Article
Medicine, Research & Experimental
Bruna Lima Correa, Nadia El Harane, Manon Desgres, Maria Perotto, Paul Alayrac, Chloe Guillas, Laetitia Pidial, Valerie Bellamy, Emilie Baron, Gwennhael Autret, Keirththana Kamaleswaran, Chloe Pezzana, Marie-Cecile Perier, Jose Vilar, Antonio Alberdi, Alain Brisson, Nisa Renault, Massimiliano Gnecchi, Jean-Sebastien Silvestre, Philippe Menasche
Summary: The study suggests that extracellular vesicles do not trigger cardiomyocyte proliferation but still improve cardiac function through other mechanisms, potentially including the regulation of fibrosis.
Article
Multidisciplinary Sciences
Ting-Chun Huang, Li-Wei Lo, Yu-Hui Chou, Wei-Lun Lin, Shih-Lin Chang, Yenn-Jiang Lin, Shin-Huei Liu, Wen-Han Cheng, Ping-Yen Liu, Shih-Ann Chen
Summary: Renal denervation (RDN) has been found to suppress the renin-angiotensin-aldosterone system and reduce inflammatory cytokines, leading to the prevention of cardiac remodeling. However, limited studies have investigated the effect of RDN on ventricular electrophysiology. This study used optical mapping to evaluate the impact of RDN on ventricular structural and electrical remodeling in a tachycardia-induced cardiomyopathy rabbit model. The results showed that RDN reversed the reduction of conduction velocity and prolongation of action potential duration, which are significant hallmarks of heart failure.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Yiyu Zhang, Guoqing Huang, Zhaohu Yuan, Yonggang Zhang, Rong Chang
Summary: DCM is a progressive heart disease that can lead to heart failure, and research on circRNAs and hiPSC technology plays important roles in DCM study. Gene mutations can cause complex cardiac disorders, and genome editing methods can help rescue these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Anne-Charlotte Bon-Mathier, Tamara Deglise, Stephanie Rignault-Clerc, Christelle Bielmann, Lucia Mazzolai, Nathalie Rosenblatt-Velin
Summary: Supplementing BNP after infarction can improve heart function and reduce heart remodeling. BNP treatment can modulate the fate of cardiomyocytes and promote their survival and proliferation.
Article
Physiology
Arlene Koerner, Matias Mosqueira, Markus Hecker, Nina D. Ullrich
Summary: The stiffness of the cell environment plays a crucial role in influencing the structural and functional properties of iPSC-CMs, with substrates in the physiological range promoting maturation and improving intercellular coupling in these cells.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Wahiba Dhahri, Tamilla Sadikov Valdman, Dan Wilkinson, Elizabeth Pereira, Eylul Ceylan, Naaz Andharia, Beiping Qiang, Hassan Masoudpour, Fanny Wulkan, Elya Quesnel, Wenlei Jiang, Shunsuke Funakoshi, Amine Mazine, M. Juliana Gomez-Garcia, Neda Latifi, Yidi Jiang, Ella Huszti, Craig A. Simmons, Gordon Keller, Michael A. Laflamme
Summary: The study showed that culturing hPSC-CMs on PDMS-lined roller bottles and transplanting these cells into a guinea pig model of myocardial infarction resulted in better structural and functional outcomes compared to conventional immature hPSC-CM populations. The PDMS-matured hPSC-CMs exhibited increased cardiac gene expression and more mature properties in vitro, and the intracardiac grafts formed with these cells showed enhanced structure and alignment, better electromechanical integration, and improved contractile function. This study provides practical methods for the scaled generation of mature hPSC-CMs and highlights the importance of using more mature cardiomyocytes for cardiac regeneration.
Article
Cardiac & Cardiovascular Systems
Yu-Che Cheng, Marvin L. Hsieh, Chen-Ju Lin, Cindy M. C. Chang, Ching-Ying Huang, Riley Puntney, Amy Wu Moy, Chien-Yu Ting, Darien Zhing Herr Chan, Martin W. Nicholson, Po-Ju Lin, Hung-Chih Chen, Gina C. Kim, Jianhua Zhang, Jennifer Coonen, Puja Basu, Heather A. Simmons, Yen-Wen Liu, Timothy A. Hacker, Timothy J. Kamp, Patrick C. H. Hsieh
Summary: We found that human iPSC-derived endothelial cells (ECs) can promote the maturity and function of hiPSC-CMs. When co-cultured with ECs, CMs showed more mature phenotypes in cellular structure and function.
Article
Health Care Sciences & Services
Diogo Biagi, Evelyn Thais Fantozzi, Julliana Carvalho Campos-Oliveira, Marcus Vinicius Naghetini, Antonio Fernando Ribeiro, Sirlene Rodrigues, Isabella Ogusuku, Rubia Vanderlinde, Michelle Lopes Araujo Christie, Debora Bastos Mello, Antonio Carlos Campos de Carvalho, Marcos Valadares, Estela Cruvinel, Rafael Dariolli
Summary: Early-stage hiPSC-derived cardiomyocytes have shown the potential to improve cardiac function in rats after myocardial infarction, suggesting a promising alternative therapy for treating heart disease.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biology
Jieh-Neng Wang, Chung-Dann Kan, Lain-Tze Lee, Lynn L. H. Huang, Ya-Li Hsiao, Allen H. Chang, Wanchun Liu, Cheng Lin, Chou-Wen Lin
Summary: This study demonstrated that the herbal extract 417W from Codonopsis pilosula can enhance cardiogenic differentiation in ES cells and improve cardiac function in infarcted hearts. The results were evaluated in mouse ES cell-based model and rat myocardial infarction model, showing significant improvements in cardiac function parameters post-treatment with 417W.
Article
Cardiac & Cardiovascular Systems
Na Wu, Chengying Li, Bin Xu, Ying Xiang, Xiaoyue Jia, Zhiquan Yuan, Long Wu, Li Zhong, Yafei Li
Summary: Our study revealed that mmu_circ_0005019 plays a protective role in the development of atrial fibrillation by regulating the miR-499-5p/Kcnn3 pathway.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cell Biology
Thuy Anh Bui, Nicholas Stafford, Delvac Oceandy
Summary: Cardiomyocyte loss cannot be treated with current therapies. Cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is a potential approach. However, engraftment rates are low, indicating a need to improve iPSC-CM technology.
Article
Biochemistry & Molecular Biology
Matthew L. Edin, Artiom Gruzdev, J. Alyce Bradbury, Joan P. Graves, Fred B. Lih, Laura M. DeGraff, Ingrid Fleming, Darryl C. Zeldin
Summary: The specific role of EPHX2 in cardiac cell types was investigated. The study found that EPHX2 expression and activity are highest in cardiomyocytes, and lower in endothelial cells. Specific disruption of EPHX2 in cardiomyocytes led to significantly reduced expression and hydrolase activity, and enhanced postischemic cardiac function.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Correction
Multidisciplinary Sciences
Keito Okazaki, Hayato Anzawa, Zun Liu, Nao Ota, Hiroshi Kitamura, Yoshiaki Onodera, Md. Morshedul Alam, Daisuke Matsumaru, Takuma Suzuki, Fumiki Katsuoka, Shu Tadaka, Ikuko Motoike, Mika Watanabe, Kazuki Hayasaka, Akira Sakurada, Yoshinori Okada, Masayuki Yamamoto, Takashi Suzuki, Kengo Kinoshita, Hiroki Sekine, Hozumi Motohashi
Summary: A correction to this paper has been published and can be accessed through the provided link.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Beata Bodi, Arpad Kovacs, Hajnalka Gulyas, Lilla Martha, Attila Toth, Csaba Matyas, Balint Andras Barta, Attila Olah, Bela Merkely, Tamas Radovits, Zoltan Papp
Summary: The preventive vardenafil treatment can promote remodeling of the left and right ventricles in the ZDF model, reduce 3-nitrotyrosine levels, increase cyclic guanosine monophosphate levels, and improve passive tension of cardiomyocytes.
Article
Cardiac & Cardiovascular Systems
Klaus Neef, Florian Drey, Vera Lepperhof, Thorsten Wahlers, Jurgen Hescheler, Yeong-Hoon Choi, Tomo Saric
Summary: Co-transplantation of iPS-CM and MSC improves cardiac regeneration after myocardial damage, demonstrating the potential of combining multiple cell types for increasing the efficacy of future cardiac cell therapies. MSCs enhance the retention of iPS-CM and result in a significantly higher left ventricular ejection fraction (LVEF) when transplanted together.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
