Review
Biotechnology & Applied Microbiology
Yajing Sun, Qingshan Yang, Xue Xia, Xiaozhe Li, Weimin Ruan, Meng Zheng, Yan Zou, Bingyang Shi
Summary: Researchers are focusing on developing polymeric nanoparticles targeted at mitochondria to enhance the efficiency of cancer therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Maliheh Entezari, Courtney Clark, Amirhossein Zabolian, Ehsan Ranjbar, Mahdi Vasheghani Farahani, Hossein Saleki, Seyed Omid Sharifzadeh, Fatemeh Bakhtiari Far, Milad Ashrafizadeh, Saeed Samarghandian, Haroon Khan, Saeid Ghavami, Ali Zarrabi, Marek J. Los
Summary: Autophagy plays a dual role in normal cells and tumors, and targeting autophagy using nanoparticles can enhance cancer therapy. Nanocarriers can deliver autophagy regulators and chemotherapeutic agents, while nanomaterials can affect key components of autophagy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Zhiduo Sun, Weiyun Zhang, Zhichao Ye, Li Yuan, Manli Fu, Xiaoming Liu, Huageng Liang, Heyou Han
Summary: This study presents the design of a novel nanocarrier DNAH for the treatment of bladder cancer, utilizing photothermal therapy to overcome the bladder mucosal barrier and enhance drug penetration. The results demonstrate the potential inhibition of bladder tumor growth by DNAH, leading to improved survival time in mice.
Article
Engineering, Biomedical
Yuan Gao, Wei Qiu, Mengyun Liang, Xianbin Ma, Mengjie Ye, Peng Xue, Yuejun Kang, Jun Deng, Zhigang Xu
Summary: In this study, active targeting redox-responsive mannosylated prodrug nanocolloids (HM NCs) were constructed for enhanced chemotherapy of colon cancer. HM NCs exhibited superior antitumor activity both in vitro and in vivo and appreciably extended mouse survival rate with good biocompatibility, providing more choices for future clinical translation.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Abhishesh Kumar Vikas, Abhishesh Kumar Mehata, Matte Kasi Viswanadh, Ankit Kumar Malik, Aseem Setia, Pooja Kumari, Sanjeev Kumar Mahto, Madaswamy S. Muthu
Summary: This research developed redox-sensitive dual-receptor-targeted nanoparticles loaded with cabazitaxel, showing significantly improved cellular uptake and anticancer activity against A549 lung cancer cells.
Article
Pharmacology & Pharmacy
Guoliang Liu, Min Wang, Hongyu He, Jiannan Li
Summary: This study developed tumor-targeting nanoparticles loaded with doxorubicin for the treatment of colorectal cancer. The nanoparticles utilize a peptide, VATANST (STP), to achieve tumor-targeting effects, have a core-shell structure, and are sensitive to the tumor microenvironment. In vivo experiments in mice demonstrated the nanoparticles' properties as drug delivery systems and their good antitumor effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Khushboo Pathania, Sangeeta P. Sah, Deepak B. Salunke, Manish Jain, Ashok Kumar Yadav, Vikramaditya G. Yadav, Sandip V. Pawar
Summary: Polymeric magnetic nanoparticles based on lignin have been developed for targeted delivery of methotrexate, showing higher efficacy in cancer diagnosis and treatment. The synthesized nanoparticles exhibit magnetic and smooth polyhedral traits with a dimension of 110-130 nm. The drug-loaded nanoparticles have high cytotoxicity in breast cancer and macrophage cell lines and exhibit sustained release of methotrexate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Nasrul Wathoni, Lisa Efriani Puluhulawa, I. Made Joni, Muchtaridi Muchtaridi, Ahmed Fouad Abdelwahab Mohammed, Khaled M. Elamin, Tiana Milanda, Dolih Gozali
Summary: Lung cancer, the second most common type of cancer, has the highest mortality rate. Nanoparticle technology is being developed for lung cancer therapies, but specific ligands are needed to enhance drug delivery precision. Monoclonal antibodies can actively target nanoparticles to cancer cells, but they have drawbacks. Formulating antibodies in nanoparticles can minimize these drawbacks and enhance drug targeting.
Article
Pharmacology & Pharmacy
Supriti Ghosh, Pradyumna Jayaram, Shama Prasada Kabekkodu, Kapaettu Satyamoorthy
Summary: Cervical cancer is a prevalent cancer among women worldwide, but it can be preventable. Nanotechnology has provided a solution for targeted drug delivery due to the limitations of conventional chemotherapeutics. This review summarizes various drug delivery approaches and nanocarriers, their advantages, limitations, and potential applications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Deepak Ganesh, Prashant Jain, Chethan Devanur Shanthamurthy, Suraj Toraskar, Raghavendra Kikkeri
Summary: Selectins are glycoproteins expressed on activated platelets, endothelial cells, and leukocytes, playing a role in early detection and inhibition of inflammatory diseases. Functionalization of selectin-binding ligands on multivalent probes can inhibit selectin-mediated biological activity and enable direct imaging of inflammation sites.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ying Huang, Lei Wang, Zhiyang Cheng, Biyu Yang, Jiahui Yu, Yi Chen, Wei Lu
Summary: The novel Mal-glu-SN38 prodrug showed selective delivery of SN38 to tumour sites and enhanced efficacy. With slower plasma clearance, increased drug exposure over time, and enhanced accumulation at the tumour site, Mal-glu-SN38 significantly delayed tumour growth after multiple doses, leading to an impressive reduction or even disappearance of tumours without observable side effects in 67% of mice.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Zhen Xu, Tianhui Shi, Fengye Mo, Wenqian Yu, Yu Shen, Qunying Jiang, Fuan Wang, Xiaoqing Liu
Summary: In this study, programmable DNA-protein superstructures were successfully assembled through biomimetic assembly, by combining programmable polymer DNA wire with alkaline protein protamine to form densely packed DNA nanospheres. These DNA-protein superstructures exhibited specifically high affinity and stability, enabling high cancer cell selectivity and reduced side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Ke Wang, Ruoyu Shen, Tingting Meng, Fuqiang Hu, Hong Yuan
Summary: Colorectal cancer is a common malignancy with high occurrence and mortality rates. Nanoparticles, as valuable drug delivery systems, offer advantages in controlling drug release and targeting CRC. This review focuses on different targeting mechanisms and recent research progress of CRC-targeted nanoparticles, providing inspiration for the design of such nanoparticles.
Review
Medicine, Research & Experimental
Hamed Hosseinalizadeh, Mehrdad Mahmoodpour, Zahra Razaghi Bahabadi, Michael R. Hamblin, Hamed Mirzaei
Summary: This review summarizes the factors affecting the uptake of nanoparticles by neutrophils, and focuses on the interaction of magnetic mesoporous silica nanoparticles, liposomes, albumin nanoparticles, and PLGA nanoparticles with neutrophils.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Lucie Jamgotchian, Laurent Devel, Robert Thai, Lucie Poupel, Thierry Huby, Emmanuel Gautier, Wilfried Le Goff, Philippe Lesnik, Edmond Gravel, Eric Doris
Summary: We developed compact and stabilized micelles incorporating a synthetic LXR agonist prodrug for passive targeting of atherosclerotic lesions and therapeutic intervention. In vivo studies demonstrated favorable pharmacokinetics/biodistribution of the nanohybrid micelles and their ability to upregulate LXR target genes to some extent without altering lipid metabolism.
Article
Engineering, Biomedical
Lingying Wu, Yuling Wu, Xun Che, Dandan Luo, Jiaju Lu, Ruibo Zhao, Muhammed Zubair Iqbal, Quan Zhang, Xiumei Wang, Xiangdong Kong
Summary: This study recruited chitosan for selenium nanoparticles synthesis and developed a thermoresponsive nanocomposite hydrogel with the addition of glycerol phosphate. Incorporation of SeNPs in the hydrogel was found to improve its mechanical properties and antioxidant activity. The combination of these two technologies could be a promising antioxidant system for drug delivery and tissue engineering.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Engineering, Biomedical
Yonghe Zhang, Ruibo Zhao, Jia Liu, Hao Kong, Kebiao Zhang, Yuan-Ning Zhang, Xiangdong Kong, Quan Zhang, Yanli Zhao
Summary: The development of boron dipyrromethene (BDP)-based nanoparticles for activatable photodynamic therapy (PDT) shows promising results in achieving tumor penetration and specific recognition by cancer cells, while also allowing for efficient disassembly into single PS molecules for effective PDT under acidic conditions.
Article
Engineering, Biomedical
Bowen Chen, Jie Cao, Kebiao Zhang, Yuan-Ning Zhang, Jiaju Lu, Muhammad Zubair Iqbal, Quan Zhang, Xiangdong Kong
Summary: A BODIPY-HA NPs was prepared for combined cancer PDT and PTT, which exhibited better anticancer effect than PTT alone, suggesting a promising nanomedicine for synergistic cancer therapy.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Pharmacology & Pharmacy
Dandan Luo, Xiaochun Xu, M. Zubair Iqbal, Qingwei Zhao, Ruibo Zhao, Jabeen Farheen, Quan Zhang, Peiliang Zhang, Xiangdong Kong
Summary: A novel nanoparticle HAp-PEI/siKras was successfully fabricated for efficient targeted delivery of siRNA to pancreatic cancer cells, achieving successful gene silencing and tumor-targeted therapy. Experimental results confirmed its effectiveness in inhibiting pancreatic cancer cell proliferation in vitro, while exhibiting no cytotoxicity towards normal pancreatic cells.
Article
Biochemistry & Molecular Biology
Marle E. J. Vleugels, Silvia Varela-Aramburu, Bas F. M. de Waal, Sandra M. C. Schoenmakers, Beatriz Maestro, Anja R. A. Palmans, Jesus M. Sanz, E. W. Meijer
Summary: The key to achieving functionality in nature lies in dynamic binding events driven by electrostatic or hydrophobic interactions. Synthetic supramolecular polymers based on benzene-1,3,5-tricarboxamide (BTA) motif show promise in mimicking this dynamicity. Functional monomers incorporating choline or atropine groups exhibit enhanced binding capabilities with essential choline-binding proteins, with copolymerization leading to dynamic fibers with increased affinity toward CBPs. This highlights the potential of BTA-based supramolecular copolymers for designing bioactive and dynamic materials with novel biotechnological properties.
Article
Biochemistry & Molecular Biology
Silvia Varela-Aramburu, Lu Su, Jesus Mosquera, Giulia Morgese, Sandra M. C. Schoenmakers, Ruth Cardinaels, Anja R. A. Palmans, E. W. Meijer
Summary: The study demonstrated the assembly of water-soluble benzene-1,3,5- tricarboxamides (BTAs) to create biomaterials with tunable stiffness during co-assembly, indicating the potential for creating dynamic complex biomaterials by forming fibers and hydrogel structures through coassembly of supramolecular polymers with polysaccharides such as hyaluronic acid.
Article
Biophysics
Yuan-Ning Zhang, Ruibo Zhao, Jie Cao, Bowen Chen, Dandan Luo, Jiaju Lu, Muhammed Zubair Iqbal, Quan Zhang, Xiangdong Kong
Summary: The study demonstrates that heptamannosylated beta-cyclodextrin derivatives can induce M2 macrophage polarization and promote wound healing, showing potential therapeutic effects in inhibiting inflammation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Biomaterials
Yuxin Wang, Daliang Zhong, Fan Xie, Siying Chen, Zaiqiang Ma, Xinyan Yang, M. Zubair Iqbal, Quan Zhang, Jiaju Lu, Shibo Wang, Ruibo Zhao, Xiangdong Kong
Summary: In this study, a one-step method for the preparation of manganese phosphate-doxorubicin nanomedicines was proposed by manganese ion and doxorubicin complexation. The nanocomplexes exhibited controlled sizes and shapes, and the drug molecules were integrated into the nanocarriers by mimetic mineralization, allowing for high-efficiency drug release and achieving significant cancer inhibition.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Jie Cao, Yonghe Zhang, Wenjun Shi, Lehan Du, Zhihua Cui, Shujie Liu, Ruibo Zhao, Shibo Wang, Quan Zhang, Xiangdong Kong
Summary: The development and use of mitochondria-targeted photosensitizers hold great promise for enhancing the efficacy of photodynamic therapy. This study synthesized boron dipyrromethene (BODIPY) photosensitizers conjugated with pyridine cations and encapsulated them with liposomal nanoparticles for increased stability. The results showed that one of the photosensitizers had the highest efficiency for targeted delivery to mitochondria and effectively inhibited tumor growth.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Liang Luan, Lehan Du, Wenjun Shi, Yunhui Li, Quan Zhang
Summary: In this study, a ligand containing benzoselenadiazole was designed and synthesized to construct a benzoselenadiazole-doped metal-organic framework (Se-MOF). The Se-MOF exhibited regular crystallinity and high porosity and effectively killed bacteria and inhibited the formation of bacterial biofilms under visible-light irradiation.
Article
Chemistry, Multidisciplinary
Bingchen Zhang, Yuehua Wang, Shengtao Wang, Yan Tang, Zibo Li, Ling Lin, Yifen Wu, Zhiqiang Yu
Summary: The study introduces a self-uncloaking nanoassembly named SRC that utilizes a dual-prodrug and a ROS-responsive probe to achieve efficient imaging and targeted release. It combines immunogenic cell death induction with RNA editing targeting to regulate immune checkpoint TIM3, resulting in synergistic activation of innate and adaptive immunity. This neoadjuvant strategy shows promise in enhancing CRC immunotherapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shengtao Wang, Kunyi Yu, Zhiyu Yu, Bingchen Zhang, Chaojie Chen, Ling Lin, Zibo Li, Zhongjun Li, Yuhua Zheng, Zhiqiang Yu
Summary: A self-delivery carrier for prodrugs, which can respond to the tumor microenvironment, shows potential to improve the challenges in clinical application of therapeutic drugs. The carrier can specifically release prodrugs in tumor cells with high levels of reactive oxygen species (ROS), minimizing side effects on normal cells. Furthermore, it optimizes the metabolism of the drug and induces apoptosis of tumor cells, achieving a synergistic anti-tumor effect.
CHINESE CHEMICAL LETTERS
(2023)
Article
Pharmacology & Pharmacy
Lehan Du, Wenjun Shi, Xin Hao, Liang Luan, Shibo Wang, Jiaju Lu, Quan Zhang
Summary: Photosensitive metal-organic framework (MOF) nanoparticles were developed to enhance the penetration of antibiotics into bacterial biofilms, achieving the eradication of biofilms through synergistic photodynamic and antibiotic therapy.
Article
Materials Science, Biomaterials
Zhe Tang, Israt Ali, Yike Hou, Ozioma Udochukwu Akakuru, Quan Zhang, Asim Mushtaq, Han Zhang, Yuguang Lu, Xuehua Ma, Jian Ge, M. Zubair Iqbal, Xiangdong Kong
Summary: In this study, a nanotheranostic agent based on plasmonic nanostructures was developed for tumor-targeted NIR-II photothermal-augmented nanocatalytic therapy. The agent exhibited excellent targeting ability and photothermal conversion efficiency, as well as peroxidase and catalase activities for catalytic therapy and relieving tumor hypoxia. In vivo experiments demonstrated remarkable therapeutic effects of the agent on tumors.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Daliang Zhong, Yuxin Wang, Fan Xie, Siying Chen, Xinyan Yang, Zaiqiang Ma, Shibo Wang, M. Zubair Iqbal, Jian Ge, Quan Zhang, Ruibo Zhao, Xiangdong Kong
Summary: Photothermal therapy using Prussian blue (PB) as a reagent has promising potential for cancer treatment. However, the low conversion efficiency and stability of PB hinder its translational potential. By integrating PB with calcium phosphate (CaP) through biomineralization, the photothermal performance and stability of PB can be significantly improved.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
