick J. Cahill, Baron Lonner, Suken A. Shah, Amer Samdani, Peter O. Newton
Summary: A study on patients undergoing surgery for AIS found that most patients with low HRQOL scores at 2 years postoperatively showed improvements in all domains at the 5-year follow-up. This indicates that a low HRQOL score 2 years after surgery does not guarantee a low score 5 years later.
Article
Clinical Neurology
Francesca Cantele, Irene Maghini, Michele Tonellato, Paolo Meneguzzo, Angela Favaro, Stefano Masiero
Summary: The study found that adolescent girls with idiopathic scoliosis have lower self-image scores and higher eating disorder scores compared to healthy females, especially when they engage in physiotherapy exercises. Girls practicing sports seem to have preserved self-image aspects.
Article
Clinical Neurology
Lauren E. V. Stone, Vidyadhar V. M. Upasani, Joshua M. D. Pahys, Nicholas D. G. Fletcher, Stephen G. A. George, Suken A. P. Shah, Tracey P. E. Bastrom, Carrie E. G. Bartley, Lawrence G. O. Lenke, Peter O. P. Newton, Michael P. Kelly
Summary: This study aimed to examine SRS-Self Image scores up to 10 years after surgery for AIS. The results showed that 75% of patients reported similar or better SRS-Self Image scores at 10 years after surgery, while nearly 25% reported worsening self-image.
Review
Health Care Sciences & Services
Huan Wang, Daniel Tetteroo, J. J. Chris Arts, Panos Markopoulos, Keita Ito
Summary: The most affected life domain in scoliosis patients undergoing brace treatment is self-image/body configuration, followed by mental health/stress and vitality. The study suggests that more attention should be paid to supporting the mental health of these patients to improve their quality of life.
QUALITY OF LIFE RESEARCH
(2021)
Article
Pediatrics
Alexandru Herdea, Mihai-Codrut Dragomirescu, Alexandru Ulici, Claudiu N. Lungu, Adham Charkaoui
Summary: Idiopathic scoliosis has a severe impact on children, but supplementation with vitamin D, calcium, and melatonin may have a positive effect on the progression of the disease.
Review
Genetics & Heredity
Duan Sun, Zihao Ding, Yong Hai, Yunzhong Cheng
Summary: Scoliosis, a three-dimensional deformity of the spine, is closely related to genetic, hormonal, and environmental factors. Epigenetic alterations in scoliosis have been studied but a comprehensive review is lacking. We analyzed 25 studies on DNA methylation, non-coding RNAs, histone modifications, and chromatin remodeling in scoliosis. DNA methylation and non-coding RNAs are well-researched, providing insights into prevention and treatment strategies. However, there is limited research on histone modifications and chromatin remodeling in scoliosis. Further exploration is needed to understand the overall effects of epigenetics in scoliosis.
FRONTIERS IN GENETICS
(2023)
Article
Rehabilitation
Mehmet Hanifi Kaya, Fatih Erbahceci, Halil Alkan, Hikmet Kocaman, Buket Buyukturan, Mehmet Canli, Oznur Buyukturan
Summary: This study aimed to identify independent predictors of quality of life in AIS patients, finding that the Children's Depression Scale, Walter Reed Visual Assessment Scale, Cobb, and anterior trunk rotation explained 52.7% of the variance as independent determinants of SRS-22.
MUSCULOSKELETAL SCIENCE AND PRACTICE
(2022)
Article
Clinical Neurology
Yangmin Lin, Jason Pui Yin Cheung, Chi Kwan Chan, Sidney Wing Fai Wong, Kenneth Man Chee Cheung, Martin Wong, Wun Ching Wong, Prudence Wing Hang Cheung, Man Sang Wong
Summary: The clinical effectiveness and quality of life (QoL) of 3D-printed orthosis (3O) and conventional orthosis (CO) for adolescent idiopathic scoliosis (AIS) were compared in this study. The results showed that both 3O and CO groups had comparable immediate in-orthosis correction. The QoL assessments did not show significant differences between the groups. The 3O group showed similar compliance and QoL compared to the CO group after 2 years of follow-up.
Article
Clinical Neurology
Meghan Cerpa, Scott L. Zuckerman, Lawrence G. Lenke, Michael P. Kelly, Burt Yaszay, Peter Newton, Paul Sponseller, Mark Erickson, Sumeet Garg, Joshua Pahys, Amer Samdani, Patrick Cahill, Richard McCarthy, David Bumpass, Daniel Sucato, Oheneba Boachie-Adjei, Suken Shah, Munish Gupta
Summary: This study aimed to compare myelopathic and non-myelopathic ambulatory patients in terms of neurologic function, operative treatment, and patient-reported outcomes. The results showed that myelopathic patients experienced significant improvement in neurologic function postoperatively, with no difference between the two groups at 1-year and 2-year postoperative. Non-myelopathic patients had higher scores in some SRS domains, but both groups showed significant improvement in all domains.
GLOBAL SPINE JOURNAL
(2023)
Article
Orthopedics
Johanna Syvanen, Willy Serlo, Jenni Jalkanen, Ia Kohonen, Arimatias Raitio, Yrjana Nietosvaara, Ilkka Helenius
Summary: This study compared the recurrence rate of benign bone cysts in children treated with allograft or bioactive glass. The results showed that both treatment options provided similar outcomes in terms of recurrence and complications.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Food Science & Technology
Carlo M. Bertoncelli, Michal Latalski, Domenico Bertoncelli, Sikha Bagui, Subhash C. Bagui, Dechelle Gautier, Federico Solla
Summary: This study developed a prediction model to identify the prognostic phenotype of children with cerebral palsy who require neurotoxin injections. Results showed that upper limbs and trunk muscle tone disorders, spasticity, dystonia, and hip dysplasia were strongly associated with neurotoxin treatments.
Review
Medicine, General & Internal
Tomasz Szponder, Michal Latalski, Anna Danielewicz, Katarzyna Krac, Aleksandra Kozera, Beata Drzewiecka, Dominika Nguyen Ngoc, Dominika Dobko, Joanna Wessely-Szponder
Summary: Osteoarthritis (OA) is a chronic, progressive disease characterized by the loss of articular cartilage in middle-aged and older patients. The immune system plays a pivotal role in the pathogenesis of OA, with both humoral and cellular mediators contributing to cartilage destruction and joint inflammation. Animal models are widely used to study the disease and potential therapies. This review provides an overview of OA signs, pathogenesis, and classification, as well as discussing the advantages and disadvantages of different animal models. Treatment options include mesenchymal stem cells, gene therapies, and blood-derived products, along with tissue engineering techniques and biomaterials.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Pawel Grabala, Kinga Danowska-Idziok, Ilkka J. Helenius
Summary: A case of Horner's syndrome occurred in a five-year-old child after spinal correction surgery for congenital kyphoscoliosis. The syndrome was caused by disruption of the sympathetic nerve pathway. The symptoms resolved and the patient fully recovered four years post-surgery.
Article
Pediatrics
Pawel Grabala, Ilkka J. Helenius, Jacob M. Buchowski, Suken A. Shah
Summary: This study aimed to evaluate the treatment outcomes of severe idiopathic scoliosis (IS) and hypothesized that surgical treatment would have a superior impact on the health-related quality of life (HRQoL), pulmonary function (PF), back pain, and sexual function. The results showed that surgical treatment could safely correct the deformity, significantly improve respiratory function, and have significant improvements in quality of life outcome scores, back pain, and sexual function.
Article
Clinical Neurology
Matti Ahonen, Johanna Syvanen, Linda Helenius, Mikko Mattila, Tanja Perokorpi, Elias Diarbakerli, Paul Gerdhem, Ilkka Helenius
Summary: This study aimed to evaluate pain and health-related quality of life (HRQoL) in surgically managed patients with a minimum follow-up of 10 years compared with patients with untreated adolescent idiopathic scoliosis (AIS) and a healthy control group. The results showed that patients undergoing surgery had better HRQoL than untreated patients with AIS, but still lower than healthy controls.
Article
Clinical Neurology
Aron Frantzen, Eetu N. Suominen, Antti J. Saarinen, Ville Ponkilainen, Johanna Syvaenen, Linda Helenius, Matti Ahonen, Ilkka Helenius
Summary: This study aimed to assess the association between Lenke classification and health-related quality of life (HRQoL) in patients who underwent spinal fusion for adolescent idiopathic scoliosis (AIS). The results showed that different types in the Lenke classification were associated with long-term HRQoL after surgery. Specifically, the curve type of major thoracic and major thoracolumbar scoliosis in the Lenke classification was related to HRQoL after surgery.
Review
Orthopedics
O. Pakarinen, V. Ponkilainen, M. Uimonen, M. Haapanen, I. Helenius, I. Kuitunen
Summary: This study aimed to analyze whether adding risk-based criteria to clinical examination-based selective ultrasound screening would increase the rates of early detected cases of developmental dysplasia of the hip (DDH) and decrease the rate of late detected cases. A systematic review with meta-analysis was conducted and it was found that using risk factors in conjunction with clinical examination in the selective ultrasound screening of DDH might lead to fewer operatively treated cases. However, more studies are needed for stronger conclusions.
BONE & JOINT JOURNAL
(2023)
Article
Medicine, General & Internal
Pawel Grabala, Ilkka J. Helenius, Piotr Kowalski, Michal Grabala, Slawomir Zacha, Jaroslaw M. Deszczynski, Tomasz Albrewczynski, Michael A. Galgano, Jacob M. Buchowski, Kelly Chamberlin, Suken A. Shah
Summary: This study evaluated the safety and accuracy of pedicle screw placement in children with spinal deformities using postoperative CT scans. The results showed that 98% of screws were accurately placed and no complications associated with screw insertion were observed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Venla Soini, Johanna Syvanen, Ilkka Helenius, Linda Helenius, Arimatias Raitio
Summary: Progressive scoliosis can lead to extensive spinal fusion surgery with a risk of significant bleeding. This study investigated the risk factors for blood loss related to pedicle screw instrumentation in adolescent idiopathic scoliosis (AIS) and neuromuscular scoliosis (NMS) patients. The analysis found that levels fused, operative time, and erythrocyte size were correlated with perioperative blood loss in both AIS and NMS groups. Additionally, male sex and osteotomy number were associated with more drain output in AIS patients, while fused levels were correlated with drain output in NMS patients.
Article
Pediatrics
Pawel Grabala, Ilkka J. Helenius, Kelly Chamberlin, Michael Galgano
Summary: Early-onset scoliosis (EOS) is a spinal deformity diagnosed before the age of ten, and surgical treatment should be considered when the curvature exceeds a certain degree. Magnetically controlled growing rods (MCGRs) offer a safe and effective option for treating EOS, allowing for non-invasive correction of spinal deformity and controlling spine growth and curvature while minimizing hospitalizations and anesthesia.
Article
Medicine, General & Internal
Pawel Grabala, Ilkka J. Helenius, Michal Grabala, Suken A. Shah
Summary: This study evaluates the effect and safety of using pedicle screws to increase the diameter of the vertebral pedicles in children with spinal deformities. The results show that the larger the diameter of the screw, the greater the expansion of the pedicle, and there is a low risk of lateral or medial breaches without increased complications. Preoperative MRI measurements of the pedicles can help with preoperative planning.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Pawel Grabala, Kelly Chamberlin, Michal Grabala, Michael A. Galgano, Ilkka J. Helenius
Summary: This study compared the differences between the use of preoperative Halo Gravity Traction and the use of a Magnetically Controlled Growing Rod as a temporary internal distraction device. The results showed that using preoperative Halo Gravity Traction may be safer and achieve similar treatment outcomes as using a Magnetically Controlled Growing Rod in the management of neglected scoliosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)
