Article
Biochemistry & Molecular Biology
Pawel Jarmuzek, Piotr Defort, Marcin Kot, Edyta Wawrzyniak-Gramacka, Barbara Morawin, Agnieszka Zembron-Lacny
Summary: Cytokines play a critical role in tumor cell development and multiplication, but their involvement in glioblastoma (GBM) is still not well understood. This study evaluated the inflammatory profile and identified potential molecular signatures specific to GBM. The results showed elevated neutrophils and neutrophil-to-lymphocyte ratio (NLR) in GBM patients, with an inverse correlation between neutrophil count and survival time. Pro-inflammatory cytokines IL-1 beta, IL-6, and IL-8 were significantly higher in GBM, while TNF alpha and HMGB1 were lower. IL-6 and IL-8 had the highest diagnostic potential for clinical prognosis, with a three-fold higher probability of GBM development above certain threshold values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Jianghong Guo, Hui Zhang, Yi Li, Meng Hao, Guoping Shi, Jiucun Wang, Zhengdong Wang, Xiaofeng Wang
Summary: This study found that an increase in NLR levels is associated with an increased risk of slow gait speed in older adults, regardless of comorbidities. Over a 3.5-year follow-up period, elevated NLR levels were significantly associated with a higher risk of developing new-onset slow gait speed.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Cell Biology
Eileen Uribe-Querol, Carlos Rosales
Summary: Obesity is characterized by increased body weight and exaggerated enlargement of adipose tissue. It is associated with various pathological complications and systemic inflammation caused by adipocyte stress, infiltration of neutrophils and other immune cells.
Article
Emergency Medicine
Hwan Song, Hyo Joon Kim, Kyu Nam Park, Soo Hyun Kim, Sang Hoon Oh, Chun Song Youn
Summary: The study found that an elevated neutrophil to lymphocyte ratio (NLR) at admission was associated with higher in-hospital mortality in older patients, and may serve as a surrogate marker of disease severity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Psychiatry
Moshui Shan, Shan Lu, Rui Cui, Yi Yang, Zhonghua Sun, Yu Pan
Summary: This study aimed to investigate the association between the neutrophil to lymphocyte ratio (NLR) and depression and its severity. Analysis of the National Health and Nutrition Examination Survey data revealed that the association between NLR and depression was not significant in the overall depressed population, but it showed significance in specific subgroups. Additionally, a non-linear relationship between NLR and depression severity was observed.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Medical Laboratory Technology
Junjun Wang, Fan Zhang, Feng Jiang, Lijuan Hu, Jian Chen, Yumin Wang
Summary: The study found that the reference interval for NLR, LMR, and PLR in Chinese healthy adults is influenced by gender and age, with the upper limits of NLR and PLR increasing with age in males but decreasing for LMR. In females, the reference upper limits showed fluctuations in different age groups, indicating a need for individualized assessment.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Immunology
Erye Zhou, Jian Wu, Xin Zhou, Yufeng Yin
Summary: This study investigated the association between neutrophil-to-lymphocyte ratio (NLR) and all-cause and cardiovascular mortality risk in individuals with rheumatoid arthritis (RA). The study found that individuals with higher NLR had a 2-fold increased risk of long-term mortality. NLR may serve as an inexpensive and widely available prognostic marker in RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Geriatrics & Gerontology
Yanli Zhao, Jirong Yue, Peng Lei, Taiping Lin, Xuchao Peng, Dongmei Xie, Langli Gao, Xiaoyu Shu, Chenkai Wu
Summary: The study found that NLR is a simple and practical marker that can predict the development of delirium in older internal medicine patients.
Article
Medicine, General & Internal
Sang-Hwa Lee, Jong-Ho Kim, Young-Suk Kwon, Jong-Hee Sohn
Summary: The study found that peripheral inflammatory markers (PIMs) significantly increased during migraine attacks, indicating that inflammation may play a role in migraines. Among different markers, NLR and NMR had poor ability to differentiate between migraine and non-migraine headaches, but performed well in distinguishing migraines from other types of headaches.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Qiang Hu, Weipu Mao, Tiange Wu, Zhipeng Xu, Junjie Yu, Can Wang, Saisai Chen, Shuqiu Chen, Bin Xu, Yueshuang Xu, Ming Chen
Summary: In RCC patients undergoing laparoscopic partial or radical nephrectomy, NLR and PLR were identified as biomarkers of systemic inflammation associated with increased risk of sarcopenia. The best cutoff points for predicting sarcopenia risk were NLR >2.88 and PLR >135.63, with higher levels indicating a greater risk. Adjusting for various variables, patients with NLR >2.88 and PLR >135.63 had significantly higher risks of developing sarcopenia compared to those with lower NLR or PLR levels.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Murat Sahin, Ayten Oguz, Dilek Tuzun, Okay Isiktas, Songul Isiktas, Cansu ulgen, Hatice Sahin, Kamile Gul
Summary: This study aimed to investigate whether the neutrophil-lymphocyte ratio (NLR), an indicator of systemic inflammation, could predict gestational diabetes mellitus (GDM). The results showed a significant increase in NLR in the 1st and 3rd trimesters in the GDM group, supporting the presence of systemic inflammation in early pregnancy and throughout pregnancy. The study also found a positive correlation between NLR and fasting plasma glucose and body mass index in both trimesters. The first trimester NLR was found to independently predict the development of GDM.
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ruilin Pan, Yaning Ren, Qingqing Li, Xuming Zhu, Jian Zhang, Yubao Cui, Hao Yin
Summary: This study evaluated the associations between neutrophil-lymphocyte ratio (NLR), NLR-alanine aminotransferase ratio (NAR), and NLR-albumin ratio (NBR) with the diagnosis of childhood asthma. The combination of NLR + NAR + NBR was found to distinguish asthmatic children with exacerbation from healthy children. Therefore, our results suggest that NLR + NAR + NBR could be used as a clinical biomarker for asthma in children.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa
Summary: Patients with multiple sclerosis showed elevated counts of total white blood cells, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Aysun Firat, Aysegul Ercan, Cengiz Mordeniz, Fatma Ferda Verit Atmaca
Summary: This study aimed to investigate whether the pretreatment hemogram parameters and their ratios can predict the endometrial transformation in patients with abnormal uterine bleeding. The study found that age, postmenopausal state, obesity, diabetes, and increased estrogen exposure were risk factors for endometrial atypia and carcinoma. Hemoglobin and hematocrit levels were significantly higher in early and advanced endometrial cancer groups, while platelet value was significantly higher in atypia and carcinoma groups.
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Elena Rodriguez-Rodriguez, M. Dolores Salas-Gonzalez, Rosa M. Ortega, Ana M. Lopez-Sobaler
Summary: The aim of this study was to investigate the relationship between markers of inflammation and insulin resistance (IR) in overweight/obese children. The results showed that elevated white blood cell values and NLR may serve as indicators of the presence of IR in these subjects.
FRONTIERS IN NUTRITION
(2022)
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Grigorios Chatzantonis, Christos-Konstantinos Antoniou, Haris Lalos, Gregory C. Bogdanis, Pantelis Nikolaou, Anastasios Spanos, Stefanos Karagiannis, Costas Tsiou, Ali Yilmaz, Christodoulos Stefanadis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation. The results suggest that an individualized CBA dosing strategy based on TTI and extended duration of CBA can reduce recurrence post-AF ablation and decrease procedure time and incidence of phrenic nerve palsy.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Maria Dolores Salas-Gonzalez, Aranzazu Aparicio, Viviana Loria-Kohen, Rosa M. Ortega, Ana M. Lopez-Sobaler
Summary: This study found that greater adherence to a healthy dietary pattern, especially in girls, as assessed by a higher HEI-2015 score, was associated with a lower risk of insulin resistance in schoolchildren.
Article
Environmental Sciences
Maria Dolores Salas-Gonzalez, Maria del Carmen Lozano-Estevan, Aranzazu Aparicio, Laura M. Bermejo, Viviana Loria-Kohen, Rosa M. Ortega, Ana M. Lopez-Sobaler
Summary: This study aimed to assess the association between breakfast quality and insulin resistance in schoolchildren. The results showed that higher-quality breakfast was associated with better overall diet quality and a lower risk of insulin resistance, especially in boys.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Pediatrics
Enrique Gutierrez-Gonzalez, Francisco Sanchez Arenas, Ana Maria Lopez-Sobaler, Blanca Andreu Ivorra, Almudena Rollan Gordo, Marta Garcia-Solano
Summary: Childhood obesity in Spain is more prevalent in low-income households, where unhealthy eating habits and sedentary lifestyles are common. In contrast, high-income households have lower rates of childhood obesity and less frequent breastfeeding and physical activity. Schools attended by children from low-income households often lack facilities such as kitchens, gyms, and sports activities.
ANALES DE PEDIATRIA
(2023)
Article
Public, Environmental & Occupational Health
Maria Dolores Salas-Gonzalez, Laura M. M. Bermejo, Liliana G. G. Gonzalez-Rodriguez, Maria Del Carmen Lozano-Estevan, Rosa M. M. Ortega, Ana M. M. Lopez-Sobaler
Summary: Being more active, being less sedentary, and sleeping enough are associated with adequate body weight and adiposity in children. Few researchers have analyzed these different lifestyle behaviors and the adherence to 24 h movement guidelines with respect to insulin resistance (IR) at school age in Spanish schoolchildren.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Ethnic Studies
Sara Palomo-Diez, Claudia Gomes, Maria Sonia Fondevila, Angel Esparza-Arroyo, Ana Maria Lopez-Parra, Maria Victoria Lareu, Eduardo Arroyo-Pardo, Juan Francisco Pastor
Summary: Through this study, the physical characteristics, biogeographical origin, and genealogical ancestry of Princess Lady Leonor of Castile have been determined using genetic analysis of her mummified remains. The results show that the mummified remains belong to a young European woman with black hair, green-hazel eyes, and white skin, consistent with historical genealogical information.
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Ethnic Studies
Ana Maria Lopez-Parra, Maria Soledad Mesa, Fernando Castilla, Eduardo Arroyo-Pardo
Summary: This study analyzed markers in the Y chromosome-specific region of individuals with the surname Castilla to determine their patrilineal relationship and possible common ancestry. The study found that the main haplogroups in the Castilla sample were R1b and E1b1b-M81. The high frequency of E1b1b-M81 haplogroup, low haplotype diversity, and young TMRCA in the Castilla sample are consistent with the historical period of surname usage.