Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

Glucose controls glucagon secretion by directly modulating cAMP in alpha cells

(2019) Qian Yu et al.   DIABETOLOGIA

Structural basis for delta cell paracrine regulation in pancreatic islets

(2019) Rafael Arrojo e Drigo et al.   Nature Communications

Regulated resurfacing of a somatostatin receptor storage compartment fine-tunes pituitary secretion

(2019) Walaa Alshafie et al.   JOURNAL OF CELL BIOLOGY

Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

(2018) Nikhil R. Gandasi et al.   Cell Metabolism

Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

(2017) Nikhil R. Gandasi et al.   JOURNAL OF CLINICAL INVESTIGATION

Imaging the recruitment and loss of proteins and lipids at single sites of calcium-triggered exocytosis

(2016) Adam J. Trexler et al.   MOLECULAR BIOLOGY OF THE CELL

Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging

(2016) Hongyan Shuai et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Glucose control of glucagon secretion—‘There’s a brand-new gimmick every year’

(2016) Erik Gylfe   UPSALA JOURNAL OF MEDICAL SCIENCES

Human islet function following 20 years of cryogenic biobanking

(2015) Jocelyn E. Manning Fox et al.   DIABETOLOGIA

Submembrane ATP and Ca2+ kinetics in α-cells: unexpected signaling for glucagon secretion

(2015) Jia Li et al.   FASEB JOURNAL

Na+current properties in islet α- and β-cells reflect cell-specificScn3aandScn9aexpression

(2014) Quan Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

(2014) Nikhil R. Gandasi et al.   Nature Communications

Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes

(2013) Quan Zhang et al.   Cell Metabolism

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells

(2012) Balrik Kailey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reduced Insulin Exocytosis in Human Pancreatic  -Cells With Gene Variants Linked to Type 2 Diabetes

(2012) A. H. Rosengren et al.   DIABETES

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Paracrine and autocrine interactions in the human islet: More than meets the eye

(2012) Alejandro Caicedo   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon

(2011) Bo Hellman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of Inverse Relationship Between Pulsatile Insulin and Glucagon Secretion in Patients With Type 2 Diabetes

(2011) B. A. Menge et al.   DIABETES

Minireview: Glucagon in the Pathogenesis of Hypoglycemia and Hyperglycemia in Diabetes

(2011) Philip E. Cryer   ENDOCRINOLOGY

Glucose-dependent docking and SNARE protein-mediated exocytosis in mouse pancreatic alpha-cell

(2011) Sofia A. Andersson et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

(2010) Yang Z. De Marinis et al.   Cell Metabolism

Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo

(2009) Dan Kawamori et al.   Cell Metabolism

Glutamate Is a Positive Autocrine Signal for Glucagon Release

(2008) Over Cabrera et al.   Cell Metabolism

Somatostatin Secreted by Islet  -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

(2008) A. C. Hauge-Evans et al.   DIABETES