Review
Engineering, Chemical
Prima F. Hillman, Chaeyoung Lee, Sang-Jip Nam
Summary: Wound healing is challenging in clinical settings and requires proper management. Acute wound healing involves cell divisions, formation of extracellular matrix, and the release of growth factors and cytokines. Factors like infection and inflammation can delay healing, and natural products have shown potential in promoting wound healing. This review discusses the research on wound healing activities of natural microbial products, aiming to contribute to the development of better wound treatments.
Article
Biophysics
Victoria L. Abdo, Lina J. Suarez, Lucca Gomes de Paula, Raphael C. Costa, Jamil Shibli, Magda Feres, Valentim A. R. Bara, Martinna Bertolini, Joao Gabriel Silva Souza
Summary: This study investigates the issue of microbial contamination of resorbable membranes, finding that different types of bacteria colonize the exposed membrane surface, thereby affecting the effectiveness of bone regeneration therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Medicine, Research & Experimental
Aaron P. Decker, Yajuan Su, Biswajit Mishra, Atul Verma, Tamara Lushnikova, Jingwei Xie, Guangshun Wang
Summary: This study investigates the effects of peptide stability on antimicrobial and antibiofilm activity and finds that peptide antimicrobial activity is critical for in vivo efficacy. Using a nanofiber/microneedle delivery device can protect peptides from degradation and provide a new approach for direct use of natural peptides or their cocktails for antimicrobial treatment.
MOLECULAR PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Adrian Miron, Calin Giurcaneanu, Mara Madalina Mihai, Cristina Beiu, Vlad Mihai Voiculescu, Marius Nicolae Popescu, Elena Soare, Liliana Gabriela Popa
Summary: Chronic wounds, such as venous and arterial leg ulcers, diabetic foot ulcers, and pressure ulcers, have common molecular features. Chronic wound infections with biofilms are difficult to manage due to antimicrobial resistance and the complex interaction between pathogens and the host. An ideal wound dressing should have multiple functions, including moisture maintenance, bacterial protection, and cost-efficiency. Antimicrobial biomaterials may provide an alternative to systemic treatment for chronic wound infections.
Article
Microbiology
Allison Campolo, Paul Shannon, Monica Crary
Summary: Acanthamoeba keratitis is a serious ocular infection caused by a ubiquitous amoeba, often resulting in corneal damage and blindness. Testing the antimicrobial efficacy of contact lens care products is crucial in treating this infection, with propidium iodide staining shown to be an effective and rapid tool for evaluating the effectiveness of these products against Acanthamoeba trophozoites.
Article
Microbiology
Zahra Farshadzadeh, Maryam Pourhajibagher, Behrouz Taheri, Alireza Ekrami, Mohammad Hossein Modarressi, Masoud Azimzadeh, Abbas Bahador
Summary: The study showed that DCD-1L can effectively inhibit adhesion and biofilm formation of Acinetobacter baumannii, reducing the likelihood of infection. DCD-1L also accelerates the process of re-epithelialization of wounds, making it a promising candidate for antimicrobial and anti-biofilm drug development.
Article
Food Science & Technology
Dinesh Kumar Bhardwaj, Neetu Kumra Taneja, D. P. Shivaprasad, Ankita Chakotiya, Praveen Patel, Pankaj Taneja, Divya Sachdev, Sarita Gupta, Madhusudana Girija Sanal
Summary: This study identified multi-drug resistant, biofilm-forming pathogenic E. coli in Indian dairy and meat products, which may serve as potential reservoirs for transmission of antimicrobial resistant genes and pose a serious food safety threat.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Review
Engineering, Biomedical
Archita Sharma, Dhavan Sharma, Feng Zhao
Summary: Impaired wound healing after trauma, disorders, and surgeries is a major challenge in chronic wound management. Novel adjuvant therapies, including topical agents, skin substitutes, growth factor delivery, and stem cell therapies, are being explored to overcome delayed wound healing. However, a comprehensive review summarizing the clinical outcomes of these therapies is lacking. This study aims to provide a statistically comprehensive understanding of the commercially available wound care products and their performance in clinical trials for chronic wounds, which will guide the development of next-generation technologies for wound management.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Joelle Saulnier, Catherine Jose, Florence Lagarde
Summary: This review provides an overview of the currently available electrochemical techniques, particularly impedimetric and voltamperometric methods, highlighting their recent advances in antibiotic susceptibility testing and microbial biofilm monitoring.
BIOELECTROCHEMISTRY
(2024)
Article
Chemistry, Physical
Ayesha Nawaz, Sher Zaman Safi, Shomaila Sikandar, Rabia Zeeshan, Saima Zulfiqar, Nadia Mehmood, Hussah M. Alobaid, Fozia Rehman, Muhammad Imran, Muhammad Tariq, Abid Ali, Talha Bin Emran, Muhammad Yar
Summary: In this study, heparin-loaded alginate wound dressings were used to enhance angiogenic potential and analyze antibacterial activity, biocompatibility, and other properties. The researchers found that heparin exhibited antibacterial activity, was not cytotoxic, and promoted angiogenesis through the VEGF pathway.
Review
Infectious Diseases
Isabel Pinto, Manuel Simoes, Ines B. Gomes
Summary: Pharmaceuticals as pollutants in ecosystems have raised global concern due to their negative impact on natural biota, despite lower detected concentrations. It is important to understand their effects on environmental native microbiota, as microbial communities can be seriously affected. Antibiotics have been studied in more detail among this class of pollutants.
Article
Engineering, Environmental
Nadia A. Samak, Mohamed S. Selim, Zhifeng Hao, Jianmin Xing
Summary: In this study, cyclic dodecapeptides rich in Arg-Trp were synthesized and immobilized on an RGO/MnO2 nanocomposite, showing excellent antimicrobial activity and ability to degrade biofilms.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Srinivas Sulugodu Ramachandra, Fekade Bruck Sime, Saiyuri Naicker, Pingping Han, Ryan S. B. Lee, Steven Wallis, Jason A. Roberts, Saso Ivanovski
Summary: This study investigated the antimicrobial effect of amoxicillin on polymicrobial microcosm biofilms derived from subgingival plaque using an in vitro dynamic bioreactor model. The results showed that amoxicillin had a significant antimicrobial effect on the biofilms and could reduce/eliminate certain bacteria.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Materials Science, Biomaterials
Jingyi Chen, Qian Jing, Yuanjie Xu, Yuxin Lin, Yuhan Mai, Liyun Chen, Guodong Wang, Zheng Chen, Lina Deng, Jincan Chen, Cai Yuan, Longguang Jiang, Peng Xu, Mingdong Huang
Summary: In this study, ZnO microparticles loaded with phthalocyanine-type photosensitizers were developed to exhibit long-term while moderate antimicrobial effects by continuously releasing Zn2+ ions, and the antimicrobial efficacies were remarkably enhanced by triggering the photodynamic effects. In a dorsal wound infection mouse model, treatment with these ZnO microparticles significantly accelerated wound recovery rates by promoting tissue remodeling and efficiently eliminating pathogens, without causing noticeable toxicity.
BIOMATERIALS ADVANCES
(2022)
Article
Microbiology
Maryam Pourhajibagher, Babak Pourakbari, Abbas Bahador
Summary: The study demonstrated that CurNisNp-mediated aPSDT may be a promising complementary approach to treat burn wound infections by reducing biofilm growth and promoting wound healing.