Article
Cell Biology
Meiting Li, Jiannan Xiong, Liqian Yang, Jie Huang, Yu Zhang, Minghui Liu, Lina Wang, Jianguo Ji, Ying Zhao, Wei-Guo Zhu, Jianyuan Luo, Haiying Wang
Summary: The study reveals a new function of p62 in base excision repair, distinct from its known functions. Loss of p62 impairs repair capacity and increases cancer cell sensitivity to alkylating and oxidizing agents. Therefore, targeting p62 may have potential for cancer therapeutics.
Article
Multidisciplinary Sciences
Qixin Wang, Isaac Kirubakaran Sundar, Joseph H. Lucas, Jun-Gyu Park, Aitor Nogales, Luis Martinez-Sobrido, Irfan Rahman
Summary: The molecular clock REV-ERB alpha plays a central role in regulating lung injuries and its decreased abundance exacerbates fibrotic progression. This study reveals that REV-ERB alpha interacts with the lysyl oxidase-collagen axis during fibrogenesis and demonstrates the therapeutic potential of Rev-erb alpha agonist against lung fibrosis.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Aldo Meizoso-Huesca, Luke Pearce, Christopher J. Barclay, Bradley S. Launikonis
Summary: This study reveals the role of RyR1 Ca2+ leak in generating heat at SR Ca2+ pump in resting muscle. The RyR1 Ca2+ leak increases cytosolic [Ca2+] near SR Ca2+ pump, amplifying thermogenesis. The gene-dose-dependent increase in RyR1 leak leads to progressive rise in leak-dependent heat. Moreover, fibers from mice exhibit greater basal RyR Ca2+ leak and heat generated by SR Ca2+ pump compared to toads.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Diego R. Coelho, Flavio R. Palma, Veronica Paviani, Katy M. LaFond, Yunping Huang, Dongmei Wang, Brian Wray, Sridhar Rao, Feng Yue, Marcelo G. Bonini, Benjamin N. Gantner
Summary: Suppressor of cytokine signaling-1 (SOCS1) controls inflammation by degrading p65 NF-κB in addition to its canonical role. However, SOCS1 selectively targets a subset of pro-inflammatory genes. The interaction between SOCS1 and p65 at promoters determines the genes activated by NF-κB during systemic inflammation, leading to significant effects on cytokine responses, immune cell mobilization, and tissue injury.
Article
Multidisciplinary Sciences
Jin-Seon Yook, Mikyoung You, Jiyoung Kim, Ashley M. Toney, Rong Fan, Bhanwar Lal Puniya, Tomas Helikar, Sophie Vaulont, Jean-Christophe Deschemin, Meshail Okla, Liwei Xie, Manik C. Ghosh, Tracey A. Rouault, Jaekwon Lee, Soonkyu Chung
Summary: This study investigates the iron-regulatory network underlying beige adipogenesis, showing that thermogenic stimulus leads to redistribution of iron into beige fat through interplay between adipocyte iron demands and systemic iron liberation. Disruption of systemic iron homeostasis impairs beige fat development, suggesting coordinated interplay between renal hypoxia and hepcidin down-regulation as a key mechanism for activating adaptive thermogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Melanie A. Sultana, Carmel Cluning, Wai-Sin Kwong, Nicole Polain, Nathan J. Pavlos, Thomas Ratajczak, John P. Walsh, Jiake Xu, Sarah L. Rea
Summary: Ajuba and SQSTM1/p62 play crucial roles in regulating NF-kappa B signaling, with SQSTM1/p62 protecting Ajuba from degradation by autophagy. This interaction impacts cellular functions and disease pathogenesis, highlighting the importance of SQSTM1/p62 in modulating Ajuba-mediated signaling pathways.
Article
Multidisciplinary Sciences
Shuang-Zhou Peng, Xiao-Hui Chen, Si-Jie Chen, Jie Zhang, Chuan-Ying Wang, Wei-Rong Liu, Duo Zhang, Ying Su, Xiao-Kun Zhang
Summary: The study reveals that Nur77 and p62/SQSTM1 form membraneless condensates through head-to-head and tail-to-tail interactions, capable of sequestering dysfunctional mitochondria and tethering them to autolysosome for degradation.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Anna Goddi, Alanis Carmona, Soo-Young Park, Gokhan Dalgin, Maria A. Gonzalez Porras, Eric M. Brey, Ronald N. Cohen
Summary: This study found that LAMA4 negatively regulates thermogenic phenotype and pathways involving mitochondrial biogenesis in adipocytes through the suppression of AMPK alpha.
Article
Multidisciplinary Sciences
Sayaka Saijo, Mikiko Ohno, Hirotaka Iwasaki, Shintaro Matsuda, Kiyoto Nishi, Yoshinori Hiraoka, Natsuki Ide, Takeshi Kimura, Eiichiro Nishi
Summary: The present results demonstrate that NRDC in BAT controls adaptive thermogenesis and body temperature homeostasis possibly via the regulation of UCP1 protein stability and ROS levels.
SCIENTIFIC REPORTS
(2022)
Article
Nanoscience & Nanotechnology
Qin Zhao, Miusi Shi, Chengcheng Yin, Zifan Zhao, Jinglun Zhang, Jinyang Wang, Kailun Shen, Lingling Zhang, Hua Tang, Yin Xiao, Yufeng Zhang
Summary: The study reveals that biomaterials, such as biphasic calcium phosphate scaffolds, can promote osteogenesis by modulating the immune responses of macrophages and dendritic cells. This demonstrates that specific regulatory capacities for immune cells in biomaterials can control early inflammatory responses of implanted materials and induce bone formation.
NANO-MICRO LETTERS
(2021)
Article
Multidisciplinary Sciences
Lasse K. Markussen, Elizabeth A. Rondini, Olivia Sveidahl Johansen, Jesper G. S. Madsen, Elahu G. Sustarsic, Ann-Britt Marcher, Jacob B. Hansen, Zachary Gerhart-Hines, James G. Granneman, Susanne Mandrup
Summary: This study uncovers the transcriptional network controlled by lipolysis in brown adipocytes and shows that lipolysis is required for the activation of the thermogenic gene program by beta-adrenergic signals. PPARs are identified as key mediators of lipolysis-induced activation of lipid metabolism and thermogenic genes. Additionally, lipolysis also activates the unfolded protein response and regulates the core circadian transcriptional machinery independently of PPARs.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Yu-Ting Tian, Li-Ping Ma, Chun-Yan Ding, Meng-Meng Liu, Si-Nian Wang, Mei Tian, Ling Gao, Qing-Jie Liu
Summary: This study found that ionizing radiation can induce premature senescence and autophagy in lung adenocarcinoma cells. Autophagy regulates X-ray radiation-induced premature senescence through the STAT3-Beclin1-p62 pathway in lung adenocarcinoma cells.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Aaron M. Hosios, Meghan E. Wilkinson, Molly C. McNamara, Krystle C. Kalafut, Margaret E. Torrence, John M. Asara, Brendan D. Manning
Summary: Inhibition of mTORC1 leads to accumulation of intracellular triglycerides through lysosome-dependent hydrolysis of phospholipid fatty acids. The liberated fatty acids can be used for triglyceride synthesis or beta-oxidation.
Article
Chemistry, Multidisciplinary
Nianyuan Shi, Jing Wang, Shaoxin Tang, Hui Zhang, Zhao Wei, Ang Li, Yufei Ma, Feng Xu
Summary: This study observed a nonlinear viscoelastic feature in normal skeletal muscles and investigated its effects on myoblast response. The strain-enhanced stress relaxation (SESR) promoted myogenesis by affecting nuclear localization and mechanotransduction. This research provides new opportunities for tissue injury treatments.
Article
Biochemistry & Molecular Biology
Bailing Zhao, Meihong Liu, Huimin Liu, Jiahan Xie, Jie Yan, Xiaobo Hou, Jingsheng Liu
Summary: ZEA stimulates the browning of adipocytes by increasing the expression of specific markers, while also promoting mitochondrial biogenesis to reduce lipid accumulation and improve energy metabolism. The promotion of browning and mitochondrial biogenesis by ZEA suggests potential therapeutic effects on obesity.
Review
Radiology, Nuclear Medicine & Medical Imaging
Judith Herrmann, Daniel Wessling, Dominik Nickel, Simon Arberet, Haidara Almansour, Carmen Afat, Saif Afat, Sebastian Gassenmaier, Ahmed E. Othman
Summary: This study evaluated the clinical performance of a deep learning-accelerated single-breath-hold half-Fourier acquisition single-shot turbo spin echo (HASTEDL)-sequence for T2-weighted fat-suppressed MRI of the abdomen at 1.5 T and 3 T, compared to the standard T2-weighted fatsuppressed multi-shot turbo spin echo-sequence. HASTEDL showed excellent image quality, good diagnostic confidence, and lesion detection capability, with a significant reduction in acquisition time compared to the standard sequence.
ACADEMIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haidara Almansour, Judith Herrmann, Sebastian Gassenmaier, Andreas Lingg, Marcel Dominik Nickel, Stephan Kannengiesser, Simon Arberet, Ahmed E. Othman, Saif Afat
Summary: The study aimed to investigate the impact of a deep learning-based super-resolution reconstruction algorithm on acquisition time and image quality for abdominal MRI. The results showed that the algorithm reduced breath-hold time, improved image sharpness and lesion conspicuity, without compromising image quality or diagnostic confidence.
ACADEMIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maryanna Chaika, Saif Afat, Daniel Wessling, Carmen Afat, Dominik Nickel, Stephan Kannengiesser, Judith Herrmann, Haidara Almansour, Simon Maennlin, Ahmed E. Othman, Sebastian Gassenmaier
Summary: The purpose of this study was to evaluate the impact of a deep learning-based super-resolution technique on the assessment of pancreatic MRI. The results indicated that the newly developed algorithm improved both the examination time and image quality in pancreatic MRI.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haidara Almansour, Judith Herrmann, Sebastian Gassenmaier, Saif Afat, Johann Jacoby, Gregor Koerzdoerfer, Dominik Nickel, Mahmoud Mostapha, Mariappan Nadar, Ahmed E. Othman
Summary: This study investigates the application of deep learning-based MRI reconstruction in spine MRI and finds that the deep learning reconstruction method can be interchangeable with the standard MRI method, with shorter examination time and excellent image quality.
Article
Endocrinology & Metabolism
Kimberly Begemann, Isabel Heyde, Pia Witt, Julica Inderhees, Brinja Leinweber, Christiane E. Koch, Olaf Joehren, Rebecca Oelkrug, Arkadiusz Liskiewicz, Timo D. Mueller, Henrik Oster
Summary: Snacking during the rest phase leads to weight gain and disruption of metabolic circadian rhythms, while snacking during the active phase does not have the same effect.
MOLECULAR METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Guenter A. Mueller, Timo D. Mueller
Summary: Glycosylphosphatidylinositol (GPI)-anchored proteins (APs) are expressed in all eukaryotic organisms and exert main physiological roles in intercellular transfer via extracellular vesicles and lipoprotein-like particles. Non-vesicular transfer is controlled by various factors and can occur directly or indirectly. This transfer induces phenotypes such as lipid and glycogen synthesis, suggesting its non-genetic inheritance nature based on the transmission of matter rather than information.
Article
Medicine, General & Internal
Giuseppe Mauro Bucolo, Tommaso D'Angelo, Ibrahim Yel, Vitali Koch, Leon D. Gruenewald, Ahmed E. Othman, Leona Soraja Alizadeh, Daniel P. Overhoff, Stephan Waldeck, Simon S. Martin, Silvio Mazziotti, Giorgio Ascenti, Alfredo Blandino, Thomas J. Vogl, Christian Booz
Summary: This study evaluated the impact of low-energy dual-energy CT (DECT) virtual mono-energetic imaging (VMI+) on quantitative and qualitative image quality in the evaluation of lower extremity vascular disease. The results showed that 40-keV and 55-keV VMI+ reconstructions had the highest objective and subjective parameters of image quality, respectively. Therefore, it is recommended to use these specific energy levels for VMI+ reconstructions in clinical practice to provide high-quality images for the evaluation of lower extremity vascular disease and potentially reduce the amount of contrast medium required.
Article
Medicine, General & Internal
Abdullah Jabas, Mario Alberto Abello Mercado, Sebastian Altmann, Florian Ringel, Christian Booz, Andrea Kronfeld, Antoine P. Sanner, Marc A. Brockmann, Ahmed E. Othman
Summary: The purpose of this study was to evaluate the effects of single-energy metal artifact reduction (SEMAR) on the image quality of ultra-high-resolution CT-angiography (UHR-CTA) in patients with intracranial implants after aneurysm treatment. The results showed that SEMAR significantly reduced metal artifacts and improved image quality in UHR-CTA images. SEMAR was more effective in patients with coils than in patients with titanium clips. The study concluded that SEMAR can effectively reduce metal artifacts and enhance diagnostic confidence in UHR-CTA with intracranial implants.
Article
Multidisciplinary Sciences
Natascha Gruenebach, Mario Alberto Abello Mercado, Nils F. Grauhan, Antoine Sanner, Andrea Kronfeld, Sergiu Groppa, Vanessa Ines Schoeffling, Tom Hilbert, Marc A. Brockmann, Ahmed E. Othman
Summary: This study evaluated the feasibility and robustness of an accelerated T2 mapping sequence (GRAPPATINI) in brain imaging and compared its synthetic T2-weighted images (sT2w) with a standard T2-weighted sequence (T2 TSE). The results showed that GRAPPATINI is a feasible and robust T2 mapping sequence of the brain, and its resulting sT2w can be compared with T2 TSE despite its inferior image quality.
Letter
Endocrinology & Metabolism
Jens Lund, Valdemar Brimnes Ingemann Johansen, Christoffer Clemmensen, Zachary Gerhart-Hines
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Anders Bue Klein, Pablo Ranea-Robles, Trine Sand Nicolaisen, Claudia Gil, Kornelia Johann, Julia Prats Quesada, Nina Pistolevij, Kathrine V. R. Hviid, Line Fich, Simone M. Offersen, Jorn Wulff Helge, Henriette Svarre Nielsen, Jaco Bakker, Maximilian Kleinert, Christoffer Clemmensen
Summary: Growth differentiation factor 15 (GDF15) is a stress-induced cytokine that may play a potential role in pregnancy. While mice and rats have a limited response to pregnancy, macaques and humans exhibit significant increases in GDF15 levels. These species-specific findings provide valuable insights for future research on GDF15 in pregnancy and for developing pharmacological strategies to treat severe nausea and hyperemesis gravidarum (HG).
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Medicine, General & Internal
Sebastian Werner, Dominik Zinsser, Michael Esser, Dominik Nickel, Konstantin Nikolaou, Ahmed E. Othman
Summary: Enhanced image processing using complex averaging can reduce artifacts, noise, and distortion in diffusion-weighted images and synthesized high b-value images, resulting in higher image quality and better detection of potentially malignant lesions.
Article
Oncology
Haidara Almansour, Fritz Schick, Marcel Nachbar, Saif Afat, Victor Fritz, Daniela Thorwarth, Daniel Zips, Felix Bertram, Arndt-Christian Mueller, Konstantin Nikolaou, Ahmed E. Othman, Daniel Wegener
Summary: This study investigated the dynamics of lesion ADC in patients with prostate cancer undergoing MR-guided radiation therapy on a 1.5T MR-Linac. The results showed a significant increase in lesion ADC during radiotherapy, suggesting that lesion ADC can be used as a biomarker for evaluating treatment response. However, the absolute ADC values calculated by the algorithm of the MR-Linac manufacturer showed systematic deviations from values obtained on a diagnostic 3T MRI system.
RADIOLOGY AND ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Eva Rial-Pensado, Laurence Canaple, Romain Guyot, Christoffer Clemmensen, Joelle Wiersema, Shijia Wu, Sabine Richard, Anita Boelen, Timo D. Mueller, Miguel Lopez, Frederic Flamant, Karine Gauthier
Summary: Thyroid hormone signaling in neurons plays an important role in stimulating energy expenditure and limiting weight gain in response to high-fat diet. Mice with dysfunctional thyroid hormone receptors in neurons exhibit impaired thermogenic potential and increased susceptibility to diet-induced obesity. However, their ability to respond to cold exposure remains unaffected. This study provides genetic evidence for the significance of thyroid hormone signaling in neurons for energy regulation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gabriel Keller, Arne Estler, Judith Herrmann, Saif Afat, Ahmed E. E. Othman, Dominik Nickel, Gregor Koerzdoerfer, Fabian Springer
Summary: This study evaluates the diagnostic performance of a deep learning-based accelerated TSE study protocol compared to a standard TSE study protocol in ankle MRI. The results show that DL TSE has high agreement with standard TSE in all analyzed structural pathologies and performs well in image quality. The total acquisition time of DL TSE is reduced by 48% compared to standard TSE.