Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Maternal high-fat diet is linked to offspring hypertension, and potential mechanisms have been revealed through animal studies. Reprogramming interventions can prevent high-fat-diet-induced hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Jiaqi Cui, Lin Song, Rui Wang, Shuyuan Hu, Zhao Yang, Zengtie Zhang, Bo Sun, Wei Cui
Summary: This study suggests that maternal metformin during gestation and lactation has the potential to overcome the negative effects of perinatal exposure to a high-fat diet in offspring. This is achieved by altering myogenesis, mitochondrial biogenesis, and dynamics through the AMPK/mTOR pathways in skeletal muscle.
Article
Nutrition & Dietetics
Thibaut Gauvrit, Hamza Benderradji, Alexandre Pelletier, Soulaimane Aboulouard, Emilie Faivre, Kevin Carvalho, Aude Deleau, Emmanuelle Vallez, Agathe Launay, Anna Bogdanova, Melanie Besegher, Stephanie Le Gras, Anne Tailleux, Michel Salzet, Luc Buee, Fabien Delahaye, David Blum, Didier Vieau
Summary: Early-life exposure to high-fat diets (HF) can program metabolic and cognitive alterations in adult offspring. The hippocampus plays a crucial role in memory and metabolic homeostasis, and maternal HF during lactation can have effects on physiological, metabolic, and cognitive parameters in young adult offspring mice. A multi-omics strategy revealed sex-specific transcriptomic and proteomic modifications in the hippocampus, with mitochondria and synapses identified as the main targets of maternal HF.
Article
Endocrinology & Metabolism
Hong Yang, Nan Chen, Lei Fan, Xiaojing Lin, Juncheng Liu, Yuehua You, Ying Zhong, Yan Chen, Jibin Li, Xiaoqiu Xiao
Summary: Maternal high-fat diet during pregnancy and lactation has long-term effects on the pathogenesis of obesity in offspring, and the early postnatal stage is a critical window for metabolic programming.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Kinga Gawlinska, Dawid Gawlinski, Malgorzata Filip, Edmund Przegalinski
Summary: A maternal high-fat diet during pregnancy and lactation can have irreversible effects on the health of offspring, leading to increased risk of depressive and aggressive behaviors, reduced cognitive development, and symptoms of metabolic syndrome. Epigenetic and molecular studies have shown that maternal nutrition during pregnancy and the suckling period can modify the development of neurotransmitter circuits and other factors important to central nervous system development.
Article
Nutrition & Dietetics
Emily J. Mort, Sophie Heritage, Susan Jones, Abigail L. Fowden, Emily J. Camm
Summary: This study aimed to investigate the impact of maternal obesity on the growth, adiposity, and behavior of offspring. The findings demonstrated that maternal obesity alters the growth, adiposity, and behavior of male and female offspring, with sex-specific differences.
Article
Nutrition & Dietetics
Dawid Gawlinski, Kinga Gawlinska, Irena Smaga
Summary: Evidence suggests that exposure to a maternal high-fat diet during pregnancy and lactation can induce changes in offspring's brain structure and function, leading to behavioral alterations such as depressive-like phenotype. This study revealed that the maternal high-fat diet triggered several epigenetic mechanisms in the brains of rat offspring, potentially impacting the next generation.
Article
Cell Biology
Dongdong Wang, Haiting Zhang, Miao Zeng, Xiaocui Tang, Xiangxiang Zhu, Yinrui Guo, Longkai Qi, Yizhen Xie, Mei Zhang, Diling Chen
Summary: A maternal high sugar and high fat diet during pregnancy was found to significantly impact the gut microbiota structure, neuronal types, and inflammation levels in the offspring. Activation of certain genes beneficial against nervous system diseases and increased expression of cholinergic and GABAergic neurons biomarker protein were observed as the offspring grew older.
Review
Nutrition & Dietetics
Hsi-Yun Liu, Chen-Hao Lee, Chien-Ning Hsu, You-Lin Tain
Summary: A balanced diet during gestation is crucial for fetal development, and excessive intake of saturated fats during this period is linked to increased risk of offspring kidney disease. Maternal high-fat diet influences kidney health and disease in offspring through renal programming. This review summarizes preclinical research on the connection between maternal high-fat diet during gestation and lactation and offspring kidney disease, the molecular mechanisms behind renal programming, and early-life interventions to mitigate adverse programming effects. Animal models suggest that perinatal supplementation with polyunsaturated fatty acids, changes in gut microbiota, and modulation of nutrient-sensing signals can improve offspring kidney health. These findings emphasize the importance of a balanced maternal diet for offspring kidney health.
Article
Multidisciplinary Sciences
Renato S. Gaspar, Amanda J. Unsworth, Alaa Al-Dibouni, Alexander P. Bye, Tanya Sage, Michelle Stewart, Sara Wells, Roger D. Cox, Jonathan M. Gibbins, Dyan Sellayah, Craig E. Hughes
Summary: Maternal and offspring high-fat diet leads to platelet hyperactivation in male mouse offspring, suggesting a novel 'double-hit' effect.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Liuqiao Sun, Xuying Tan, Xiaoping Liang, Hangjun Chen, Qian Ou, Qiongmei Wu, Xinxue Yu, Hanqing Zhao, Qiaoli Huang, Zehua Yi, Jun Wei, Feng Wu, Huilian Zhu, Lijun Wang
Summary: Maternal betaine supplementation alleviates NAFLD in offspring through regulating gut microbiota and SCFAs.
Article
Biochemistry & Molecular Biology
Jozef Mizera, Grzegorz Kazek, Ewa Niedzielska-Andres, Lucyna Pomierny-Chamiolo
Summary: Research shows that a maternal high-sugar diet can affect memory processes in offspring by disrupting NMDA receptor composition and regulation, leading to impaired recognition memory in adolescent males and altered spatial memory in females.
Article
Food Science & Technology
Helena Cesar, Marcela Nascimento Sertorio, Aline Santamarina, Esther Alves de Souza, Lais Valles Mennitti, Giovana Jamar, Andrea Juca, Breno Picin Casagrande, Debora Estadela, Luciana Pellegrini Pisani
Summary: Parental high-fat, high-sugar diet can influence the programming of the gut-brain axis, leading to increased visceral adiposity and weight of male offspring at weaning, with lasting effects into adulthood.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Cell Biology
Marcela Nascimento Sertorio, Helena Cesar, Esther Alves de Souza, Lais Vales Mennitti, Aline Boveto Santamarina, Leonardo Mendes De Souza Mesquita, Andrea Juca, Breno Picin Casagrande, Debora Estadella, Odair Aguiar Jr, Luciana Pellegrini Pisani
Summary: Parental nutrition can have a significant impact on the health and reproductive development of future generations. Maternal and paternal intake of high-fat diets can adversely affect male reproductive health, leading to hormonal imbalances, oxidative stress, and changes in sperm quality. In this study, epigenetic markers, inflammatory response, and oxidative balance were evaluated in the testes and epididymis of adult offspring. The results showed that the maternal diet had a significant effect on testicular epigenetic parameters, inflammation, and daily sperm production, while the paternal diet influenced serum testosterone levels. The combined intake of a high-fat high-sugar diet by both parents exacerbated the decrease in daily sperm production. These findings highlight the importance of parental nutrition in programming the reproductive health of male offspring.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Gintare Urbonaite, Agne Knyzeliene, Fanny Sophia Bunn, Adomas Smalskys, Urte Neniskyte
Summary: A maternal high-fat diet can have long-term consequences on offspring neurodevelopment and may lead to neurodevelopmental disorders. This is due to inflammatory activation, gut microbial dysbiosis, and molecular and cellular changes in the offspring's brain.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Liubov S. Kalinichenko, Laila Abdel-Hafiz, An-Li Wang, Christiane Muehle, Nadine Roesel, Fabian Schumacher, Burkhard Kleuser, Irena Smaga, Malgorzata Frankowska, Malgorzata Filip, Gerd Schaller, Tanja Richter-Schmidinger, Bernd Lenz, Erich Gulbins, Johannes Kornhuber, Andre W. C. Oliveira, Marilia Barros, Joseph P. Huston, Christian P. Mueller
Summary: The study found that sphingolipids play a crucial role in appetitively motivated learning and memory, with regionally enhanced neutral sphingomyelinase (NSM) activity being associated with superior performance. An opposite interaction was observed in aversively motivated tasks. NSM was confirmed to have a role in learning through its control of N-methyl-D-aspartate receptor subunit expression.
Review
Pharmacology & Pharmacy
Lucia Caffino, Francesca Mottarlini, Gianmaria Zita, Dawid Gawlinski, Kinga Gawlinska, Karolina Wydra, Edmund Przegalinski, Fabio Fumagalli
Summary: Drug addiction is a devastating disorder that poses a huge economic and social burden on modern society, with adolescents being particularly vulnerable. Research has shown that exposure to cocaine during adolescence confers a vulnerable endophenotype primarily by inducing changes in neuroplasticity.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kinga Gawlinska, Dawid Gawlinski, Malgorzata Filip, Edmund Przegalinski
Summary: Recent studies have shown a relationship between maternal diet composition and the risk of mental illnesses in offspring by affecting serotonin receptors in the brain. Different maternal diets, such as high-fat, high-carbohydrate, and mixed diets, induce specific changes in 5-HT2C and 5-HT2A receptor levels in different brain regions of the offspring. Specifically, high-fat maternal diet reduces 5-HT2C receptor expression in male rats at PND 28 but increases it at PND 63 in certain brain regions.
PHARMACOLOGICAL REPORTS
(2021)
Article
Nutrition & Dietetics
Kinga Gawlinska, Dawid Gawlinski, Malgorzata Borczyk, Michal Korostynski, Edmund Przegalinski, Malgorzata Filip
Summary: This study investigated the impact of maternal high-fat diet on the risk of autism in offspring, revealing significant changes in the expression of ASD-related genes in the frontal cortex of male offspring. Furthermore, exposure to maternal HFD led to sex- and age-dependent alterations in protein levels and differences in DNA methylation levels in the offspring's brain regions.
Article
Pharmacology & Pharmacy
Adrian Podkowa, Dawid Gawlinski, Kinga Gawlinska, Bozena Muszynska, Wlodzimierz Opoka
Summary: This study focused on the impact of different diets consumed by dams on the levels of zinc and magnesium in the teeth of their offspring rats. It was found that zinc levels did not significantly differ among different diet groups, but a high-fat diet led to higher levels of magnesium in the teeth of the offspring rats.
ACTA POLONIAE PHARMACEUTICA
(2022)
Article
Biochemistry & Molecular Biology
Dawid Gawlinski, Kinga Gawlinska, Malgorzata Frankowska, Malgorzata Filip
Summary: Recent studies have shown that Wnt/beta-catenin signaling plays an important role in the pathophysiology of mental illnesses, including cocaine use disorder. Chronic cocaine self-administration affects the expression of Wnt signaling elements in the brain, and early abstinence periods show different patterns of gene expression changes. Additionally, exposure to cocaine reduces the expression of miR-374 and miR-544, which can regulate Wnt5a levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Joanna Jastrzebska, Malgorzata Frankowska, Irena Smaga, Magdalena Hubalewska-Mazgaj, Agata Suder, Renata Pieniazek, Edmund Przegalinski, Malgorzata Filip
Summary: The study revealed the key role of 5-HT2C receptors in treating CUD and comorbid depression and CUD, supporting further research into pharmacological strategies targeting these receptors.
PHARMACOLOGICAL REPORTS
(2023)
Article
Behavioral Sciences
Irena Smaga, Kinga Gawlinska, Dawid Gawlinski, Paulina Surowka, Malgorzata Filip
Summary: Maternal high-fat diet during pregnancy and lactation disrupts short-term memory in adolescent and young adult females, likely due to dysregulation of glutamatergic system in the hippocampus. Changes in glutamatergic transporters and NMDA receptor subunits, AMPA receptor subunits, as well as BDNF levels may contribute to the behavioral changes observed in offspring.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Frankowska, Karolina Wydra, Agata Suder, Magdalena Zaniewska, Dawid Gawlinski, Joanna Miszkiel, Anna Furgala-Wojas, Kinga Salat, Malgorzata Filip, Christa E. Mueller, Katarzyna Kiec-Kononowicz, Magdalena Kotanska
Summary: This study discovered three novel selective ligands for GPR18, including one agonist and two antagonists. The activation of GPR18 has similar effects to the CB receptor system, impacting emotional behavior, food intake, and pain activity. Therefore, GPR18 represents a potential therapeutic target for mood, pain, and/or eating disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Urszula Glowacka, Kinga Gawlinska, Marcin Magierowski, Zbigniew Sliwowski, Dominik Bakalarz, Katarzyna Magierowska, Edyta Korbut, Tomasz Brzozowski