Article
Parasitology
J. Thannesberger, N. Rascovan, A. Eisenmann, I Klymiuk, C. Zittra, H. P. Fuehrer, T. Scantlebury-Manning, M. Gittens-St Hilaire, S. Austin, R. C. Landis, C. Steininger
Summary: The study investigated local vector biology and characterized metagenomic arbovirus diversity in Aedes mosquitoes during the ongoing 2015/2016 ZIKV epidemic. Aedes aegypti appeared to be the likely vector of ZIKV, with the detection of two different ZIKV genotypes, including a novel one, through arbovirus sequence enrichment of metagenomic DNA preparations. The new approach presented in this study may be useful for identifying epidemic-causing arboviruses and collecting phylogenetic information on their source.
PARASITES & VECTORS
(2021)
Article
Parasitology
Maria C. Carrasquilla, Mario I. Ortiz, Cielo Leon, Silvia Rondon, Manisha A. Kulkarni, Benoit Talbot, Beate Sander, Heriberto Vasquez, Juan M. Cordovez, Camila Gonzalez
Summary: A study conducted in Ibague, Colombia found that Aedes aegypti and Aedes albopictus mosquitoes are vectors for dengue, Zika, and chikungunya viruses, with dengue and chikungunya circulating in the area but Zika virus remaining undetected. The research results showed that mosquitoes were mainly found in low socioeconomic areas and indoors, with a higher number of female mosquitoes that have fed on human blood, indicating a high risk of arbovirus transmission in Ibague.
PARASITES & VECTORS
(2021)
Article
Pharmacology & Pharmacy
Lanjiao Wang, Aboubakar Sanon, Zakiyatul Khoiriyah, Sam Verwimp, Rana Abdelnabi, Leen Delang
Summary: The antimalarial drug atovaquone has been found to inhibit the replication of chikungunya virus (CHIKV) and Zika virus (ZIKV) in vitro. It can also block the transmission of Plasmodium parasite by mosquitoes when the mosquitoes are exposed to low concentrations of atovaquone on treated surfaces. This study evaluated the antiviral effects of atovaquone via tarsal exposure in Aedes aegypti mosquitoes, and found that atovaquone exerted a dose-dependent antiviral effect on CHIKV and ZIKV replication in mosquito-derived cells.
ANTIVIRAL RESEARCH
(2023)
Article
Microbiology
Cassandra Koh, Annabelle Henrion-Lacritick, Lionel Frangeul, Maria-Carla Saleh
Summary: Palm Creek virus can interfere with mosquito-borne flavivirus replication in Culex mosquitoes, but does not have an effect on the transmission of Zika and chikungunya viruses in Aedes mosquitoes. Additionally, the interference mechanism is unlikely to be through RNA interference.
Article
Immunology
Brian Custer, Eduard Grebe, Renata Buccheri, Sonia Bakkour, Mars Stone, Ligia Capuani, Cecilia Alencar, Luiz Amorim, Paula Loureiro, Anna Barbara Carneiro-Proietti, Alfredo Mendrone-Junior, Thelma Goncalez, Kui Gao, Kristin W. Livezey, Jeffrey M. Linnen, Don Brambilla, Chris McClure, Michael P. Busch, Ester C. Sabino
Summary: Testing blood donations for arboviruses in Brazil can contribute to public health, as the study found that transfusion recipients were likely exposed to Zika virus, chikungunya virus, and dengue virus viremic blood components during the study period.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Microbiology
Awadalkareem Adam, Christian Jassoy
Summary: Arbovirus infections are prevalent in Africa due to the lack of established epidemiological surveillance systems and accurate differential diagnosis. Studies indicate these infections are endemic in most African countries, highlighting the need for improved monitoring to enhance diagnostic accuracy. Healthcare providers should be informed about prevalent arboviral diseases to better identify and manage possible cases.
Article
Immunology
Thiago H. J. F. Leite, Alvaro G. A. Ferreira, Jean-Luc Imler, Joao T. Marques
Summary: Hemocytes play a dual role in controlling viral infections in Aedes aegypti mosquitoes, with phagocytosis not required in the midgut but essential to restrict systemic dissemination of dengue and Zika viruses. Understanding this mechanism could help in designing strategies to prevent the transmission of arboviruses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Parasitology
Silvia Tortosa-La Osa, Eva Martin-Ruiz, Angela Galan-Relano, Antonio Olry de Labry-Lima
Summary: This systematic review evaluates the effectiveness of environmental interventions for the prevention and reduction of vector-borne diseases such as dengue, Zika, and chikungunya. The findings suggest that interventions such as eliminating small containers, manipulating large tanks, and cleaning outdoor spaces can significantly reduce pupae indices, with easy implementation and low resource requirements. However, the evidence on whether reducing mosquito abundance leads to a reduction in disease transmission risk is limited. It is recommended to consider epidemiological, environmental, and sociodemographic factors in addition to entomological indicators.
Article
Public, Environmental & Occupational Health
Cristiane Cunha Frota, Francisco Gustavo Silveira Correia, Lucas Romao Alves Vasconcelos, Paulo Rafael Cardoso de Sousa, Marco Levi da Silva Ferreira, Susy Pereira Saraiva, Rafael Mota Ferreira, Kalil Andrade Mubarac Romcy, Ronald Feitosa Pinheiro, Roberta Taiane Germano de Oliveira, Francisco Marto Leal Pinheiro Junior, Adriano Ferreira Martins, Carlos Sanhueza-Sanzana, Rosa Livia Freitas de Almeida, Carl Kendall, Ivo Castelo Branco Coelho, Roberto da Justa Pires Neto, Italo Wesley Oliveira Aguiar, Ligia Regina Franco Sansigolo Kerr
Summary: In Fortaleza, Brazil, there was simultaneous circulation and co-infection of Zika virus (ZIKV), dengue virus (DENV), and chikungunya virus (CHIKV) in women after a Zika epidemic. Socioeconomic and environmental factors associated with arbovirus positivity included low socioeconomic class and the presence of a water box sealing in the household.
PATHOGENS AND GLOBAL HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Ayman Ahmed, Mustafa Abubakr, Hamza Sami, Isam Mahdi, Nouh S. Mohamed, Jakob Zinsstag
Summary: This study investigated the mosquito species in four Sudanese states and found an invasive vector mosquito, Aedes albopictus, originating from Southeast Asia. Its presence was associated with an increase in outbreaks of chikungunya and dengue, posing a serious threat to public health. The study highlights the need for enhanced vector surveillance and control systems and the implementation of the One Health strategy for the prevention and control of future pandemics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Zhuanzhuan Liu, Qingxin Zhang, Liya Li, Junjie He, Jinyang Guo, Zichen Wang, Yige Huang, Zimeng Xi, Fei Yuan, Yiji Li, Tingting Li
Summary: This review explores the correlations between temperature and dengue epidemics, including the distribution and development of Aedes mosquitoes, the structure of DENV, and the vector competence of Aedes mosquitoes. Additionally, it discusses the immune and metabolic mechanism through which temperature affects the vector competence of Aedes mosquitoes to transmit DENV.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Virology
Rachel Milomba Velu, Geoffrey Kwenda, Samuel Bosomprah, Moses Ngongo Chisola, Michelo Simunyandi, Caroline Cleopatra Chisenga, Flavien Nsoni Bumbangi, Nicholus Chintu Sande, Limonty Simubali, Monicah Mirai Mburu, John Tembo, Matthew Bates, Martin Chitolongo Simuunza, Roma Chilengi, Yasuko Orba, Hirofumi Sawa, Edgar Simulundu
Summary: This study aims to predict and evaluate the potential risk areas for West Nile Virus (WNV) and Chikungunya Virus (CHIKV) transmission in Zambia based on climate and mosquito species data. The findings identified Lake Kariba, the Kafue River, and the Luangwa Rivers, as well as the Mumbwa, Chibombo, Kapiri Mposhi, and Mpika districts as suitable habitats for the mosquito species that can transmit the viruses. Rainfall and temperature extremes were identified as the most influential variables in the predictive models.
Article
Infectious Diseases
Ana Paula Razal Dalvi, Gerusa Gibson, Alberto Novaes Ramos Jr, Katia V. Bloch, Geziel dos Santos de Sousa, Thiago Luiz Nogueira da Silva, Jose Ueleres Braga, Marcia C. Castro, Guilherme Loureiro Werneck
Summary: This study aimed to identify sociodemographic and environmental risk factors for the occurrence of Zika, dengue, and chikungunya in adolescents. The study found that adolescents with better socioeconomic conditions had a lower risk of infection. Additionally, a higher risk of arboviral diseases was associated with a high mosquito infestation index in the school's region. These findings can contribute to the implementation of control measures in population groups and priority locations.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Entomology
Teng-Fei Zhou, Ze-Tian Lai, Shuang Liu, Jia-Yong Zhou, Yang Liu, Yang Wu, Ye Xu, Kun Wu, Jin-Bao Gu, Gong Cheng, Xiao-Guang Chen
Summary: The study found that PRVABC59 had higher susceptibility to Aedes spp. mosquitoes than FSS13025, and Ae. aegypti was more susceptible to Zika virus than Ae. albopictus. Specific differential expression profiles correlated with Ae. aegypti and Ae. albopictus during PRVABC59 infection, and susceptibility was significantly affected when three targeted genes were successfully knocked down.
Article
Immunology
Juliana Santana de Curcio, Silvia Maria Salem-Izacc, Luiz Moreira Pereira Neto, Eliane Blanco Nunes, Carlos Eduardo Anunciacao, Elisangela de Paula Silveira-Lacerda
Summary: This study aimed to identify the presence of Mayaro virus (MAYV) in Aedes aegypti mosquitoes in Goiania, Brazil. The findings suggest the potential for vertical transmission of MAYV in this vector.
MICROBES AND INFECTION
(2022)
Article
Pharmacology & Pharmacy
Matthew M. Loiacono, Christopher B. Nelson, Paul Grootendorst, Matthew D. Webb, Laura Lee Hall, Jeffrey C. Kwong, Nicholas Mitsakakis, Stacy Zulueta, Ayman Chit
Summary: The study showed that implementing behavioral peer comparisons (PC) interventions in community pharmacies can increase SIV uptake, especially among large-format pharmacies, with historically low-performing pharmacies showing the greatest impact.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2021)
Article
Medicine, General & Internal
Salome Samant, Tanaz Petigara, Jyoti Aggarwal, Monica Mercer, Christopher B. Nelson, Evangelos Zormpas, Avril Melissa Houston, Ana Pena-Molina, Gary S. Marshall
Summary: This study investigated physician preferences for various attributes of pediatric combination vaccines. The results showed that physicians in the US prefer combination vaccines that reduce the number of injections, improve completion and timeliness rates, and have been available for more than 1 year.
CURRENT MEDICAL RESEARCH AND OPINION
(2022)
Review
Immunology
Lauren C. Bylsma, Mina Suh, Naimisha Movva, Jon P. Fryzek, Christopher B. Nelson
Summary: A systematic literature review was conducted to summarize the mortality rates of US infants and children aged <5 years with respiratory syncytial virus (RSV) or all-cause bronchiolitis (ACB). The study found that the reported RSV mortality rates vary greatly and there is a need for nationally representative estimates for otherwise healthy, late-preterm to full-term infants and children.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Mina Suh, Naimisha Movva, Xiaohui Jiang, Lauren C. Bylsma, Heidi Reichert, Jon P. Fryzek, Christopher B. Nelson
Summary: This study demonstrates that acute bronchiolitis due to RSV is the leading cause of hospitalizations in US infants, especially during the winter months.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Mina Suh, Naimisha Movva, Xiaohui Jiang, Heidi Reichert, Lauren C. Bylsma, Jon P. Fryzek, Christopher B. Nelson
Summary: This study highlights the importance of ensuring access to RSV preventive measures for all infants and reveals the rates and trends of RSV hospitalizations and emergency department visits among infants with different insurance types.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Elizabeth L. Glaser, Dhwani Hariharan, Diana M. Bowser, Raissa M. Gervasio, Katharine R. Rowlands, Lauren Buckley, Christopher B. Nelson, Donald S. Shepard
Summary: This study systematically reviewed and analyzed the burden of illness from respiratory syncytial virus (RSV) among infants. The results indicated that RSV reduces the quality of life of children, caregivers, and families. However, the existing data mainly focus on hospitalized premature infants, and more research is needed for full-term healthy children.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Naimisha Movva, Mina Suh, Lauren C. Bylsma, Jon P. Fryzek, Christopher B. Nelson
Summary: This systematic literature review examines RSV testing patterns and finds that not all infants and children with LRTI are tested for RSV, leading to an underestimation of the RSV burden in all settings.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Mina Suh, Naimisha Movva, Lauren C. Bylsma, Jon P. Fryzek, Christopher B. Nelson
Summary: A systematic review of studies on respiratory syncytial virus (RSV) and bronchiolitis in US infants revealed substantial variability in the burden and healthcare utilization rates. Nationally representative studies are needed to understand the impact of RSV and healthcare utilization.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Erin N. Hodges, Meghan White, Christopher B. Nelson
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Jason R. Gantenberg, Robertus van Aalst, Nicole Zimmerman, Brendan Limone, Sandra S. Chaves, William V. La Via, Christopher B. Nelson, Christopher Rizzo, David A. Savitz, Andrew R. Zullo
Summary: RSV is a major cause of infant hospitalization in the United States. While preterm infants and those with specific comorbidities are at high risk, 80% of RSV infections occur in term infants without comorbidities. Future prevention efforts should target all infants.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Diana M. Bowser, Katharine R. Rowlands, Dhwani Hariharan, Raissa M. Gervasio, Lauren Buckley, Yara Halasa-Rappel, Elizabeth L. Glaser, Christopher B. Nelson, Donald S. Shepard
Summary: This study examines the economic costs of respiratory syncytial virus (RSV) infections among infants and young children in the United States. The findings suggest that public sources bear the majority of the medical costs associated with infants' RSV treatment, and full-term infants account for the majority of RSV hospitalizations and costs.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Gabriela B. Gomez, Christopher B. Nelson, Christopher Rizzo, Donald S. Shepard, Sandra S. Chaves
Summary: The target populations and financing mechanisms for a new health technology may affect health inequalities in access and impact. Using alternative reimbursement pathway scenarios, we projected the distributional consequences of introducing nirsevimab for prevention of respiratory syncytial virus. The vaccine pathway would cover 32% more infants than a pharmaceutical pathway and have greater benefits in reducing hospitalizations and emergency room visits, especially for publicly insured infants.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Dhwani Hariharan, V. S. Senthil Kumar, Elizabeth L. Glaser, William H. Crown, Zachary A. Wolf, Kimberley A. Fisher, Charles T. Wood, William F. Malcolm, Christopher B. Nelson, Donald S. Shepard
Summary: This study estimates the quality of life for healthy US infants with RSV-LRTI and their caregivers and corrects for selective testing. It found that the quality of life for RSV-LRTI patients was significantly lower, and this loss was also present in outpatient cases.
HEALTH SCIENCE REPORTS
(2023)
Article
Immunology
Christopher B. Nelson, Brenna L. Brady, Megan Richards, Carolyn R. Lew, William La Via, Michael Greenberg, Christopher Rizzo
Summary: The objective of this study was to assess the time from birth hospitalization discharge to the first outpatient visit (FOV) among US infants in order to determine optimal site of administration for the extended half-life antibody. The results found that Medicaid infants had a significantly lower completion rate of FOV compared to commercially insured infants. For US infants born during the RSV season, administration of extended half-life RSV antibodies in the newborn nursery prior to discharge would ensure optimal uptake and minimize access disparities.
Article
Immunology
Heidi Reichert, Mina Suh, Xiaohui Jiang, Naimisha Movva, Lauren C. Bylsma, Jon P. Fryzek, Christopher B. Nelson
Summary: This study describes the mortality rate of infants in the United States due to respiratory syncytial virus (RSV). The highest mortality rates were observed among infants with a gestational age of less than 29 weeks, American Indian/Alaskan Native infants, and Medicaid-insured infants. However, the burden of RSV mortality was greatest in full-term infants, white infants, and Medicaid-insured infants.
JOURNAL OF INFECTIOUS DISEASES
(2022)
