A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision

How the cell cycle clock ticks

(2019) Mihkel Örd et al.   MOLECULAR BIOLOGY OF THE CELL

Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle

(2019) Mihkel Örd et al.   MOLECULAR CELL

Multisite phosphorylation code of CDK

(2019) Mihkel Örd et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CDK and MAPK Synergistically Regulate Signaling Dynamics via a Shared Multi-site Phosphorylation Region on the Scaffold Protein Ste5

(2018) María Victoria Repetto et al.   MOLECULAR CELL

Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe

(2018) Matthew P. Swaffer et al.   Cell Reports

The Temporal Ordering of Cell-Cycle Phosphorylation

(2017) Julia Kamenz et al.   MOLECULAR CELL

TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1

(2017) Marta Moreno-Torres et al.   Cell Discovery

CDK Substrate Phosphorylation and Ordering the Cell Cycle

(2016) Matthew P. Swaffer et al.   CELL

Cryptic sequence features within the disordered protein p27Kip1regulate cell cycle signaling

(2016) Rahul K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Variation in Arabidopsis Cvi-0 Accession Reveals an Important Role of MPK12 in Guard Cell CO2 Signaling

(2016) Liina Jakobson et al.   PLOS BIOLOGY

Compartmentalization of a Bistable Switch Enables Memory to Cross a Feedback-Driven Transition

(2015) Andreas Doncic et al.   CELL

The Activity and Stability of the Intrinsically Disordered Cip/Kip Protein Family AreRegulated by Non-Receptor TyrosineKinases

(2015) Yongqi Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

TORC1 controls G1–S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway

(2015) Marta Moreno-Torres et al.   Nature Communications

A single cyclin–CDK complex is sufficient for both mitotic and meiotic progression in fission yeast

(2015) Pilar Gutiérrez-Escribano et al.   Nature Communications

Multistep phosphorylation systems: tunable components of biological signaling circuits

(2014) Evin Valk et al.   MOLECULAR BIOLOGY OF THE CELL

Functional overlap among distinct G1/S inhibitory pathways allows robust G1 arrest by yeast mating pheromones

(2013) Patricia A. Pope et al.   MOLECULAR BIOLOGY OF THE CELL

Feedforward Regulation Ensures Stability and Rapid Reversibility of a Cellular State

(2013) Andreas Doncic et al.   MOLECULAR CELL

Cks confers specificity to phosphorylation-dependent CDK signaling pathways

(2013) Denise A McGrath et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multisite phosphorylation networks as signal processors for Cdk1

(2013) Mardo Kõivomägi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Algorithm to Automate Yeast Segmentation and Tracking

(2013) Andreas Doncic et al.   PLoS One

Design Principles of the Yeast G1/S Switch

(2013) Xiaojing Yang et al.   PLOS BIOLOGY

Mechanism of Cell Cycle Entry Mediated by the Intrinsically Disordered Protein p27Kip1

(2012) Li Ou et al.   ACS Chemical Biology

Motif switches: decision-making in cell regulation

(2012) Kim Van Roey et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Double-negative feedback between S-phase cyclin-CDK and CKI generates abruptness in the G1/S switch

(2012) Rainis Venta et al.   Frontiers in Physiology

Incomplete Folding upon Binding Mediates Cdk4/Cyclin D Complex Activation by Tyrosine Phosphorylation of Inhibitor p27 Protein

(2011) Li Ou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Interactions Select and Maintain a Specific Cell Fate

(2011) Andreas Doncic et al.   MOLECULAR CELL

Dynamics of Cdk1 Substrate Specificity during the Cell Cycle

(2011) Mardo Kõivomägi et al.   MOLECULAR CELL

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase

(2011) Mardo Kõivomägi et al.   NATURE

An overview of Cdk1-controlled targets and processes

(2010) Jorrit M Enserink et al.   Cell Division

Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution

(2009) L. J. Holt et al.   SCIENCE

Role of Intrinsic Flexibility in Signal Transduction Mediated by the Cell Cycle Regulator, p27Kip1

(2008) Charles A. Galea et al.   JOURNAL OF MOLECULAR BIOLOGY

Positive feedback of G1 cyclins ensures coherent cell cycle entry

(2008) Jan M. Skotheim et al.   NATURE