Article
Immunology
Barbara P. Gonzalez-Garcia, Sergi Mari, Ariadna Cilleros-Portet, Alba Hernangomez-Laderas, Nora Fernandez-Jimenez, Iraia Garcia-Santisteban, Jose Ramon Bilbao
Summary: The study suggests a bidirectional relationship between gut microbiota and celiac disease in individuals with HLA-DQ2 high risk haplotype.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Ting Li, Yan Feng, Chun Wang, Tian Shi, Adilai Abudurexiti, Mengxia Zhang, Feng Gao
Summary: The causal effect of gut microbiota and metabolites on celiac disease (CD) was investigated using Mendelian randomization (MR). The study revealed potential associations between specific bacterial taxa and metabolites with CD risk, suggesting novel therapeutic targets for CD treatment.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Fan Xue, Zheng He, De-Zheng Zhuang, Feng Lin
Summary: This study provides evidence for the causal effects of specific gut microbial taxa on circulating inflammatory cytokines and sheds light on their potential roles in the development and progression of various host diseases.
Article
Clinical Neurology
Li Jiang, Jin-chen Li, Bei-sha Tang, Ji-feng Guo
Summary: This study used a genetic approach to investigate the relationship between Parkinson's disease and the gut microbiome. The results showed that alterations in the microbiome were associated with increased risk and earlier onset of Parkinson's disease, specifically with the levels of certain short-chain fatty acid-producing bacteria. These findings suggest a bidirectional relationship between gut dysbiosis and Parkinson's disease.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Yu Cao, Hao Lu, Wangzi Xu, Ming Zhong
Summary: The study reveals a causal relationship between gut microbiota composition and Sjogren's Syndrome risk, with some microbial species positively correlated and others negatively correlated. Additionally, four genes related to gut microbiota were found to have a causal effect on Sjogren's Syndrome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Min Chen, Chao-Rong Xie, Yun-Zhou Shi, Tai-Chun Tang, Hui Zheng
Summary: This study using Mendelian randomization found that Actinobacteria, Bifidobacterium, and Ruminococcus have protective effects on major depressive disorders, while Streptococcaceae may have an anti-protective effect. Further research is needed to validate these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Nutrition & Dietetics
Ning Li, Yi Wang, Ping Wei, Yu Min, Manshu Yu, Guowei Zhou, Gui Yuan, Jinyi Sun, Huibo Dai, Enchao Zhou, Weiming He, Meixiao Sheng, Kun Gao, Min Zheng, Wei Sun, Dong Zhou, Lu Zhang
Summary: By using genetic prediction methods, we found a causal relationship between gut microbiota and the incidence and progression of chronic kidney disease (CKD), which may provide helpful biomarkers for early disease diagnosis and potential therapeutic targets for CKD.
Article
Microbiology
Binxu Qiu, Zixiong Shen, Dongliang Yang, Xinxin Qin, Wenyong Ren, Quan Wang
Summary: This study used Mendelian randomization analysis to assess the causal relationships between gut microbiota and eight common gastrointestinal diseases. The results showed potential causal relationships between 62 gut microbiota and gastrointestinal disorders.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Qian Xu, Jing-Jing Ni, Bai-Xue Han, Shan-Shan Yan, Xin-Tong Wei, Gui-Juan Feng, Hong Zhang, Lei Zhang, Bin Li, Yu-Fang Pei
Summary: This study revealed a causal relationship between the Bifidobacterium genus and T1D and CeD, providing novel insights into the gut microbiota-mediated development mechanism of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Feihong Ren, Qiubai Jin, Qi Jin, Yiyun Qian, Xuelei Ren, Tongtong Liu, Yongli Zhan
Summary: This study reveals the causal relationships between gut microbiota (GM) and chronic kidney disease (CKD), as well as GM and chronic systemic inflammation in CKD. It also expands the knowledge on specific causal gut microbiota. These causal gut microbiota may have the potential to serve as new biomarkers for targeted prevention of CKD and chronic systemic inflammation in CKD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Manjun Luo, Mengting Sun, Tingting Wang, Senmao Zhang, Xinli Song, Xiaoying Liu, Jianhui Wei, Qian Chen, Taowei Zhong, Jiabi Qin
Summary: This study used two-sample bidirectional mendelian randomization to evaluate the causal relationship between gut microbiota and T1D. The results showed that the Bacteroidetes phylum, Bacteroidia class, and Bacteroidales order of gut microbiota increase the risk of T1D, while the Eubacterium eligens group genus belonging to the Firmicutes phylum decreases the risk of T1D.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Mingli Luo, Jiahao Cai, Shulu Luo, Xiaosi Hong, Lingxin Xu, Honghong Lin, Xiong Chen, Wen Fu
Summary: Using mendelian randomization, we found that Desulfovibrionales and nine other taxa are associated with chronic kidney disease (CKD), confirming the important role of gut microbiota in the pathogenesis of CKD. Our findings provide new potential indicators and targets for screening and prevention of CKD.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Jingya You, Xiaogang Bi, Kouxing Zhang, Dan Xie, Yiwen Chai, Sha Wen, Ying Xian, Min Fan, Wen Xu, Mingliang Li, Xiaofeng Yuan
Summary: By performing a two-sample Mendelian randomization study, we identified specific intestinal flora that had a causal relationship with the risk and prognosis of sepsis at the gene level, which could provide helpful biomarkers for early disease diagnosis and potential therapeutic targets for sepsis.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Zhaofa Yin, Bohan Liu, Shijian Feng, Yushi He, Cai Tang, Pengan Chen, Xinyi Wang, Kunjie Wang
Summary: This study confirms the association between specific gut microbial taxa and urological cancers. It provides insights into the mechanism of how the gut microbiota affects urological cancers and offers potential targets for screening and treatment. The results contribute to clinical research by providing new ideas and perspectives in this area.
Article
Immunology
Yuexuan Chen, Mengjiao Zhao, Kaisong Ji, Jingjing Li, Shuxin Wang, Liming Lu, Zhenhu Chen, Jingchun Zeng
Summary: This study used a bidirectional Mendelian randomization analysis to investigate the causal relationship between nicotine dependence and gut microbiota. The results confirmed a causal link between genetically predicted risk of nicotine dependence and genetically predicted abundance of gut microbiota. Certain bacterial groups were found to be risk factors or protective factors for nicotine dependence.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ane Olazagoitia-Garmendia, Linda Zhang, Paula Mera, Julie K. Godbout, Maialen Sebastian-DelaCruz, Iraia Garcia-Santisteban, Luis Manuel Mendoza, Alain Huerta, Inaki Irastorza, Govind Bhagat, Peter H. Green, Laura Herrero, Dolors Serra, Jose Antonio Rodriguez, Elena F. Verdu, Chuan He, Jose Ramon Bilbao, Ainara Castellanos-Rubio
Summary: This study identifies a novel m(6)A-XPO1-NFkB pathway that is activated in CD patients, prompting the development of new therapeutic approaches directed at m(6)A proteins and XPO1, a target under evaluation for the treatment of intestinal disorders. The functional involvement of a CD-associated SNP located in the 5'UTR of XPO1 is described, shedding light on the role of this SNP in triggering inflammation in coeliac intestinal epithelium.
Article
Gastroenterology & Hepatology
Koldo Garcia-Etxebarria, Florencia Carbone, Maris Teder-Laving, Anita Pandit, Lieselot Holvoet, Vincent Thijs, Robin Lemmens, Luis Bujanda, Andre Franke, Sebastian Zollner, Michael Boehnke, Matthew Zawistowski, Tonu Esko, Tack Jan, Mauro D'Amato
Summary: Functional dyspepsia (FD) has a weak heritable component with genetic correlations to multiple diseases and traits in European ancestry populations, showing significant comorbidities with certain diseases.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Correction
Microbiology
Caroline Ivanne Le Roy, Alexander Kurilshikov, Emily R. Leeming, Alessia Visconti, Ruth C. E. Bowyer, Cristina Menni, Mario Fachi, Hana Koutnikova, Patrick Veiga, Alexandra Zhernakova, Muriel Derrien, Tim D. Spector
Article
Multidisciplinary Sciences
R. Gacesa, A. Kurilshikov, A. Vich Vila, T. Sinha, M. A. Y. Klaassen, L. A. Bolte, S. Andreu-Sanchez, L. Chen, V. Collij, S. Hu, J. A. M. Dekens, V. C. Lenters, J. R. Bjork, J. C. Swarte, M. A. Swertz, B. H. Jansen, J. Gelderloos-Arends, S. Jankipersadsing, M. Hofker, R. C. H. Vermeulen, S. Sanna, H. J. M. Harmsen, C. Wijmenga, J. Fu, A. Zhernakova, R. K. Weersma
Summary: This study analyzed the gut microbiome of 8,208 individuals from the Netherlands and found that the microbiome is primarily shaped by the environment and cohabitation. Only about 6.6% of microbial taxa are heritable, while around 48.6% of taxa are significantly influenced by cohabitation. Additionally, the study identified numerous associations between the microbiome and health, diet, socioeconomic factors, and early-life and current exposome.
Article
Multidisciplinary Sciences
Koldo Garcia-Etxebarria, Olga Merino, Adrian Gaite-Reguero, Pedro M. Rodrigues, Amaia Herrarte, Ane Etxart, David Ellinghaus, Horacio Alonso-Galan, Andre Franke, Urko M. Marigorta, Luis Bujanda, Mauro D'Amato
Summary: This study analyzed the genetic architecture of inflammatory bowel disease (IBD) in the Basque population and found multiple loci associated with IBD, Crohn's disease (CD), and ulcerative colitis (UC). These loci contain both previously associated genes with IBD and potential new genes involved in its development. The genetic correlation between European populations and the Basque population was high for IBD and CD, but lower for UC. Genetic risk scores based on previous GWAS findings showed good performance in the Basque population.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Agnes Svensson, Koldo Garcia-Etxebarria, Anna Akesson, Christer Borgfeldt, Bodil Roth, Malin Ek, Mauro D'Amato, Bodil Ohlsson
Summary: This study aimed to investigate the association between polygenic risk scores (PRS) for endometriosis and the clinical presentation of the disease. The results revealed inverse associations between PRS and spread of endometriosis, involvement of the gastrointestinal tract, and hormone treatment. However, the significance was lost when calculated as p for trend and the specificity and sensitivity were low.
Article
Gastroenterology & Hepatology
Zlatan Mujagic, Melpomeni Kasapi, Daisy M. A. E. Jonkers, Isabel Garcia-Perez, Lisa Vork, Zsa Zsa R. M. Weerts, Jose Ivan Serrano-Contreras, Alexandra Zhernakova, Alexander Kurilshikov, Jamie Scotcher, Elaine Holmes, Cisca Wijmenga, Daniel Keszthelyi, Jeremy K. Nicholson, Joram M. Posma, Ad A. M. Masclee
Summary: Combining microbiome and metabolome data can distinguish between irritable bowel syndrome (IBS) patients and healthy controls. Unsupervised clustering based on fecal microbiome-metabolome data revealed distinct subsets of IBS patients. The study also found associations between altered serotonin metabolism, unfavorable stress response related to gastrointestinal symptoms, and IBS, supporting the importance of the microbiome-gut-brain axis in the pathogenesis of IBS.
Correction
Genetics & Heredity
Esteban A. Lopera-Maya, Alexander Kurilshikov, Adriaan van der Graaf, Shixian Hu, Sergio Andreu-Sanchez, Lianmin Chen, Arnau Vich Vila, Ranko Gacesa, Trishla Sinha, Valerie Collij, Marjiolein A. Y. Klaassen, Laura A. Bolte, Milla F. Brandao Gois, Pieter B. T. Neerincx, Morris A. Swertz, Hermie J. M. Harmsen, Cisca Wijmenga, Jingyuan Fu, Rinse K. Weersma, Alexandra Zhernakova, Serena Sanna
Article
Biology
Sergio Andreu-Sanchez, Geraldine Aubert, Aida Ripoll-Cladellas, Sandra Henkelman, Daria Zhernakova, Trishla Sinha, Alexander Kurilshikov, Maria Carmen Cenit, Marc Jan Bonder, Lude Franke, Cisca Wijmenga, Jingyuan Fu, Monique G. P. van der Wijst, Marta Mele, Peter Lansdorp, Alexandra Zhernakova
Summary: This study reveals the cell-type-specific differences in telomere biology in humans and its relationship with gene expression, epigenetic signals mediated by parental phenotypes, and expression changes at the single cell level. It confirms the role of perinatal factors in determining telomere lengths, and highlights the influence of genetics, lifestyle, and other factors on this variation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biology
Nora Fernandez-Jimenez, Ruby Fore, Ariadna Cilleros-Portet, Johanna Lepeule, Patrice Perron, Tuomas Kvist, Fu-Ying Tian, Corina Lesseur, Alexandra M. Binder, Manuel Lozano, Jordi Martorell-Marugan, Yuk J. Loke, Kelly M. Bakulski, Yihui Zhu, Anne Forhan, Sara Sammallahti, Todd M. Everson, Jia Chen, Karin B. Michels, Thalia Belmonte, Pedro Carmona-Saez, Jane Halliday, M. Daniele Fallin, Janine M. LaSalle, Jorg Tost, Darina Czamara, Mariana F. Fernandez, Antonio Gomez-Martin, Jeffrey M. Craig, Beatriz Gonzalez-Alzaga, Rebecca J. Schmidt, John F. Dou, Evelyne Muggli, Marina Lacasana, Martine Vrijheid, Carmen J. Marsit, Margaret R. Karagas, Katri Raikkonen, Luigi Bouchard, Barbara Heude, Loreto Santa-Marina, Mariona Bustamante, Marie-France Hivert, Jose Ramon Bilbao
Summary: This study investigates the association between pre-pregnancy maternal body mass index (ppBMI) and placental DNA methylation. The research identifies 27 CpG sites that are associated with ppBMI, which are located in open sea regions and are related to obesity-related genes and cancer and oxidative stress pathways.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Gerard Badia-Bringue, Maria Canive, Nora Fernandez-Jimenez, Jose Luis Lavin, Rosa Casais, Cristina Blanco-Vazquez, Patricia Vazquez, Almudena Fernandez, Jose Ramon Bilbao, Joseba M. Garrido, Ramon A. Juste, Oscar Gonzalez-Recio, Marta Alonso-Hearn
Summary: In this study, using genomic association studies and expression quantitative trait loci (cis-eQTL) analysis, novel genetic variants associated with paratuberculosis susceptibility were identified in Spanish Holstein cows. These findings contribute to a better understanding of the genetic factors influencing paratuberculosis outcomes.
Article
Immunology
Barbara P. Gonzalez-Garcia, Sergi Mari, Ariadna Cilleros-Portet, Alba Hernangomez-Laderas, Nora Fernandez-Jimenez, Iraia Garcia-Santisteban, Jose Ramon Bilbao
Summary: The study suggests a bidirectional relationship between gut microbiota and celiac disease in individuals with HLA-DQ2 high risk haplotype.
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Aintzane Rueda-Martinez, Barbara Paola Gonzalez-Garcia, Aiara Garitazelaia, Ariadna Cilleros-Portet, Sergi Mari, Rebeca Arauzo, Jokin de Miguel, Nora Fernandez-Jimenez, Jose Ramon Bilbao, Iraia Garcia-Santisteban
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Ariadna Cilleros-Portet, Sergi Mari, Barbara Paola Gonzalez-Garcia, Iraia Garcia-Santisteban, Mariona Bustamante, Loreto Santa Marina, Jose Ramon Bilbao, Nora Fernandez-Jimenez
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)