Review
Medicine, General & Internal
Sneha Mishra, Patress A. Persons, Andrea M. Lorenzo, Swarna S. Chaliki, Sophie Bersoux
Summary: New research suggests that time-restricted eating (TRE) has positive effects on weight loss and various diseases, such as nonalcoholic fatty liver disease, cancer, and cardiovascular disease. It is found to be equivalent to calorie restriction for weight loss.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Iwona Swiatkiewicz, Alina Wozniak, Pam R. Taub
Summary: Metabolic syndrome affects about 30% of adults, posing increased risks of cardiovascular diseases and diabetes. Irregular eating patterns in MetS patients can disrupt circadian rhythms, leading to adverse metabolic health. Implementing time-restricted eating (TRE) shows promising outcomes in improving cardiometabolic health in MetS individuals.
Review
Peripheral Vascular Disease
Daisy Duan, Salman Bhat, Jonathan C. Jun, Aniket Sidhaye
Summary: Clinical studies on time-restricted eating (TRE) show mixed results on blood pressure outcomes, with protocols starting and ending earlier having more pronounced effects on lowering blood pressure. Narrower eating windows also tend to result in lower blood pressure.
CURRENT HYPERTENSION REPORTS
(2022)
Article
Nutrition & Dietetics
Iwona Swiatkiewicz, Celestyna Mila-Kierzenkowska, Alina Wozniak, Karolina Szewczyk-Golec, Jaroslaw Nuszkiewicz, Joanna Wroblewska, Pawel Rajewski, Simone J. P. M. Eussen, Kristine Faerch, Emily N. C. Manoogian, Satchidananda Panda, Pam R. Taub
Summary: The study explores the impact of time-restricted eating on metabolic and neuroendocrine homeostasis, inflammation, and oxidative stress, aiming to improve cardiometabolic health by restricting eating periods. It will conduct a pilot clinical trial on European adult patients with metabolic syndrome, monitoring changes in their eating window, body weight and composition, biomarkers, and rhythms of behavior.
Article
Nutrition & Dietetics
Emily W. Flanagan, Maryam Kebbe, Joshua R. Sparks, Leanne M. Redman
Summary: This study investigated the perceptions and barriers to adopting a time-restricted eating (TRE) pattern in pregnant women. The results showed that about 23.7% of pregnant women were willing to try a TRE pattern. The top barriers included concerns for safety, nausea, and hunger. The most supported mechanisms included the ability to choose the eating window, more frequent prenatal visits, and feedback from a dietician/nutritionist. Non-White pregnant women expressed a higher willingness to try a TRE pattern.
JOURNAL OF NUTRITION
(2022)
Review
Endocrinology & Metabolism
Emily N. C. Manoogian, Lisa S. Chow, Pam R. Taub, Blandine Laferrere, Satchidananda Panda
Summary: Time-restricted feeding and time-restricted eating are emerging behavioral interventions based on circadian rhythms to improve health by limiting calorie intake within a specific time window. Animal and human studies have shown promising results in reducing the risk for obesity, diabetes, and cardiovascular diseases through this approach.
Article
Endocrinology & Metabolism
Lili Liu, Wei Chen, Dan Wu, Fang Hu
Summary: This meta-analysis and systematic review suggests that time-restricted eating may be an effective approach to improving the metabolic state of nonobese individuals, particularly overweight individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Juanhong Liu, Pan Yi, Feng Liu
Summary: A network meta-analysis compared the effects of early and later time-restricted eating (TRE) interventions on weight loss and metabolic health. The results showed that both early and later TRE were effective in reducing body weight and insulin resistance, with early TRE being more effective in improving insulin resistance. No significant difference was found in weight loss between early and later TRE.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Yiming Guo, Christopher Livelo, Girish C. Melkani
Summary: Time-restricted feeding/eating (TRF/TRE) can modulate lipid metabolism in multiple organs and tissues, promoting health benefits. It synchronizes gene expression rhythms and temporally separates anabolic and catabolic processes to maintain lipid metabolic homeostasis in various tissues.
Review
Biochemistry & Molecular Biology
Min-Dian Li
Summary: Time-restricted eating limits daily meal timing to a 6-12 hour window, reducing the risks of cardiometabolic diseases by consolidating circadian rhythms of metabolism and physiology. Recent research shows that canonical circadian clocks are not essential for TRE effects in the liver, and that meal timing synchronizes circadian rhythms in peripheral tissues in a tissue-specific manner.
TRENDS IN MOLECULAR MEDICINE
(2022)
Review
Endocrinology & Metabolism
Bettina Schuppelius, Beeke Peters, Agnieszka Ottawa, Olga Pivovarova-Ramich
Summary: Time-restricted eating (TRE) is an attractive and easy-to-adapt dietary strategy that may be beneficial for weight loss, improving cardiometabolic health, and overall well-being. However, the effects of TRE on glucose and lipid metabolism are controversial. Current evidence shows that TRE can lower blood glucose, triglycerides, and cholesterol levels, as well as improve insulin sensitivity, but some studies suggest that TRE may not have positive effects in all individuals. Further research is needed to confirm these effects and understand the mechanisms underlying TRE's impact on metabolic health.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Food Science & Technology
Ruonan Yan, Chung S. Yang, Xin Zhang
Summary: Circadian rhythms and gut microbiota play crucial roles in optimizing host health, with time-restricted eating being a burgeoning approach. Understanding the mechanisms of host circadian rhythm generation and maintenance, as well as the consequences of circadian rhythm disruption, is important for preventing metabolic diseases.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Review
Physiology
Wai-Yin Cheng, Louis Desmet, Inge Depoortere
Summary: The circadian timing system allows organisms to adapt to cyclic environmental changes. Misalignment between internal rhythms and external cues is associated with various diseases. Time-restricted eating has emerged as a dietary approach with multiple health benefits beyond weight management. This review discusses the effects of time-restricted eating on energy metabolism, gut microbiota, cardiovascular health, and cancer, as well as the role of circadian clocks in optimizing this dietary strategy.
Editorial Material
Cell Biology
Zhangyuan Yin, Daniel J. Klionsky
Summary: Macroautophagy/autophagy plays a crucial role in aging and age-related diseases. A recent study showed that a newly designed dietary regimen, called intermittent time-restricted feeding (iTRF), can extend the healthspan and lifespan of flies through the circadian rhythm-dependent activation of autophagy. Specifically, the induction of autophagy during the night is both necessary and sufficient for the health benefits of iTRF. This study suggests that novel interventions promoting night-specific autophagy could be used to promote healthy aging.
Review
Food Science & Technology
Torsak Tippairote, Sarah Janssen, Rodjana Chunhabundit
Summary: The characteristics of healthy bioenergetics include energy balance, metabolic fuel switching, and eating/fasting rhythm. Time-restricted eating (TRE) helps improve metabolic flexibility and reduce food intake, showing beneficial metabolic effects on overweight and obese individuals. Further research is needed to explore the long-term effects of TRE on preventing common metabolic diseases in healthy subjects.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Medicine, General & Internal
J. Park, M-Y Park, Y. Kim, Y. Jun, U. Lee, C-M Oh
Summary: This study found that [Pyr1]-Apelin-13 can protect cells from viral infection by inhibiting the binding of ACE2 to the SARS-CoV-2 spike protein. It also regulates inflammatory responses by inhibiting the nuclear factor kappa B pathway. These findings suggest that Apelin may be a potential therapeutic candidate against SARS-CoV-2 infection.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Nutrition & Dietetics
Hyuk Joo Lee, Seunghyup Yoo, Jung Kyung Hong, Jun Seok Ahn, Eunyoung Lee, Hanul Moon, Sunhyoung Koo, Tae Kim, Jaehyeok Park, In-Young Yoon
Summary: This study found that a prototype wearable LED UVB device was effective in improving serum 25-hydroxyvitamin D levels, with an average production of 0.031 ng/mL of vitamin D per 1 cm² of skin area.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Victor James Drew, Mincheol Park, Tae Kim
Summary: This study examined the relationship between sleep disturbances and regional neuron and astrocyte pathologies in Alzheimer's disease (AD). The findings showed that 5XFAD mice demonstrated reduced NREM and REM sleep duration and bout counts, as well as decreased theta EEG power frequency during REM sleep. Sleep disturbances were correlated with the number and ratio of GFAP-positive astrocytes in sleep-promoting brain regions. This study reveals the link between neurotoxic reactive astrogliosis and sleep disturbances in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Tanes I. Lima, Pirkka-Pekka Laurila, Martin Wohlwend, Jean David Morel, Ludger J. E. Goeminne, Hao Li, Mario Romani, Xiaoxu Li, Chang-Myung Oh, Dohyun Park, Sandra Rodriguez-Lopez, Julijana Ivanisevic, Hector Gallart-Ayala, Barbara Crisol, Florence Delort, Sabrina Batonnet-Pichon, Leonardo R. Silveira, Lakshmi Sankabattula Pavani Veera Venkata, Anil K. Padala, Suresh Jain, Johan Auwerx
Summary: Disruption of ceramide biosynthesis leads to the decline in mitochondrial and protein homeostasis during muscle aging. Through transcriptome analysis of muscle biopsies, it was found that disturbance in ceramide biosynthesis, mitochondrial function, and protein homeostasis are prevalent features in aged individuals and patients with muscle disorders. Inhibition of ceramide biosynthesis restores proteostasis and mitochondrial function, improving muscle health and lifespan in both nematodes and mice.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Jee Hyun Kim, Chang-Myung Oh, Jun Hwan Yoo
Summary: Obesity is common in patients with inflammatory bowel disease (IBD), especially in newly developed countries. It has been suggested that 15%-40% of IBD patients are obese, and obesity may play a role in the development of IBD. Dysfunction of mesenteric fat can worsen the inflammation in Crohn's disease and lead to the formation of strictures or fistulas. Additionally, obesity can affect the course of the disease and the response to treatment in IBD. As a result, obesity control is being proposed as a novel management approach for IBD, and this review aims to discuss the impact of obesity on IBD treatment outcomes and the current status of pharmacologic or surgical anti-obesity treatments in IBD patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Joon Kim, Hangyul Song, Junghoon Lee, Yoon Jung Kim, Hye Soo Chung, Jae Myung Yu, Gyuho Jang, Raekil Park, Wankyo Chung, Chang-Myung Oh, Shinje Moon
Summary: Cigarette smoking is a major cause of preventable and premature death, and passive smoking also leads to respiratory diseases and related mortalities. This study aimed to evaluate the effects of smoking and passive smoking on all-cause and disease-specific mortality, particularly mediated by cadmium. The results showed that both current smoking and passive smoking were associated with an increased risk of all-cause, CVD-related, and cancer-related mortality, with passive smoking having a synergistic effect with smoking status. The accumulation of cadmium in the blood due to smoking and passive smoking mediated the increased risk of all-cause mortality.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Jibeom Lee, Jiseung Kang, Yumin Kim, Sunjae Lee, Chang-Myung Oh, Tae Kim
Summary: This study investigated the effects of sleep deprivation (SD) and high-fat diet (HFD)-induced obesity on gut microbiota and host responses. The results showed that HFD significantly altered the gut microbiota, while SD had a major impact on the gut transcriptome. When combined, SD and HFD severely disrupted the brain's inflammatory system. In addition, inosine-5' phosphate may be a key metabolite mediating microbiota-gut-brain interactions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Donghyun Kim, Wooju Jeong, Yumin Kim, Jibeom Lee, Sung Woo Cho, Chang-Myung Oh, Raekil Park
Summary: Pharmacological activation of ACE2 improves cardiac function and structure in diabetic cardiomyopathy by suppressing oxidative stress and pathways related to cardiac hypertrophy.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Biology
Jieun Jung, Jiseung Kang, Tae Kim
Summary: The study found a direct link between vitamin D deficiency and disruptions in sleep and rest-activity circadian rhythm. Vitamin D-deficient mice showed reduced wake time during the light period and increased NREM sleep time. During the dark period, the wake EEG power spectrum shifted to the theta band frequency and slow-wave energy was suppressed. The mice also exhibited changes in circadian behavior, including increased circadian period and decreased activity levels.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Sung Jin Kim, Sung Gon Park, Sahyun Pak, Ohseong Kwon, Young Goo Lee, Sung Tae Cho
Summary: This study aimed to identify preoperative factors that could predict persisting storage symptoms after HoLEP. The medical records of 257 patients were reviewed, and preoperative data were collected. The results showed that OAB history, terminal DO, and IPSS urgency item were possible predictive factors for post-HoLEP medication use.
INTERNATIONAL JOURNAL OF UROLOGY
(2023)
Article
Psychiatry
Jiseung Kang, Mincheol Park, Chang-Myung Oh, Tae Kim
Summary: Consumption of a high-fat diet (HFD) is associated with reduced wakefulness and various behavioral deficits. It affects the dopaminergic system, which plays a crucial role in sleep and ADHD. This study investigated the effects of HFD on the dopaminergic system and its association with behavioral deficits in male mice. The results suggest that HFD-induced behavioral deficits resemble ADHD-like phenotypes and disturb REM sleep by dysregulating the dopaminergic system.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Jiseung Kang, Jaeyu Park, Hojae Lee, Myeongcheol Lee, Sunyoung Kim, Ai Koyanagi, Lee Smith, Min Seo Kim, Masoud Rahmati, Guillaume Fond, Laurent Boyer, Guillermo F. Lopez Sanchez, Dragioti Elena, Samuele Cortese, Tae Kim, Dong Keon Yon
Summary: This study examines the prevalence and risk factors of depression and suicide attempts among South Korean adults during the COVID-19 pandemic. The findings suggest an increased prevalence of depression but a stable rate of suicide attempts. The study highlights the importance of targeted mental health support strategies for different population subgroups.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Urology & Nephrology
Eui-Sun Kim, Dong Jin Shin, Sung Tae Cho, Kyung Jin Chung
Summary: Research has shown that stroke can affect the symptoms and presentation of neurogenic bladder, including abnormal facial and linguistic characteristics. This study proposes a platform that accurately analyzes the voices of stroke patients with neurogenic bladder, enabling early detection and prevention of the condition.
INTERNATIONAL NEUROUROLOGY JOURNAL
(2023)
