4.8 Article

Water-Accelerated Nickel-Catalyzed α-Crotylation of Simple Ketones with 1,3-Butadiene under pH and Redox-Neutral Conditions

期刊

ACS CATALYSIS
卷 10, 期 7, 页码 4238-4243

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acscatal.0c00019

关键词

nickel; 1,3-butadiene; crotylation; ketone; pH-neutral; atom-economy

资金

  1. Natural Science Foundation of China [NSFC: 21772043]
  2. Natural Science Foundation [CHE-1855556]
  3. Shanghai Pujiang program [19PJ1403000]

向作者/读者索取更多资源

We report a nickel/NHC-catalyzed branched-selective acrotylation of simple ketones using 1,3-butadiene as the alkylation agent. This reaction is regioselective and operated under pH and redox-neutral conditions. Water was used as the sole additive, which significantly accelerates the transformation.

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