期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 52, 页码 18729-18732出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201604256
关键词
4-aryl-2-quinolinone; carbon dioxide fixation; heterocycles; multi-component reaction; N-tosylhydrazone
资金
- National Natural Science Foundation of China [21272028, 21572025, 21602019]
- Innovation & Entrepreneurship Talents Introduction Plan of Jiangsu Province
- Key University Science Research Project of Jiangsu Province [15KJA150001]
- Jiangsu Key Laboratory of Advanced Catalytic Materials Technology [BM2012110]
- Advanced Catalysis and Green Manufacturing Collaborative Innovation Center
- Young Natural Science Foundation of Jiangsu Province [BK20150263]
A palladium-catalyzed three-component reaction between N-tosylhydrazones, 2-iodoanilines and atmospheric pressure CO2 was developed whereby a tandem carbene migration insertion/lactamization strategy afforded 4-aryl-2-quinolinones in moderate to good yields. Notably, a wide range of functional groups were tolerated in this procedure. This protocol features the simultaneous formation of four novel bonds; two C-C, one C=C and one C-N (amide), representing an efficient methodology for incorporation of CO2 into heterocycles.
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