期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 29, 页码 9886-9900出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503543
关键词
aptamers; biosensors; nanotheranostics; nucleic acids; SELEX; targeting
资金
- National Science Foundation of China [21325522, 21205100, 21275122]
- National Basic Research Program of China [2013CB933703]
- National Instrumentation Program [2011YQ03012412]
Nucleic acid aptamers are short synthetic DNA or RNA sequences that can bind to a wide range of targets with high affinity and specificity. In recent years, aptamers have attracted increasing research interest due to their unique features of high binding affinity and specificity, small size, excellent chemical stability, easy chemical synthesis, facile modification, and minimal immunogenicity. These properties make aptamers ideal recognition ligands for bioanalysis, disease diagnosis, and cancer therapy. This review highlights the recent progress in aptamer selection and the latest applications of aptamer-based functional probes in the fields of bioanalysis and biomedicine.
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