期刊
NUTRIENTS
卷 12, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/nu12051326
关键词
hypertension; asymmetric dimethylarginine; dietary inflammatory index; endothelial dysfunction; inflammation; medical nutrition therapy
资金
- Aristotle University of Thessaloniki's Research Committee [91770]
Lifestyle modification is an important component of essential hypertension (EH) therapy. The aim of the Hypertension Intensive Nutrition Treatment (HINTreat) parallel, randomized controlled trial was to examine the effect of a 6-month intensive lifestyle treatment (ILT) (diet plus exercise with monthly visits) compared to the usual care. A total of 76 adults with stage 1 EH were randomized (38 in each group). Dietary analysis, anthropometry, physical activity, biochemical and urine profile, blood pressure (BP), asymmetric dimethylarginine (ADMA), central hemodynamics, beta-stiffness index and carotid intima media-thickness were evaluated. The dietary inflammatory index (DII) was calculated for each participant from the intake of 29 nutrients/food components. At the end of the trial, participants in the ILT group reduced their 24h urinary Na excretion (p <= 0.001), daytime systolic BP (p <= 0.048) and mean carotid beta-stiffness index (p <= 0.005) and ameliorated their lipidemic profile compared to the standard care. Univariate analysis for the total sample showed a strong association between DII and ADMA levels (beta = 0.089,p <= 0.01). ILT is effective in improving the inflammatory components of the diet and selected cardiometabolic parameters, including arterial stiffness.
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