期刊
FRONTIERS IN CELLULAR NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2020.00107
关键词
in vivo reprogramming; adult neurogenesis; traumatic brain injury (TBI); spinal cord injury (SCI); retinopathy; Alzheimer's diseases (AD); Parkinson's disease (PD)
资金
- Welch Foundation [I-1724]
- Decherd Foundation
- Pape Adams Foundation
- Kent Waldrep Foundation Center for Basic Research on Nerve Growth and Regeneration
- NIH [NS099073, NS092616, NS088095, NS093502, 1R01 100531, 1R01 NS103481]
- U.S. Department of Veterans Affairs [I01 BX002356, I01 BX003705, I01 RX002687]
The adult mammalian central nervous system (CNS) has very limited regenerative capacity upon neural injuries or under degenerative conditions. In recent years, however, significant progress has been made on in vivo cell fate reprogramming for neural regeneration. Resident glial cells can be reprogrammed into neuronal progenitors and mature neurons in the CNS of adult mammals. In this review article, we briefly summarize the current knowledge on innate adult neurogenesis under pathological conditions and then focus on induced neurogenesis through cell fate reprogramming. We discuss how the reprogramming process can be regulated and raise critical issues requiring careful considerations to move the field forward. With emerging evidence, we envision that fate reprogramming-based regenerative medicine will have a great potential for treating neurological conditions such as brain injury, spinal cord injury (SCI), Alzheimer's disease (AD), Parkinson's disease (PD), and retinopathy.
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