Article
Mechanics
Bowen Wang, Shundong Yu, Jian Mao, Yaohui Wang, Mengjia Li, Xiping Li
Summary: Short basalt fiber reinforced PEEK composites exhibit increased surface roughness, decreased friction coefficient, and the lowest specific wear rate, along with good ultimate tensile strength and elongation at break. Thermal and rheological behaviors of the composites were also investigated to understand the effect of basalt fiber on the crystallization performance and flow abilities of PEEK composites.
COMPOSITE STRUCTURES
(2021)
Article
Polymer Science
Jinghui Yang, Jun Xie, Kaipeng Ji, Xianghong Wang, Xiaolong Jiao, Zhinong Xu, Peng Zhao
Summary: Microcellular PEEK was prepared by injection molding and the effects of process parameters on its properties were studied. Two types of microcellular PEEK with good performance were obtained after optimization, and the effect of carbon fiber was preliminarily investigated.
Review
Oncology
Naresh Kumar, Keith Gerard Lopez, Sridharan Alathur Ramakrishnan, James Thomas Patrick Decourcy Hallinan, Jerry Ying Hsi Fuh, Naveen Pandita, Sirisha Madhu, Aravind Kumar, Lorin M. Benneker, Balamurugan A. Vellayappan
Summary: Ti6Al4V is widely used in metastatic spine tumor surgery, but it has issues like stress-shielding and imaging interference. PEEK is a promising alternative due to its low Young's modulus and minimal imaging artifacts, but faces challenges in providing immediate stability postoperatively.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Clinical Neurology
Naresh Kumar, Sridharan Alathur Ramakrishnan, Keith Gerard Lopez, Sirisha Madhu, Miguel Rafael D. Ramos, Jerry Ying Hsi Fuh, James Hallinan, Colum P. Nolan, Lorin M. Benneker, Balamurugan A. Vellayappan
Summary: Instrumentation in metastatic spine tumor surgery (MSTS) plays a crucial role in providing stability to the spinal column. Titanium, the current material of choice, poses challenges in radiotherapy planning due to artifacts it generates, while PEEK, an emerging alternative, offers minimal stress shielding but lacks bioactivity and rigidity. Surface modification and composite formation may improve the bioactivity and mechanical properties of PEEK implants. Despite difficulties in handling, PEEK and modified PEEK implants show promise for future development in MSTS.
WORLD NEUROSURGERY
(2021)
Article
Materials Science, Composites
Zhonglue Hu, Wei Chen, Xin Ye, Jietai Ding, Xinying Luo, Sisi Wang, Yuhui Ou, Yakuang Zhang, Xiping Li
Summary: This study focuses on improving the mechanical strength of 3D-printed PEEK material through the addition of high-loading carbon fibers and annealing treatment. The results show that the composite with 10 wt% CF exhibits the highest strength, and the annealing treatment further increases the strength both at room temperature and high-temperature.
POLYMER COMPOSITES
(2023)
Article
Materials Science, Multidisciplinary
Wenyuan Jia, Dan Cui, Yun Liu, Xuan Ji, Maolei Sun, Zhiqiang Cheng, Yungang Luo, Guomin Liu
Summary: This study successfully fabricated PEEK/PMMA/CF ternary composites through electrospinning and hot-pressing methods, with Young's moduli similar to human bones, good biocompatibility, and low cytotoxicity.
MATERIALS & DESIGN
(2021)
Article
Materials Science, Characterization & Testing
Nan Jiang, Peijie Tan, Miaomiao He, Jie Zhang, Dan Sun, Songsong Zhu
Summary: In this study, graphene nanoplatelet reinforced PEEK composites were fabricated and evaluated for their mechanical properties, biocompatibility, and bone repair function. The results showed that adding graphene significantly enhances the material's toughness and promotes adhesion and differentiation of rat bone marrow stromal cells.
Article
Materials Science, Characterization & Testing
Dong Yang, Yi Cao, Zhikun Zhang, Yifa Yin, Dichen Li
Summary: This study proposes a novel process to control the crystallinity of 3D-printed CF/PEEK composites, affecting their mechanical properties to resemble those fabricated via injection molding. This work is of positive significance for promoting the application of 3D printed PEEK composite materials in aerospace and orthopedic implants.
Article
Engineering, Multidisciplinary
Jia Li, Yutong Fu, Wenli Pi, Yuanqing Li, Shaoyun Fu
Summary: This study combines the optimal fiber content and annealing treatment to significantly improve the mechanical properties of FFF-3D printed SCF/PEEK composites at both room and elevated temperatures. The increase of interface strength and crystalline region as well as the reduction of residual stress during annealing are responsible for the observed improvements.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Honggang Dong, Zuyang Tang, Peng Li, Baosheng Wu, Xiaohu Hao, Chaoqun Ma
Summary: The study focused on the weldability of a hybrid structure made of aluminum alloy and carbon fiber reinforced plastics. Through friction stir spot welding, joint fabrication of the materials revealed that dwell time and plunge speed were crucial factors affecting the ultimate tensile shear load. The interface was divided into different zones, with the shoulder-affected zone and pin-affected zone being vital for mechanical properties. Bonding mechanism involved adhesive bonding, macro-mechanical interlocking, and micro-mechanical interlocking, providing insights for improving mechanical properties.
MATERIALS & DESIGN
(2021)
Review
Chemistry, Multidisciplinary
Hongyun Ma, Angxiu Suonan, Jingyuan Zhou, Qiling Yuan, Liang Liu, Xiaoming Zhao, Xiaoxiao Lou, Chuncheng Yang, Dichen Li, Yin-gang Zhang
Summary: The article discusses the challenges of large bone defects caused by tumors and traumas, the development of orthopedic implants and bone tissue engineering materials, with a focus on the research progress and advantages of PEEK materials, and their successful clinical applications and achievements.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Polymer Science
Ruoxiang Gao, Jun Xie, Jinghui Yang, Chaojie Zhuo, Jianzhong Fu, Peng Zhao
Summary: By conducting single factor experiments, the impact of raster angle and infill density on PEEK parts was determined, while orthogonal experiments were used to analyze the effects of printing speed, nozzle temperature, and other parameters. Through optimization, significant reductions in warpage deformation and improvements in tensile strength were achieved, supporting the development of FDM for PEEK.
Article
Materials Science, Multidisciplinary
Maihemuti Yakufu, Zongliang Wang, Jianguo Liu, Peibiao Zhang
Summary: Porous polyether ether ketone (PEEK) scaffolds with hydroxyapatite (HA) layer coated on the pore wall surface were prepared using a sacrificial porogen of HA-coated sodium chloride (NaCl) microspheres. The PEEK@HA scaffolds exhibited superior in vitro biomineralization and in vivo osseointegration, providing a facile manufacturing strategy for integratedly fabricating bio-nic porous PEEK scaffolds with a mineralized coating layer.
MATERIALS & DESIGN
(2022)
Article
Materials Science, Multidisciplinary
Jinghui Yang, Jun Xie, Kaipeng Ji, Xianghong Wang, Xiaolong Jiao, Zhinong Xu, Peng Zhao
Summary: Microcellular PEEK with a weight reduction of 49.6% was prepared by mold-opening microcellular injection molding (MOMIM). Incremental holding time and holding pressure could increase PEEK's density and promote the formation of dense cells, improving mechanical properties.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Biotechnology & Applied Microbiology
Rupak Dua, Onessa Sharufa, Joi Terry, William Dunn, Indu Khurana, Jagasivamani Vadivel, Yue Zhang, Henry J. Donahue
Summary: In this study, a porous PEEK structure was developed using a chemical etching method, and three post-treatments were performed to improve bone cell adhesion and proliferation. Surface characterization showed that the treated groups had porous structures with increased roughness and different surface chemistry. Cell toxicity decreased, and alkaline phosphatase activity increased, indicating enhanced osteoblastic cell differentiation and osteogenic potential.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Oncology
Marcus Beck, Manfred Sassowsky, Sami Schaer, Etienne Mathier, Matthias Halter, Daniel R. Zwahlen, Tobias Hoelscher, Winfried Arnold, Bulent Polat, Guido Hildebrandt, Arndt-Christian Mueller, Paul M. Putora, Alexandros Papachristofilou, Stefanie Hayoz, Corinne Schaer, Qiyu Li, Marcin Sumila, Kathrin Zaugg, Matthias Guckenberger, Piet Ost, Davide G. Bosetti, Christiane Reuter, Silvia Gomez, Kaouthar Khanfir, Daniel M. Aebersold, Pirus Ghadjar, Alan Dal Pra
Summary: This study evaluated the results of a radiation therapy quality assurance program in patients with biochemically recurrent prostate cancer after prostatectomy. The study found that there were significant deviations from the treatment protocol guidelines and recommendations, which were associated with an increased risk of acute or late gastrointestinal or genitourinary toxicity and a trend towards worse freedom from biochemical progression (FFBP).
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
M. Pavic, M. Niyazi, L. Wilke, S. Corradini, M. Vornhuelz, U. Mansmann, A. Al Tawil, R. Fritsch, J. Hoerner-Rieber, J. Debus, M. Guckenberger, C. Belka, J. Mayerle, G. Beyer
Summary: This study aims to investigate the impact of SBRT on pain control in patients with mPDAC by embedding MR-guided adaptive SBRT of the pPca in between standard chemotherapy cycles. A total of 92 eligible patients will be enrolled in a randomized controlled trial across 3 centers in Germany and Switzerland to evaluate the added benefit of MR-guided SBRT for pain control and prevention.
RADIATION ONCOLOGY
(2022)
Article
Oncology
J. Ristau, J. Hoerner-Rieber, C. Buchele, S. Klueter, C. Jaekel, L. Baumann, N. Andratschke, H. Garcia Schueler, M. Guckenberger, M. Li, M. Niyazi, C. Belka, K. Herfarth, J. Debus, S. A. Koerber
Summary: This study aims to evaluate the safety and feasibility of MRI-guided stereotactic radiotherapy for localized prostate cancer. Moderate hypofractionation has become the standard treatment for prostate cancer, and ultrahypofractionation may further reduce treatment time. MRI-guided radiotherapy can avoid invasive procedures and, combined with gating and plan adaptation, can improve treatment effectiveness and reduce toxicity.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Willem J. A. Witlox, Bram L. T. Ramaekers, Benjamin Lacas, Cecile Le Pechoux, Alexander Sun, Si-Yu Wang, Chen Hu, Mary Redman, Vincent van der Noort, Ning Li, Matthias Guckenberger, Harm van Tinteren, Lizza E. L. Hendriks, Harry J. M. Groen, Manuela A. Joore, Dirk K. M. De Ruysscher
Summary: This study assessed the cost-effectiveness of prophylactic cranial irradiation (PCI) compared to no PCI in stage III non-small cell lung cancer (NSCLC) from a Dutch societal perspective. The findings indicate that PCI is cost-effective compared to no PCI at a willingness-to-pay threshold of 80,000 per quality-adjusted life year (QALY).
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Tiuri E. Kroese, Sebastian M. Christ, Peter S. N. van Rossum, Matthijs D. L. Burger, George S. Buijs, Urs Muhlematter, Nicolaus Andratschke, Jelle P. Ruurda, Martin Hullner, Christian A. Gutschow, Richard van Hillegersberg, Matthias Guckenberger
Summary: This multicenter study assessed the incidence and survival of patients with esophagogastric cancer and oligometastatic disease (OMD) in two tertiary referral cancer centers in The Netherlands and Switzerland. The study found that local treatment plus systemic therapy was associated with improved overall survival compared to systemic therapy alone.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Therese MJ. Kang, Nicholas Hardcastle, Anurag K. Singh, Ben J. Slotman, Gregory M. M. Videtic, Kevin L. Stephans, Felipe Coun Counago, Alexander V. Louie, Matthias Guckenberger, Susan V. Harden, Nikki M. Plumridge, Shankar Siva
Summary: SABR is an effective treatment for inoperable early-stage NSCLC and pulmonary oligometastases. Single-fraction SABR, with its excellent local control and safety profiles, has advantages in terms of resource efficiency and reduced hospital visits, especially during the COVID-19 pandemic.
Article
Oncology
Stephanie Tanadini-Lang, Geoff Budgell, Omar Bohoudi, Stefanie Corradini, Davide Cusumano, Gorkem Gungor, Linda G. W. Kerkmeijer, Faisal Mahmood, Simeon Nill, Miguel A. Palacios, Michael Reiner, Daniela Thorwarth, Lotte Wilke, Jochem Wolthaus
Summary: The objective of this study was to define QA tests for oMRgRT systems and to identify important medical physics aspects for installation and commissioning. Twenty-four potentially important QA tests were identified, along with eleven tasks and aspects related to construction, workflow development, and training. A program for QA and commissioning of oMRgRT systems was developed to support safe handling of such systems.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Ilker Uckay, Stephan Wirth, Bjoern Zoerner, Sandro Fucentese, Karl Wieser, Andreas Schweizer, Daniel Mueller, Patrick Zingg, Mazda Farshad
Summary: In order to reduce antibiotic use and associated adverse events, we conducted two similar randomized controlled trials to explore the appropriate duration of post-surgical antibiotic therapy for orthopedic infections. The primary outcomes were remission and microbiologically-identical recurrences, while the main secondary outcome was antibiotic-related adverse events.
Article
Oncology
Mireille Conrad, Riccardo Dal Bello, Janita E. van Timmeren, Nicolaus Andratschke, Lotte Wilke, Matthias Guckenberger, Stephanie Tanadini-Lang, Panagiotis Balermpas
Summary: This study compares the effect of MR-guided radiotherapy and conventional radiotherapy on the surface dose of head and neck cancer patients, and finds that using MR-linac can effectively cover superficial tissue and reduce side effects.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Meeting Abstract
Oncology
I. Wahlstedt, N. Andratschke, C. P. Behrens, S. Ehrbar, H. S. Gabrys, H. Garcia Schueler, M. Guckenberger, A. G. Smith, S. Tanadini-Lang, J. D. Tascon-Vidarte, I. R. Vogelius, J. E. van Timmeren
RADIOTHERAPY AND ONCOLOGY
(2022)
Meeting Abstract
Oncology
P. Wallimann, M. Mayinger, M. Bogowicz, M. Guckenberger, N. Andratschke, S. Tanadini-Lang, J. E. van Timmeren
RADIOTHERAPY AND ONCOLOGY
(2022)
Meeting Abstract
Oncology
J. Willmann, E. Vlaskou Badra, S. Adilovic, J. E. van Timmeren, M. Mayinger, M. Guckenberger, N. Andratschke
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Sebastian M. Christ, Michael Denner, Nicolaus Andratschke, Panagiotis Balermpas, Brigitte Hilty, Stephanie Tanadini-Lang, Lotte Wilke, Sophie Perryck, Matthias Guckenberger
Summary: During the first year of the COVID-19 pandemic, weekly online surveys were conducted to monitor stress levels and health concerns among employees in a radiation oncology department. The surveys were found to be feasible and valuable in identifying profession and workplace specific stress patterns and guiding tailored interventions.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2022)
Article
Oncology
Natalia Saltybaeva, Stephanie Tanadini-Lang, Diem Vuong, Simon Burgermeister, Michael Mayinger, Andrea Bink, Nicolaus Andratschke, Matthias Guckenberger, Marta Bogowicz
Summary: The study showed that different image normalization methods have varying effects on the stability of radiomic features, with histogram matching based on the tumor region being the most stable. Histogram matching also improved the prognostic value of the images, which is significant for multicenter studies.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2022)
Meeting Abstract
Oncology
J. A. Buchner, F. Kofler, M. Mayinger, T. Brunner, A. Wittig, B. Menze, C. Zimmer, B. Meyer, M. Guckenberger, N. Andratschke, R. A. E. Shafie, J. Peter Debus, S. Rogers, O. Riesterer, K. Schulze, H. J. Feldmann, O. Blanck, C. Zamboglou, K. Ferentinos, K. A. Eitz, S. Combs, D. Bernhardt, B. Wiestler, J. Peeken
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)