Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition

Right Ventricular Fibrosis

(2019) Stine Andersen et al.   CIRCULATION

Integration of Metabolomics and Transcriptomics Reveals the Therapeutic Mechanism Underlying Paeoniflorin for the Treatment of Allergic Asthma

(2019) Qiyang Shou et al.   Frontiers in Pharmacology

The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6′-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases

(2019) Jiajie Tu et al.   Frontiers in Pharmacology

Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoA/ROCK Signaling in Glioblastoma

(2019) Guoyong Yu et al.   Biomed Research International

Paeoniflorin improves pressure overload-induced cardiac remodeling by modulating the MAPK signaling pathway in spontaneously hypertensive rats

(2019) Xin Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Potential Role of Cartilage Oligomeric Matrix Protein in the Modulation of Pulmonary Arterial Smooth Muscle Superoxide by Hypoxia

(2019) Hang Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Paeoniflorin protects against intestinal ischemia/reperfusion by activating LKB1/AMPK and promoting autophagy

(2019) Jin Wen et al.   PHARMACOLOGICAL RESEARCH

Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension

(2018) Toshio Suzuki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration

(2018) Hui Zhang et al.   CIRCULATION RESEARCH

Paeoniflorin ameliorates collagen-induced arthritis via suppressing nuclear factor-κ B signalling pathway in osteoclast differentiation

(2018) Haiyan Xu et al.   IMMUNOLOGY

Effects of sulfur-fumigation on the pharmacokinetics, metabolites and analgesic activity of Radix Paeoniae Alba

(2018) Ming Kong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Paeoniflorin prevents endoplasmic reticulum stress-associated inflammation in lipopolysaccharide-stimulated human umbilical vein endothelial cells via the IRE1α/NF-κB signaling pathway

(2018) Juan Chen et al.   Food & Function

Toll-like Receptor 3 is a Therapeutic Target for Pulmonary Hypertension

(2018) Daniela Farkas et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TGFβ and BMPRII signalling pathways in the pathogenesis of pulmonary arterial hypertension

(2018) Birger Tielemans et al.   DRUG DISCOVERY TODAY

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

(2018) Marc Humbert et al.   EUROPEAN RESPIRATORY JOURNAL

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Clinical trial design and new therapies for pulmonary arterial hypertension

(2018) Olivier Sitbon et al.   EUROPEAN RESPIRATORY JOURNAL

Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series)

(2017) Benoît Ranchoux et al.   Pulmonary Circulation

Paeoniflorin suppresses TGF-β mediated epithelial-mesenchymal transition in pulmonary fibrosis through a Smad-dependent pathway

(2016) Yu Ji et al.   ACTA PHARMACOLOGICA SINICA

A Selective Transforming Growth Factor-β Ligand Trap Attenuates Pulmonary Hypertension

(2016) Lai-Ming Yung et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target SlugCLINICAL PERSPECTIVE

(2016) Rachel K. Hopper et al.   CIRCULATION

Paeoniflorin prevents hypoxia-induced epithelial–mesenchymal transition in human breast cancer cells

(2016) Zhenyu Zhou et al.   OncoTargets and Therapy

BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis

(2016) Jonathan D W Evans et al.   Lancet Respiratory Medicine

Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2015) Robert B. Good et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

(2015) B. Ranchoux et al.   CIRCULATION

Hypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells

(2015) Yan Zeng et al.   Scientific Reports

SuHx rat model: partly reversible pulmonary hypertension and progressive intima obstruction

(2014) M. A. de Raaf et al.   EUROPEAN RESPIRATORY JOURNAL

Paeoniflorin of Paeonia lactiflora prevents renal interstitial fibrosis induced by unilateral ureteral obstruction in mice

(2013) Junnan Zeng et al.   PHYTOMEDICINE

Paeoniflorin protects human EA.hy926 endothelial cells against gamma-radiation induced oxidative injury by activating the NF-E2-related factor 2/heme oxygenase-1 pathway

(2013) Jing Yu et al.   TOXICOLOGY LETTERS

Critical Role for the Advanced Glycation End‐Products Receptor in Pulmonary Arterial Hypertension Etiology

(2013) Jolyane Meloche et al.   Journal of the American Heart Association

Protective effects of paeoniflorin against cobalt chloride-induced apoptosis of endothelial cells via HIF-1α pathway

(2012) Qiaoli Ji et al.   TOXICOLOGY IN VITRO

BMPR2 expression is suppressed by signaling through the estrogen receptor

(2012) Eric D Austin et al.   Biology of Sex Differences

Targeted gene delivery of BMPR2 attenuates pulmonary hypertension

(2011) A. M. Reynolds et al.   EUROPEAN RESPIRATORY JOURNAL