Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

(2020) Jarred M Griffin et al.   EMBO Molecular Medicine

SorCS2 facilitates release of endostatin from astrocytes and controls post‐stroke angiogenesis

(2020) Anna R. Malik et al.   GLIA

Astroglial TLR9 antagonism promotes chemotaxis and alternative activation of macrophages via modulation of astrocyte-derived signals: implications for spinal cord injury

(2020) Lun Li et al.   Journal of Neuroinflammation

Novel Direct Conversion of Microglia to Neurons

(2019) Dorit Trudler et al.   TRENDS IN MOLECULAR MEDICINE

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

(2019) Victor Bellver-Landete et al.   Nature Communications

Conditional ablation of reactive astrocytes to dissect their roles in spinal cord injury and repair

(2019) Yakun Gu et al.   BRAIN BEHAVIOR AND IMMUNITY

Macrophage migration inhibitory factor facilitates prostaglandin E2 production of astrocytes to tune inflammatory milieu following spinal cord injury

(2019) Yuxin Zhang et al.   Journal of Neuroinflammation

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

(2019) Kazu Kobayakawa et al.   Science Advances

TGF-β Secretion by M2 Macrophages Induces Glial Scar Formation by Activating Astrocytes In Vitro

(2019) Gongyu Song et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Spinal cord repair: advances in biology and technology

(2019) Grégoire Courtine et al.   NATURE MEDICINE

Blocking Notch signal pathway suppresses the activation of neurotoxic A1 astrocytes after spinal cord injury

(2019) Dingfei Qian et al.   CELL CYCLE

Questions and (some) answers on reactive astrocytes

(2019) Carole Escartin et al.   GLIA

Epac2 elevation reverses inhibition by chondroitin sulfate proteoglycans in vitro and transforms post-lesion inhibitory environment to promote axonal outgrowth in an ex vivo model of spinal cord injury

(2019) Alba Guijarro-Belmar et al.   JOURNAL OF NEUROSCIENCE

Moving beyond the glial scar for spinal cord repair

(2019) Elizabeth J. Bradbury et al.   Nature Communications

Polarization of Reactive Astrocytes in Response to Spinal Cord Injury is Enhanced by M2 Macrophage–Mediated Activation of Wnt/β-Catenin Pathway

(2019) Iki Sonn et al.   MOLECULAR NEUROBIOLOGY

In vivo conversion of rat astrocytes into neuronal cells through neural stem cells in injured spinal cord with a single zinc-finger transcription factor

(2019) Masoumeh Zarei-Kheirabadi et al.   Stem Cell Research & Therapy

Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury

(2018) Hilary Z Hu et al.   BRAIN

OUP accepted manuscript

(2018)   BRAIN

Comparison of subacute and chronic scar tissues after complete spinal cord transection

(2018) Xing Li et al.   EXPERIMENTAL NEUROLOGY

Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury

(2018) Scott Dyck et al.   Journal of Neuroinflammation

Safety and Efficacy of Rose Bengal Derivatives for Glial Scar Ablation in Chronic Spinal Cord Injury

(2018) Nandadevi Patil et al.   JOURNAL OF NEUROTRAUMA

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Fibronectin EDA forms the chronic fibrotic scar after contusive spinal cord injury

(2018) John G. Cooper et al.   NEUROBIOLOGY OF DISEASE

The Extracellular Environment of the CNS: Influence on Plasticity, Sprouting, and Axonal Regeneration after Spinal Cord Injury

(2018) Shmma Quraishe et al.   NEURAL PLASTICITY

Macrophage migration inhibitory factor facilitates production of CCL5 in astrocytes following rat spinal cord injury

(2018) Yue Zhou et al.   Journal of Neuroinflammation

Required growth facilitators propel axon regeneration across complete spinal cord injury

(2018) Mark A. Anderson et al.   NATURE

Combination of biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration after spinal cord injury

(2018) Bin Yu et al.   Frontiers of Medicine

LAR and PTPσ receptors are negative regulators of oligodendrogenesis and oligodendrocyte integrity in spinal cord injury

(2018) Scott Dyck et al.   GLIA

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Spencer L James et al.   LANCET NEUROLOGY

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

(2018) Gang Chen et al.   NEURON

Rapid and robust restoration of breathing long after spinal cord injury

(2018) Philippa M. Warren et al.   Nature Communications

Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury

(2018) Andrew D. Greenhalgh et al.   PLOS BIOLOGY

Proliferating NG2-Cell-Dependent Angiogenesis and Scar Formation Alter Axon Growth and Functional Recovery After Spinal Cord Injury in Mice

(2017) Zoe C. Hesp et al.   JOURNAL OF NEUROSCIENCE

Collagen scaffold combined with human umbilical cord-derived mesenchymal stem cells promote functional recovery after scar resection in rats with chronic spinal cord injury

(2017) Nuo Wang et al.   Journal of Tissue Engineering and Regenerative Medicine

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after spinal cord injury

(2017) Masamitsu Hara et al.   NATURE MEDICINE

The diversity and disparity of the glial scar

(2017) Katrina L. Adams et al.   NATURE NEUROSCIENCE

Extracellular matrix components as therapeutics for spinal cord injury

(2017) Agnes E. Haggerty et al.   NEUROSCIENCE LETTERS

Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury

(2017) Yilong Ren et al.   Scientific Reports

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y 1 Receptor Downregulation

(2017) Youichi Shinozaki et al.   Cell Reports

Neural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury

(2017) Hidenori Suzuki et al.   PLoS One

The reactions and role of NG2 glia in spinal cord injury

(2016) Joel Levine   BRAIN RESEARCH

Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury

(2016) Hong Fan et al.   Molecular Neurodegeneration

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury

(2016) Amber R. Hackett et al.   NEUROBIOLOGY OF DISEASE

The complex STATes of astrocyte reactivity: How are they controlled by the JAK–STAT3 pathway?

(2016) Kelly Ceyzériat et al.   NEUROSCIENCE

Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish

(2016) M. H. Mokalled et al.   SCIENCE

High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury

(2016) Athanasios Didangelos et al.   Scientific Reports

Understanding the NG2 Glial Scar after Spinal Cord Injury

(2016) Amber R. Hackett et al.   Frontiers in Neurology

Crosstalk between macrophages and astrocytes affects proliferation, reactive phenotype and inflammatory response, suggesting a role during reactive gliosis following spinal cord injury

(2015) Niels Haan et al.   Journal of Neuroinflammation

Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord Injury

(2015) K. Du et al.   JOURNAL OF NEUROSCIENCE

Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission

(2015) Ciaran Murphy-Royal et al.   NATURE NEUROSCIENCE

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Peripheral Nerve Transplantation Combined with Acidic Fibroblast Growth Factor and Chondroitinase Induces Regeneration and Improves Urinary Function in Complete Spinal Cord Transected Adult Mice

(2015) Marc A. DePaul et al.   PLoS One

Nogo limits neural plasticity and recovery from injury

(2014) Martin E Schwab et al.   CURRENT OPINION IN NEUROBIOLOGY

Contributions of chondroitin sulfate proteoglycans to neurodevelopment, injury, and cancer

(2014) Daniel J Silver et al.   CURRENT OPINION IN NEUROBIOLOGY

Extracellular matrix regulation of inflammation in the healthy and injured spinal cord

(2014) Andrew D. Gaudet et al.   EXPERIMENTAL NEUROLOGY

High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury

(2014) Teresa A. Evans et al.   EXPERIMENTAL NEUROLOGY

Abrogation of  -Catenin Signaling in Oligodendrocyte Precursor Cells Reduces Glial Scarring and Promotes Axon Regeneration after CNS Injury

(2014) J. P. Rodriguez et al.   JOURNAL OF NEUROSCIENCE

Astroglial-Derived Periostin Promotes Axonal Regeneration after Spinal Cord Injury

(2014) C.-H. Shih et al.   JOURNAL OF NEUROSCIENCE

Entrapment via Synaptic-Like Connections between NG2 Proteoglycan+ Cells and Dystrophic Axons in the Lesion Plays a Role in Regeneration Failure after Spinal Cord Injury

(2014) Angela R. Filous et al.   JOURNAL OF NEUROSCIENCE

Differences in the Phagocytic Response of Microglia and Peripheral Macrophages after Spinal Cord Injury and Its Effects on Cell Death

(2014) A. D. Greenhalgh et al.   JOURNAL OF NEUROSCIENCE

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

(2014) Bradley T. Lang et al.   NATURE

Early Activation of STAT3 Regulates Reactive Astrogliosis Induced by Diverse Forms of Neurotoxicity

(2014) James P. O'Callaghan et al.   PLoS One

In vivo conversion of astrocytes to neurons in the injured adult spinal cord

(2014) Zhida Su et al.   Nature Communications

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices

(2013) Takahiro Takano et al.   GLIA

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Neutralization of Inhibitory Molecule NG2 Improves Synaptic Transmission, Retrograde Transport, and Locomotor Function after Spinal Cord Injury in Adult Rats

(2013) H. A. Petrosyan et al.   JOURNAL OF NEUROSCIENCE

Short Hairpin RNA against PTEN Enhances Regenerative Growth of Corticospinal Tract Axons after Spinal Cord Injury

(2013) K. Zukor et al.   JOURNAL OF NEUROSCIENCE

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury

(2013) Kosei Takeuchi et al.   Nature Communications

Astrocyte signaling controls spike timing–dependent depression at neocortical synapses

(2012) Rogier Min et al.   NATURE NEUROSCIENCE

Eph receptors and ephrins in neuron-astrocyte communication at synapses

(2011) Keith K. Murai et al.   GLIA

Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord

(2011) Karolina Kucharova et al.   Journal of Neuroinflammation

Astrocytes from the Contused Spinal Cord Inhibit Oligodendrocyte Differentiation of Adult Oligodendrocyte Precursor Cells by Increasing the Expression of Bone Morphogenetic Proteins

(2011) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Functional regeneration of respiratory pathways after spinal cord injury

(2011) Warren J. Alilain et al.   NATURE

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Emerging Concepts in Myeloid Cell Biology after Spinal Cord Injury

(2011) Alicia L. Hawthorne et al.   Neurotherapeutics

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

(2011) F. Hellal et al.   SCIENCE

Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment

(2010) Kevin D. Beck et al.   BRAIN

Angiotensin II Type 1 receptor (AT1) signaling in astrocytes regulates synaptic degeneration-induced leukocyte entry to the central nervous system

(2010) L. Füchtbauer et al.   BRAIN BEHAVIOR AND IMMUNITY

BMPR1a and BMPR1b Signaling Exert Opposing Effects on Gliosis after Spinal Cord Injury

(2010) V. Sahni et al.   JOURNAL OF NEUROSCIENCE

Cellular Strategies of Axonal Pathfinding

(2010) J. Raper et al.   Cold Spring Harbor Perspectives in Biology

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN

Transgenic inhibition of astroglial NF-κB leads to increased axonal sparing and sprouting following spinal cord injury

(2009) Roberta Brambilla et al.   JOURNAL OF NEUROCHEMISTRY

Postinjury Niches Induce Temporal Shifts in Progenitor Fates to Direct Lesion Repair after Spinal Cord Injury

(2009) D. L. Sellers et al.   JOURNAL OF NEUROSCIENCE

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

(2009) Jennifer Bradford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE