期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 27, 页码 9125-9129出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201601430
关键词
alkynylbenzylaldehyde; bridgehead; diene; gold; polycycles
资金
- NSFC [21402106, 21475075, 21475074]
- Shandong Natural Science Foundation [ZR2014BQ024, ZR2013BM007]
- SRF for ROCS, SEM
- Shandong Higher Educational Science and Technology Program [J15LA02]
- Research Start-up Foundation of Qufu Normal University [bsqd20130115]
An unprecedented access to strained tetracyclic bridgehead alkenes by reaction of easily accessible ortho-alkynylarylaldehydes with conjugated dienes is described. The process involves a chemo-and stereo-selective, gold-catalyzed, tandem intermolecular [3+2] cycloaddition/Prins-type ring-closing reaction that allows generating structural complexity in a straightforward manner. This approach for the preparation of anti-Bredt compounds is synthetically superior to those previously reported: the procedure is easy to implement, operates under mild experimental conditions, is efficient, and exhibits a good substrate scope.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据