Article
Virology
Maelle Locatelli, Suzanne Faure-Dupuy
Summary: In this review, the authors summarize the current knowledge of how viruses use epigenetic modifications to counteract host antiviral immune responses and discuss the potential use of epigenetic modulators in combating viral infections and virus-induced diseases.
JOURNAL OF VIROLOGY
(2023)
Article
Critical Care Medicine
Robert T. Mankowski, Ryan M. Thomas, Dijoia B. Darden, Raad Z. Gharaibeh, Russell B. Hawkins, Michael C. Cox, Camille Apple, Dina C. Nacionales, Ricardo F. Ungaro, Marvin L. Dirain, Fredrick A. Moore, Christiaan Leeuwenburgh, Scott C. Brakenridge, Thomas L. Clanton, Orlando Laitano, Lyle L. Moldawer, Alicia M. Mohr, Philip A. Efron
Summary: Old adult mice showed significant alterations in gut microbiota after infection, while young adult mice maintained stability. These microbiota changes may contribute to worse outcomes in older adults after sepsis. Further research is needed to explore potential therapeutic targets.
Review
Medicine, General & Internal
Dijoia B. Darden, Lauren S. Kelly, Brittany P. Fenner, Lyle L. Moldawer, Alicia M. Mohr, Philip A. Efron
Summary: Protocolized surveillance, diagnosis, and management of septic patients, especially surgical sepsis patients, can significantly increase the number of patients surviving their initial hospitalization. However, some patients may develop chronic critical illness, with elderly and comorbid patients being particularly susceptible to poor outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Astrid Fabri, Khalil Kandara, Remy Coudereau, Morgane Gossez, Paul Abraham, Celine Monard, Martin Cour, Thomas Rimmele, Laurent Argaud, Guillaume Monneret, Fabienne Venet
Summary: The study analyzed the impact of IL-10 production in septic patients' whole blood, revealing monocytes and CD4+ T cells as the main IL-10 producers associated with global immunosuppression in septic shock. Further research is needed to determine the pathophysiological mechanisms leading to increased IL-10 production in monocytes and CD4+ T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jose Luis Garcia-Gimenez, Eva Garcia-Lopez, Salvador Mena-Molla, Jesus Beltran-Garcia, Rebeca Osca-Verdegal, Elena Nacher-Sendra, Carmen Aguado-Velasco, German Casabo-Valles, Carlos Roma-Mateo, Maria Rodriguez-Gimillo, Oreto Antunez, Jose Ferreres, Federico V. Pallardo, Nieves Carbonell
Summary: This study validates a quantitative mass spectrometry method to measure circulating histone levels in plasma samples for the diagnosis and prognosis of sepsis and septic shock patients. In an extended laboratory testing, it was found that circulating histone levels are associated with the severity of patient conditions and can predict fatal outcomes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Neurosciences
Brandon Signal, Thalia Gabriela Perez Suarez, Phillippa C. Taberlay, Adele Woodhouse
Summary: Different cell types in the brain have distinct roles in the progression of Alzheimer's disease (AD). Epigenetic mechanisms can explain the genetic and environmental factors associated with AD, but analyzing purified cell populations or single cells is necessary. Studies have revealed that different cell types contribute and react differently to AD progression through epigenetic alterations.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Medicine, Research & Experimental
Yukun Liu, Dongfang Wang, Tianyu Li, Ligang Xu, Zhanfei Li, Xiangjun Bai, Manli Tang, Yuchang Wang
Summary: Septic myopathy, also known as ICU acquired weakness, is a clinical symptom of sepsis patients, characterized by muscle weakness and muscular atrophy, which affects respiratory and motor systems, reduces quality of life, and even threatens survival. Melatonin, a hormone secreted by the pineal gland, has multiple biological functions such as anti-inflammatory, antioxidant, and mitochondrial protection, and may play a role in the repair and regeneration of skeletal muscle atrophy in septic myopathy. This article critically discusses and reviews the effects of melatonin on sepsis and skeletal muscle depletion based on previous research results.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Yukun Liu, Yongsheng Zhang, Chuntao Wang, Qinxin Liu, Tianyu Li, Wei Wang, Fan Yang, Zhanfei Li, Xiangjun Bai, Yuchang Wang
Summary: The study investigated the effect of RK-33, a specific inhibitor of DDX3X, on the progression of sepsis to PICS. It was found that RK-33 reduced inflammation and oxidative stress, improved immunosuppression and skeletal muscle atrophy, and improved survival in septic mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Yupei Li, Dingyuan Wan, Xinyao Luo, Tao Song, Yiran Wang, Qiao Yu, Luojia Jiang, Ruoxi Liao, Weifeng Zhao, Baihai Su
Summary: Sepsis is a life-threatening condition caused by dysregulated host response to infection, with circulating histones playing a crucial role in inflammation amplification, organ injury, and coagulation activation. Elevated levels of circulating histones are closely correlated with disease severity and mortality in sepsis patients. Current anti-histone therapies offer promising approaches for sepsis treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Li Wen, Hong-Liu Yang, Lin Lin, Liang Ma, Ping Fu
Summary: This review highlights the role of epigenetic methylation in kidney disease and discusses the regulation and implication of DNA methylation, histone methylation, and non-histone methylation in various forms of kidney diseases.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Oncology
Erison Santana dos Santos, Vivian Petersen Wagner, Joab Cabral Ramos, Daniel W. Lambert, Rogerio Moraes Castilho, Adriana Franco Paes Leme
Summary: Head and neck cancer poses a global challenge with resistance to therapy and aggressive behavior. The tumor microenvironment and epigenetic events play crucial roles in the development of this cancer, offering potential new strategies for treatment. Further research into the modulation of the tumor microenvironment and epigenetic events could lead to innovative therapeutic approaches for managing head and neck cancer.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Oncology
Ariana Cabrera-Licona, X. Isidro Perez-Anorve, Mauricio Flores-Fortis, Oscar del Moral-Hernandez, H. Claudia Gonzalez-de la Rosa, Rocio Suarez-Sanchez, Margarita Chavez-Saldana, Elena Arechaga-Ocampo
Summary: Radiotherapy, along with surgery and systemic chemotherapy, is crucial in the clinical management of cancer, but radioresistance remains a major challenge. Epigenetic mechanisms regulating cancer hallmarks play a key role in the development of radiation resistance, and targeting these mechanisms can enhance treatment effectiveness.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jesus Beltran-Garcia, Juan J. Manclus, Eva M. Garcia-Lopez, Nieves Carbonell, Jose Ferreres, Maria Rodriguez-Gimillo, Concepcion Garces, Federico Pallardo, Jose L. Garcia-Gimenez, Angel Montoya, Carlos Roma-Mateo
Summary: The study evaluated the potential of chromatin-related biomarkers in decision making and outcome prediction, with HMGB1/citrullinated H3 determination in plasma showing the most promising clinical tool for monitoring and stratifying septic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Xiaoliang Zeng, Jihua Feng, Yanli Yang, Ruzhi Zhao, Qiao Yu, Han Qin, Lile Wei, Pan Ji, Hongyuan Li, Zimeng Wu, Jianfeng Zhang
Summary: This study identified key biomarkers associated with sepsis and septic shock through bioinformatic analysis, revealing up-regulated inflammatory and metabolic responses, along with down-regulated immune responses. The research also found decreased immune cell infiltration in sepsis patients, suggesting impaired immune function. Additionally, the expression of key genes was found to be modulated by DNA methylation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sara Monteiro-Reis, Vera Miranda-Goncalves, Catarina Guimaraes-Teixeira, Claudia Martins-Lima, Joao Lobo, Diana Montezuma, Paula C. Dias, Helene Neyret-Kahn, Isabelle Bernard-Pierrot, Rui Henrique, Carmen Jeronimo
Summary: In this study, we found that the VIM promoter is epigenetically regulated in normal and neoplastic urothelium, leading to a switch in VIM expression associated with EMT and the acquisition of invasive and metastatic properties. These findings might contribute to the development of novel therapeutic strategies for bladder cancer based on epigenetics.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Ignacio Martin-Loeches, Anna Motos, Rosario Menendez, Albert Gabarrus, Jessica Gonzalez, Laia Fernandez-Barat, Adrian Ceccato, Raquel Perez-Arnal, Dario Garcia-Gasulla, Ricard Ferrer, Jordi Riera, Jose Angel Lorente, Oscar Penuelas, Jesus F. Bermejo-Martin, David de Gonzalo-Calvo, Alejandro Rodriguez, Ferran Barbe, Luciano Aguilera, Rosario Amaya-Villar, Carme Barbera, Jose Barberan, Aaron Blandino Ortiz, Elena Bustamante-Munguira, Jesus Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalan-Gonzalez, Cristobal Galban, Victor D. Gumucio-Sanguino, Maria del Carmen de la Torre, Emili Diaz, Elena Gallego, Jose Luis Garcia Garmendia, Jose Garnacho-Montero, Jose M. Gomez, Ruth Noemi Jorge Garcia, Ana Loza-Vazquez, Judith Marin-Corral, Amalia Martinez de la Gandara, Ignacio Martinez Varela, Juan Lopez Messa, Guillermo M. Albaiceta, Mariana Andrea Novo, Yhivian Penasco, Pilar Ricart, Luis Urrelo-Cerron, Angel Sanchez-Miralles, Susana Sancho Chinesta, Lorenzo Socias, Jordi Sole-Violan, Luis Tamayo Lomas, Pablo Vidal, Antoni Torres
Summary: Persistent post-COVID-19 symptoms were found in more than two-thirds of patients, with female sex, duration of ICU stay, development of ICUAP, and ARDS identified as independent factors contributing to poor health post-COVID-19. Preventing ICUAP may have beneficial effects on post-COVID-19 recovery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jesus Beltran-Garcia, Rebeca Osca-Verdegal, Beatriz Javega, Guadalupe Herrera, Jose-Enrique O'connor, Eva Garcia-Lopez, German Casabo-Valles, Maria Rodriguez-Gimillo, Jose Ferreres, Nieves Carbonell, Federico Pallardo, Jose Luis Garcia-Gimenez
Summary: Sepsis is a life-threatening condition characterized by a malfunction of the immune system. This study aims to analyze the immune response in early stages of sepsis. The results show that the innate immune system attempts to counteract infection in the early stages of sepsis, while the adaptive immune system is not fully activated. Additionally, immunosuppressive responses and pro-coagulation signals are active in patients with septic shock.
Review
Biochemistry & Molecular Biology
Ahlam Fatmi, Wiam Saadi, Jesus Beltran-Garcia, Jose Luis Garcia-Gimenez, Federico Pallardo
Summary: Sepsis in newborns, especially preterm-born neonates, carries a significant risk of morbidity and mortality. Endothelial glycocalyx (eGC) shedding is an essential pathophysiological process in sepsis, contributing to microvascular dysfunction and organ failure. These processes have been extensively studied in adults, but are poorly understood in neonatal sepsis. Further research is needed to understand the composition, development, and mechanisms of eGC disruption in neonates, and to explore eGC dysfunction as a diagnostic and prognostic biomarker.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marisa Iborra, Ines Moret, Enrique Buso, Jose Luis Garcia-Gimenez, Elena Ricart, Javier P. Gisbert, Eduard Cabre, Maria Esteve, Lucia Marquez-Mosquera, Esther Garcia-Planella, Jordi Guardiola, Federico Pallardo, Carolina Serena, Francisco Algaba-Chueca, Eugeni Domenech, Pilar Nos, Belen Beltran
Summary: This study suggests an association between single nucleotide polymorphisms (SNPs) in the catalase (CAT) enzyme and the risk of Crohn's disease (CD) associated with high levels of oxidative stress. The inhibition of CAT activity in peripheral white mononuclear cells (PWMCs) of CD patients was related to low levels of CAT gene and protein expression caused by downregulation of CAT-gene transcription.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Carlos Roma-Mateo, Sheila Lorente-Pozo, Lucia Marquez-Thibaut, Mireia Moreno-Estelles, Concepcion Garces, Dayme Gonzalez, Marcos Lahuerta, Carmen Aguado, Jose Luis Garcia-Gimenez, Pascual Sanz, Federico V. V. Pallardo
Summary: Lafora disease is a rare, fatal form of progressive myoclonus epilepsy characterized by intracellular accumulation of abnormal polyglucosan granules. Experimental mouse models deficient in laforin or malin proteins provide evidence of molecular and cellular alterations in neural tissue. Overexpression of miR-155 and miR-146a in an age-dependent manner and altered gene expression in brain extracts indicate their potential role as biomarkers for disease progression in LD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Irene Canovas-Cervera, Elena Nacher-Sendra, Rebeca Osca-Verdegal, Enric Dolz-Andres, Jesus Beltran-Garcia, Maria Rodriguez-Gimillo, Carolina Ferrando-Sanchez, Nieves Carbonell, Jose Luis Garcia-Gimenez
Summary: Disseminated Intravascular Coagulation (DIC) is a type of tissue and organ dysregulation in sepsis, with underlying molecular mechanisms that are not fully understood. Current biomarkers for DIC provide poor diagnosis and prognosis, thus non-coding RNAs are studied as potential biomarkers. This review focuses on the relationship between non-coding RNAs and DIC, particularly the PI3K/AKT/mTOR axis, and identifies several ncRNAs involved in its regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Daniel Perez-Cremades, Carlos Bueno-Beti, Jose Luis Garcia-Gimenez, Jose Santiago Ibanez-Cabellos, Federico Pallardo, Carlos Hermenegildo, Susana Novella
Summary: This study reveals that extracellular histones can increase endothelial cell activation by increasing cytosolic reactive oxygen species production and triggering the overexpression of cell adhesion molecules. The study also identifies cyclooxygenase and NADPH oxidase as sources of reactive oxygen species production. These findings enhance our understanding of how extracellular histones contribute to systemic inflammatory responses in diseases.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Oncology
Wiam Saadi, Ahlam Fatmi, Federico Pallardo, Jose Luis Garcia-Gimenez, Salvador Mena-Molla
Summary: Many non-coding RNAs play a role in cancer by controlling immune regulatory proteins, enabling tumor cells to evade the immune response. Understanding the mechanisms of these RNAs is crucial for developing therapeutic strategies and improving cancer immunotherapy. The focus of this review is to describe the role of long non-coding RNAs (lncRNAs) and their targets in regulating immune checkpoints.
Article
Medicine, Research & Experimental
Jose Luis Garcia-Gimenez, Eva Garcia-Lopez, Salvador Mena-Molla, Jesus Beltran-Garcia, Rebeca Osca-Verdegal, Elena Nacher-Sendra, Carmen Aguado-Velasco, German Casabo-Valles, Carlos Roma-Mateo, Maria Rodriguez-Gimillo, Oreto Antunez, Jose Ferreres, Federico V. Pallardo, Nieves Carbonell
Summary: This study validates a quantitative mass spectrometry method to measure circulating histone levels in plasma samples for the diagnosis and prognosis of sepsis and septic shock patients. In an extended laboratory testing, it was found that circulating histone levels are associated with the severity of patient conditions and can predict fatal outcomes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Jose Santiago Ibanez-Cabellos, Federico V. Pallardo, Jose Luis Garcia-Gimenez, Marta Seco-Cervera
Summary: Autoimmune diseases (ADs) such as Sjogren's syndrome, Kawasaki disease, and systemic sclerosis are characterized by chronic inflammation, oxidative stress, and autoantibodies, which cause joint tissue damage, vascular injury, fibrosis, and debilitation. Epigenetics participate in immune cell proliferation and differentiation, which regulates the development and function of the immune system, and ultimately interacts with other tissues. This review aims to shed light on the key mechanisms of ADs by exploring the complex regulation of ROS/miRNA/inflammation axis and highlighting the importance of redox-sensitive miRNAs and inflamma-miRs in personalized medicine for these diseases.
Review
Clinical Neurology
Martha Cecilia Pineros-Fernandez, Beatriz Morte, Jose Luis Garcia-Gimenez
Summary: Whole exome sequencing (WES) plays an important role in the diagnosis of pediatric-onset neuromuscular diseases (NMD), helping to determine genetic diagnosis and treatment selection, especially in cases where other technologies have failed or in complex situations.
NEUROLOGICAL SCIENCES
(2023)