Article
Energy & Fuels
Xiaoyuan Jiang, Shengqiang Yang, Buzhuang Zhou, Lin Lan
Summary: This study investigated the oxidation characteristics of coal at different stages of low-temperature oxidation. It analyzed the changes in radical concentration and g factor, studied the variations in coal temperature, and analyzed the characteristics of gas products and oxygen consumption. The results showed that coal exhibited auto-oxidation characteristics at a constant temperature of 130℃, and the auto-oxidation phenomenon significantly intensified at 180℃, accompanied by the release of CO and CO2.
Article
Microbiology
Gangzheng Wang, Xianglian Chen, Chenghua Zhang, Min Li, Chengyuan Sun, Ning Zhan, Xueshuang Huang, Taihui Li, Wangqiu Deng
Summary: This study investigated the melatonin biosynthesis pathway in the highly valued edible fungus Tolypocladium guangdongense for the first time, revealing that Congo red, cold, and heat stresses can significantly increase melatonin content while causing a notable decrease in most intermediates. Additionally, exogenous melatonin promotes resistance to various abiotic stressors and the formation of primordia.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Environmental Sciences
V. F. Vazquez, A. M. Garcia-Hoz, F. Teran, A. Gil-Abarca, S. E. Paje
Summary: Cold-In place-Recycled (CIR) pavements are an environmentally friendly option for road rehabilitation on aged pavements, with new additives and enhancements allowing them to be used in different ways. Research on the functional characteristics of CIR pavements is important for evaluating their performance and expanding their application as a noise mitigation measure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Materials Science, Multidisciplinary
Shuaipeng Wang, Haibo Li, Gan Li, Tao Tang, Yuejiao Gu, Yin Hu, Xianglin Chen, Yun Wang, Junbo Lv, Wenhua Luo
Summary: The oxidative kinetics of uranium at different stages, including the parabolic stage, transition stage, linear stage, and decline stage, was researched using reflectance spectroscopy and the oxygen-consumption method. Oxidative kinetics models were established, and the underlying mechanism behind the kinetics laws was analyzed. Importantly, the kinetics of the rarely reported transition stage, which connects the initial parabolic stage and the linear stage, was quantitatively obtained. The kinetics models covering different stages of oxidation can support the prediction of uranium corrosion degree in long-period storage.
Article
Multidisciplinary Sciences
Mirelle Marcio Santos Cabral, Yeda Medeiros Bastos De Almeida, Samara Alvachian Cardoso Andrade, Celso Silva Caldas, Jonnathan Duarte de Freitas, Clara Andrezza Crisostomo Bezerra Costa, Joao Inacio Soletti
Summary: This study investigated the relationship between color formation and phenolic compounds during the sugar manufacturing process. The presence of phenolic compounds significantly affects the color formation of sugarcane processing products, with chlorogenic acid being the most significant compound.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Alice Reis, Andre Scarlate Rovai, Paulo da Cunha Lana, Francisco Barros
Summary: Mangroves and saltmarshes are important coastal habitats that provide various services to humans. There are both positive and negative interactions between these ecosystems, with different effects observed during different stages of their life cycles.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Food Science & Technology
Linjie Xi, Jing Zhang, Ruixiao Wu, Tian Wang, Wu Ding
Summary: Zhenba bacon, a type of Chinese traditional bacon, undergoes changes in aroma components during different stages of its production process, with an increase in esters and phenols observed. Lipid oxidation was found to play a crucial role in the formation of volatile flavor components of bacon.
Article
Food Science & Technology
Mengyue Hu, Shanyu Wang, Qi Liu, Rong Cao, Yong Xue
Summary: This study analyzed the flavor profiles of shrimp at different processing stages using various techniques, revealing the similarity in aroma profiles between boiled and dried shrimp, while raw shrimp differed. Boiling significantly increased the total content of volatile compounds in shrimp. Unique compounds were produced during the drying process, with pyrazines notably increasing in the later drying period.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Huimin Zhou, Bing Zhao, Shunliang Zhang, Qianrong Wu, Ning Zhu, Su Li, Xiaoqian Pan, Shouwei Wang, Xiaoling Qiao
Summary: The effects of process and storage on the volatiles and odorant profile of Chinese dry sausage were evaluated, showing that microbial esterification, wine, and lipid oxidation played key roles in flavor development. Different volatile compounds showed either significant increase during processing or gradual decrease during storage, with some specific compounds serving as discriminators of process stage or marker compounds of storage time. An objective method was established to evaluate the stages of process and storage for the samples.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Chemistry, Applied
Maoyuan Wang, Mei Zhang, Qing Yang, Qinglong Wang, Bokai Ma, Zhiying Li, Wen Cheng, Huan Tang, Shixiu Feng, Zhunian Wang
Summary: This study systematically evaluated the metabolomic profiling of Millettia speciosa root extracts at different growth stages. Significant differences were found among extracts from different ages, and 110 compounds were identified. Pharmacological studies suggested that 5-year old roots may have better fat-lowering and hepatoprotective effects, which could be beneficial for improving NAFLD.
Article
Multidisciplinary Sciences
Adolfo Flores-Saiffe Farias, Alejandro Chavez-Badiola, Gerardo Mendizabal-Ruiz, Roberto Valencia-Murillo, Andrew Drakeley, Jacques Cohen, Elizabeth Cardenas-Esparza
Summary: We propose the first automatic method for segmenting all morphological structures during the different developmental stages of the blastocyst. Our method is able to automatically segment blastocysts from different laboratory settings and developmental phases, increasing the knowledge base for embryo selection.
SCIENTIFIC REPORTS
(2023)
Article
Health Care Sciences & Services
Zhuo Yu, Yan Jiao, Yinhuan Zhao, Weikuan Gu
Summary: Estrogen levels have an impact on women's lifespan, but the management methods vary depending on different life stages. Life quality is related to an individual's health, comfort, and life experiences.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Engineering, Civil
Richard D. Crago, Russell Qualls, Jozsef Szilagyi
Summary: This study aims to compare multiple versions of the Complementary Relationship (CR) between actual regional evaporation and apparent potential evaporation, and investigate their response to changes in spatial and temporal scaling. By using data from seven eddy-covariance flux stations in Australia and global ERA5 reanalysis data, the performance and parameter values of these versions were assessed.
JOURNAL OF HYDROLOGY
(2022)
Article
Biology
Gehad M. Mohamed, Ahmed M. Amer, Neama H. Osman, Mohammed Z. Sedikc, Mona H. Hussein
Summary: Plant tissue culture technology provides a solution for meeting the commercial demand on economically important plants like rice, but the choice of gelling agents can significantly impact rice regeneration efficiency. The study showed that different gelling agents have varying effects on rice regeneration, with Gellan gum (Gelrite and Phytagel) performing superiorly in callus induction.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Jaime Benavides, Sebastian T. Rowland, Jenni A. Shearston, Yanelli Nunez, Darby W. Jack, Marianthi-Anna Kioumourtzoglou
Summary: Evaluating the environmental health impacts of urban policies involves using different research questions and methods at different stages, along with facing challenges and opportunities. Most studies focus on single stages, lacking research using a multistage approach, and primarily investigate intended impacts of policies while neglecting unintended impacts.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2022)
Article
Oncology
Elisabetta Grillo, Michela Corsini, Cosetta Ravelli, Margherita di Somma, Luca Zammataro, Eugenio Monti, Marco Presta, Stefania Mitola
Summary: Mutations in certain tyrosine kinase receptors, such as VEGFR2, can increase enzymatic activity and tumorigenic potential of cancer cells, as well as enhance the sensitivity to specific targeted inhibitors. These findings suggest that screening for such mutations may help predict patient prognosis and drug response in cancer therapy.
Article
Oncology
Michela Corsini, Cosetta Ravelli, Elisabetta Grillo, Patrizia Dell'Era, Marco Presta, Stefania Mitola
Summary: The study developed a novel experimental model to investigate vessel formation during tumor growth by grafting murine ESCs onto the chick embryo CAM, demonstrating the occurrence of both vasculogenic and angiogenic events in the tumor mass.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Immunology
Tizibt Ashine Bogale, Gaia Faustini, Francesca Longhena, Stefania Mitola, Marina Pizzi, Arianna Bellucci
Summary: Alpha-synuclein plays a crucial role in neurodegenerative diseases by potentially affecting the functions of endothelial cells and border associated macrophages, thereby influencing the interplay and effects on other cells in the brain perivascular environment. Its contribution to neurodegeneration through inducing homeostatic changes in the blood-brain barrier in different neurological conditions is highlighted as a gap in current knowledge.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Alicia Gonzalez, Carolina Alonso-Gonzalez, Alicia Gonzalez-Gonzalez, Javier Menendez-Menendez, Samuel Cos, Carlos Martinez-Campa
Summary: Melatonin acts as a promising sensitizer molecule for cancer cells, enhancing the efficacy of chemotherapy and radiotherapy by inhibiting angiogenesis. Its antiangiogenic effects help to overcome the pro-angiogenic factors induced by chemotherapy, making tumors more sensitive to treatment. Melatonin also regulates factors involved in angiogenesis and acts as a radiosensitizer, increasing the effects of radiation on tumor cells.
Article
Biochemistry & Molecular Biology
Elisabetta Grillo, Cosetta Ravelli, Michela Corsini, Carolina Gaudenzi, Luca Zammataro, Stefania Mitola
Summary: Fibroblast growth factor receptors (FGFRs) are frequently altered by single nucleotide variants (SNVs) in many human cancers, with mutations occurring at different frequencies depending on the cancer type. Mutations in the kinase domain of FGFRs, especially those occurring in tumors such as urothelial carcinoma, are potential targets for cancer therapy. The study used bioinformatics analysis to identify novel mutations in the kinase domain of FGFRs, highlighting the importance of understanding the functional impact of alterations clustering on similar residues in analogous proteins.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Stefania Mitola, Cosetta Ravelli, Michela Corsini, Alessandra Gianoncelli, Federico Galvagni, Kurt Ballmer-Hofer, Marco Presta, Elisabetta Grillo
Summary: In this study, we propose a multi-step approach for the expression and purification of histidine-tagged recombinant dimeric Gremlin-1 protein, which can act as a BMP antagonist and a VEGFR2 agonist, using HEK293T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Vliora, Elisabetta Grillo, Michela Corsini, Cosetta Ravelli, Eleni Nintou, Eleni Karligiotou, Andreas D. Flouris, Stefania Mitola
Summary: Irisin affects mitochondrial respiration and lipolysis in a time-dependent manner through the regulation of PI3K-AKT pathway. Irisin also induces the expression of UCP1 and the regulation of NF-kappa B, and CREB and ERK pathways.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Laura Marchetti, David Porciani, Stefania Mitola, Chiara Giacomelli
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Carolina Alonso-Gonzalez, Cristina Gonzalez-Abalde, Javier Menendez-Menendez, Alicia Gonzalez-Gonzalez, Virginia Alvarez-Garcia, Alicia Gonzalez-Cabeza, Carlos Martinez-Campa, Samuel Cos
Summary: Radiation therapy is a crucial part of cancer treatment, but it has adverse effects. Melatonin, as an adjuvant molecule, can limit damage to normal tissues and enhance the efficacy of radiation therapy in breast cancer. This study revealed that melatonin can potentiate the anti-proliferative effect of radiation, modulate gene and microRNA expression, and enhance the inhibition of cancer growth. Melatonin shows promise as both a radiosensitizer and radioprotector in breast cancer treatment.
Review
Biochemistry & Molecular Biology
Maria Vliora, Cosetta Ravelli, Elisabetta Grillo, Michela Corsini, Andreas D. Flouris, Stefania Mitola
Summary: Adipose tissue is an active endocrine organ, which secretes adipokines that have various functions in the body. The plasticity of adipose tissue is associated with angiogenesis, which supports tissue expansion. Abnormal production or loss of certain adipokines can lead to metabolic dysfunction related to obesity. Understanding the role of adipokines in angiogenesis may offer new therapeutic approaches for treating obesity and metabolic diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Maria Vliora, Eleni Nintou, Eleni Karligiotou, Leonidas G. Ioannou, Elisabetta Grillo, Stefania Mitola, Andreas D. Flouris
Summary: Irisin plays a role in cancer, with decreased expression in cancer patients making it a useful biomarker for diagnosis. It may have a significant role in tumor progression and metastasis by promoting cell proliferation and migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Silvia Codenotti, Daniela Zizioli, Luca Mignani, Sara Rezzola, Giovanna Tabellini, Silvia Parolini, Arianna Giacomini, Michela Asperti, Maura Poli, Delia Mandracchia, Marika Vezzoli, Simona Bernardi, Domenico Russo, Stefania Mitola, Eugenio Monti, Luca Triggiani, Davide Tomasini, Stefano Gastaldello, Matteo Cassandri, Rossella Rota, Francesco Marampon, Alessandro Fanzani
Summary: In pediatric rhabdomyosarcoma, elevated Akt signaling promotes tumor malignancy by hyperactivating the mTOR/p70S6K pathway and enhancing cell invasion and migration. Inhibiting PI3K and Akt signaling can reverse the aggressive phenotype of tumor cells, while mTOR inhibition fails to block cell dissemination. Additionally, pronounced Akt1 signaling increases the susceptibility of tumor cells to certain treatments, such as 2-DG and lovastatin.
Article
Biochemistry & Molecular Biology
Luca Mignani, Nicola Facchinello, Marco Varinelli, Elena Massardi, Natascia Tiso, Cosetta Ravelli, Stefania Mitola, Peter Schu, Eugenio Monti, Giuseppe Borsani, Dario Finazzi, Daniela Zizioli
Summary: In vertebrates, two homologous heterotetrameric AP1 complexes play vital roles in regulating intracellular protein sorting in a vesicle-dependent manner. These complexes, composed of four subunits (gamma, beta 1, mu 1, and sigma 1), are ubiquitously expressed and essential for development. The knockout of specific subunits in animal models demonstrated their importance in multicellular organism development, neuronal and epithelial cell specification. Mutations in genes encoding for these subunits have been associated with various human diseases, including adaptinopathies, which affect intracellular vesicular traffic. A zebrafish model with an ap1g1 knockout was used to study the molecular mechanisms underlying adaptinopathies, revealing dysregulated cell adhesion and providing potential targets for therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)